Date Added to Catalog PUBMEDID First Author Date Journal Link Study Disease/Trait Initial Sample Size Replication Sample Size Region Chr_id Chr_pos Reported Gene(s) Mapped_gene Upstream_gene_id Downstream_gene_id Snp_gene_ids Upstream_gene_distance Downstream_gene_distance Strongest SNP-Risk Allele SNPs Merged Snp_id_current Context Intergenic Risk Allele Frequency p-Value Pvalue_mlog p-Value (text) OR or beta 95% CI (text) Platform [SNPs passing QC] CNV 06/20/2013 23496005 Luca G 03/18/2013 J Sleep Res http://www.ncbi.nlm.nih.gov/pubmed/23496005 Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study. Narcolepsy with cataplexy 585 European ancestry cases 387 European ancestry cases 8q12.1 8 59324162 UBXN2B - 137886 rs2859998-? rs2859998 0 2859998 intron 0 NR 1E-7 7 (Age EDS onset) 4.41 [NR] unit decrease NR N 06/20/2013 23496005 Luca G 03/18/2013 J Sleep Res http://www.ncbi.nlm.nih.gov/pubmed/23496005 Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study. Narcolepsy with cataplexy 585 European ancestry cases 387 European ancestry cases 20q13.13 20 47379811 NR - 57580 rs2426087-? rs2426087 0 2426087 intron 0 NR 2E-6 5.698970004336018 (SE) 10.46 [NR] unit increase NR N 06/20/2013 23496005 Luca G 03/18/2013 J Sleep Res http://www.ncbi.nlm.nih.gov/pubmed/23496005 Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study. Narcolepsy with cataplexy 585 European ancestry cases 387 European ancestry cases 19q12 19 32158464 NR 57616 22847 318.27 678.05 rs16966122-? rs16966122 0 16966122 1 NR 2E-6 5.698970004336018 (ESS) 1.60 [NR] unit decrease NR N 06/20/2013 23496005 Luca G 03/18/2013 J Sleep Res http://www.ncbi.nlm.nih.gov/pubmed/23496005 Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study. Narcolepsy with cataplexy 585 European ancestry cases 387 European ancestry cases 12p13.33 12 3164923 TEAD4 7004 100271603 15.08 15.79 rs12425451-? rs12425451 0 12425451 1 NR 2E-7 6.698970004336019 (Age cataplexy onset) 6.79 [NR] unit decrease NR N 06/21/2013 23502781 Germain M 03/17/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23502781 Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension. Pulmonary arterial hypertension (without BMPR2 mutations) 340 European ancestry cases, 1,068 European ancestry controls 285 cases, 457 controls 18q22.3 18 70150939 CBLN2 342808 147381 2052.54 52.98 rs2217560-G rs2217560 0 2217560 1 0.069 7E-10 9.154901959985741 1.97 [1.59-2.45] Illumina [462,499] N 06/18/2013 23561647 van Setten J 03/13/2013 Atherosclerosis http://www.ncbi.nlm.nih.gov/pubmed/23561647 Genome-wide association study of coronary and aortic calcification implicates risk loci for coronary artery disease and myocardial infarction. Coronary artery calcification 2,620 European ancestry males 15q25.1 15 79089111 ADAMTS7 - 11173 rs3825807-A rs3825807 0 3825807 missense 0 0.57 7E-6 5.154901959985742 .36 [0.21-0.52] unit increase Illumina [2.5 Million] (Imputed) N 06/18/2013 23561647 van Setten J 03/13/2013 Atherosclerosis http://www.ncbi.nlm.nih.gov/pubmed/23561647 Genome-wide association study of coronary and aortic calcification implicates risk loci for coronary artery disease and myocardial infarction. Coronary artery calcification 2,620 European ancestry males 9p21.3 9 22084310 CDKN2A,CDKN2B - 100048912 rs1537370-T rs1537370 0 1537370 intron 0 0.46 2E-11 10.69897000433602 .53 [0.38-0.69] unit increase Illumina [2.5 Million] (Imputed) N 06/18/2013 23536807 Scheetz TE 03/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23536807 A genome-wide association study for primary open angle glaucoma and macular degeneration reveals novel Loci. Age-related macular degeneration 200 NR cases, 197 NR controls 200 NR cases, 200 NR controls NR PLEKHA1, ARMS2, HTRA1 - SNP_A-1841655-? SNP_A-1841655 0.20 1E-16 3.14 [2.49-3.97] Affymetrix [500,000] N 06/18/2013 23536807 Scheetz TE 03/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23536807 A genome-wide association study for primary open angle glaucoma and macular degeneration reveals novel Loci. Age-related macular degeneration 200 NR cases, 197 NR controls 200 NR cases, 200 NR controls NR KCNT2, CFH, CFHR3, CFHR1P, CFHR4, CFHR2, CFHR5, F13B, ASPM, ZBTB41 - SNP_A-2171106-? SNP_A-2171106 0.39 1E-16 3.75 [2.91-4.82] Affymetrix [500,000] N 06/16/2013 23474815 Stambolian D 03/07/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23474815 Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error. Refractive error 6,597 European ancestry individuals, 683 Sardinian inidividuals 19,763 European ancestry individuals 16p13.3 16 7459347 RBFOX1 - 54715 rs10500355-? rs10500355 0 10500355 intron 0 .3721 4E-9 8.397940008672036 .11 [0.074-0.147] unit decrease Illumina & Affymetrix [2,093,862] (Imputed) N 06/21/2013 23470693 Zeng Z 03/07/2013 J Dent Res http://www.ncbi.nlm.nih.gov/pubmed/23470693 Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. Pit-and-Fissure caries 996 European ancestry individuals Xp11.4 23 39885630 BCOR 642687 54880 160.44 24.87 rs17145638-C rs17145638 0 17145638 1 0.1169 2E-7 6.698970004336019 2.33 [NR] unit decrease Illumina [1.2 Million] (Imputed) N 06/21/2013 23470693 Zeng Z 03/07/2013 J Dent Res http://www.ncbi.nlm.nih.gov/pubmed/23470693 Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. Pit-and-Fissure caries 996 European ancestry individuals 6p25.3 6 577820 NR - 55770 rs9504361-G rs9504361 0 9504361 intron 0 0.4504 6E-6 5.221848749616356 1.16 [NR] unit increase Illumina [1.2 Million] (Imputed) N 06/21/2013 23470693 Zeng Z 03/07/2013 J Dent Res http://www.ncbi.nlm.nih.gov/pubmed/23470693 Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. Pit-and-Fissure caries 996 European ancestry individuals 3p14.2 3 60001825 NR - 2272 rs9311745-C rs9311745 0 9311745 intron 0 0.0466 5E-6 5.301029995663981 2.99 [NR] unit increase Illumina [1.2 Million] (Imputed) N 06/21/2013 23470693 Zeng Z 03/07/2013 J Dent Res http://www.ncbi.nlm.nih.gov/pubmed/23470693 Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. Pit-and-Fissure caries 996 European ancestry individuals 9q21.11 9 71471912 NR - 8395 rs6560397-T rs6560397 0 6560397 intron 0 0.4671 2E-7 6.698970004336019 1.29 [NR] unit decrease Illumina [1.2 Million] (Imputed) N 06/21/2013 23470693 Zeng Z 03/07/2013 J Dent Res http://www.ncbi.nlm.nih.gov/pubmed/23470693 Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. Pit-and-Fissure caries 996 European ancestry individuals 7p14.1 7 41811908 INHBA,INHBA-AS1 - 285954 rs10486722-C rs10486722 0 10486722 intron 0 0.3349 7E-6 5.154901959985742 1.22 [NR] unit increase Illumina [1.2 Million] (Imputed) N 06/21/2013 23470693 Zeng Z 03/07/2013 J Dent Res http://www.ncbi.nlm.nih.gov/pubmed/23470693 Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. Pit-and-Fissure caries 996 European ancestry individuals 22q12.3 22 37199806 NR - 5816 rs2022068-A rs2022068 0 2022068 intron 0 0.3926 7E-6 5.154901959985742 1.18 [NR] unit increase Illumina [1.2 Million] (Imputed) N 06/21/2013 23470693 Zeng Z 03/07/2013 J Dent Res http://www.ncbi.nlm.nih.gov/pubmed/23470693 Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. Pit-and-Fissure caries 996 European ancestry individuals 3q21.3 3 128282697 NR 100129727 23434 25.22 8.15 rs6806253-A rs6806253 0 6806253 1 0.8295 6E-6 5.221848749616356 1.56 [NR] unit decrease Illumina [1.2 Million] (Imputed) N 06/21/2013 23470693 Zeng Z 03/07/2013 J Dent Res http://www.ncbi.nlm.nih.gov/pubmed/23470693 Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. Pit-and-Fissure caries 996 European ancestry individuals 8q21.3 8 90211100 Intergenic 4325 8767 871.38 558.88 rs2046315-T rs2046315 0 2046315 1 0.1322 7E-7 6.154901959985743 1.87 [NR] unit increase Illumina [1.2 Million] (Imputed) N 06/21/2013 23470693 Zeng Z 03/07/2013 J Dent Res http://www.ncbi.nlm.nih.gov/pubmed/23470693 Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. Smooth-surface caries 982 European ancestry individuals 20q13.11 20 41991601 NR 170536 170510 131.50 59.95 rs2010809-C rs2010809 0 2010809 1 0.9883 2E-6 5.698970004336018 14.07 [NR] unit decrease Illumina [1.2 Million] (Imputed) N 06/21/2013 23470693 Zeng Z 03/07/2013 J Dent Res http://www.ncbi.nlm.nih.gov/pubmed/23470693 Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. Smooth-surface caries 982 European ancestry individuals 11q14.1 11 81235150 NR 729790 100422823 870.12 366.63 rs2032381-G rs2032381 0 2032381 1 0.9212 4E-6 5.397940008672037 5.69 [NR] unit decrease Illumina [1.2 Million] (Imputed) N 06/21/2013 23470693 Zeng Z 03/07/2013 J Dent Res http://www.ncbi.nlm.nih.gov/pubmed/23470693 Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. Smooth-surface caries 982 European ancestry individuals 8q21.3 8 90211100 Intergenic 4325 8767 871.38 558.88 rs2046315-T rs2046315 0 2046315 1 0.1322 8E-8 7.096910013008055 5.19 [NR] unit increase Illumina [1.2 Million] (Imputed) N 06/21/2013 23470693 Zeng Z 03/07/2013 J Dent Res http://www.ncbi.nlm.nih.gov/pubmed/23470693 Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. Smooth-surface caries 982 European ancestry individuals 9q22.33 9 102234323 NR 347265 8013 165.19 349.81 rs649057-T rs649057 0 649057 1 0.05057 8E-6 5.096910013008055 6.81 [NR] unit increase Illumina [1.2 Million] (Imputed) N 06/21/2013 23470693 Zeng Z 03/07/2013 J Dent Res http://www.ncbi.nlm.nih.gov/pubmed/23470693 Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. Smooth-surface caries 982 European ancestry individuals 11q25 11 133120937 NR - 4978 rs2078454-A rs2078454 0 2078454 intron 0 0.2094 6E-6 5.221848749616356 3.60 [NR] unit decrease Illumina [1.2 Million] (Imputed) N 06/21/2013 23470693 Zeng Z 03/07/2013 J Dent Res http://www.ncbi.nlm.nih.gov/pubmed/23470693 Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. Smooth-surface caries 982 European ancestry individuals 1q32.2 1 210898263 NR - 3756 rs1934620-A rs1934620 0 1934620 intron 0 .8656 8E-6 5.096910013008055 4.25 [NR] unit increase Illumina [1.2 Million] (Imputed) N 06/21/2013 23470693 Zeng Z 03/07/2013 J Dent Res http://www.ncbi.nlm.nih.gov/pubmed/23470693 Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. Smooth-surface caries 982 European ancestry individuals 8q21.3 8 89993488 NR 4325 8767 653.77 776.49 rs10429371-C rs10429371 0 10429371 1 .2142 3E-6 5.522878745280337 3.80 [NR] unit increase Illumina [1.2 Million] (Imputed) N 06/21/2013 23470693 Zeng Z 03/07/2013 J Dent Res http://www.ncbi.nlm.nih.gov/pubmed/23470693 Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. Smooth-surface caries 982 European ancestry individuals 4q31.22 4 146875551 NR 152485 11157 15.94 221.28 rs723794-G rs723794 0 723794 1 0.2686 6E-7 6.221848749616355 3.65 [NR] unit increase Illumina [1.2 Million] (Imputed) N 06/21/2013 23470693 Zeng Z 03/07/2013 J Dent Res http://www.ncbi.nlm.nih.gov/pubmed/23470693 Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. Smooth-surface caries 982 European ancestry individuals 2q35 2 219130514 AAMP,CXCR1,CXCR2 - 14 rs1079204-A rs1079204 0 1079204 intron 0 0.0378 2E-6 5.698970004336018 8.45 [NR] unit increase Illumina [1.2 Million] (Imputed) N 06/21/2013 23470693 Zeng Z 03/07/2013 J Dent Res http://www.ncbi.nlm.nih.gov/pubmed/23470693 Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. Smooth-surface caries 982 European ancestry individuals 4p15.32 4 16022540 NR - 8842 rs2677780-A rs2677780 0 2677780 intron 0 0.9356 2E-6 5.698970004336018 6.35 [NR] unit decrease Illumina [1.2 Million] (Imputed) N 06/21/2013 23470693 Zeng Z 03/07/2013 J Dent Res http://www.ncbi.nlm.nih.gov/pubmed/23470693 Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. Smooth-surface caries 982 European ancestry individuals 5q35.1 5 170240423 NR - 2568 rs11134654-A rs11134654 0 11134654 UTR-3 0 0.1735 2E-7 6.698970004336019 4.61 [NR] unit increase Illumina [1.2 Million] (Imputed) N 06/20/2013 23472165 Albertsen HM 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472165 Genome-wide association study link novel loci to endometriosis. Endometriosis 1,514 European ancestry casses, 12,660 European ancestry controls 505 European ancestry cases, 1,811 European ancestry controls 14q32.12 14 93644379 ITPK1, MOAP1 1531 64112 39.26 4.16 rs1268843-A rs1268843 0 1268843 1 0.263 3E-6 5.522878745280337 1.19 [NR] Illumina [580,699] N 06/20/2013 23472165 Albertsen HM 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472165 Genome-wide association study link novel loci to endometriosis. Endometriosis 1,514 European ancestry casses, 12,660 European ancestry controls 505 European ancestry cases, 1,811 European ancestry controls 12q24.23 12 118106194 KSR2 - 283455 rs10431397-A rs10431397 0 10431397 intron 0 0.012 7E-6 5.154901959985742 1.73 [NR] Illumina [580,699] N 06/20/2013 23472165 Albertsen HM 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472165 Genome-wide association study link novel loci to endometriosis. Endometriosis 1,514 European ancestry casses, 12,660 European ancestry controls 505 European ancestry cases, 1,811 European ancestry controls 12q22 12 95696420 VEZT - 55591 rs3596-G rs3596 0 3596 ncRNA 0 0.472 2E-6 5.698970004336018 1.17 [NR] Illumina [580,699] N 06/20/2013 23472165 Albertsen HM 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472165 Genome-wide association study link novel loci to endometriosis. Endometriosis 1,514 European ancestry casses, 12,660 European ancestry controls 505 European ancestry cases, 1,811 European ancestry controls 10q11.21 10 44541565 HNRNPA3P1, LOC100130539 100506835 6387 150.68 324.04 rs10508881-A rs10508881 0 10508881 1 0.405 4E-7 6.397940008672037 1.19 [1.11-1.27] Illumina [580,699] N 06/20/2013 23472165 Albertsen HM 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472165 Genome-wide association study link novel loci to endometriosis. Endometriosis 1,514 European ancestry casses, 12,660 European ancestry controls 505 European ancestry cases, 1,811 European ancestry controls 8p23.2 8 5071412 CSMD1, LOC100287015 100129861 100271466 140.97 262.62 rs7816936-A rs7816936 0 7816936 1 0.446 6E-6 5.221848749616356 1.16 [NR] Illumina [580,699] N 06/20/2013 23472165 Albertsen HM 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472165 Genome-wide association study link novel loci to endometriosis. Endometriosis 1,514 European ancestry casses, 12,660 European ancestry controls 505 European ancestry cases, 1,811 European ancestry controls 7p14.3 7 31904027 PDE1C - 5137 rs2270221-A rs2270221 0 2270221 intron 0 0.267 1E-6 5.999999999999999 1.20 [NR] Illumina [580,699] N 06/20/2013 23472165 Albertsen HM 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472165 Genome-wide association study link novel loci to endometriosis. Endometriosis 1,514 European ancestry casses, 12,660 European ancestry controls 505 European ancestry cases, 1,811 European ancestry controls 10q25.1 10 109374384 SORCS1, LOC100128304 114815 100130409 449.92 1920.03 rs11193561-A rs11193561 0 11193561 1 0.239 6E-6 5.221848749616356 1.19 [NR] Illumina [580,699] N 06/20/2013 23472165 Albertsen HM 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472165 Genome-wide association study link novel loci to endometriosis. Endometriosis 1,514 European ancestry casses, 12,660 European ancestry controls 505 European ancestry cases, 1,811 European ancestry controls 1p36.12 1 22450487 WNT4,LOC100289113,ZBTB40 - 54361 rs2235529-A rs2235529 0 2235529 intron 0 0.153 3E-9 8.522878745280337 1.30 [1.19-1.41] Illumina [580,699] N 06/20/2013 23472165 Albertsen HM 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472165 Genome-wide association study link novel loci to endometriosis. Endometriosis 1,514 European ancestry casses, 12,660 European ancestry controls 505 European ancestry cases, 1,811 European ancestry controls 9p24.1 9 6253571 IL33 - 90865 rs10975519-A rs10975519 0 10975519 cds-synon 0 0.3 9E-7 6.045757490560675 1.19 [NR] Illumina [580,699] N 06/20/2013 23472165 Albertsen HM 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472165 Genome-wide association study link novel loci to endometriosis. Endometriosis 1,514 European ancestry casses, 12,660 European ancestry controls 505 European ancestry cases, 1,811 European ancestry controls 2q23.3 2 151635832 RND3 , RBM43 390 344332 291.62 406.84 rs6757804-G rs6757804 0 6757804 1 0.401 6E-8 7.221848749616355 1.20 [1.13-1.29] Illumina [580,699] N 06/20/2013 23472165 Albertsen HM 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472165 Genome-wide association study link novel loci to endometriosis. Endometriosis 1,514 European ancestry casses, 12,660 European ancestry controls 505 European ancestry cases, 1,811 European ancestry controls 6p22.3 6 19803768 RNF144B , ID4 - 100506885 rs6907340-A rs6907340 0 6907340 ncRNA 0 0.371 2E-7 6.698970004336019 1.20 [1.12-1.28] Illumina [580,699] N 06/20/2013 23472165 Albertsen HM 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472165 Genome-wide association study link novel loci to endometriosis. Endometriosis 1,514 European ancestry casses, 12,660 European ancestry controls 505 European ancestry cases, 1,811 European ancestry controls 17p13.3 17 3029554 OR1D2, OR1G1 - 8390 rs12449465-G rs12449465 0 12449465 nearGene-3 0 0.125 1E-6 5.999999999999999 1.26 [NR] Illumina [580,699] N 06/20/2013 23472165 Albertsen HM 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472165 Genome-wide association study link novel loci to endometriosis. Endometriosis 1,514 European ancestry casses, 12,660 European ancestry controls 505 European ancestry cases, 1,811 European ancestry controls 1p36.12[rs10917151]; 1p36.12[rs4654783] WNT4 - 5-SNP Haplotype rs10917151, rs4654783, rs2235529, rs16826658, rs7521902 0.134 8E-7 (Haplotype - ATTGA) 1.25 [NR] Illumina [580,699] N 06/20/2013 23472165 Albertsen HM 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472165 Genome-wide association study link novel loci to endometriosis. Endometriosis 1,514 European ancestry casses, 12,660 European ancestry controls 505 European ancestry cases, 1,811 European ancestry controls 1p36.12[rs10917151]; 1p36.12[rs4654783] WNT4 - 3-SNP Haplotype rs10917151, rs4654783, rs2235529 0.709 6E-6 (Haplotype - GCC) 1.19 [NR] Illumina [580,699] N 06/20/2013 23472165 Albertsen HM 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472165 Genome-wide association study link novel loci to endometriosis. Endometriosis 1,514 European ancestry casses, 12,660 European ancestry controls 505 European ancestry cases, 1,811 European ancestry controls 1p36.12[rs10917151]; 1p36.12[rs4654783] WNT4 - 3-SNP Haplotype rs10917151, rs4654783, rs2235529 0.152 7E-9 (Haplotype - ATT) 1.28 [NR] Illumina [580,699] N 06/14/2013 23459443 Avery CL 03/05/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23459443 Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. QT interval (interaction) 33,781 Euroepan ancestry individuals 8p22 8 18233582 AACP 11 392206 4.20 7.17 rs7006687-T rs7006687 0 7006687 1 0.57 2E-6 5.698970004336018 (Sulfonylurea Hypoglycemic agents) NR NR Illumina & Affymetrix [~2.5 Million] (imputed) N 06/14/2013 23459443 Avery CL 03/05/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23459443 Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. QT interval (interaction) 33,781 Euroepan ancestry individuals 6q16.1 6 98588754 POU3F2 100302164 5454 116.26 693.83 rs9375225-T rs9375225 0 9375225 1 0.48 6E-6 5.221848749616356 (Tri-Tetra/cyclic antidepressants) NR NR Illumina & Affymetrix [~2.5 Million] (imputed) N 06/14/2013 23459443 Avery CL 03/05/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23459443 Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. QT interval (interaction) 33,781 Euroepan ancestry individuals 12p13.32 12 4399970 CCND2 - 894 rs3217869-A rs3217869 0 3217869 intron 0 0.41 4E-6 5.397940008672037 (Tri-Tetra/cyclic antidepressants) NR NR Illumina & Affymetrix [~2.5 Million] (imputed) N 06/14/2013 23459443 Avery CL 03/05/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23459443 Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. QT interval (interaction) 33,781 Euroepan ancestry individuals 1p21.2 1 101540999 DPH5 - 100506051 rs17450029-T rs17450029 0 17450029 intron 0 0.23 3E-6 5.522878745280337 (Tri-Tetra/cyclic antidepressants) NR NR Illumina & Affymetrix [~2.5 Million] (imputed) N 06/14/2013 23459443 Avery CL 03/05/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23459443 Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. QT interval (interaction) 33,781 Euroepan ancestry individuals 14q21.1 14 41702598 LRFN5 254170 145581 1800.89 374.17 rs1612141-A rs1612141 0 1612141 1 0.21 5E-6 5.301029995663981 (Sulfonylurea Hypoglycemic agents) NR NR Illumina & Affymetrix [~2.5 Million] (imputed) N 06/14/2013 23459443 Avery CL 03/05/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23459443 Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. QT interval (interaction) 33,781 Euroepan ancestry individuals 11q22.3 11 108873119 SKCG-1 360180 399947 179.74 419.73 rs10890920-A rs10890920 0 10890920 1 0.57 3E-6 5.522878745280337 (Sulfonylurea Hypoglycemic agents) NR NR Illumina & Affymetrix [~2.5 Million] (imputed) N 06/14/2013 23459443 Avery CL 03/05/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23459443 Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. QT interval (interaction) 33,781 Euroepan ancestry individuals 16p13.3 16 3796147 CREBBP - 1387 rs129963-T rs129963 0 129963 intron 0 0.42 9E-6 5.045757490560675 (Thiazides) NR NR Illumina & Affymetrix [~2.5 Million] (imputed) N 06/14/2013 23459443 Avery CL 03/05/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23459443 Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. QT interval (interaction) 33,781 Euroepan ancestry individuals 18p11.21 18 11759432 GNAL - 2774 rs9947295-T rs9947295 0 9947295 intron 0 0.11 8E-6 5.096910013008055 (UAZ Cert) NR NR Illumina & Affymetrix [~2.5 Million] (imputed) N 06/14/2013 23459443 Avery CL 03/05/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23459443 Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. QT interval (interaction) 33,781 Euroepan ancestry individuals 6q22.1 6 117730819 ROS1 - 6098 rs2273601-A rs2273601 0 2273601 intron 0 0.23 8E-6 5.096910013008055 (UAZ Cert) NR NR Illumina & Affymetrix [~2.5 Million] (imputed) N 06/14/2013 23459443 Avery CL 03/05/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23459443 Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. QT interval (interaction) 33,781 Euroepan ancestry individuals 15q25.1 15 81359137 LOC647020 59274 100652899 62.79 50.46 rs2663905-A rs2663905 0 2663905 1 0.75 5E-6 5.301029995663981 (UAZ Cert) NR NR Illumina & Affymetrix [~2.5 Million] (imputed) N 06/14/2013 23459443 Avery CL 03/05/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23459443 Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. QT interval (interaction) 33,781 Euroepan ancestry individuals 9p22.1 9 18761099 ADAMTSL1 - 92949 rs1978746-A rs1978746 0 1978746 intron 0 0.79 8E-6 5.096910013008055 (Thiazides) NR NR Illumina & Affymetrix [~2.5 Million] (imputed) N 06/14/2013 23459443 Avery CL 03/05/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23459443 Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. QT interval (interaction) 33,781 Euroepan ancestry individuals 10p13 10 12675061 CAMK1D - 57118 rs10906189-A rs10906189 0 10906189 intron 0 0.58 6E-6 5.221848749616356 (Thiazides) NR NR Illumina & Affymetrix [~2.5 Million] (imputed) N 06/14/2013 23459443 Avery CL 03/05/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23459443 Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. QT interval (interaction) 33,781 Euroepan ancestry individuals 20q13.13 20 49739860 RPSAP1 3755 170529 100.19 7.38 rs230014-A rs230014 0 230014 1 0.48 4E-6 5.397940008672037 (Sulfonylurea Hypoglycemic agents) NR NR Illumina & Affymetrix [~2.5 Million] (imputed) N 06/14/2013 23459443 Avery CL 03/05/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23459443 Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. QT interval (interaction) 33,781 Euroepan ancestry individuals 1q42.11 1 224256348 FBX028 730978 23219 119.19 45.44 rs10916248-A rs10916248 0 10916248 1 0.8 5E-6 5.301029995663981 (Sulfonylurea Hypoglycemic agents) NR NR Illumina & Affymetrix [~2.5 Million] (imputed) N 06/14/2013 23459443 Avery CL 03/05/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23459443 Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. QT interval (interaction) 33,781 Euroepan ancestry individuals 7q11.21 7 63346886 GABPAP 100422848 8327 265.34 6.56 rs13437751-T rs13437751 0 13437751 1 0.09 9E-6 5.045757490560675 (UAZ Cert) NR NR Illumina & Affymetrix [~2.5 Million] (imputed) N 06/14/2013 23459443 Avery CL 03/05/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23459443 Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. QT interval (interaction) 33,781 Euroepan ancestry individuals 2q33.3 2 207717783 FASTKD2 100423002 130749 69.75 86.50 rs6755560-T rs6755560 0 6755560 1 0.32 2E-6 5.698970004336018 (Tri-Tetra/cyclic antidepressants) NR NR Illumina & Affymetrix [~2.5 Million] (imputed) N 06/14/2013 23459443 Avery CL 03/05/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23459443 Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. QT interval (interaction) 33,781 Euroepan ancestry individuals 7q35 7 147577537 CNTNAP2 - 26047 rs2708240-A rs2708240 0 2708240 intron 0 0.51 4E-6 5.397940008672037 (Tri-Tetra/cyclic antidepressants) NR NR Illumina & Affymetrix [~2.5 Million] (imputed) N 06/18/2013 23471985 Jahanshad N 03/05/2013 Proc Natl Acad Sci U S A http://www.ncbi.nlm.nih.gov/pubmed/23471985 Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. Brain connectivity 331 European ancestry individuals 20p12.1 20 16054982 MACROD2 170511 170540 454.37 149.41 rs16997087-? rs16997087 0 16997087 1 NR 1E-10 10 (Strength - R paracentral) NR NR Illumina [428,287] N 06/18/2013 23471985 Jahanshad N 03/05/2013 Proc Natl Acad Sci U S A http://www.ncbi.nlm.nih.gov/pubmed/23471985 Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. Brain connectivity 331 European ancestry individuals 15q21.3 15 56210929 NEDD4 - 4734 rs17819300-? rs17819300 0 17819300 intron 0 NR 1E-10 10 (Strength - R-banks of the superior temporal sulcus) NR NR Illumina [428,287] N 06/18/2013 23471985 Jahanshad N 03/05/2013 Proc Natl Acad Sci U S A http://www.ncbi.nlm.nih.gov/pubmed/23471985 Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. Brain connectivity 331 European ancestry individuals Xq24 23 118716987 UBE2A - 7319 rs7879933-? rs7879933 0 7879933 intron 0 NR 2E-10 9.698970004336017 (strength - R-inferior parietal) NR NR Illumina [428,287] N 06/18/2013 23471985 Jahanshad N 03/05/2013 Proc Natl Acad Sci U S A http://www.ncbi.nlm.nih.gov/pubmed/23471985 Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. Brain connectivity 331 European ancestry individuals 10q22.1 10 72114378 LRRC20 - 55222 rs4747011-? rs4747011 0 4747011 intron 0 NR 9E-10 9.045757490560675 (Strength - L-transverse temporal) NR NR Illumina [428,287] N 06/18/2013 23471985 Jahanshad N 03/05/2013 Proc Natl Acad Sci U S A http://www.ncbi.nlm.nih.gov/pubmed/23471985 Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. Brain connectivity 331 European ancestry individuals 6q16.1 6 95156418 Intergenic 2045 360172 1027.12 795.64 rs2224003-? rs2224003 0 2224003 1 NR 1E-9 8.999999999999998 (Strength - R-pars opercularis) NR NR Illumina [428,287] N 06/18/2013 23471985 Jahanshad N 03/05/2013 Proc Natl Acad Sci U S A http://www.ncbi.nlm.nih.gov/pubmed/23471985 Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. Brain connectivity 331 European ancestry individuals 3p26.2 3 3055247 CNTN4 - 152330 rs17024684-? rs17024684 0 17024684 intron 0 NR 2E-9 8.698970004336019 (Clustering coefficient - L-isthmus of the cingulate) NR NR Illumina [428,287] N 06/18/2013 23471985 Jahanshad N 03/05/2013 Proc Natl Acad Sci U S A http://www.ncbi.nlm.nih.gov/pubmed/23471985 Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. Brain connectivity 331 European ancestry individuals 20p12.1 20 16054982 MACROD2 170511 170540 454.37 149.41 rs16997087-? rs16997087 0 16997087 1 NR 2E-9 8.698970004336019 (Efficiency - R-paracentral) NR NR Illumina [428,287] N 06/18/2013 23471985 Jahanshad N 03/05/2013 Proc Natl Acad Sci U S A http://www.ncbi.nlm.nih.gov/pubmed/23471985 Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. Brain connectivity 331 European ancestry individuals 3p11.2 3 87495550 Intergenic 402134 643766 121.49 183.71 rs9834692-? rs9834692 0 9834692 1 NR 3E-9 8.522878745280337 (Clustering coefficient - R-insula) NR NR Illumina [428,287] N 06/18/2013 23471985 Jahanshad N 03/05/2013 Proc Natl Acad Sci U S A http://www.ncbi.nlm.nih.gov/pubmed/23471985 Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. Brain connectivity 331 European ancestry individuals 3p11.2 3 87525449 Intergenic 402134 643766 151.39 153.81 rs9883474-? rs9883474 0 9883474 1 NR 3E-9 8.522878745280337 (Clustering coefficient - R-insula) NR NR Illumina [428,287] N 06/18/2013 23471985 Jahanshad N 03/05/2013 Proc Natl Acad Sci U S A http://www.ncbi.nlm.nih.gov/pubmed/23471985 Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. Brain connectivity 331 European ancestry individuals 2p12 2 75419714 TACR1 - 6869 rs3771863-? rs3771863 0 3771863 intron 0 NR 3E-9 8.522878745280337 (Strength - L-inferior parietal) NR NR Illumina [428,287] N 06/18/2013 23471985 Jahanshad N 03/05/2013 Proc Natl Acad Sci U S A http://www.ncbi.nlm.nih.gov/pubmed/23471985 Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. Brain connectivity 331 European ancestry individuals 6q16.1 6 95156454 Intergenic 2045 360172 1027.15 795.60 rs10485022-? rs10485022 0 10485022 1 NR 5E-9 8.301029995663981 (Strength - R-pars opercularis) NR NR Illumina [428,287] N 06/18/2013 23471985 Jahanshad N 03/05/2013 Proc Natl Acad Sci U S A http://www.ncbi.nlm.nih.gov/pubmed/23471985 Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. Brain connectivity 331 European ancestry individuals 11p15.2 11 14021639 SPON1 - 10418 rs2618516-T rs2618516 0 2618516 0 0.36 6E-10 9.221848749616356 (connectivity pattern) .00 [NR] unit increase Illumina [428,287] N 06/13/2013 23472185 Mero IL 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472185 Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles. Multiple sclerosis (OCB status) 1,367 European ancestry OCB positive cases, 161 European ancestry OCB negative cases 3,029 European ancestry OCB positive cases, 374 European ancestry OCB negative cases 6p21.32 6 32368087 BTNL2 - 56244 rs3817963-? rs3817963 0 3817963 intron 0 NR 6E-10 9.221848749616356 1.61 [1.38-1.87] Illumina [495,970] N 06/13/2013 23472185 Mero IL 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472185 Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles. Multiple sclerosis (OCB status) 1,367 European ancestry OCB positive cases, 161 European ancestry OCB negative cases 3,029 European ancestry OCB positive cases, 374 European ancestry OCB negative cases 6p21.32 6 32406342 HLA-DRA - 3122 rs3129871-? rs3129871 0 3129871 nearGene-5 0 NR 6E-15 14.22184874961635 1.72 [1.59-1.86] Illumina [495,970] N 06/13/2013 23472185 Mero IL 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472185 Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles. Multiple sclerosis (OCB status) 1,367 European ancestry OCB positive cases, 161 European ancestry OCB negative cases, 428 European ancestry controls 6p21.32 6 32677912 HLA-DQA2 404026 3118 3.33 31.25 rs9275563-? rs9275563 0 9275563 1 NR 6E-11 10.22184874961635 (OCB positive vs. controls) 1.75 [1.47-2.04] Illumina [495,970] N 06/13/2013 23472185 Mero IL 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472185 Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles. Multiple sclerosis (OCB status) 1,367 European ancestry OCB positive cases, 161 European ancestry OCB negative cases, 428 European ancestry controls 6p21.32 6 32663631 HLA-DQB1 3119 404026 29.17 10.29 rs3129720-? rs3129720 0 3129720 1 NR 5E-15 14.30102999566398 (OCB positive vs. controls) 1.91 [1.62-2.24] Illumina [495,970] N 06/13/2013 23472185 Mero IL 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472185 Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles. Multiple sclerosis (OCB status) 1,367 European ancestry OCB positive cases, 161 European ancestry OCB negative cases, 428 European ancestry controls 6p21.32 6 32592200 HLA-DQA1 3123 3117 34.59 12.98 rs9271640-? rs9271640 0 9271640 1 NR 2E-20 19.69897000433602 (OCB positive vs. controls) 2.37 [1.97-2.84] Illumina [495,970] N 06/13/2013 23472185 Mero IL 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472185 Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles. Multiple sclerosis (OCB status) 1,367 European ancestry OCB positive cases, 161 European ancestry OCB negative cases 3,029 European ancestry OCB positive cases, 374 European ancestry OCB negative cases 3q23 3 140099693 CLSTN2 - 64084 rs17411949-? rs17411949 0 17411949 intron 0 NR 8E-7 6.096910013008056 1.85 [1.45-2.37] Illumina [495,970] N 06/13/2013 23472185 Mero IL 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472185 Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles. Multiple sclerosis (OCB status) 1,367 European ancestry OCB positive cases, 161 European ancestry OCB negative cases, 428 European ancestry controls 6p21.32 6 32406342 HLA-DRA - 3122 rs3129871-? rs3129871 0 3129871 nearGene-5 0 NR 1E-16 16 (OCB positive vs. controls) 1.98 [1.68-2.32] Illumina [495,970] N 06/13/2013 23472185 Mero IL 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472185 Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles. Multiple sclerosis (OCB status) 1,367 European ancestry OCB positive cases, 161 European ancestry OCB negative cases, 428 European ancestry controls 6p21.32 6 32368087 BTNL2 - 56244 rs3817963-? rs3817963 0 3817963 intron 0 NR 8E-6 5.096910013008055 (OCB positive vs. controls) 1.52 [1.27-1.79] Illumina [495,970] N 06/13/2013 23472185 Mero IL 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472185 Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles. Multiple sclerosis (OCB status) 1,367 European ancestry OCB positive cases, 161 European ancestry OCB negative cases, 428 European ancestry controls 2q31.2 2 179296271 PRKRA - 8575 rs9283487-? rs9283487 0 9283487 UTR-3 0 NR 3E-7 6.522878745280337 (OCB positive vs. controls) 1.61 [1.33-1.92] Illumina [495,970] N 06/13/2013 23472185 Mero IL 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472185 Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles. Multiple sclerosis (OCB status) 1,367 European ancestry OCB positive cases, 161 European ancestry OCB negative cases, 428 European ancestry controls 1q23.2 1 159818513 C10ORF204 - 284677 rs6659742-? rs6659742 0 6659742 intron 0 NR 7E-7 6.154901959985743 (OCB negative vs. controls) 1.99 [1.52-2.61] Illumina [495,970] N 06/13/2013 23472185 Mero IL 03/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23472185 Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles. Multiple sclerosis (OCB status) 1,367 European ancestry OCB positive cases, 161 European ancestry OCB negative cases, 428 European ancestry controls 6p21.32 6 32520907 HLA-DRB1 - 3128 rs3828840-? rs3828840 0 3828840 intron 0 NR 5E-15 14.30102999566398 (OCB positive vs. controls) 1.94 [1.64-2.29] Illumina [495,970] N 06/13/2013 23463857 Ritchie MD 03/05/2013 Circulation http://www.ncbi.nlm.nih.gov/pubmed/23463857 Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk. Electrocardiographic conduction measures 5,272 European ancestry indiviudals 40,407 European ancestry individuals 6q22.31 6 118962740 C6orf204 - 387119 rs6906287-C rs6906287 0 6906287 intron 0 0.451 6E-16 15.22184874961635 (QRS duration - CHARGE) .54 [NR] msec increase Illumina [528,508] N 06/13/2013 23463857 Ritchie MD 03/05/2013 Circulation http://www.ncbi.nlm.nih.gov/pubmed/23463857 Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk. Electrocardiographic conduction measures 5,272 European ancestry indiviudals 40,407 European ancestry individuals 6p21.2 6 36618821 CDKN1A 100500885 389386 28.53 22.71 rs1321313-C rs1321313 0 1321313 1 0.742 5E-25 24.30102999566398 (QRS duration - CHARGE) .81 [NR] msec decrease Illumina [528,508] N 06/13/2013 23463857 Ritchie MD 03/05/2013 Circulation http://www.ncbi.nlm.nih.gov/pubmed/23463857 Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk. Electrocardiographic conduction measures 5,272 European ancestry indiviudals 40,407 European ancestry individuals 3p22.2 3 38766675 SCN10A - 6336 rs6795970-A rs6795970 0 6795970 missense 0 0.396 5E-27 26.30102999566398 (QRS duration - CHARGE) .75 [NR] msec increase Illumina [528,508] N 06/13/2013 23463857 Ritchie MD 03/05/2013 Circulation http://www.ncbi.nlm.nih.gov/pubmed/23463857 Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk. Electrocardiographic conduction measures 5,272 European ancestry indiviudals 40,407 European ancestry individuals 1p31.3 1 61897967 NFIA - 4774 rs2207790-A rs2207790 0 2207790 intron 0 0.461 6E-18 17.22184874961635 (QRS duration - CHARGE) .60 [NR] msec decrease Illumina [528,508] N 06/13/2013 23463857 Ritchie MD 03/05/2013 Circulation http://www.ncbi.nlm.nih.gov/pubmed/23463857 Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk. Electrocardiographic conduction measures 5,272 European ancestry indiviudals 40,407 European ancestry individuals 3p22.2 3 38592406 SCN5A - 6331 rs1805126-A rs1805126 0 1805126 cds-synon 0 0.655 3E-20 19.52287874528034 (QRS duration - CHARGE) .66 [NR] msec decrease Illumina [528,508] N 06/11/2013 23459936 Divaris K 03/04/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23459936 Exploring the genetic basis of chronic periodontitis: a genome-wide association study. Periodontitis 4,504 European ancestry individuals 656 European ancestry and African American individuals 6p21.1 6 41379315 NCR2 9436 116113 60.69 134.85 rs7762544-? rs7762544 0 7762544 1 NR 8E-8 7.096910013008055 (Moderate CPd) 1.40 [1.24-1.59] Affymetrix [2,135,236] (imputed) N 06/11/2013 23459936 Divaris K 03/04/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23459936 Exploring the genetic basis of chronic periodontitis: a genome-wide association study. Periodontitis 4,504 European ancestry individuals 656 European ancestry and African American individuals 19p13.3 19 6887736 EMR1, VAV1 - 2015 rs3826782-? rs3826782 0 3826782 intron 0 NR 8E-7 6.096910013008056 (Moderate CPd) 2.01 [1.52-2.65] Affymetrix [2,135,236] (imputed) N 06/11/2013 23459936 Divaris K 03/04/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23459936 Exploring the genetic basis of chronic periodontitis: a genome-wide association study. Periodontitis 4,504 European ancestry individuals 656 European ancestry and African American individuals 7p15.3 7 24378040 NPY 4852 51678 46.56 235.05 rs2521634-? rs2521634 0 2521634 1 NR 4E-7 6.397940008672037 (Severe CPd) 1.49 [1.28-1.73] Affymetrix [2,135,236] (imputed) N 04/11/2013 23314186 Crosslin DR 03/03/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23314186 Genetic variation associated with circulating monocyte count in the eMERGE Network. Monocyte count 9,849 European ancestry individuals, 894 African ancestry individuals, 271 other ancestry individuals NR 2q31.3 2 182328214 ITGA4 - 3676 rs2124440-G rs2124440 0 2124440 intron 0 0.45 5E-17 16.30102999566398 .22 [NR] unit decrease Illumina [NR] N 04/11/2013 23314186 Crosslin DR 03/03/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23314186 Genetic variation associated with circulating monocyte count in the eMERGE Network. Monocyte count 9,849 European ancestry individuals, 894 African ancestry individuals, 271 other ancestry individuals NR 3p22.1 3 42906116 CCBP2 - 1238 rs2228467-G rs2228467 0 2228467 missense 0 0.06 2E-7 6.698970004336019 .30 unit increase Illumina [NR] N 04/11/2013 23314186 Crosslin DR 03/03/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23314186 Genetic variation associated with circulating monocyte count in the eMERGE Network. Monocyte count 9,849 European ancestry individuals, 894 African ancestry individuals, 271 other ancestry individuals NR 3q21.3 3 128338600 RPN1 - 6184 rs2712381-A rs2712381 0 2712381 nearGene-3 0 0.40 2E-16 15.69897000433602 .23 unit decrease Illumina [NR] N 04/11/2013 23314186 Crosslin DR 03/03/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23314186 Genetic variation associated with circulating monocyte count in the eMERGE Network. Monocyte count 9,849 European ancestry individuals, 894 African ancestry individuals, 271 other ancestry individuals NR 9q31.3 9 114348617 PTGR1 - 22949 rs2273788-A rs2273788 0 2273788 intron 0 0.26 5E-7 6.30102999566398 .16 unit increase Illumina [NR] N 04/11/2013 23314186 Crosslin DR 03/03/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23314186 Genetic variation associated with circulating monocyte count in the eMERGE Network. Monocyte count 9,849 European ancestry individuals, 894 African ancestry individuals, 271 other ancestry individuals NR 3p22.1 3 42907112 CCBP2 - 1238 rs2228468-C rs2228468 0 2228468 missense 0 0.36 5E-7 6.30102999566398 .14 unit decrease Illumina [NR] N 04/11/2013 23314186 Crosslin DR 03/03/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23314186 Genetic variation associated with circulating monocyte count in the eMERGE Network. Monocyte count 9,849 European ancestry individuals, 894 African ancestry individuals, 271 other ancestry individuals NR 16q24.1 16 85946450 IRF8 - 3394 rs424971-G rs424971 0 424971 intron 0 0.47 3E-16 15.52287874528034 .22 unit decrease Illumina [NR] N 06/01/2013 23456168 Hao Y 03/03/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23456168 Genome-wide association study in Han Chinese identifies three novel loci for human height. Height 6,534 Han Chinese ancestry individuals 1,881 Han Chinese ancestry individuals from 637 families 12q24.32 12 129186190 TMEM132C - 92293 rs10773568-A rs10773568 0 10773568 intron 0 0.42 3E-6 5.522878745280337 .07 [0.043-0.105] unit increase Affymetrix [1,532,051] (Imputed) N 06/01/2013 23456168 Hao Y 03/03/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23456168 Genome-wide association study in Han Chinese identifies three novel loci for human height. Height 6,534 Han Chinese ancestry individuals 1,881 Han Chinese ancestry individuals from 637 families 12q13.3 12 56680745 CS, STAT2 - 1431 rs3816804-C rs3816804 0 3816804 intron 0 0.77 3E-9 8.522878745280337 .12 [0.082-0.164] unit increase Affymetrix [1,532,051] (Imputed) N 06/01/2013 23456168 Hao Y 03/03/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23456168 Genome-wide association study in Han Chinese identifies three novel loci for human height. Height 6,534 Han Chinese ancestry individuals 1,881 Han Chinese ancestry individuals from 637 families 16q24.3 16 89726035 C16orf55 - 5119 rs154663-T rs154663 0 154663 nearGene-5 0 0.29 9E-7 6.045757490560675 .08 [0.051-0.117] unit increase Affymetrix [1,532,051] (Imputed) N 06/01/2013 23456168 Hao Y 03/03/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23456168 Genome-wide association study in Han Chinese identifies three novel loci for human height. Height 6,534 Han Chinese ancestry individuals 1,881 Han Chinese ancestry individuals from 637 families 10q21.1 10 60210790 TFAM 7019 80114 51.80 62.11 rs10509091-T rs10509091 0 10509091 1 0.35 6E-6 5.221848749616356 .07 [0.043-0.105] unit increase Affymetrix [1,532,051] (Imputed) N 06/01/2013 23456168 Hao Y 03/03/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23456168 Genome-wide association study in Han Chinese identifies three novel loci for human height. Height 6,534 Han Chinese ancestry individuals 1,881 Han Chinese ancestry individuals from 637 families 6p22.1 6 29520877 OR2I1P 9292 442197 14.45 .01 rs16895057-T rs16895057 0 16895057 1 0.95 3E-6 5.522878745280337 .15 [0.088-0.218] unit increase Affymetrix [1,532,051] (Imputed) N 06/01/2013 23456168 Hao Y 03/03/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23456168 Genome-wide association study in Han Chinese identifies three novel loci for human height. Height 6,534 Han Chinese ancestry individuals 1,881 Han Chinese ancestry individuals from 637 families 3q26.32 3 175927451 NAALADL2 100129423 100873259 140.76 800.76 rs11923600-G rs11923600 0 11923600 1 0.71 8E-6 5.096910013008055 .08 [0.047-0.121] unit increase Affymetrix [1,532,051] (Imputed) N 06/01/2013 23456168 Hao Y 03/03/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23456168 Genome-wide association study in Han Chinese identifies three novel loci for human height. Height 6,534 Han Chinese ancestry individuals 1,881 Han Chinese ancestry individuals from 637 families 18q21.1 18 45865597 C18orf12 201501 100616366 201.92 331.37 rs11082671-G rs11082671 0 11082671 1 0.79 2E-8 7.698970004336018 .11 [0.07-0.144] unit increase Affymetrix [1,532,051] (Imputed) N 06/01/2013 23456168 Hao Y 03/03/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23456168 Genome-wide association study in Han Chinese identifies three novel loci for human height. Height 6,534 Han Chinese ancestry individuals 1,881 Han Chinese ancestry individuals from 637 families 15q21.2 15 51573533 CYP19A1 - 1588 rs3751599-G rs3751599 0 3751599 intron 0 0.93 5E-10 9.301029995663981 .19 [0.13-0.25] unit increase Affymetrix [1,532,051] (Imputed) N 06/01/2013 23456168 Hao Y 03/03/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23456168 Genome-wide association study in Han Chinese identifies three novel loci for human height. Height 6,534 Han Chinese ancestry individuals 1,881 Han Chinese ancestry individuals from 637 families 11q21 11 95995448 MAML2 - 84441 rs11021504-A rs11021504 0 11021504 intron 0 0.51 8E-9 8.096910013008056 .08 [0.054-0.112] unit increase Affymetrix [1,532,051] (Imputed) N 06/01/2013 23456168 Hao Y 03/03/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23456168 Genome-wide association study in Han Chinese identifies three novel loci for human height. Height 6,534 Han Chinese ancestry individuals 1,881 Han Chinese ancestry individuals from 637 families 2p13.2 2 71525785 ZNF638 400961 27332 71.55 33.10 rs12612930-C rs12612930 0 12612930 1 0.6 2E-10 9.698970004336017 .10 [0.069-0.131] unit increase Affymetrix [1,532,051] (Imputed) N 06/01/2013 23456168 Hao Y 03/03/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23456168 Genome-wide association study in Han Chinese identifies three novel loci for human height. Height 6,534 Han Chinese ancestry individuals 1,881 Han Chinese ancestry individuals from 637 families 2q37.3 2 242053546 PASK - 23178 rs17382723-C rs17382723 0 17382723 intron 0 0.96 3E-7 6.522878745280337 .21 [0.13-0.28] unit increase Affymetrix [1,532,051] (Imputed) N 06/11/2013 23455637 Iles MM 03/03/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23455637 A variant in FTO shows association with melanoma risk not due to BMI. Melanoma 1,353 European ancestry cases, 3,566 European ancestry controls 12,313 European ancestry cases, Up to 55,667 European ancestry controls 16q12.2 16 54114824 FTO - 79068 rs16953002-A rs16953002 0 16953002 intron 0 0.17 4E-12 11.39794000867204 1.16 [1.11-1.20] Illumina [2.6 million] (Imputed) N 03/22/2013 23281178 Hong MG 03/01/2013 Hum Mutat http://www.ncbi.nlm.nih.gov/pubmed/23281178 A genome-wide assessment of variability in human serum metabolism. Metabolite levels 214 European ancestry prostate cancer cases and 188 European ancestry controls 489 European ancestry prostate cancer cases 2q37.1 2 234668570 UGT1A8 - 54575;54576;54577;54578;54579;54600;54657;54658;54659 rs887829-T rs887829 0 887829 intron;intron;intron;intron;intron;intron;intron;nearGene-5;intron 0 NR 9E-25 24.04575749056067 (Bilirubin) NR NR Affymetrix [333,722] N 03/22/2013 23281178 Hong MG 03/01/2013 Hum Mutat http://www.ncbi.nlm.nih.gov/pubmed/23281178 A genome-wide assessment of variability in human serum metabolism. Metabolite levels 214 European ancestry prostate cancer cases and 188 European ancestry controls 489 European ancestry prostate cancer cases 17q23.3 17 61569732 ACE - 1636 rs4351-A rs4351 0 4351 intron 0 NR 9E-13 12.04575749056067 (Unknown) NR NR Affymetrix [333,722] N 03/22/2013 23281178 Hong MG 03/01/2013 Hum Mutat http://www.ncbi.nlm.nih.gov/pubmed/23281178 A genome-wide assessment of variability in human serum metabolism. Metabolite levels 214 European ancestry prostate cancer cases and 188 European ancestry controls 489 European ancestry prostate cancer cases 15q21.3 15 58731153 LIPC - 3990 rs261342-C rs261342 0 261342 intron 0 NR 9E-13 12.04575749056067 (Glycerophospho-N-Palmitoyl Ethanolamine) NR NR Affymetrix [333,722] N 03/22/2013 23281178 Hong MG 03/01/2013 Hum Mutat http://www.ncbi.nlm.nih.gov/pubmed/23281178 A genome-wide assessment of variability in human serum metabolism. Metabolite levels 214 European ancestry prostate cancer cases and 188 European ancestry controls 489 European ancestry prostate cancer cases 12p12.1 12 21382619 SLCO1B1 - 10599 rs11045879-C rs11045879 0 11045879 intron 0 NR 5E-15 14.30102999566398 (Glycochenodeoxycholic acid 3-glucuronide) NR NR Affymetrix [333,722] N 03/22/2013 23281178 Hong MG 03/01/2013 Hum Mutat http://www.ncbi.nlm.nih.gov/pubmed/23281178 A genome-wide assessment of variability in human serum metabolism. Metabolite levels 214 European ancestry prostate cancer cases and 188 European ancestry controls 489 European ancestry prostate cancer cases 7q21.3 7 94938257 PON1 - 5444 rs2057681-G rs2057681 0 2057681 intron 0 NR 7E-15 14.15490195998574 (C9H14Ona) NR NR Affymetrix [333,722] N 03/22/2013 23281178 Hong MG 03/01/2013 Hum Mutat http://www.ncbi.nlm.nih.gov/pubmed/23281178 A genome-wide assessment of variability in human serum metabolism. Metabolite levels 214 European ancestry prostate cancer cases and 188 European ancestry controls 489 European ancestry prostate cancer cases 19p13.12 19 15990431 CYP4F2 - 8529 rs2108622-T rs2108622 0 2108622 missense 0 NR 9E-24 23.04575749056067 (Glycerolphosphocholine) NR NR Affymetrix [333,722] N 03/22/2013 23281178 Hong MG 03/01/2013 Hum Mutat http://www.ncbi.nlm.nih.gov/pubmed/23281178 A genome-wide assessment of variability in human serum metabolism. Metabolite levels 214 European ancestry prostate cancer cases and 188 European ancestry controls 489 European ancestry prostate cancer cases 2q34 2 211074909 ACADL - 33 rs3764913-T rs3764913 0 3764913 intron 0 NR 4E-29 28.39794000867204 (2,6 dimethylheptanoyl carnitine) NR NR Affymetrix [333,722] N 03/22/2013 23281178 Hong MG 03/01/2013 Hum Mutat http://www.ncbi.nlm.nih.gov/pubmed/23281178 A genome-wide assessment of variability in human serum metabolism. Metabolite levels 214 European ancestry prostate cancer cases and 188 European ancestry controls 489 European ancestry prostate cancer cases 11q12.2 11 61571382 FADS1 - 3992 rs174549-G rs174549 0 174549 intron 0 NR 2E-30 29.69897000433602 (Glycerolphosphocholine) NR NR Affymetrix [333,722] N 03/22/2013 23281178 Hong MG 03/01/2013 Hum Mutat http://www.ncbi.nlm.nih.gov/pubmed/23281178 A genome-wide assessment of variability in human serum metabolism. Metabolite levels 214 European ancestry prostate cancer cases and 188 European ancestry controls 489 European ancestry prostate cancer cases 10q24.2 10 100147060 PYROXD2 - 84795 rs4345897-G rs4345897 0 4345897 cds-synon 0 NR 2E-91 90.69897000433602 (Caprolactam) NR NR Affymetrix [333,722] N 06/18/2013 23456092 Park BL 03/01/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23456092 Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. Alcohol dependence 117 Korean ancestry cases, 279 Korean ancestry controls 504 Korean ancestry cases, 471 Korean ancestry controls 4q23 4 100239319 ADH5, ADH4, ADH6, ADH1A, ADH7, ADH1B, ADH1C - 125 rs1229984-? rs1229984 0 1229984 missense 0 NR 3E-21 20.52287874528034 2.35 [1.95-2.84] Illumina [427,349] N 05/30/2013 23533358 Liu Z 02/28/2013 ScientificWorldJournal http://www.ncbi.nlm.nih.gov/pubmed/23533358 NCK2 is significantly associated with opiates addiction in African-origin men. Addiction 1,393 European ancestry women, 1,131 European ancestry men, 568 African ancestry women, 535 African ancestry men NR 2q12.2 2 106457291 NCK2 - 8440 rs2377339-G rs2377339 0 2377339 intron 0 .0159 1E-11 11 (Opiates - African ancestry men - allelic test) 13.87 NR unit increase Illumina [859,185] N 05/30/2013 23533358 Liu Z 02/28/2013 ScientificWorldJournal http://www.ncbi.nlm.nih.gov/pubmed/23533358 NCK2 is significantly associated with opiates addiction in African-origin men. Addiction 1,393 European ancestry women, 1,131 European ancestry men, 568 African ancestry women, 535 African ancestry men NR 2q12.2 2 106457291 NCK2 - 8440 rs2377339-G rs2377339 0 2377339 intron 0 .0159 2E-8 7.698970004336018 (codependence - African ancestry men - adjusted analysis) NR NR Illumina [859,185] N 05/30/2013 23533358 Liu Z 02/28/2013 ScientificWorldJournal http://www.ncbi.nlm.nih.gov/pubmed/23533358 NCK2 is significantly associated with opiates addiction in African-origin men. Addiction 1,393 European ancestry women, 1,131 European ancestry men, 568 African ancestry women, 535 African ancestry men NR 1q32.1[rs12043259]; 2q12.2[rs6747023] NCK2 - 14-SNP Haplotype rs12043259, rs6747023, rs7589342, rs12995333, rs4851870, rs1465641, rs1465639, rs6741172, rs12995849, rs2163350, rs7589561, rs4851095, rs2377339, rs2163349 NR 2E-11 (AGTTCAGATCTCGT - Opiates) NR NR Illumina [859,185] N 05/26/2013 23406873 Shi Y 02/28/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23406873 A genome-wide meta-analysis identifies two novel loci associated with high myopia in the Han Chinese population. Myopia (pathological) 665 Han Chinese ancestry cases, 960 Han Chinese ancestry controls 2,128 Han Chinese ancestry cases, 3,683 Han Chinese ancestry controls 8q24.12[rs7839488]; 8q24.12[rs4395927] SNTB1 - 3-SNP Haplotype rs7839488, rs4395927, rs4455882 0.728 8E-12 (rs7839488-G, rs4395927-C, rs4455882-A) 1.31 [1.22-1.42] Illumina [286,031] N 05/26/2013 23406873 Shi Y 02/28/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23406873 A genome-wide meta-analysis identifies two novel loci associated with high myopia in the Han Chinese population. Myopia (pathological) 665 Han Chinese ancestry cases, 960 Han Chinese ancestry controls 2,128 Han Chinese ancestry cases, 3,683 Han Chinese ancestry controls 8q24.12[rs7839488]; 8q24.12[rs4395927] SNTB1 - 3-SNP Haplotype rs7839488, rs4395927, 4455882 0.235 4E-10 (rs7839488-A, rs4395927-T, 4455882-G) 1.30 [1.2-1.41] Illumina [286,031] N 05/26/2013 23406873 Shi Y 02/28/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23406873 A genome-wide meta-analysis identifies two novel loci associated with high myopia in the Han Chinese population. Myopia (pathological) 665 Han Chinese ancestry cases, 960 Han Chinese ancestry controls 2,128 Han Chinese ancestry cases, 3,683 Han Chinese ancestry controls 8q24.12 8 121562418 SNTB1 - 6641 rs4455882-A rs7839488 0 7839488 intron 0 0.765 2E-11 10.69897000433602 1.32 [1.22-1.43] Illumina [286,031] N 05/26/2013 23406873 Shi Y 02/28/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23406873 A genome-wide meta-analysis identifies two novel loci associated with high myopia in the Han Chinese population. Myopia (pathological) 665 Han Chinese ancestry cases, 960 Han Chinese ancestry controls 2,128 Han Chinese ancestry cases, 3,683 Han Chinese ancestry controls 7q36.3 7 158846929 VIPR2 - 7434 rs2730260-C rs2730260 0 2730260 intron 0 0.238 9E-14 13.04575749056067 1.33 [1.23-1.44] Illumina [286,031] N 05/26/2013 23406873 Shi Y 02/28/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23406873 A genome-wide meta-analysis identifies two novel loci associated with high myopia in the Han Chinese population. Myopia (pathological) 665 Han Chinese ancestry cases, 960 Han Chinese ancestry controls 2,128 Han Chinese ancestry cases, 3,683 Han Chinese ancestry controls 5q31.3 5 141189168 PCDH1 64411 5097 127.37 43.50 rs248471-G rs248471 0 248471 1 0.277 2E-6 5.698970004336018 1.19 [1.11-1.28] Illumina [286,031] N 06/06/2013 23468962 Song C 02/28/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23468962 A genome-wide scan for breast cancer risk haplotypes among African American women. Breast cancer 3,016 African American cases; 2,745 African American controls 10p15.1[rs17141741]; 10p15.1[rs2386661] NR - 3-SNP Haplotype rs17141741,rs2386661,rs4414128 0.78 5E-6 (Haplotype - ???) 1.27 [1.14-1.39] Illumina [1,006,480] N 06/06/2013 23468962 Song C 02/28/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23468962 A genome-wide scan for breast cancer risk haplotypes among African American women. Breast cancer 3,016 African American cases; 2,745 African American controls 4q27[rs17435444]; 4q27[rs6835704] NR - 5-SNP Haplotype rs17435444, rs6835704 NR 2E-6 (Haplotype-?????) NR NR Illumina [1,006,480] N 06/06/2013 23468962 Song C 02/28/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23468962 A genome-wide scan for breast cancer risk haplotypes among African American women. Breast cancer 3,016 African American cases; 2,745 African American controls 5p15.32[rs3806872]; 5p15.32[rs16875333] NR - 5-SNP Haplotype rs3806872, rs16875333 NR 3E-6 (Haplotype-?????) NR NR Illumina [1,006,480] N 06/06/2013 23468962 Song C 02/28/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23468962 A genome-wide scan for breast cancer risk haplotypes among African American women. Breast cancer 3,016 African American cases; 2,745 African American controls 12q22[rs11613298]; 12q22[rs2230754] NR - 5-SNP Haplotype rs11613298, rs2230754 NR 5E-6 (Haplotype-?????) NR NR Illumina [1,006,480] N 06/06/2013 23468962 Song C 02/28/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23468962 A genome-wide scan for breast cancer risk haplotypes among African American women. Breast cancer 3,016 African American cases; 2,745 African American controls 10q22.3 10 81055626 NR - 57178 rs12355688-T rs12355688 0 12355688 intron 0 0.22 6E-6 5.221848749616356 1.24 [1.13-1.36] Illumina [1,006,480] N 06/06/2013 23468962 Song C 02/28/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23468962 A genome-wide scan for breast cancer risk haplotypes among African American women. Breast cancer 3,016 African American cases; 2,745 African American controls 1p36.23[rs9628987]; 1p36.23[rs7535752] NR - 5-SNP Haplotype rs9628987, rs7535752 NR 5E-6 (Haplotype-?????) NR NR Illumina [1,006,480] N 06/06/2013 23468962 Song C 02/28/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23468962 A genome-wide scan for breast cancer risk haplotypes among African American women. Breast cancer 3,016 African American cases; 2,745 African American controls 4q27[rs17435444]; 4q27[rs13116936] TNIP3 - 2-SNP haplotype rs17435444,rs13116936 0.64 3E-7 (Haplotype - AG) 1.23 [1.13-1.33] Illumina [1,006,480] N 06/06/2013 23468962 Song C 02/28/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23468962 A genome-wide scan for breast cancer risk haplotypes among African American women. Breast cancer 3,016 African American cases; 2,745 African American controls 4q27[rs17051310]; 4q27[rs13116936] NR - 5-SNP Haplotype rs17051310, rs13116936 NR 2E-6 (Haplotype-?????) NR NR Illumina [1,006,480] N 06/06/2013 23468962 Song C 02/28/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23468962 A genome-wide scan for breast cancer risk haplotypes among African American women. Breast cancer 3,016 African American cases; 2,745 African American controls 4q27[rs921551]; 4q27[rs4455437] NR - 5-SNP Haplotype rs921551, rs4455437 NR 2E-6 (Haplotype-?????) NR NR Illumina [1,006,480] N 06/06/2013 23468962 Song C 02/28/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23468962 A genome-wide scan for breast cancer risk haplotypes among African American women. Breast cancer 3,016 African American cases; 2,745 African American controls 1p36.23[rs9628987]; 1p36.23[rs2289731] SLC45A1 - 5-SNP haplotype rs9628987,rs2289731,rs12711517,rs2305016,rs7535752 0.76 5E-6 (Haplotype - ?????) 1.23 [1.12-1.35] Illumina [1,006,480] N 06/06/2013 23468962 Song C 02/28/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23468962 A genome-wide scan for breast cancer risk haplotypes among African American women. Breast cancer 3,016 African American cases; 2,745 African American controls 17q23.2[rs3785856]; 17q23.2[rs10853029] NR - 5-SNP Haplotype rs3785856, rs10853029 NR 8E-6 (Haplotype-?????) NR NR Illumina [1,006,480] N 06/06/2013 23468962 Song C 02/28/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23468962 A genome-wide scan for breast cancer risk haplotypes among African American women. Breast cancer 3,016 African American cases; 2,745 African American controls 14q24.1[rs765899]; 14q24.1[rs737387] NR - 6-SNP Haplotype rs765899,rs737387,rs2842347,rs757369,rs10132579,rs2842346 0.95 2E-6 (Haplotype - ??????) 1.67 [1.35-2.08] Illumina [1,006,480] N 06/06/2013 23468962 Song C 02/28/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23468962 A genome-wide scan for breast cancer risk haplotypes among African American women. Breast cancer 3,016 African American cases; 2,745 African American controls 3p26.1[rs6797852]; 3p26.1[rs1810320] NR - 5-SNP Haplotype rs6797852, rs1810320 NR 3E-6 (Haplotype-?????) NR NR Illumina [1,006,480] N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics up to 5,043 European ancestry males, up to 5,756 European ancestry females 6p21.31 6 34763982 C6orf106 - 54887 rs9469890-C rs9469890 0 9469890 intron 0 0.88 9E-8 7.045757490560674 (Pubertal growth) .12 [0.077-0.163] unit decrease Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics up to 5,043 European ancestry males, up to 5,756 European ancestry females 6q16.3 6 105378954 LIN28B 57531 100113403 71.16 5.22 rs7759938-C rs7759938 0 7759938 1 0.32 4E-9 8.397940008672036 (Late pubertal growth) .11 [0.079-0.141] unit increase Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics up to 5,043 European ancestry males, up to 5,756 European ancestry females 2p23.3 2 25169200 ADCY3,DNAJC27,POMC - 51277 rs1172294-G rs1172294 0 1172294 UTR-3 0 0.45 1E-8 8 (Pubertal growth) .08 [0.053-0.107] unit decrease Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics up to 5,043 European ancestry males, up to 5,756 European ancestry females 3p12.1 3 86850618 VGLL3 100422711 389136 786.15 136.51 rs7628864-G rs7628864 0 7628864 1 0.38 3E-9 8.522878745280337 (Pubertal growth, females) .11 [0.073-0.147] unit decrease Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics up to 5,043 European ancestry males, up to 5,756 European ancestry females 9q31.3 9 114293634 ZNF483 - 158399 rs10980926-G rs10980926 0 10980926 intron 0 0.65 2E-7 6.698970004336019 (Pubertal growth) .07 [0.043-0.097] unit decrease Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics up to 5,043 European ancestry males, up to 5,756 European ancestry females 6p21.32 6 32383050 HLA-DRA,TAP2 56244 3122 8.15 24.57 rs4959027-G rs4959027 0 4959027 1 0.82 9E-7 6.045757490560675 (Pubertal growth) .09 [0.057-0.123] unit decrease Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics up to 5,043 European ancestry males, up to 5,756 European ancestry females 4q21.21 4 82144926 PRKG2, BMP3 5593 153020 18.71 203.29 rs1662853-C rs1662853 0 1662853 1 0.76 1E-7 7 (Pubertal growth) .08 [0.051-0.109] unit decrease Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics up to 5,043 European ancestry males, up to 5,756 European ancestry females 12q22 12 93983554 SOCS2 8835 8738 13.03 87.60 rs7953508-C rs7953508 0 7953508 1 0.72 4E-6 5.397940008672037 (Pubertal growth) .07 [0.041-0.099] unit decrease Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics up to 5,043 European ancestry males, up to 5,756 European ancestry females 6p21.33 6 31360255 MICA,VARS2 267015 100507436 9.99 7.31 rs7751505-C rs7751505 0 7751505 1 0.28 4E-6 5.397940008672037 (Pubertal growth) .07 [0.041-0.099] unit decrease Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics up to 5,043 European ancestry males, up to 5,756 European ancestry females 13q14.3 13 51106788 DLEU7 100130718 220107 170.89 179.97 rs3118906-G rs3118906 0 3118906 1 0.69 5E-6 5.301029995663981 (Pubertal growth) .07 [0.043-0.097] unit increase Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics up to 5,043 European ancestry males, up to 5,756 European ancestry females 1p31.1 1 74993063 TNNI3K - 51086;100526835 rs1514174-C rs1514174 0 1514174 intron;intron 0 0.47 6E-6 5.221848749616356 (Pubertal growth, females) .08 [0.045-0.115] unit decrease Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics up to 5,043 European ancestry males, up to 5,756 European ancestry females 9q31.3 9 114293634 ZNF483 - 158399 rs10980926-G rs10980926 0 10980926 intron 0 0.65 3E-6 5.522878745280337 (Pubertal growth,males) .10 [0.059-0.141] unit decrease Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics up to 5,043 European ancestry males, up to 5,756 European ancestry females 6q16.3 6 105364421 LIN28B 57531 100113403 56.63 19.75 rs11156429-G rs11156429 0 11156429 1 0.55 2E-7 6.698970004336019 (Late pubertal growth, females) .11 [0.071-0.149] unit decrease Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics up to 5,043 European ancestry males, up to 5,756 European ancestry females 9q31.2 9 108967088 TMEM38B 100129319 58499 354.21 658.29 rs2090409-C rs2090409 0 2090409 1 0.66 2E-6 5.698970004336018 (Late pubertal growth, males) .11 [0.065-0.155] unit increase Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics 7,161 European ancestry males, 6,879 European ancestry females 5,133 European ancestry males, 4,577 European ancestry females 16p11.2 16 29967434 MAPK3 253980 124446 29.89 5.92 rs4788196-G rs4788196 0 4788196 1 0.44 9E-11 10.04575749056067 (Single Height) .07 [0.048-0.092] unit increase Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics 7,161 European ancestry males, 6,879 European ancestry females 5,133 European ancestry males, 4,577 European ancestry females 1q32.1 1 205689807 NUCKS1,RAB7L1 - 64710 rs823094-G rs823094 0 823094 intron 0 0.43 2E-7 6.698970004336019 (Single Height) .05 [0.03-0.07] unit decrease Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics 7,161 European ancestry males, 6,879 European ancestry females 5,133 European ancestry males, 4,577 European ancestry females 9q21.12 9 73157416 TRPM3 - 80036 rs10780944-G rs10780944 0 10780944 intron 0 0.19 8E-7 6.096910013008056 (Single Height-males) .09 [0.053-0.127] unit increase Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics 7,161 European ancestry males, 6,879 European ancestry females 5,133 European ancestry males, 4,577 European ancestry females 6p22.1 6 28129789 ZNF 7745 493821 4.55 14.18 rs1150668-G rs1150668 0 1150668 1 0.43 2E-7 6.698970004336019 (Single Height) .06 [0.038-0.082] unit decrease Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics 7,161 European ancestry males, 6,879 European ancestry females 5,133 European ancestry males, 4,577 European ancestry females 11q22.1 11 102009280 YAP1 - 10413 rs11225148-G rs11225148 0 11225148 intron 0 0.06 2E-6 5.698970004336018 (Single Height) .10 [0.051-0.149] unit decrease Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics 7,161 European ancestry males, 6,879 European ancestry females 5,133 European ancestry males, 4,577 European ancestry females 1p31.1 1 76477207 ST6 127247 256435 79.09 63.18 rs12122440-C rs12122440 0 12122440 1 0.16 2E-6 5.698970004336018 (Single Height) .08 [0.049-0.111] unit increase Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics 7,161 European ancestry males, 6,879 European ancestry females 5,133 European ancestry males, 4,577 European ancestry females 5q35.3 5 178426319 GRM6 2916 345462 4.20 24.46 rs11249608-C rs11249608 0 11249608 1 0.69 6E-7 6.221848749616355 (Single Height-female) .08 [0.049-0.111] unit increase Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics 7,161 European ancestry males, 6,879 European ancestry females 5,133 European ancestry males, 4,577 European ancestry females 1p32.2 1 57625932 DAB1 - 1600 rs17541203-C rs17541203 0 17541203 intron 0 0.082 2E-6 5.698970004336018 (Single Height-female) .13 [0.073-0.187] unit decrease Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics 7,161 European ancestry males, 6,879 European ancestry females 5,133 European ancestry males, 4,577 European ancestry females 19q13.33 19 49214274 MAMSTR 2524 284358 5.08 1.98 rs281379-G rs281379 0 281379 1 0.52 5E-8 7.30102999566398 (Single Height-males) .07 [0.043-0.097] unit increase Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics 7,161 European ancestry males, 6,879 European ancestry females 5,133 European ancestry males, 4,577 European ancestry females 12q24.31 12 124085502 DDX55 - 57696 rs786425-G rs786425 0 786425 nearGene-5 0 0.4 3E-6 5.522878745280337 (Single Height) .06 [0.038-0.082] unit increase Illumina & Affymetrix [~2.5 million] (imputed) N 05/31/2013 23449627 Cousminer DL 02/27/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23449627 Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Pubertal anthropometrics 7,161 European ancestry males, 6,879 European ancestry females 5,133 European ancestry males, 4,577 European ancestry females 12p12.3 12 14966604 C12orf60,HIST4H4 - 144608;440087 rs4764124-C rs4764124 0 4764124 intron;intron 0 0.52 8E-7 6.096910013008056 (Single Height) .05 [0.03-0.07] unit increase Illumina & Affymetrix [~2.5 million] (imputed) N 05/26/2013 23454411 Lin MT 02/27/2013 Transl Res http://www.ncbi.nlm.nih.gov/pubmed/23454411 A genome-wide association analysis identifies novel susceptibility loci for coronary arterial lesions in patients with Kawasaki disease. Coronary arterial lesions in patients with Kawasaki disease 64 East Asian ancestry serious cases, 70 East Asian ancestry minor cases 117 East Asian ancestry serious cases, 128 East Asian ancestry minor cases NR NR - NR NR NR NS NS NR NR Affymetrix [470,949] N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 8q21.3 8 89760311 MMP16 4325 8767 420.59 1009.66 rs7004633-? rs7004633 0 7004633 1 0.184 3E-8 7.522878745280337 (Modelling analysis) NR NR NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 2p16.3 2 48649705 NR 3344 129285 43.27 18.20 rs7565792-C rs7565792 0 7565792 1 NR 7E-6 5.154901959985742 (5 degree of freedom test) 1.03 [1.00-1.06] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 10q21.2 10 62279124 ANK3 - 288 rs10994397-? rs10994397 0 10994397 intron 0 0.065 7E-9 8.154901959985743 NR NR NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 12q23.1 12 99498187 ANKS1B - 56899 rs10860392-T rs10860392 0 10860392 intron 0 NR 2E-6 5.698970004336018 (Modelling analysis) 1.06 [1.04-1.09] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 4q24 4 102589283 BANK1 90024 55024 319.24 122.48 rs7700191-A rs7700191 0 7700191 1 NR 4E-6 5.397940008672037 (Modelling analysis) 1.12 [1.06-1.17] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 8q22.3 8 106142333 ZFPM2 644103 100128132 118.43 64.60 rs9297357-T rs9297357 0 9297357 1 NR 4E-7 6.397940008672037 (Modelling analysis) 1.07 [1.04-1.10] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 7q31.1 7 110047964 Intergenic 646620 54674 408.26 683.10 rs4730430-T rs4730430 0 4730430 1 NR 3E-6 5.522878745280337 (Modelling analysis) 1.06 [1.03-1.08] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 6q25.2 6 152790573 SYNE1 - 23345 rs9371601-? rs9371601 0 9371601 intron 0 0.346 4E-9 8.397940008672036 (Modelling analysis) NR NR NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 4q35.2 4 189861251 Intergenic 100420038 2483 225.07 1000.72 rs11731175-T rs11731175 0 11731175 1 NR 5E-6 5.301029995663981 (Modelling analysis) 1.06 [1.03-1.09] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 6p21.33 6 30913458 NR - 135656 rs3132581-G rs3132581 0 3132581 intron 0 NR 2E-7 6.698970004336019 (Modelling analysis) NR NR NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 11q14.1 11 79077193 ODZ4 - 26011 rs12576775-? rs12576775 0 12576775 intron 0 0.175 4E-8 7.397940008672037 (Modelling analysis) NR NR NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 6p22.1 6 30174131 MHC region - 7726 rs2021722-? rs2021722 0 2021722 intron 0 0.789 2E-12 11.69897000433602 (Modelling analysis) NR NR NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 18q21.2 18 52752017 CCDC68 387615 6925 129.75 137.55 rs12966547-? rs12966547 0 12966547 1 0.588 3E-10 9.522878745280336 (Modelling analysis) NR NR NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 10q24.32 10 104775908 CNNM2 - 54805 rs7914558-? rs7914558 0 7914558 intron 0 0.587 2E-9 8.698970004336019 (Modelling analysis) NR NR NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 10q24.33 10 104906211 NT5C2 - 22978 rs11191580-? rs11191580 0 11191580 intron 0 0.911 1E-8 8 (Modelling analysis) NR NR NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 8p23.2 8 4180844 CSMD1 - 64478 rs10503253-? rs10503253 0 10503253 intron 0 0.193 4E-8 7.397940008672037 (Modelling analysis) NR NR NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 2q32.3 2 193984621 PCGEM1 100271070 343981 345.47 1009.40 rs17662626-? rs17662626 0 17662626 1 0.915 5E-8 7.30102999566398 (Modelling analysis) NR NR NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 11q24.2 11 125461709 STT3A - 3703 rs548181-? rs548181 0 548181 nearGene-5 0 0.884 9E-7 6.045757490560675 (Modelling analysis) NR NR NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 20p13 20 594780 NR 6939 140809 3.87 32.48 rs1533087-T rs1533087 0 1533087 1 NR 9E-6 5.045757490560675 (Modelling analysis) 1.06 [1.03-1.09] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 7p22.3 7 2041432 NR - 8379 rs1107592-A rs1107592 0 1107592 intron 0 NR 5E-6 5.301029995663981 (Modelling analysis) 1.06 [1.03-1.09] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 10p14 10 6946263 Intergenic 100507127 57713 61.40 254.32 rs6602217-T rs6602217 0 6602217 1 NR 2E-6 5.698970004336018 (Modelling analysis) 1.12 [1.07-1.17] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 16p13.2 16 9675246 Intergenic 653737 2903 424.47 172.02 rs12325410-T rs12325410 0 12325410 1 NR 1E-6 5.999999999999999 (Modelling analysis) 1.09 [1.05-1.13] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 11p14.3 11 22312566 ANO5, SLC17A6 203859 57084 7.65 47.10 rs11827962-C rs11827962 0 11827962 1 NR 6E-6 5.221848749616356 (5 degree of freedom test) 1.04 [0.94-1.15] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 20p13 20 4352104 Intergenic 146 128668 122.45 219.48 rs159788-G rs159788 0 159788 1 NR 7E-6 5.154901959985742 (5 degree of freedom test) 1.01 [0.97-1.05] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 1q21.3 1 150324284 NR - 9129 rs11587682-C rs11587682 0 11587682 intron 0 NR 7E-6 5.154901959985742 (5 degree of freedom test) 1.09 [1.05-1.12] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 2q32.1 2 185533580 ZNF804A - 91752 rs7597593-T rs7597593 0 7597593 intron 0 NR 8E-6 5.096910013008055 (5 degree of freedom test) 1.06 [1.03-1.08] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 2q23.1 2 149865250 KIF5C, LYPD6B 3800 130576 178.33 29.73 rs6435387-G rs6435387 0 6435387 1 NR 8E-6 5.096910013008055 (5 degree of freedom test) 1.13 [1.06-1.19] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 9p21.3 9 22819576 Intergenic - 441389 rs7849973-? rs7849973 0 7849973 intron 0 NR 8E-6 5.096910013008055 (5 degree of freedom test) 1.05 [1.02-1.08] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 7q33 7 136146536 Intergenic 136319 392100 484.33 252.04 rs10250997-C rs10250997 0 10250997 1 NR 8E-6 5.096910013008055 (5 degree of freedom test) 1.03 [0.99-1.07] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 9p24.3 9 2194227 SMARCA2 6595 7436 .60 427.57 rs4741652-T rs4741652 0 4741652 1 NR 7E-6 5.154901959985742 (Modelling analysis) 1.07 [1.04-1.12] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 10q21.2 10 62222107 ANK3 - 288 rs10994359-C rs10994359 0 10994359 intron 0 NR 3E-9 8.522878745280337 (5 degree of freedom test) 1.08 [1.03-1.13] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 12p13.33 12 2345295 CACNA1C, DCP1B - 775 rs1006737-? rs1006737 0 1006737 intron 0 NR 5E-9 8.301029995663981 (5 degree of freedom test) 1.07 [1.05-1.10] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 6p22.1 6 30032522 MHC region - 30834 rs8321-? rs8321 0 8321 UTR-3 0 NR 8E-9 8.096910013008056 (5 degree of freedom test) 1.08 [1.04-1.12] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 1p36.23 1 8422676 SLC45A1, RERE, ENO1 - 473 rs2252865-T rs2252865 0 2252865 intron 0 NR 5E-7 6.30102999566398 (5 degree of freedom test) 1.03 [1.00-1.06] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR NR NR - rs1715-T rs1715 NR 6E-7 6.221848749616355 (5 degree of freedom test) 1.41 [1.29-1.53] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 1p31.1 1 79238015 IFI44L, IFI44 100130630 64123 105.63 117.43 rs4650608-T rs4650608 0 4650608 1 NR 1E-6 5.999999999999999 (5 degree of freedom test) 1.06 [1.03-1.09] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 7q21.11 7 83772415 SEMA3A - 10371 rs447-C rs447 0 447 intron 0 NR 4E-6 5.397940008672037 (5 degree of freedom test) 1.03 [1.00-1.05] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 7p22.3 7 2278226 NR - 29960 rs7799006-C rs7799006 0 7799006 intron 0 NR 5E-6 5.301029995663981 (5 degree of freedom test) 1.06 [1.03-1.08] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 21q21.3 21 31013159 GRIK1 - 2897 rs363598-C rs363598 0 363598 intron 0 NR 5E-6 5.301029995663981 (5 degree of freedom test) 1.01 [0.98-1.03] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 2q37.1 2 233736244 NR - 389084 rs2675968-T rs2675968 0 2675968 intron 0 NR 5E-6 5.301029995663981 (5 degree of freedom test) 1.02 [0.99-1.04] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 10q22.3 10 80953136 ZMIZ1 - 57178 rs703970-C rs703970 0 703970 intron 0 NR 5E-6 5.301029995663981 (5 degree of freedom test) 1.01 [0.99-1.03] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 11q23.3 11 118341649 NR - 4297 rs7948661-C rs7948661 0 7948661 intron 0 NR 5E-6 5.301029995663981 (5 degree of freedom test) 1.05 [1.00-1.10] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 16p13.2 16 9911386 GRIN2A - 2903 rs8058295-A rs8058295 0 8058295 intron 0 NR 7E-6 5.154901959985742 (Modelling analysis) 1.06 [1.04-1.09] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 19p13.12 19 14713493 NR - 388512 rs7254215-A rs7254215 0 7254215 intron 0 NR 7E-6 5.154901959985742 (Modelling analysis) 1.09 [1.05-1.13] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 10p12.32 10 18601928 CACNB2 - 783 rs2799573 -? rs2799573 0 2799573 intron 0 0.715 4E-8 7.397940008672037 (Modelling analysis) 1.08 [1.05-1.12] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 16p12.2 16 23640467 NR - 79728 rs249954-A rs249954 0 249954 intron 0 NR 2E-6 5.698970004336018 (Modelling analysis) 1.07 [1.04-1.10] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 7p15.3 7 24692552 Intergenic - 51678 rs2721800-C rs2721800 0 2721800 0 NR 6E-7 6.221848749616355 (Modelling analysis) 1.08 [1.05-1.12] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 1p35.2 1 30437268 Intergenic 10076 4146 783.94 746.86 rs6694545-A rs6694545 0 6694545 1 NR 1E-6 5.999999999999999 (Modelling analysis) 1.07 [1.04-1.11] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 6p21.32 6 32675109 Intergenic 404026 3118 .53 34.05 rs9275524-T rs9275524 0 9275524 1 NR 2E-7 6.698970004336019 (Modelling analysis) 1.07 [1.04-1.09] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 8p12 8 34236992 Intergenic 137107 100133273 55.80 494.65 rs2609653-T rs2609653 0 2609653 1 NR 3E-6 5.522878745280337 (Modelling analysis) 1.13 [1.07-1.19] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 3p22.2 3 36842623 NR 645548 9881 32.25 25.69 rs13072940-A rs13072940 0 13072940 1 NR 9E-6 5.045757490560675 (Modelling analysis) 1.06 [1.03-1.08] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 18q21.2 18 52821124 Intergenic 387615 6925 198.86 68.44 rs9951150-A rs9951150 0 9951150 1 NR 6E-7 6.221848749616355 (Modelling analysis) 1.06 [1.04-1.09] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 18q21.2 18 53066328 TCF4 - 6925 rs11152369-A rs11152369 0 11152369 intron 0 NR 2E-7 6.698970004336019 (Modelling analysis) 1.19 [1.12-1.28] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 3p21.1 3 52733106 NR - 55830 rs6765687-T rs6765687 0 6765687 intron 0 NR 5E-6 5.301029995663981 (Modelling analysis) 1.07 [1.04-1.11] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 3p21.1 3 52833219 ITIH3 - 3699 rs2535629-? rs2535629 0 2535629 intron 0 0.651 3E-12 11.52287874528034 1.10 [1.07-1.12] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 1p31.1 1 79263805 ELTD1 100130630 64123 131.42 91.64 rs10873998-T rs10873998 0 10873998 1 NR 4E-6 5.397940008672037 (Modelling analysis) 1.06 [1.03-1.09] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 15q25.3 15 88723712 NTRK3 - 4916 rs1104918-T rs1104918 0 1104918 intron 0 NR 6E-6 5.221848749616356 (Modelling analysis) 1.07 [1.04-1.10] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 16q24.3 16 89741496 NR 124045 8558 3.82 11.58 rs12443954-A rs12443954 0 12443954 1 NR 1E-6 5.999999999999999 (Modelling analysis) 1.08 [1.04-1.11] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 1p21.3 1 98502934 DPYD, MIR137 - 400765 rs1625579-? rs1625579 0 1625579 intron 0 0.801 2E-11 10.69897000433602 (Modelling analysis) NR NR NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 2q11.2 2 102663628 MAP4K4, IL1R2 7850 3554 18.74 106.77 rs2310173-T rs2310173 0 2310173 1 NR 3E-6 5.522878745280337 (Modelling analysis) 1.06 [1.03-1.08] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 10q24.32 10 104660004 AS3MT - 57412;100528007 rs11191454-? rs11191454 0 11191454 intron;intron 0 0.91 1E-8 8 1.13 [1.08-1.18] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 10q24.33 10 105297770 NR - 9148 rs7069733-C rs7069733 0 7069733 intron 0 NR 7E-6 5.154901959985742 (Modelling analysis) 1.08 [1.04-1.12] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 11q22.3 11 107756551 SLC35F2, RAB39 54733 643949 26.64 22.52 rs2186903-A rs2186903 0 2186903 1 NR 4E-6 5.397940008672037 (Modelling analysis) 1.07 [1.04-1.11] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 13q33.3 13 108668547 FAM155A 100302286 3981 484.95 191.24 rs12871532-T rs12871532 0 12871532 1 NR 1E-6 5.999999999999999 (Modelling analysis) 1.06 [1.04-1.09] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 5q23.3 5 130413981 NR 133629 3094 87.82 80.89 rs6867265-A rs6867265 0 6867265 1 NR 2E-6 5.698970004336018 (Modelling analysis) 1.11 [1.06-1.16] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 7q33 7 137858766 Intergenic 100616226 442726 50.20 124.04 rs10255295-A rs10255295 0 10255295 1 NR 5E-6 5.301029995663981 (Modelling analysis) 1.10 [1.06-1.14] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 5q32 5 146225244 PPP2R2B - 5521 rs609412-A rs609412 0 609412 intron 0 NR 2E-6 5.698970004336018 (Modelling analysis) 1.07 [1.04-1.10] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 4q31.3 4 152908169 Intergenic 5188 55294 225.99 334.24 rs360932-A rs360932 0 360932 1 NR 8E-6 5.096910013008055 (Modelling analysis) 1.06 [1.03-1.08] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 2q31.3 2 181076749 Intergenic 57703 729009 204.97 660.67 rs13418455-T rs13418455 0 13418455 1 NR 1E-6 5.999999999999999 (Modelling analysis) 1.06 [1.04-1.09] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 1q32.1 1 200960307 NR - 23046 rs2297909-A rs2297909 0 2297909 intron 0 NR 2E-6 5.698970004336018 (Modelling analysis) 1.06 [1.04-1.09] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 2q37.3 2 240112972 HDAC4, MGC16025 - 9759 rs3791556-A rs3791556 0 3791556 intron 0 NR 8E-6 5.096910013008055 (Modelling analysis) 1.08 [1.04-1.11] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 6p21.32 6 32913246 NR 3109 3108 4.40 3.15 rs1480380-C rs1480380 0 1480380 1 0.908 6E-7 6.221848749616355 (Modelling analysis) NR NR NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 8p12 8 34126948 Intergenic 349198 137107 299.55 53.53 rs6990255-T rs6990255 0 6990255 1 NR 2E-6 5.698970004336018 (5 degree of freedom test) 1.15 [1.09-1.20] NR [1,252,901] (imputed) N 06/06/2013 23453885 Smoller JW 02/27/2013 Lancet http://www.ncbi.nlm.nih.gov/pubmed/23453885 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) 6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls NR 3p22.2 3 36856030 NR 645548 9881 45.65 12.28 rs9834970-C rs9834970 0 9834970 1 NR 2E-6 5.698970004336018 (5 degree of freedom test) 1.05 [1.03-1.07] NR [1,252,901] (imputed) N 05/26/2013 23455491 Zuo L 02/27/2013 Drug Alcohol Depend http://www.ncbi.nlm.nih.gov/pubmed/23455491 NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. Alcohol dependence 1,409 European ancestry cases, 1,518 European ancestry controls 6,438 European ancestry individuals from 1,645 affected families 1p35.2 1 31883925 NKAIN1, SNRNP40, ZCCHC17, FABP3, SERINC2 - 347735 rs4478858-G rs4478858 0 4478858 intron 0 NR 3E-8 7.522878745280337 1.26 Illumina [805,814] N 05/26/2013 23509613 Kamboh MI 02/24/2013 Autoimmune Dis http://www.ncbi.nlm.nih.gov/pubmed/23509613 Genome-wide association study of antiphospholipid antibodies. Presence of antiphospholipid antibodies 183 European ancestry ACL-positive cases, 487 European ancestry ACL-negative controls, 127 European ancestry LAC-positive cases, 581 European ancestry LAC-negative controls, 136 European ancestry Anti-B2GPI-positive cases, 360 European ancestry Anti-B2GPI-negative controls NR 5q11.2 5 51706906 PELO 100271072 53918 128.21 376.87 rs6889746-? rs6889746 0 6889746 1 .3534 6E-6 5.221848749616356 (ACL) 1.78 [NR] Affymetrix [906,600] N 05/26/2013 23509613 Kamboh MI 02/24/2013 Autoimmune Dis http://www.ncbi.nlm.nih.gov/pubmed/23509613 Genome-wide association study of antiphospholipid antibodies. Presence of antiphospholipid antibodies 183 European ancestry ACL-positive cases, 487 European ancestry ACL-negative controls, 127 European ancestry LAC-positive cases, 581 European ancestry LAC-negative controls, 136 European ancestry Anti-B2GPI-positive cases, 360 European ancestry Anti-B2GPI-negative controls NR 1p31.3 1 67123057 SGIP1 - 84251 rs6681460-? rs6681460 0 6681460 intron 0 0.3755 7E-6 5.154901959985742 (ACL) 1.83 [NR] Affymetrix [906,600] N 05/26/2013 23509613 Kamboh MI 02/24/2013 Autoimmune Dis http://www.ncbi.nlm.nih.gov/pubmed/23509613 Genome-wide association study of antiphospholipid antibodies. Presence of antiphospholipid antibodies 183 European ancestry ACL-positive cases, 487 European ancestry ACL-negative controls, 127 European ancestry LAC-positive cases, 581 European ancestry LAC-negative controls, 136 European ancestry Anti-B2GPI-positive cases, 360 European ancestry Anti-B2GPI-negative controls NR 6q14.1 6 80156259 LCA5 1624 167691 9.31 38.45 rs12204683-? rs12204683 0 12204683 1 0.2378 7E-6 5.154901959985742 (ACL) 1.88 [NR] Affymetrix [906,600] N 05/26/2013 23509613 Kamboh MI 02/24/2013 Autoimmune Dis http://www.ncbi.nlm.nih.gov/pubmed/23509613 Genome-wide association study of antiphospholipid antibodies. Presence of antiphospholipid antibodies 183 European ancestry ACL-positive cases, 487 European ancestry ACL-negative controls, 127 European ancestry LAC-positive cases, 581 European ancestry LAC-negative controls, 136 European ancestry Anti-B2GPI-positive cases, 360 European ancestry Anti-B2GPI-negative controls NR 22q11.21 22 18448113 MICAL3 - 57553 rs1978968-? rs1978968 0 1978968 intron 0 0.2144 2E-6 5.698970004336018 (LAC) 2.24 [NR] Affymetrix [906,600] N 05/26/2013 23509613 Kamboh MI 02/24/2013 Autoimmune Dis http://www.ncbi.nlm.nih.gov/pubmed/23509613 Genome-wide association study of antiphospholipid antibodies. Presence of antiphospholipid antibodies 183 European ancestry ACL-positive cases, 487 European ancestry ACL-negative controls, 127 European ancestry LAC-positive cases, 581 European ancestry LAC-negative controls, 136 European ancestry Anti-B2GPI-positive cases, 360 European ancestry Anti-B2GPI-negative controls NR 2p12 2 75790489 FAM176A - 84141 rs17011455-? rs17011455 0 17011455 intron 0 0.01661 5E-6 5.301029995663981 (LAC) 5.21 [NR] Affymetrix [906,600] N 05/26/2013 23509613 Kamboh MI 02/24/2013 Autoimmune Dis http://www.ncbi.nlm.nih.gov/pubmed/23509613 Genome-wide association study of antiphospholipid antibodies. Presence of antiphospholipid antibodies 183 European ancestry ACL-positive cases, 487 European ancestry ACL-negative controls, 127 European ancestry LAC-positive cases, 581 European ancestry LAC-negative controls, 136 European ancestry Anti-B2GPI-positive cases, 360 European ancestry Anti-B2GPI-negative controls NR 20p12.1 20 17566069 DSTN - 11034 rs17791782-? rs17791782 0 17791782 intron 0 0.07867 6E-6 5.221848749616356 (LAC) 2.63 [NR] Affymetrix [906,600] N 05/26/2013 23509613 Kamboh MI 02/24/2013 Autoimmune Dis http://www.ncbi.nlm.nih.gov/pubmed/23509613 Genome-wide association study of antiphospholipid antibodies. Presence of antiphospholipid antibodies 183 European ancestry ACL-positive cases, 487 European ancestry ACL-negative controls, 127 European ancestry LAC-positive cases, 581 European ancestry LAC-negative controls, 136 European ancestry Anti-B2GPI-positive cases, 360 European ancestry Anti-B2GPI-negative controls NR 2q31.2 2 180216731 SESTD1 91404 151126 87.38 89.98 rs13403289-? rs13403289 0 13403289 1 0.3857 6E-6 5.221848749616356 (ACL, LAC, or anti-B2 GPI) 2.42 [NR] Affymetrix [906,600] N 05/26/2013 23509613 Kamboh MI 02/24/2013 Autoimmune Dis http://www.ncbi.nlm.nih.gov/pubmed/23509613 Genome-wide association study of antiphospholipid antibodies. Presence of antiphospholipid antibodies 183 European ancestry ACL-positive cases, 487 European ancestry ACL-negative controls, 127 European ancestry LAC-positive cases, 581 European ancestry LAC-negative controls, 136 European ancestry Anti-B2GPI-positive cases, 360 European ancestry Anti-B2GPI-negative controls NR 7p14.3 7 32189540 PDE1C - 5137 rs11975235-? rs11975235 0 11975235 intron 0 0.4843 3E-6 5.522878745280337 (anti-B2 GPI) 2.14 [NR] Affymetrix [906,600] N 05/26/2013 23509613 Kamboh MI 02/24/2013 Autoimmune Dis http://www.ncbi.nlm.nih.gov/pubmed/23509613 Genome-wide association study of antiphospholipid antibodies. Presence of antiphospholipid antibodies 183 European ancestry ACL-positive cases, 487 European ancestry ACL-negative controls, 127 European ancestry LAC-positive cases, 581 European ancestry LAC-negative controls, 136 European ancestry Anti-B2GPI-positive cases, 360 European ancestry Anti-B2GPI-negative controls NR 2q24.2 2 161886103 TANK 100616364 10010 621.71 107.36 rs2357982-? rs2357982 0 2357982 1 0.3885 3E-6 5.522878745280337 (anti-B2 GPI) 2.19 [NR] Affymetrix [906,600] N 05/26/2013 23509613 Kamboh MI 02/24/2013 Autoimmune Dis http://www.ncbi.nlm.nih.gov/pubmed/23509613 Genome-wide association study of antiphospholipid antibodies. Presence of antiphospholipid antibodies 183 European ancestry ACL-positive cases, 487 European ancestry ACL-negative controls, 127 European ancestry LAC-positive cases, 581 European ancestry LAC-negative controls, 136 European ancestry Anti-B2GPI-positive cases, 360 European ancestry Anti-B2GPI-negative controls NR 13q14.11 13 40741907 FLJ42392 100874397 100874127 349.72 14.04 rs9315762-? rs9315762 0 9315762 1 0.1535 7E-6 5.154901959985742 (anti-B2 GPI) 2.26 [NR] Affymetrix [906,600] N 05/26/2013 23509613 Kamboh MI 02/24/2013 Autoimmune Dis http://www.ncbi.nlm.nih.gov/pubmed/23509613 Genome-wide association study of antiphospholipid antibodies. Presence of antiphospholipid antibodies 183 European ancestry ACL-positive cases, 487 European ancestry ACL-negative controls, 127 European ancestry LAC-positive cases, 581 European ancestry LAC-negative controls, 136 European ancestry Anti-B2GPI-positive cases, 360 European ancestry Anti-B2GPI-negative controls NR 20p12.1 20 16003406 MACROD2 - 140733 rs6080100-? rs6080100 0 6080100 intron 0 0.2655 7E-6 5.154901959985742 (anti-B2 GPI) 2.09 [NR] Affymetrix [906,600] N 05/26/2013 23509613 Kamboh MI 02/24/2013 Autoimmune Dis http://www.ncbi.nlm.nih.gov/pubmed/23509613 Genome-wide association study of antiphospholipid antibodies. Presence of antiphospholipid antibodies 183 European ancestry ACL-positive cases, 487 European ancestry ACL-negative controls, 127 European ancestry LAC-positive cases, 581 European ancestry LAC-negative controls, 136 European ancestry Anti-B2GPI-positive cases, 360 European ancestry Anti-B2GPI-negative controls NR 16q23.2 16 80192605 DYNLRB2 4094 83657 557.98 382.25 rs8060581-? rs8060581 0 8060581 1 0.02466 1E-6 5.999999999999999 (ACL, LAC, or Anti-B2 GPI) 6.71 [NR] Affymetrix [906,600] N 05/26/2013 23509613 Kamboh MI 02/24/2013 Autoimmune Dis http://www.ncbi.nlm.nih.gov/pubmed/23509613 Genome-wide association study of antiphospholipid antibodies. Presence of antiphospholipid antibodies 183 European ancestry ACL-positive cases, 487 European ancestry ACL-negative controls, 127 European ancestry LAC-positive cases, 581 European ancestry LAC-negative controls, 136 European ancestry Anti-B2GPI-positive cases, 360 European ancestry Anti-B2GPI-negative controls NR 13q33.3 13 109380726 MYO16 - 23026 rs10492418-? rs10492418 0 10492418 0 0.4292 2E-6 5.698970004336018 (anti-B2 GPI) 2.17 [NR] Affymetrix [906,600] N 06/04/2013 23432519 O'Brien RP 02/21/2013 Clin Transplant http://www.ncbi.nlm.nih.gov/pubmed/23432519 A genome-wide association study of recipient genotype and medium-term kidney allograft function. Renal transplant outcome 263 European ancestry individuals 13q34 13 112836655 NR 6656 122258 110.64 194.00 rs9324268-A rs9324268 0 9324268 1 NR 2E-6 5.698970004336018 (Five-year creatinine) .17 [NR] unit increase Illumina [511,662] N 06/04/2013 23432519 O'Brien RP 02/21/2013 Clin Transplant http://www.ncbi.nlm.nih.gov/pubmed/23432519 A genome-wide association study of recipient genotype and medium-term kidney allograft function. Renal transplant outcome 263 European ancestry individuals 11q13.4 11 70665521 NR - 22941 rs3017493-G rs3017493 0 3017493 intron 0 NR 5E-6 5.301029995663981 (Five-year creatinine) .26 [NR] unit increase Illumina [511,662] N 06/04/2013 23432519 O'Brien RP 02/21/2013 Clin Transplant http://www.ncbi.nlm.nih.gov/pubmed/23432519 A genome-wide association study of recipient genotype and medium-term kidney allograft function. Renal transplant outcome 263 European ancestry individuals 14q11.2 14 22481824 TRAV19, TRAV20 28664 28663 5.40 27.09 rs3811321-C rs3811321 0 3811321 1 NR 8E-8 7.096910013008055 (Five-year creatinine) .48 [NR] unit increase Illumina [511,662] N 06/04/2013 23432519 O'Brien RP 02/21/2013 Clin Transplant http://www.ncbi.nlm.nih.gov/pubmed/23432519 A genome-wide association study of recipient genotype and medium-term kidney allograft function. Renal transplant outcome 263 European ancestry individuals 18q23 18 74182975 ZNF516 - 9658 rs6565887-G rs6565887 0 6565887 intron 0 NR 4E-8 7.397940008672037 (Five-year creatinine) .29 [NR] unit increase Illumina [511,662] N 05/21/2013 23437003 Paternoster L 02/21/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23437003 Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure. Bone mineral density up to 5,878 European ancestry individuals up to 1,052 European ancestry individuals 6q25.1 6 151895456 C6orf97, ESR1 - 80129 rs6909279-G rs6909279 0 6909279 intron 0 0.40 1E-9 8.999999999999998 (Cortical vBMD) .09 [0.070-0.110] unit decrease Illumina [2,401,124] (Imputed) N 05/21/2013 23437003 Paternoster L 02/21/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23437003 Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure. Bone mineral density up to 5,878 European ancestry individuals up to 1,052 European ancestry individuals 13q14.11 13 42956621 TNFSF11 56677 8600 12.73 180.25 rs17638544-T rs17638544 0 17638544 1 0.07 5E-6 5.301029995663981 (Cortical vBMD - conditional on rs1021188) .13 [0.071-0.189] unit increase Illumina [2,401,124] (Imputed) N 05/21/2013 23437003 Paternoster L 02/21/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23437003 Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure. Bone mineral density up to 5,878 European ancestry individuals up to 1,052 European ancestry individuals 8q24.12 8 119976542 TNFRSF11B 4982 10584 12.16 102.88 rs7839059-A rs7839059 0 7839059 1 0.34 1E-10 10 (Cortical vBMD) .10 [0.061-0.139] unit decrease Illumina [2,401,124] (Imputed) N 05/21/2013 23437003 Paternoster L 02/21/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23437003 Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure. Bone mineral density up to 5,878 European ancestry individuals up to 1,052 European ancestry individuals 6q23.2 6 133315804 LOC285735 100129706 442260 125.81 2.91 rs271170-T rs271170 0 271170 1 0.33 3E-12 11.52287874528034 (Cortical vBMD) .11 [0.071-0.149] unit decrease Illumina [2,401,124] (Imputed) N 05/21/2013 23437003 Paternoster L 02/21/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23437003 Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure. Bone mineral density up to 5,878 European ancestry individuals up to 1,052 European ancestry individuals 1q43 1 240597214 FMN2 - 56776 rs9287237-T rs9287237 0 9287237 intron 0 0.15 2E-9 8.698970004336019 (Trabecular vBMD) .19 [0.13-0.25] unit increase Illumina [2,401,124] (Imputed) N 05/21/2013 23437003 Paternoster L 02/21/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23437003 Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure. Bone mineral density up to 5,878 European ancestry individuals up to 1,052 European ancestry individuals 8q24.12 8 120007420 TNFRSF11B 4982 10584 43.04 72.00 rs2062377-A rs2062377 0 2062377 1 0.57 1E-7 7 (Cortical vBMD) .08 [0.041-0.119] unit decrease Illumina [2,401,124] (Imputed) N 05/21/2013 23437003 Paternoster L 02/21/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23437003 Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure. Bone mineral density up to 5,878 European ancestry individuals up to 1,052 European ancestry individuals 13q14.11 13 43116133 TNFSF11 56677 8600 172.24 20.74 rs1021188-C rs1021188 0 1021188 1 0.17 4E-14 13.39794000867204 (Cortical vBMD) .15 [0.11-0.19] unit decrease Illumina [2,401,124] (Imputed) N 05/16/2013 23423446 Hein R 02/20/2013 Breast Cancer Res Treat http://www.ncbi.nlm.nih.gov/pubmed/23423446 A genome-wide association study to identify genetic susceptibility loci that modify ductal and lobular postmenopausal breast cancer risk associated with menopausal hormone therapy use: a two-stage design with replication. Breast cancer (menopausal hormone therapy interaction) 731 European ancestry cases 7,965 European and East Asian ancestry cases, 8,128 European and East Asian ancestry controls NR NR - NR NR NR NS NS NR NR Illumina [316,974] N 06/06/2013 23420232 Duggal P 02/19/2013 Ann Intern Med http://www.ncbi.nlm.nih.gov/pubmed/23420232 Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts. Chronic Hepatitis C infection 1,482 chronic HCV patients, 919 spontaneously cleared HCV patients 461 chronic HCV patients, 284 spontaneously cleared HCV patients NR NR - NR NR NR NS NS NR NR Illumina [792,721] (Imputed) N 05/17/2013 23423138 Ludwig KU 02/19/2013 Transl Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23423138 A common variant in Myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults. Mathematical ability in children with dyslexia 200 European ancestry cases 510 European ancestry cases 22q12.1 22 26159289 MYO18B - 84700 rs133885-? rs133885 0 133885 missense 0 NR 8E-10 9.096910013008054 4.87 % increase Illumina [NR] N 06/06/2013 23419831 Ramanan VK 02/19/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23419831 APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. Alzheimer's disease biomarkers 555 European ancestry individuals NR 5q11.2 5 51805742 ITGA1 100271072 53918 227.05 278.03 rs7702276-T rs7702276 0 7702276 1 0.36 1E-6 5.999999999999999 (Cortical Ab) NR NR Illumina [6,108,668] (imputed) N 06/06/2013 23419831 Ramanan VK 02/19/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23419831 APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. Alzheimer's disease biomarkers 555 European ancestry individuals NR 22q12.3 PIK3R1 - rs24449894-A rs24449894 0.17 2E-6 5.698970004336018 (Cortical Ab) NR NR Illumina [6,108,668] (imputed) N 06/06/2013 23419831 Ramanan VK 02/19/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23419831 APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. Alzheimer's disease biomarkers 555 European ancestry individuals NR 9p23 9 14064741 NFIB 100131893 100271211 22.86 139.48 rs7039300-G rs7039300 0 7039300 1 0.23 2E-6 5.698970004336018 (Cortical Ab) NR NR Illumina [6,108,668] (imputed) N 06/06/2013 23419831 Ramanan VK 02/19/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23419831 APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. Alzheimer's disease biomarkers 555 European ancestry individuals NR 6q25.3 6 157009381 ARID1B 100189513 100616154 140.26 91.43 rs9384488-A rs9384488 0 9384488 1 0.35 3E-6 5.522878745280337 (Cortical Ab) NR NR Illumina [6,108,668] (imputed) N 06/06/2013 23419831 Ramanan VK 02/19/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23419831 APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. Alzheimer's disease biomarkers 555 European ancestry individuals NR 12q23.3 12 106108719 NUAK1, C12orf75 387882 144638 343.42 300.87 rs10219670-C rs10219670 0 10219670 1 0.42 4E-6 5.397940008672037 (Cortical Ab) NR NR Illumina [6,108,668] (imputed) N 06/06/2013 23419831 Ramanan VK 02/19/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23419831 APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. Alzheimer's disease biomarkers 555 European ancestry individuals NR NR ITGA6 - Position 173336636-A Position 173336636 0.43 6E-7 (Cortical Ab) NR NR Illumina [6,108,668] (imputed) N 06/06/2013 23419831 Ramanan VK 02/19/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23419831 APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. Alzheimer's disease biomarkers 555 European ancestry individuals NR 3q26.1 3 166014469 BCHE 100873183 100287630 135.57 394.51 rs509208-G rs509208 0 509208 1 0.16 3E-8 7.522878745280337 (Cortical Ab) NR NR Illumina [6,108,668] (imputed) N 06/06/2013 23419831 Ramanan VK 02/19/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23419831 APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. Alzheimer's disease biomarkers 555 European ancestry individuals NR 5q14.3 5 84084776 EDIL3 10085 100820741 404.17 401.67 rs113524839-T rs113524839 0 113524839 1 0.11 8E-7 6.096910013008056 (Cortical Ab) NR NR Illumina [6,108,668] (imputed) N 06/06/2013 23419831 Ramanan VK 02/19/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23419831 APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. Alzheimer's disease biomarkers 555 European ancestry individuals NR 5q21.3 5 107111176 EFNA5 1946 64839 104.58 83.56 rs1422438-G rs1422438 0 1422438 1 0.30 6E-7 6.221848749616355 (Cortical Ab) NR NR Illumina [6,108,668] (imputed) N 06/06/2013 23419831 Ramanan VK 02/19/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23419831 APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. Alzheimer's disease biomarkers 555 European ancestry individuals NR 19q13.32 19 45411941 APOE - 348 rs429358-C rs429358 0 429358 missense 0 0.28 5E-14 13.30102999566398 (Cortical Ab) NR NR Illumina [6,108,668] (imputed) N 06/06/2013 23419831 Ramanan VK 02/19/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23419831 APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. Alzheimer's disease biomarkers 555 European ancestry individuals NR 19q13.32 19 45396665 TOMM40 - 10452 rs59007384-T rs59007384 0 59007384 intron 0 0.32 7E-9 8.154901959985743 (Cortical Ab) NR NR Illumina [6,108,668] (imputed) N 06/06/2013 23419831 Ramanan VK 02/19/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23419831 APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. Alzheimer's disease biomarkers 555 European ancestry individuals NR 19q13.32 19 45392254 PVRL2 - 5819 rs6857-T rs6857 0 6857 UTR-3 0 0.28 1E-10 10 (Cortical Ab) NR NR Illumina [6,108,668] (imputed) N 06/06/2013 23419831 Ramanan VK 02/19/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23419831 APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. Alzheimer's disease biomarkers 555 European ancestry individuals NR 19q13.32 19 45422846 APOC1 - 341 rs56131196-A rs56131196 0 56131196 nearGene-3 0 0.29 4E-12 11.39794000867204 (Cortical Ab) NR NR Illumina [6,108,668] (imputed) N 06/06/2013 23417110 Tin A 02/16/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23417110 Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin. Beta-2 microglubulin plasma levels 6,728 European ancestry individuals NR HLA-C - HLA-C*07:01 HLA-C*07:01 0.16 1E-18 .05 [0.042-0.066] unit increase Affymetrix [2.5 million] (Imputed) N 06/06/2013 23417110 Tin A 02/16/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23417110 Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin. Beta-2 microglubulin plasma levels 6,728 European ancestry individuals 6p21.33 6 31362310 HLA-B 267015 100507436 12.05 5.25 rs16899524-C rs16899524 0 16899524 1 0.93 1E-8 8 .04 [0.026-0.054] unit increase Affymetrix [2.5 million] (Imputed) N 06/06/2013 23417110 Tin A 02/16/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23417110 Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin. Beta-2 microglubulin plasma levels 6,728 European ancestry individuals 12q24.12 12 111884608 SH2B3, ATXN2 - 10019 rs3184504-C rs3184504 0 3184504 missense 0 0.49 3E-8 7.522878745280337 .02 [0.012-0.028] unit decrease Affymetrix [2.5 million] (Imputed) N 06/06/2013 23417110 Tin A 02/16/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23417110 Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin. Beta-2 microglubulin plasma levels 6,728 European ancestry individuals NR HLA-A - HLA-A*01:01 HLA-A*01:01 0.17 1E-8 .03 [0.018-0.042] unit increase Affymetrix [2.5 million] (Imputed) N 06/06/2013 23417110 Tin A 02/16/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23417110 Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin. Beta-2 microglubulin plasma levels 6,728 European ancestry individuals NR HLA-A - HLA-A*03:01 HLA-A*03:01 0.16 2E-6 .03 [0.018-0.042] unit increase Affymetrix [2.5 million] (Imputed) N 06/06/2013 23417110 Tin A 02/16/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23417110 Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin. Beta-2 microglubulin plasma levels 6,728 European ancestry individuals NR HLA-B - HLA-B*08:01 HLA-B*08:01 0.13 2E-20 .06 [0.046-0.074] unit increase Affymetrix [2.5 million] (Imputed) N 06/06/2013 23417110 Tin A 02/16/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23417110 Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin. Beta-2 microglubulin plasma levels 6,728 European ancestry individuals NR HLA-B - HLA-B*15:01 HLA-B*15:01 0.07 2E-10 .05 [0.034-0.066] unit decrease Affymetrix [2.5 million] (Imputed) N 06/06/2013 23417110 Tin A 02/16/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23417110 Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin. Beta-2 microglubulin plasma levels 6,728 European ancestry individuals NR HLA-B - HLA-B*57:01 HLA-B*57:01 0.04 4E-7 .06 [0.038-0.082] unit decrease Affymetrix [2.5 million] (Imputed) N 06/06/2013 23417110 Tin A 02/16/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23417110 Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin. Beta-2 microglubulin plasma levels 6,728 European ancestry individuals NR HLA-C - HLA-C*03:04 HLA-C*03:04 0.08 8E-8 .04 [0.027-0.059] unit decrease Affymetrix [2.5 million] (Imputed) N 06/06/2013 23417110 Tin A 02/16/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23417110 Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin. Beta-2 microglubulin plasma levels 6,728 European ancestry individuals 6p21.33 6 31405617 MICA 100507436 267016 22.53 24.01 rs2596466-C rs2596466 0 2596466 1 0.07 2E-12 11.69897000433602 .05 [0.034-0.066] unit decrease Affymetrix [2.5 million] (Imputed) N 06/06/2013 23417110 Tin A 02/16/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23417110 Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin. Beta-2 microglubulin plasma levels 6,728 European ancestry individuals 6p22.1 6 29920332 HLA-A 3105 353002 6.67 2.65 rs9260489-G rs9260489 0 9260489 1 0.58 2E-22 21.69897000433602 .04 [0.032-0.048] unit decrease Affymetrix [2.5 million] (Imputed) N 06/06/2013 23417110 Tin A 02/16/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23417110 Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin. Beta-2 microglubulin plasma levels 6,728 European ancestry individuals NR HLA-A - HLA-A*02:01 HLA-A*02:01 0.27 9E-10 .03 [0.020-0.040] unit decrease Affymetrix [2.5 million] (Imputed) N 06/06/2013 23417110 Tin A 02/16/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23417110 Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin. Beta-2 microglubulin plasma levels 6,728 European ancestry individuals 6p22.1 6 30075864 TRIM31 - 11074 rs2023472-A rs2023472 0 2023472 missense 0 0.38 3E-15 14.52287874528034 .03 [0.022-0.038] unit increase Affymetrix [2.5 million] (Imputed) N 06/06/2013 23417110 Tin A 02/16/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23417110 Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin. Beta-2 microglubulin plasma levels 6,728 European ancestry individuals 6p21.33 6 31238318 HLA-C - 3107 rs9264638-A rs9264638 0 9264638 intron 0 0.58 2E-23 22.69897000433602 .04 [0.032-0.048] unit decrease Affymetrix [2.5 million] (Imputed) N 06/06/2013 23417110 Tin A 02/16/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23417110 Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin. Beta-2 microglubulin plasma levels 6,728 European ancestry individuals 6p21.33 6 31322559 HLA-B - 3106 rs2523608-A rs2523608 0 2523608 intron 0 0.59 9E-9 8.045757490560675 .02 [0.012-0.028] unit increase Affymetrix [2.5 million] (Imputed) N 06/06/2013 23417110 Tin A 02/16/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23417110 Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin. Beta-2 microglubulin plasma levels 6,728 European ancestry individuals NR HLA-C - HLA-C*03:03 HLA-C*03:03 0.05 1E-6 .05 [0.030-0.070] unit decrease Affymetrix [2.5 million] (Imputed) N 05/24/2013 23406172 Milton JN 02/14/2013 Br J Haematol http://www.ncbi.nlm.nih.gov/pubmed/23406172 Genetic determinants of haemolysis in sickle cell anaemia. Sickle cell anemia (haemolysis) 1,117 individuals 958 African, West African, Afro-Caribbean, NR individuals 16p13.3 16 184390 NPRL3 - 8131 rs7203560-C rs7203560 0 7203560 intron 0 0.07 2E-9 8.698970004336019 .44 [0.30-0.58] unit decrease Illumina [569,554] N 05/24/2013 23406172 Milton JN 02/14/2013 Br J Haematol http://www.ncbi.nlm.nih.gov/pubmed/23406172 Genetic determinants of haemolysis in sickle cell anaemia. Sickle cell anemia (haemolysis) 1,117 individuals 958 African, West African, Afro-Caribbean, NR individuals 11p15.4 11 5029703 OR51L1 119682 79300 8.54 6.56 rs2445284-G rs2445284 0 2445284 1 0.05 1E-29 28.99999999999999 .82 [0.68-0.96] unit decrease Illumina [569,554] N 05/24/2013 23406172 Milton JN 02/14/2013 Br J Haematol http://www.ncbi.nlm.nih.gov/pubmed/23406172 Genetic determinants of haemolysis in sickle cell anaemia. Sickle cell anemia (haemolysis) 1,117 individuals 958 African, West African, Afro-Caribbean, NR individuals 2p16.1 2 60719970 BCL11A - 53335 rs766432-? rs766432 0 766432 intron 0 NR 9E-7 6.045757490560675 .22 NR unit increase Illumina [569,554] N 05/24/2013 23406172 Milton JN 02/14/2013 Br J Haematol http://www.ncbi.nlm.nih.gov/pubmed/23406172 Genetic determinants of haemolysis in sickle cell anaemia. Sickle cell anemia (haemolysis) 1,117 individuals 958 African, West African, Afro-Caribbean, NR individuals 11p15.4 11 5471746 OR51I1, OR51I2 390063 390064 8.96 2.89 rs7948471-A rs7948471 0 7948471 1 .21 3E-10 9.522878745280336 .26 [0.18-0.34] unit decrease Illumina [569,554] N 05/14/2013 23408455 Wakai K 02/14/2013 Obesity (Silver Spring) http://www.ncbi.nlm.nih.gov/pubmed/23408455 Genome-wide association study of the genetic factors related to confectionery intake: Potential roles of the ADIPOQ gene. Confectionary intake 939 Japanese ancestry individuals 4,491 Japanese ancestry individuals NR NR - NR NR NR NS NS NR NR Illumina [491,738] N 06/05/2013 23412934 Gourraud PA 02/13/2013 Brain http://www.ncbi.nlm.nih.gov/pubmed/23412934 A genome-wide association study of brain lesion distribution in multiple sclerosis. Multiple sclerosis 284 European ancestry individuals 1q25.3 1 182549019 RNASEL - 6041 rs533259-? rs533259 0 533259 intron 0 NR 6E-9 8.221848749616356 (Cluxel size) NR NR Illumina [208,975] N 06/05/2013 23412934 Gourraud PA 02/13/2013 Brain http://www.ncbi.nlm.nih.gov/pubmed/23412934 A genome-wide association study of brain lesion distribution in multiple sclerosis. Multiple sclerosis 284 European ancestry individuals 1q25.1 1 173284199 AK127238 - 100506023 rs4916321-? rs4916321 0 4916321 intron 0 NR 7E-6 5.154901959985742 (Cluxel size) NR NR Illumina [208,975] N 06/05/2013 23412934 Gourraud PA 02/13/2013 Brain http://www.ncbi.nlm.nih.gov/pubmed/23412934 A genome-wide association study of brain lesion distribution in multiple sclerosis. Multiple sclerosis 284 European ancestry individuals Xp21.1 23 34892503 TMEM47 83604 170062 217.10 68.41 rs4271113-? rs4271113 0 4271113 1 NR 9E-7 6.045757490560675 (Cluxel minimum distance) NR NR Illumina [208,975] N 06/05/2013 23412934 Gourraud PA 02/13/2013 Brain http://www.ncbi.nlm.nih.gov/pubmed/23412934 A genome-wide association study of brain lesion distribution in multiple sclerosis. Multiple sclerosis 284 European ancestry individuals 18q12.1 18 28789725 DSC1 1823 1828 46.91 108.33 rs2920001-? rs2920001 0 2920001 1 NR 1E-6 5.999999999999999 (Cluxel minimum distance) NR NR Illumina [208,975] N 06/05/2013 23412934 Gourraud PA 02/13/2013 Brain http://www.ncbi.nlm.nih.gov/pubmed/23412934 A genome-wide association study of brain lesion distribution in multiple sclerosis. Multiple sclerosis 284 European ancestry individuals Xp22.2 23 13615118 EGFL6 - 25975 rs5978649-? rs5978649 0 5978649 intron 0 NR 4E-6 5.397940008672037 (Cluxel minimum distance) NR NR Illumina [208,975] N 06/05/2013 23412934 Gourraud PA 02/13/2013 Brain http://www.ncbi.nlm.nih.gov/pubmed/23412934 A genome-wide association study of brain lesion distribution in multiple sclerosis. Multiple sclerosis 284 European ancestry individuals 11p15.4 11 3259809 MRGPRE 116534 4699 6.19 83.29 rs11026091-? rs11026091 0 11026091 1 NR 2E-6 5.698970004336018 (Cluxel minimum distance) NR NR Illumina [208,975] N 06/05/2013 23412934 Gourraud PA 02/13/2013 Brain http://www.ncbi.nlm.nih.gov/pubmed/23412934 A genome-wide association study of brain lesion distribution in multiple sclerosis. Multiple sclerosis 284 European ancestry individuals 8p23.3 8 1883352 ARHGEF10 - 9639;100131395 rs13279485-? rs13279485 0 13279485 intron;ncRNA 0 NR 1E-6 5.999999999999999 (Cluxel size) NR NR Illumina [208,975] N 06/05/2013 23412934 Gourraud PA 02/13/2013 Brain http://www.ncbi.nlm.nih.gov/pubmed/23412934 A genome-wide association study of brain lesion distribution in multiple sclerosis. Multiple sclerosis 284 European ancestry individuals 2p25.1 2 8053597 LOC339788 9781 100874413 869.29 689.62 rs4669226-? rs4669226 0 4669226 1 NR 5E-6 5.301029995663981 (Cluxel size) NR NR Illumina [208,975] N 06/05/2013 23412934 Gourraud PA 02/13/2013 Brain http://www.ncbi.nlm.nih.gov/pubmed/23412934 A genome-wide association study of brain lesion distribution in multiple sclerosis. Multiple sclerosis 284 European ancestry individuals 13q14.2 13 50185204 ARL11 55213 115761 25.49 17.23 rs9568281-? rs9568281 0 9568281 1 NR 3E-7 6.522878745280337 (Cluxel size) NR NR Illumina [208,975] N 06/05/2013 23412934 Gourraud PA 02/13/2013 Brain http://www.ncbi.nlm.nih.gov/pubmed/23412934 A genome-wide association study of brain lesion distribution in multiple sclerosis. Multiple sclerosis 284 European ancestry individuals 11q22.2 11 102628052 MMP10 - 100128088 rs7924357-? rs7924357 0 7924357 0 NR 1E-6 5.999999999999999 (Cluxel size) NR NR Illumina [208,975] N 06/05/2013 23412934 Gourraud PA 02/13/2013 Brain http://www.ncbi.nlm.nih.gov/pubmed/23412934 A genome-wide association study of brain lesion distribution in multiple sclerosis. Multiple sclerosis 284 European ancestry individuals 6q16.3 6 105223864 HACE1 - 57531 rs733724-? rs733724 0 733724 intron 0 NR 3E-7 6.522878745280337 (Cluxel size) NR NR Illumina [208,975] N 06/05/2013 23412934 Gourraud PA 02/13/2013 Brain http://www.ncbi.nlm.nih.gov/pubmed/23412934 A genome-wide association study of brain lesion distribution in multiple sclerosis. Multiple sclerosis 284 European ancestry individuals 10q25.2 10 114388272 VTI1A - 143187 rs17267338-? rs17267338 0 17267338 intron 0 NR 8E-6 5.096910013008055 (Cluxel size) NR NR Illumina [208,975] N 06/05/2013 23412934 Gourraud PA 02/13/2013 Brain http://www.ncbi.nlm.nih.gov/pubmed/23412934 A genome-wide association study of brain lesion distribution in multiple sclerosis. Multiple sclerosis 284 European ancestry individuals 8q24.12 8 119391409 SAMD12 - 401474 rs17749211-? rs17749211 0 17749211 intron 0 NR 8E-6 5.096910013008055 (Cluxel size) NR NR Illumina [208,975] N 06/05/2013 23412934 Gourraud PA 02/13/2013 Brain http://www.ncbi.nlm.nih.gov/pubmed/23412934 A genome-wide association study of brain lesion distribution in multiple sclerosis. Multiple sclerosis 284 European ancestry individuals 2q21.2 2 134230217 NAP5 - 344148 rs1821625-? rs1821625 0 1821625 intron 0 NR 7E-6 5.154901959985742 (Cluxel size) NR NR Illumina [208,975] N 06/05/2013 23412934 Gourraud PA 02/13/2013 Brain http://www.ncbi.nlm.nih.gov/pubmed/23412934 A genome-wide association study of brain lesion distribution in multiple sclerosis. Multiple sclerosis 284 European ancestry individuals 4q32.3 4 166830364 TLL1 - 7092 rs12513380-? rs12513380 0 12513380 intron 0 NR 5E-6 5.301029995663981 (Cluxel size) NR NR Illumina [208,975] N 06/05/2013 23412934 Gourraud PA 02/13/2013 Brain http://www.ncbi.nlm.nih.gov/pubmed/23412934 A genome-wide association study of brain lesion distribution in multiple sclerosis. Multiple sclerosis 284 European ancestry individuals 4q34.3 4 180667647 LOC285501 391719 728081 1459.13 1317.60 rs17090640-? rs17090640 0 17090640 1 NR 3E-6 5.522878745280337 (Cluxel size) NR NR Illumina [208,975] N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 7p15.1 7 28004198 JAZF1 - 221895 rs4722750-T rs4722750 0 4722750 intron 0 0.1 9E-6 5.045757490560675 (EA-triglyceride response) 31.88 [17.85-45.91] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 1q43 1 240283736 CHRM3 - 56776 rs11810574-G rs11810574 0 11810574 intron 0 0.15 4E-6 5.397940008672037 (AA-triglyceride response) 23.12 [13.34-32.9] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 12p13.2 12 10471050 KLRA1 3824 22914 1.20 53.90 rs12303914-A rs12303914 0 12303914 1 0.35 6E-6 5.221848749616356 (EA-triglyceride response) 20.39 [11.51-29.27] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 17q24.3 17 70594629 SLC39A11 - 400619 rs11077614-G rs11077614 0 11077614 ncRNA 0 0.49 3E-6 5.522878745280337 (EA-glucose response) 3.25 [1.92-4.58] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 18p11.21 18 11064409 FAM38B - 63895 rs12455924-T rs12455924 0 12455924 intron 0 0.36 3E-7 6.522878745280337 (AA-triglyceride response) 17.88 [11.04-24.72] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 12p13.31 12 7855271 GDF3 9573 359787 6.91 8.82 rs12307997-G rs12307997 0 12307997 1 0.22 6E-7 6.221848749616355 (AA-triglyceride response) 22.11 [13.41-30.81] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 11p13 11 35123051 CD44 8050 960 105.38 37.37 rs1559759-A rs1559759 0 1559759 1 0.15 9E-6 5.045757490560675 (EA-triglyceride response) 25.59 [14.3-36.88] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 6q24.1 6 142512136 GPR126 - 51534 rs225675-G rs225675 0 225675 intron 0 0.19 1E-7 7 (AA-glucose response) 5.29 [3.35-7.23] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 10q21.1 10 55407091 PCDH15 100874423 65217 608.79 155.44 rs7077606-T rs7077606 0 7077606 1 0.12 5E-7 6.30102999566398 (AA-glucose response) 5.44 [3.32-7.56] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 7p12.2 7 49329680 CDC14C 168448 375567 362.63 483.58 rs7801534-G rs7801534 0 7801534 1 0.17 7E-7 6.154901959985743 (AA-glucose response) 4.96 [3.02-6.9] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 12q23.2 12 102965329 IGF1 3479 5053 90.95 266.78 rs7964748-G rs7964748 0 7964748 1 0.28 3E-6 5.522878745280337 (AA-glucose response) 4.06 [2.37-5.75] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 4q34.1 4 175071602 FBXO8 100128266 26269 516.07 86.21 rs12507634-G rs12507634 0 12507634 1 0.19 4E-6 5.397940008672037 (AA-glucose response) 4.84 [2.78-6.9] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 8q22.2 8 99317739 NIPAL2 79815 3788 11.12 121.51 rs11785622-T rs11785622 0 11785622 1 0.07 4E-6 5.397940008672037 (AA-glucose response) 7.21 [4.15-10.27] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 12q21.31 12 80463084 PPP1R12A 120872 400055 39.60 33.56 rs10778699-A rs10778699 0 10778699 1 0.24 4E-6 5.397940008672037 (AA-glucose response) 4.28 [2.46-6.1] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 10p15.3 10 1343017 WDR37 - 105 rs11599315-T rs11599315 0 11599315 intron 0 0.37 5E-6 5.301029995663981 (AA-glucose response) 3.88 [2.21-5.55] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 2q12.1 2 103512292 MFSD9,SCL9A2 130827 402093 78.15 1499.17 rs13402330-A rs13402330 0 13402330 1 0.19 6E-6 5.221848749616356 (AA-glucose response) 5.27 [3-7.54] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 12p12.1 12 25484193 BCAT1 3845 100133222 80.34 78.02 rs7965364-T rs7965364 0 7965364 1 0.37 6E-6 5.221848749616356 (AA-glucose response) 3.79 [2.14-5.44] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 17q22 17 50293638 CA10 56934 100506650 56.26 769.24 rs16951120-T rs16951120 0 16951120 1 0.15 6E-6 5.221848749616356 (AA-glucose response) 4.49 [2.55-6.43] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 19p12 19 20846271 ZNF626 - 199777 rs4808260-C rs4808260 0 4808260 nearGene-5 0 0.3 7E-6 5.154901959985742 (AA-glucose response) 3.71 [2.08-5.34] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 8q24.3 8 141574194 EIF2C2 - 27161 rs2944755-A rs2944755 0 2944755 intron 0 0.06 8E-6 5.096910013008055 (AA-glucose response) 9.45 [5.31-13.59] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 15q21.2 15 51513729 CYP19A1 - 1588 rs6493487-G rs6493487 0 6493487 intron 0 0.09 8E-6 5.096910013008055 (AA-glucose response) 5.96 [3.35-8.57] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 5p15.1 5 17003085 MYO10 643003 100288979 100.31 199.26 rs6870564-A rs6870564 0 6870564 1 0.13 4E-6 5.397940008672037 (EA-glucose response) 3.84 [2.21-5.47] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 16q22.3 16 73829270 Intergenic 283902 645656 701.60 145.20 rs427576-C rs427576 0 427576 1 0.43 4E-6 5.397940008672037 (EA-glucose response) 2.62 [1.5-3.74] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 4q28.2 4 129696221 PHF17 10424 79960 486.24 34.56 rs1974942-A rs1974942 0 1974942 1 0.1 4E-6 5.397940008672037 (EA-glucose response) 5.29 [3.04-7.54] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 2q37.1 2 232192305 NMUR1,HTR2B - 80210 rs1669070-T rs1669070 0 1669070 intron 0 0.4 4E-6 5.397940008672037 (EA-glucose response) 3.02 [1.73-4.31] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 4p15.2 4 23588462 PPARGC1A 57733 10891 767.27 205.18 rs1511453-A rs1511453 0 1511453 1 0.08 5E-6 5.301029995663981 (EA-glucose response) 4.95 [2.83-7.07] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 9q31.1 9 104867838 GRIN3A 100131629 100131879 49.73 505.55 rs10989824-T rs10989824 0 10989824 1 0.06 7E-6 5.154901959985742 (EA-glucose response) 5.85 [3.3-8.4] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 6q27 6 170113244 IDDM8 - 55274 rs7762018-A rs7762018 0 7762018 intron 0 0.13 8E-6 5.096910013008055 (EA-glucose response) 3.65 [2.06-5.24] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 5q23.2 5 121436596 LOX 4015 133923 22.54 28.62 rs890749-C rs890749 0 890749 1 0.19 8E-6 5.096910013008055 (EA-glucose response) 3.25 [1.82-4.68] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 5q35.3 5 180205938 MGAT1 134083 4245 38.88 11.60 rs6859974-T rs6859974 0 6859974 1 0.14 8E-6 5.096910013008055 (EA-glucose response) 3.67 [2.06-5.28] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 10q26.2 10 127829012 ADAM12 - 8038 rs1551678-C rs1551678 0 1551678 intron 0 0.37 9E-6 5.045757490560675 (EA-glucose response) 2.65 [1.49-3.81] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 5q14.3 5 88183651 MEF2C - 4208 rs17560407-G rs17560407 0 17560407 intron 0 0.27 5E-7 6.30102999566398 (EA-triglyceride response) 23.23 [14.14-32.32] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 1p22.1 1 94674726 GCLM - 9411 rs2274788-C rs2274788 0 2274788 intron 0 0.25 1E-6 5.999999999999999 (EA-triglyceride response) 23.07 [13.8-32.34] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 11q23.3 11 118117018 PHLDB1 - 196264 rs11216831-A rs11216831 0 11216831 0 0.07 4E-6 5.397940008672037 (EA-triglyceride response) 42.47 [24.4-60.54] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 8q12.3 8 65999963 CYP7B1 9420 100271201 288.62 67.68 rs2980003-T rs2980003 0 2980003 1 0.27 5E-6 5.301029995663981 (EA-triglyceride response) 22.07 [12.6-31.54] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 16q24.1 16 85906616 COX4I1 401863 3394 56.44 26.16 rs11648716-G rs11648716 0 11648716 1 0.08 7E-6 5.154901959985742 (EA-triglyceride response) 39.68 [22.37-56.99] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 6q14.1 6 81302805 BCKDHB 442232 55603 218.48 1152.64 rs10943724-A rs10943724 0 10943724 1 0.31 7E-6 5.154901959985742 (EA-triglyceride response) 19.77 [11.15-28.39] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 4q34.3 4 182222727 Intergenic 728081 100302270 142.43 867.72 rs17183114-T rs17183114 0 17183114 1 0.14 8E-6 5.096910013008055 (EA-triglyceride response) 26.49 [14.89-38.09] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 14q32.11 14 90396574 c14ORF143 - 90141 rs7147996-A rs7147996 0 7147996 intron 0 0.12 6E-6 5.221848749616356 (AA-triglyceride response) 28.09 [15.96-40.22] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 11q13.4 11 74971557 ARRB1 - 408 rs17133858-T rs17133858 0 17133858 UTR-3 0 0.14 6E-6 5.221848749616356 (AA-triglyceride response) 20.99 [11.92-30.06] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 15q23 15 71424009 CT62 196993 645292 16.17 32.00 rs12904863-C rs12904863 0 12904863 1 0.08 6E-6 5.221848749616356 (AA-triglyceride response) 30.31 [17.22-43.4] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 4q35.1 4 184921299 STOX2 - 56977 rs12498735-T rs12498735 0 12498735 intron 0 0.25 8E-6 5.096910013008055 (AA-triglyceride response) 19.13 [10.74-27.52] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 5q21.1 5 102764048 NUDT12 90355 83594 149.69 120.51 rs2099077-A rs2099077 0 2099077 1 0.29 8E-6 5.096910013008055 (AA-triglyceride response) 16.53 [9.26-23.8] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 6q23.3 6 137673302 OLIG3 3459 167826 132.74 140.03 rs6928289-G rs6928289 0 6928289 1 0.45 9E-6 5.045757490560675 (AA-triglyceride response) 15.56 [8.68-22.44] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 5q13.3 5 76224171 IQGAP2 170591 1393 7.12 24.51 rs2460504-C rs2460504 0 2460504 1 0.18 5E-6 5.301029995663981 (AA-triglyceride response) 24.57 [14.06-35.08] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 15q25.3 15 86854590 AGBL1 - 123624;727915 rs10152811-A rs10152811 0 10152811 intron;intron 0 0.69 8E-7 6.096910013008056 (AA-triglyceride response) 18.81 [11.32-26.3] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 10q11.23 10 52010708 ASAH2 56624 728532 2.34 14.02 rs10508921-T rs10508921 0 10508921 1 0.13 9E-7 6.045757490560675 (AA-triglyceride response) 25.70 [15.47-35.93] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 1q44 1 244167801 ZNF238 - 339529 rs12127679-T rs12127679 0 12127679 intron 0 0.19 1E-6 5.999999999999999 (AA-triglyceride response) 22.31 [13.24-31.38] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 10q24.31 10 102256197 ERLIN1 - 25956 rs9420790-A rs9420790 0 9420790 intron 0 0.08 2E-6 5.698970004336018 (AA-triglyceride response) 34.63 [20.46-48.8] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 9q33.2 9 124549642 DAB2IP 153090 158135 1.83 34.56 rs10985375-A rs10985375 0 10985375 1 0.1 2E-6 5.698970004336018 (AA-triglyceride response) 33.94 [19.81-48.07] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 17q25.3 17 76110518 TNRC6C - 11322 rs2613514-G rs2613514 0 2613514 intron 0 0.22 3E-6 5.522878745280337 (AA-triglyceride response) 20.12 [11.65-28.59] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 19p13.2 19 10310392 ANGPTL6,UBL5 1786 9294 4.64 21.72 rs2116940-G rs2116940 0 2116940 1 0.19 3E-6 5.522878745280337 (AA-triglyceride response) 19.71 [11.4-28.02] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 16p13.2 16 10188060 GRIN2A - 2903 rs7203315-T rs7203315 0 7203315 intron 0 0.34 4E-6 5.397940008672037 (AA-triglyceride response) 15.83 [9.13-22.53] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 20q13.12 20 45680502 EYA2 - 2139 rs878131-A rs878131 0 878131 intron 0 0.25 4E-6 5.397940008672037 (AA-triglyceride response) 17.21 [9.92-24.5] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 6q22.31 6 118618981 SLC35F1 - 222553 rs166881-C rs166881 0 166881 intron 0 0.18 4E-6 5.397940008672037 (AA-triglyceride response) 22.26 [12.79-31.73] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 13q12.11 13 21876096 ZDHHC20 - 650794 rs9788333-G rs9788333 0 9788333 intron 0 0.11 4E-6 5.397940008672037 (AA-triglyceride response) 28.65 [16.46-40.84] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 16q22.2 16 72257699 PMFBMP1 83449 342374 51.35 504.77 rs17668704-A rs17668704 0 17668704 1 0.61 9E-6 5.045757490560675 (AA-glucose response) 3.38 [1.89-4.87] mg/dL decrease Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 11p15.1 11 21565079 NELL-1 - 4745 rs12279250-C rs12279250 0 12279250 intron 0 0.15 7E-9 8.154901959985743 (AA-triglyceride response) 28.20 [18.67-37.73] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/11/2013 23400010 Del-Aguila JL 02/12/2013 Pharmacogenomics J http://www.ncbi.nlm.nih.gov/pubmed/23400010 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Thiazide-induced adverse metabolic effects in hypertensive patients 425 European ancestry cases, 342 African American cases NR 3q26.2 3 167897821 GOLIM4 27333 93556 84.40 69.49 rs2686586-T rs2686586 0 2686586 1 0.47 6E-8 7.221848749616355 (AA-triglyceride response) 18.93 [11.89-25.97] mg/dL increase Illumina and Affymetrics [>2 million] (Imputed) N 05/16/2013 23372042 Lane J 02/10/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23372042 A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A. HIV-1 susceptibility 430 exposed uninfected Haemophilia cases, 765 HIV positive controls NR NR NR - NR NR NR NS NS NR NR Illumina [1,081,435] (Imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 10q21.1 10 60265404 BICC1 7019 80114 106.41 7.50 rs7084402-G rs7084402 0 7084402 1 0.48 2E-13 12.69897000433602 .11 [0.079-0.137] unit decrease Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 13q32.3 13 100818092 PCCA, ZIC2 - 5095 rs2184971-G rs2184971 0 2184971 intron 0 0.44 2E-8 7.698970004336018 .09 [0.056-0.114] unit increase Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 17q24.3 17 68718734 KCNJ2 100128390 6662 480.22 1398.43 rs4793501-C rs4793501 0 4793501 1 0.42 3E-8 7.522878745280337 .08 [0.053-0.107] unit increase Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 12q15 12 71249996 PTPRR - 5801 rs12229663-G rs12229663 0 12229663 intron 0 0.27 5E-9 8.301029995663981 .10 [0.066-0.132] unit increase Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 20p12.3 20 6761765 BMP2 650 171472 .86 1050.58 rs235770-T rs235770 0 235770 1 0.39 2E-8 7.698970004336018 .09 [0.058-0.12] unit decrease Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 2q37.1 2 233406998 CHRNG, PRSS56 - 1146 rs1881492-T rs1881492 0 1881492 intron 0 0.22 5E-11 10.30102999566398 .14 [0.098-0.18] unit decrease Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 3p21.1 3 53847408 CACNA1D 776 55349 .92 2.92 rs14165-A rs14165 0 14165 1 0.32 2E-8 7.698970004336018 .10 [0.063-0.129] unit increase Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 4q21.21 4 81930814 BMP3 255119 651 45.90 21.31 rs1960445-C rs1960445 0 1960445 1 0.017 1E-6 5.999999999999999 .11 [0.067-0.161] unit decrease Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 6q22.33 6 129834629 LAMA2 - 3908 rs12205363-C rs12205363 0 12205363 intron 0 0.1 2E-12 11.69897000433602 .24 [0.17-0.3] unit increase Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 8p11.21 8 40726394 ZMAT4 - 79698 rs7829127-G rs7829127 0 7829127 intron 0 0.25 4E-10 9.397940008672037 .12 [0.081-0.151] unit increase Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 9q21.13 9 77149837 RORB - 6096 rs7042950-G rs7042950 0 7042950 intron 0 0.24 4E-8 7.397940008672037 .10 [0.061-0.131] unit decrease Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 10q23.33 10 94924324 CYP26A1 1592 643863 86.68 119.40 rs10882165-T rs10882165 0 10882165 1 0.42 1E-11 11 .11 [0.076-0.138] unit decrease Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 11q22.3 11 105556598 GRIA4 - 2893 rs11601239-C rs11601239 0 11601239 intron 0 0.46 6E-9 8.221848749616356 .10 [0.064-0.126] unit decrease Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 12q13.2 12 56114769 RDH5 - 5959;100528022 rs3138144-C rs3138144 0 3138144 intron;intron 0 0.48 4E-12 11.39794000867204 .12 [0.086-0.152] unit increase Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 15q14 15 35005886 GJD2 440270 57369 130.12 38.76 rs524952-A rs524952 0 524952 1 0.48 1E-15 15 .16 [0.12-0.2] unit decrease Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 15q25.1 15 79372875 RASGRF1 - 5923 rs4778879-G rs4778879 0 4778879 intron 0 0.44 4E-11 10.39794000867204 .10 [0.073-0.131] unit decrease Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 17q11.2 17 31078272 MYO1D - 4642 rs17183295-T rs17183295 0 17183295 0 0.23 1E-10 10 .13 [0.092-0.17] unit decrease Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 18q22.3 18 72174023 CNDP2 - 55748 rs12971120-G rs12971120 0 12971120 intron 0 0.23 2E-7 6.698970004336019 .10 [0.062-0.136] unit increase Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 4q21.21 4 80530671 LOC100506035 79273 118425 21.43 217.95 rs9307551-A rs9307551 0 9307551 1 0.25 1E-8 8 .10 [0.066-0.132] unit decrease Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 6q13 6 73643289 KCNQ5 - 56479 rs7744813-C rs7744813 0 7744813 intron 0 0.41 4E-9 8.397940008672036 .11 [0.075-0.149] unit increase Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 9q21.11 9 71766593 TJP2 - 9414 rs11145465-A rs11145465 0 11145465 UTR-5 0 0.25 7E-9 8.154901959985743 .12 [0.083-0.165] unit decrease Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 14q23.1 14 60903757 SIX6 - 317761 rs1254319-A rs1254319 0 1254319 0 0.32 1E-8 8 .09 [0.059-0.117] unit decrease Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 16p13.3 16 7459683 RBFOX1 - 54715 rs17648524-C rs17648524 0 17648524 intron 0 0.36 6E-10 9.221848749616356 .12 [0.081-0.155] unit decrease Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 17p12 17 11407901 SHISA6 - 388336 rs2969180-A rs2969180 0 2969180 intron 0 0.36 7E-11 10.15490195998574 .10 [0.072-0.13] unit decrease Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 2q37.1 2 233379941 PRSS56 9427 646960 27.41 5.23 rs1656404-A rs1656404 0 1656404 1 0.21 8E-11 10.09691001300805 .15 [0.11-0.20] unit decrease Illumina & Affymetrix [2.5 million] (imputed) N 06/06/2013 23396134 Verhoeven VJ 02/10/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23396134 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Refractive error 37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Chinese Singaporean ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals 8q12.1 8 60179086 CHD7, TOX 9760 574532 147.32 290.93 rs7837791-T rs7837791 0 7837791 1 0.49 4E-12 11.39794000867204 .11 [0.077-0.135] unit increase Illumina & Affymetrix [2.5 million] (imputed) N 05/14/2013 23392654 Lewis JP 02/07/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23392654 Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes. Response to antiplatelet therapy 565 Amish individuals 710 European ancestry individuals, 237 African American/Afro-Caribbean individuals, 276 Hispanic individuals, 4 individuals NR NR - NR NR NR NS NS NR NR Affymetrix [400,230] N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 9q34.2 9 136139265 ABO - 28 rs657152-A rs657152 0 657152 intron 0 0.343 1E-6 5.999999999999999 (TSH - Males) .07 [0.04-0.094] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 6q24.3 6 148521292 SASH1 389432 23328 630.14 142.44 rs9497965-T rs9497965 0 9497965 1 0.415 3E-8 7.522878745280337 (TSH - Females) .07 [0.043-0.091] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 9p24.2 9 4267209 GLIS3 - 169792 rs1571583-A rs1571583 0 1571583 intron 0 0.249 1E-6 5.999999999999999 (TSH - Males) .07 [0.045-0.103] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 1p32.3 1 54375570 DIO1 - 1733 rs2235544-A rs2235544 0 2235544 intron 0 0.51 3E-18 17.52287874528034 (FT4-Females) .13 [0.1-0.16] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 1p32.3 1 54375570 DIO1 - 1733 rs2235544-A rs2235544 0 2235544 intron 0 0.51 5E-15 14.30102999566398 (FT4-Males) .14 [0.11-0.18] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 9q34.3 9 139089679 LHX3 - 8022 rs7860634-A rs7860634 0 7860634 intron 0 0.53 5E-8 7.30102999566398 (FT4-Females) .10 [0.063-0.133] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 9q34.3 9 139089679 LHX3 - 8022 rs7860634-A rs7860634 0 7860634 intron 0 0.53 2E-8 7.698970004336018 (FT4-Males) .11 [0.071-0.145] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 9q22.33 9 100591463 FOXE1 392371 2304 128.38 24.07 rs7045138-T rs7045138 0 7045138 1 0.553 3E-6 5.522878745280337 (FT4-Females) .09 [0.054-0.132] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 5q13.3 5 76530349 PDE8B - 8622 rs6885099-A rs6885099 0 6885099 intron 0 0.594 2E-26 25.69897000433602 (TSH) .14 [0.12-0.16] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 6q27 6 166046483 PDE10A - 10846 rs753760-C rs753760 0 753760 intron 0 0.691 1E-24 24 (TSH) .10 [0.08-0.12] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 1p36.13 1 19841174 CAPZB 832 644068 29.11 93.40 rs10799824-A rs10799824 0 10799824 1 0.161 4E-21 20.39794000867204 (TSH) .11 [0.089-0.137] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 16q23.2 16 79749353 MAF,LOC440389 4094 83657 114.73 825.50 rs3813582-T rs3813582 0 3813582 1 0.674 8E-18 17.09691001300806 (TSH) .08 [0.062-0.102] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 6p21.1 6 43811762 VEGFA 7422 221416 57.54 156.58 rs9472138-T rs9472138 0 9472138 1 0.285 7E-16 15.15490195998574 (TSH) .08 [0.059-0.099] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 6p21.1 6 43904780 VEGFA - 100132354 rs11755845-T rs11755845 0 11755845 ncRNA 0 0.266 2E-10 9.698970004336017 (TSH) .07 [0.045-0.085] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 4q31.23 4 149669506 NR3C2 100130396 166614 44.52 1329.92 rs10032216-T rs10032216 0 10032216 1 0.781 9E-16 15.04575749056067 (TSH) .09 [0.065-0.109] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 2q35 2 217625523 IGFBP5 3488 100129310 65.25 24.94 rs13015993-A rs13015993 0 13015993 1 0.736 3E-15 14.52287874528034 (TSH) .08 [0.058-0.098] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 17q24.3 17 70127536 SOX9 6662 100499467 4.98 271.93 rs9915657-T rs9915657 0 9915657 1 0.541 8E-13 12.09691001300806 (TSH) .06 [0.046-0.082] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 1p31.3 1 61620496 NFIA - 4774 rs334699-A rs334699 0 334699 intron 0 0.052 5E-12 11.30102999566398 (TSH) .14 [0.1-0.182] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 15q21.2 15 49746364 FGF7 - 2252;196951 rs10519227-A rs10519227 0 10519227 intron;intron 0 0.245 1E-11 11 (TSH) .07 [0.05-0.094] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 11p11.2 11 45227567 PRDM11 - 56981 rs17723470-T rs17723470 0 17723470 intron 0 0.279 9E-11 10.04575749056067 (TSH) .07 [0.045-0.085] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 15q26.1 15 89119104 MIR1179 55070 100302235 29.19 32.23 rs17776563-A rs17776563 0 17776563 1 0.322 3E-10 9.522878745280336 (TSH) .06 [0.04-0.08] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 19p13.2 19 7223848 INSR - 3643;100996405 rs4804416-T rs4804416 0 4804416 intron;nearGene-3 0 0.569 3E-10 9.522878745280336 (TSH) .06 [0.039-0.075] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 9q34.2 9 136139265 ABO - 28 rs657152-A rs657152 0 657152 intron 0 0.343 4E-10 9.397940008672037 (TSH) .06 [0.04-0.076] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 8p12 8 32416274 NRG1 - 3084 rs7825175-A rs7825175 0 7825175 intron 0 0.21 3E-9 8.522878745280337 (TSH) .07 [0.044-0.088] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 14q13.2 14 36574018 MBIP rs1537424-T rs1537424 0 1537424 1 0.608 1E-8 8 (TSH) .05 [0.034-0.07] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 6q24.3 6 148521292 SASH1 389432 23328 630.14 142.44 rs9497965-T rs9497965 0 9497965 1 0.415 2E-8 7.698970004336018 (TSH) .05 [0.033-0.069] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 9p24.2 9 4267209 GLIS3 - 169792 rs1571583-A rs1571583 0 1571583 intron 0 0.249 3E-8 7.522878745280337 (TSH) .06 [0.037-0.077] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 9q34.3 9 139089679 LHX3 - 8022 rs7860634-A rs7860634 0 7860634 intron 0 0.53 2E-14 13.69897000433602 (FT4) .10 [0.077-0.127] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 9q22.33 9 100591463 FOXE1 392371 2304 128.38 24.07 rs7045138-T rs7045138 0 7045138 1 0.553 2E-11 10.69897000433602 (FT4) .10 [0.069-0.127] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 4q33 4 171053519 AADAT 51166 442117 42.15 1681.06 rs11726248-A rs11726248 0 11726248 1 0.106 5E-9 8.301029995663981 (FT4) .11 [0.074-0.148] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 5q13.3 5 76530349 PDE8B - 8622 rs6885099-A rs6885099 0 6885099 intron 0 0.594 6E-24 23.22184874961635 (TSH - Females) .12 [0.096-0.144] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 5q13.3 5 76530349 PDE8B - 8622 rs6885099-A rs6885099 0 6885099 intron 0 0.594 3E-38 37.52287874528033 (TSH - Males) .17 [0.14-0.19] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 6q27 6 166046483 PDE10A - 10846 rs753760-C rs753760 0 753760 intron 0 0.691 5E-9 8.301029995663981 (TSH - Females) .08 [0.051-0.101] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 1p36.13 1 19841174 CAPZB 832 644068 29.11 93.40 rs10799824-A rs10799824 0 10799824 1 0.161 3E-14 13.52287874528034 (TSH - Females) .12 [0.092-0.154] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 1p36.13 1 19841174 CAPZB 832 644068 29.11 93.40 rs10799824-A rs10799824 0 10799824 1 0.161 1E-8 8 (TSH - Males) .10 [0.066-0.132] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 6p21.1 6 43811762 VEGFA 7422 221416 57.54 156.58 rs9472138-T rs9472138 0 9472138 1 0.285 6E-12 11.22184874961635 (TSH - Females) .09 [0.065-0.115] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 6p21.1 6 43811762 VEGFA 7422 221416 57.54 156.58 rs9472138-T rs9472138 0 9472138 1 0.285 5E-6 5.301029995663981 (TSH - Males) .07 [0.038-0.092] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 6p21.1 6 43904780 VEGFA - 100132354 rs11755845-T rs11755845 0 11755845 ncRNA 0 0.266 3E-7 6.522878745280337 (TSH - Males) .08 [0.047-0.105] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 4q31.23 4 149669506 NR3C2 100130396 166614 44.52 1329.92 rs10032216-T rs10032216 0 10032216 1 0.781 2E-13 12.69897000433602 (TSH - Females) .11 [0.079-0.133] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 2q35 2 217625523 IGFBP5 3488 100129310 65.25 24.94 rs13015993-A rs13015993 0 13015993 1 0.736 8E-11 10.09691001300805 (TSH - Males) .10 [0.066-0.124] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 17q24.3 17 70127536 SOX9 6662 100499467 4.98 271.93 rs9915657-T rs9915657 0 9915657 1 0.541 1E-7 7 (TSH - Females) .06 [0.039-0.087] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 17q24.3 17 70127536 SOX9 6662 100499467 4.98 271.93 rs9915657-T rs9915657 0 9915657 1 0.541 2E-7 6.698970004336019 (TSH - Males) .07 [0.043-0.093] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 1p31.3 1 61620496 NFIA - 4774 rs334699-A rs334699 0 334699 intron 0 0.052 6E-7 6.221848749616355 (TSH - Males) .15 [0.09-0.208] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 15q21.2 15 49746364 FGF7 - 2252;196951 rs10519227-A rs10519227 0 10519227 intron;intron 0 0.245 6E-10 9.221848749616356 (TSH - Males) .10 [0.066-0.124] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 14q32.12 14 93595591 ITPK1 319085 1531 57.09 8.71 rs11624776-A rs11624776 0 11624776 1 0.66 2E-9 8.698970004336019 (TSH) .06 [0.042-0.086] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 1p32.3 1 54375570 DIO1 - 1733 rs2235544-A rs2235544 0 2235544 intron 0 0.51 8E-32 31.09691001300805 (FT4) .14 [0.11-0.16] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 16q12.2 16 55604128 LPCAT2,CAPNS2 - 54947 rs6499766-A rs6499766 0 6499766 intron 0 0.478 1E-6 5.999999999999999 (FT4) .06 [0.032-0.08] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 6q27 6 166046483 PDE10A - 10846 rs753760-C rs753760 0 753760 intron 0 0.691 6E-20 19.22184874961636 (TSH - Males) .13 [0.1-0.16] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 16q23.2 16 79749353 MAF,LOC440389 4094 83657 114.73 825.50 rs3813582-T rs3813582 0 3813582 1 0.674 6E-17 16.22184874961636 (TSH - Males) .12 [0.088-0.142] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 2q35 2 217625523 IGFBP5 3488 100129310 65.25 24.94 rs13015993-A rs13015993 0 13015993 1 0.736 2E-7 6.698970004336019 (TSH - Females) .07 [0.044-0.094] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 1p31.3 1 61620496 NFIA - 4774 rs334699-A rs334699 0 334699 intron 0 0.052 2E-7 6.698970004336019 (TSH - Females) .14 [0.09-0.196] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 9q22.33 9 100591463 FOXE1 392371 2304 128.38 24.07 rs7045138-T rs7045138 0 7045138 1 0.553 5E-7 6.30102999566398 (FT4-Males) .11 [0.064-0.146] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 4q33 4 171053519 AADAT 51166 442117 42.15 1681.06 rs11726248-A rs11726248 0 11726248 1 0.106 4E-7 6.397940008672037 (FT4-Females) .12 [0.076-0.17] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 16q12.2 16 55604128 LPCAT2,CAPNS2 - 54947 rs6499766-A rs6499766 0 6499766 intron 0 0.478 5E-8 7.30102999566398 (FT4-Males) .10 [0.064-0.134] unit increase Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 18q22.3 18 71167752 NETO1,FBXO15 100847083 201456 647.14 572.84 rs7240777-A rs7240777 0 7240777 1 0.5632 3E-8 7.522878745280337 (FT4-Females) .08 [0.054-0.112] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 11p11.2 11 45227567 PRDM11 - 56981 rs17723470-T rs17723470 0 17723470 intron 0 0.279 3E-7 6.522878745280337 (TSH - Females) .07 [0.044-0.094] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 15q26.1 15 89119104 MIR1179 55070 100302235 29.19 32.23 rs17776563-A rs17776563 0 17776563 1 0.322 6E-7 6.221848749616355 (TSH - Males) .07 [0.042-0.096] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 19p13.2 19 7223848 INSR - 3643;100996405 rs4804416-T rs4804416 0 4804416 intron;nearGene-3 0 0.569 2E-6 5.698970004336018 (TSH - Females) .06 [0.034-0.082] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 14q32.12 14 93595591 ITPK1 319085 1531 57.09 8.71 rs11624776-A rs11624776 0 11624776 1 0.66 3E-6 5.522878745280337 (TSH - Males) .07 [0.04-0.098] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23408906 Porcu E 02/07/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23408906 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. Thyroid hormone levels up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males NR 8p12 8 32416274 NRG1 - 3084 rs7825175-A rs7825175 0 7825175 intron 0 0.21 2E-8 7.698970004336018 (TSH - Females) .08 [0.055-0.113] unit decrease Illumina, Affymetrix [~2.5 Million] (Imputed) N 05/14/2013 23393555 Jensen RA 02/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23393555 Genome-wide association study of retinopathy in individuals without diabetes. Retinopathy in non-diabetics 19,411 European ancestry individuals NR 8q12.3 8 65730207 CYP7B1 9420 100271201 18.86 337.44 rs6472155-A rs6472155 0 6472155 1 0.51 4E-6 5.397940008672037 .23 [0.13-0.33] unit decrease Illumina [2,675,979] (Imputed) N 05/14/2013 23393555 Jensen RA 02/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23393555 Genome-wide association study of retinopathy in individuals without diabetes. Retinopathy in non-diabetics 19,411 European ancestry individuals NR 8q24.21 8 130676639 MLZE 100500839 56169 180.25 83.80 rs9918807-T rs9918807 0 9918807 1 0.94 5E-6 5.301029995663981 .47 [0.27-0.67] unit decrease Illumina [2,675,979] (Imputed) N 05/14/2013 23393555 Jensen RA 02/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23393555 Genome-wide association study of retinopathy in individuals without diabetes. Retinopathy in non-diabetics 19,411 European ancestry individuals NR 10q23.1 10 83188953 NRG3 389990 10718 291.87 446.12 rs1329201-T rs1329201 0 1329201 1 0.34 8E-6 5.096910013008055 .22 [0.12-0.32] unit decrease Illumina [2,675,979] (Imputed) N 05/14/2013 23393555 Jensen RA 02/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23393555 Genome-wide association study of retinopathy in individuals without diabetes. Retinopathy in non-diabetics 19,411 European ancestry individuals NR 11q14.1 11 78659145 ODZ4 - 26011 rs11826937-A rs11826937 0 11826937 intron 0 0.97 3E-6 5.522878745280337 .60 [0.35-0.85] unit decrease Illumina [2,675,979] (Imputed) N 05/14/2013 23393555 Jensen RA 02/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23393555 Genome-wide association study of retinopathy in individuals without diabetes. Retinopathy in non-diabetics 19,411 European ancestry individuals NR 12p11.22 12 28008769 KLHDC5 57542 5744 52.80 102.25 rs258401-T rs258401 0 258401 1 0.26 6E-6 5.221848749616356 .24 [0.14-0.34] unit increase Illumina [2,675,979] (Imputed) N 05/14/2013 23393555 Jensen RA 02/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23393555 Genome-wide association study of retinopathy in individuals without diabetes. Retinopathy in non-diabetics 19,411 European ancestry individuals NR 7p21.1 7 18428921 HDAC9 - 9734 rs12155400-A rs12155400 0 12155400 intron 0 0.98 8E-6 5.096910013008055 .73 [0.42-1.04] unit decrease Illumina [2,675,979] (Imputed) N 05/14/2013 23393555 Jensen RA 02/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23393555 Genome-wide association study of retinopathy in individuals without diabetes. Retinopathy in non-diabetics 19,411 European ancestry individuals NR 22q11.21 22 20797289 KLHL22 - 84861 rs5763911-T rs5763911 0 5763911 intron 0 0.96 6E-6 5.221848749616356 .52 [0.3-0.74] unit decrease Illumina [2,675,979] (Imputed) N 05/14/2013 23393555 Jensen RA 02/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23393555 Genome-wide association study of retinopathy in individuals without diabetes. Retinopathy in non-diabetics 19,411 European ancestry individuals NR 1q32.3 1 211691706 RD3 343035 7779 25.45 56.68 rs7553035-T rs7553035 0 7553035 1 0.07 4E-6 5.397940008672037 .37 [0.21-0.53] unit increase Illumina [2,675,979] (Imputed) N 05/14/2013 23393555 Jensen RA 02/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23393555 Genome-wide association study of retinopathy in individuals without diabetes. Retinopathy in non-diabetics 19,411 European ancestry individuals NR 4q28.3 4 138154812 PCDH18 646316 100131921 877.32 67.35 rs10004839-T rs10004839 0 10004839 1 0.02 5E-6 5.301029995663981 .57 [0.32-0.82] unit increase Illumina [2,675,979] (Imputed) N 05/14/2013 23393555 Jensen RA 02/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23393555 Genome-wide association study of retinopathy in individuals without diabetes. Retinopathy in non-diabetics 19,411 European ancestry individuals NR 6p22.1 6 29351784 OR12D3 81797 26529 8.72 12.63 rs9378134-A rs9378134 0 9378134 1 0.04 3E-6 5.522878745280337 .49 [0.29-0.69] unit increase Illumina [2,675,979] (Imputed) N 05/14/2013 23393555 Jensen RA 02/05/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23393555 Genome-wide association study of retinopathy in individuals without diabetes. Retinopathy in non-diabetics 19,411 European ancestry individuals NR 20q11.23 20 36068389 SRC 6714 140756 34.57 4.69 rs17194885-A rs17194885 0 17194885 1 0.96 4E-6 5.397940008672037 .61 [0.36-0.86] unit decrease Illumina [2,675,979] (Imputed) N 05/09/2013 23381795 Verweij N 02/04/2013 Hypertension http://www.ncbi.nlm.nih.gov/pubmed/23381795 Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1. Circulating vasoactive peptide levels 3,444 Euorpean ancestry individuals 3,230 European ancestry individuals 1q32.2 1 211168759 KCNH1 - 3756 rs1501550-A rs1501550 0 1501550 intron 0 0.21 2E-6 5.698970004336018 (ADM) .01 [0.0071-0.0149] nmol/l decrease Illumina [2,269,099] (Imputed) N 05/09/2013 23381795 Verweij N 02/04/2013 Hypertension http://www.ncbi.nlm.nih.gov/pubmed/23381795 Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1. Circulating vasoactive peptide levels 3,444 Euorpean ancestry individuals 3,230 European ancestry individuals 4q35.2 4 187148387 KLKB1 - 3818 rs4253238-C rs4253238 0 4253238 nearGene-5 0 0.46 4E-52 51.39794000867203 (ADM) .03 [0.027-0.035] nmol/l increase Illumina [2,269,099] (Imputed) N 05/09/2013 23381795 Verweij N 02/04/2013 Hypertension http://www.ncbi.nlm.nih.gov/pubmed/23381795 Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1. Circulating vasoactive peptide levels 3,444 Euorpean ancestry individuals 3,230 European ancestry individuals 4q35.2 4 187148387 KLKB1 - 3818 rs4253238-C rs4253238 0 4253238 nearGene-5 0 0.46 1E-122 122 (ET) 5.14 [4.71-5.56] pmol/l increase Illumina [2,269,099] (Imputed) N 05/09/2013 23381795 Verweij N 02/04/2013 Hypertension http://www.ncbi.nlm.nih.gov/pubmed/23381795 Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1. Circulating vasoactive peptide levels 3,444 Euorpean ancestry individuals 3,230 European ancestry individuals 11p15.4 11 10368119 ADM 133 272 39.20 103.75 rs2957692-G rs2957692 0 2957692 1 0.40 1E-12 12 (ADM) .02 [0.011-0.019] nmol/l decrease Illumina [2,269,099] (Imputed) N 05/09/2013 23381795 Verweij N 02/04/2013 Hypertension http://www.ncbi.nlm.nih.gov/pubmed/23381795 Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1. Circulating vasoactive peptide levels 3,444 Euorpean ancestry individuals 3,230 European ancestry individuals 5q35.3 5 176842474 F12 2161 2870 5.90 11.21 rs2731672-T rs2731672 0 2731672 1 0.24 1E-67 67 (ET) 4.61 [4.09-5.13] pmol/l increase Illumina [2,269,099] (Imputed) N 05/09/2013 23381795 Verweij N 02/04/2013 Hypertension http://www.ncbi.nlm.nih.gov/pubmed/23381795 Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1. Circulating vasoactive peptide levels 3,444 Euorpean ancestry individuals 3,230 European ancestry individuals 6p24.1 6 12296255 EDN1 - 1906 rs5370-T rs5370 0 5370 missense 0 0.22 1E-27 27 (ET) 2.96 [2.42-3.49] pmol/l increase Illumina [2,269,099] (Imputed) N 05/09/2013 23381795 Verweij N 02/04/2013 Hypertension http://www.ncbi.nlm.nih.gov/pubmed/23381795 Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1. Circulating vasoactive peptide levels 3,444 Euorpean ancestry individuals 3,230 European ancestry individuals 5q35.3 5 176842474 F12 2161 2870 5.90 11.21 rs2731672-T rs2731672 0 2731672 1 0.24 6E-24 23.22184874961635 (ADM) .02 [0.018-0.026] nmol/l increase Illumina [2,269,099] (Imputed) N 05/08/2013 23571483 Aberg KA 02/01/2013 JAMA Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23571483 A comprehensive family-based replication study of schizophrenia genes. Schizophrenia 11,185 European ancestry cases, 10,768 European ancestry controls 1,262 African American ancestry individuals, 2,740 European ancestry individuals, 2,296 Asian ancestry individuals 6q22.31 6 124342663 NKAIN2 - 154215 rs6917824-G rs6917824L 0 6917824 intron 0 0.83 4E-6 5.397940008672037 (EA) 1.30 [NR] NR [1,085,772] (Imputed) N 05/08/2013 23571483 Aberg KA 02/01/2013 JAMA Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23571483 A comprehensive family-based replication study of schizophrenia genes. Schizophrenia 11,185 European ancestry cases, 10,768 European ancestry controls 1,262 African American ancestry individuals, 2,740 European ancestry individuals, 2,296 Asian ancestry individuals 18q21.2 18 52949657 TCF4 - 6925 rs1261117-T rs1261117 0 1261117 intron 0 0.06 3E-10 9.522878745280336 (EA) 1.60 [NR] NR [1,085,772] (Imputed) N 05/08/2013 23571483 Aberg KA 02/01/2013 JAMA Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23571483 A comprehensive family-based replication study of schizophrenia genes. Schizophrenia 11,185 European ancestry cases, 10,768 European ancestry controls 1,262 African American ancestry individuals, 2,740 European ancestry individuals, 2,296 Asian ancestry individuals 19q13.2 19 40229409 CLC, LGALS17A - 1178 rs12611334-G rs12611334 0 12611334 nearGene-5 0 0.70 2E-6 5.698970004336018 (EA) 1.40 [NR] NR [1,085,772] (Imputed) N 05/08/2013 23571483 Aberg KA 02/01/2013 JAMA Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23571483 A comprehensive family-based replication study of schizophrenia genes. Schizophrenia 11,185 European ancestry cases, 10,768 European ancestry controls 1,262 African American ancestry individuals, 2,740 European ancestry individuals, 2,296 Asian ancestry individuals 11q24.2 11 125313599 FEZ1 63876 9638 10.31 2.04 rs7930295-G rs7930295 0 7930295 1 0.86 3E-6 5.522878745280337 (EA) 1.30 [NR] NR [1,085,772] (Imputed) N 05/08/2013 23571483 Aberg KA 02/01/2013 JAMA Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23571483 A comprehensive family-based replication study of schizophrenia genes. Schizophrenia 11,185 European ancestry cases, 10,768 European ancestry controls 1,262 African American ancestry individuals, 2,740 European ancestry individuals, 2,296 Asian ancestry individuals 6p21.33 6 31602967 PRRC2A, BAG6 - 7916 rs1046089-G rs1046089 0 1046089 missense 0 0.34 4E-6 5.397940008672037 (EA) 1.30 [NR] NR [1,085,772] (Imputed) N 05/08/2013 23571483 Aberg KA 02/01/2013 JAMA Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23571483 A comprehensive family-based replication study of schizophrenia genes. Schizophrenia 11,185 European ancestry cases, 10,768 European ancestry controls 1,262 African American ancestry individuals, 2,740 European ancestry individuals, 2,296 Asian ancestry individuals 6p21.32 6 32171075 NOTCH4 - 4855 rs3132935-? rs3132935 0 3132935 intron 0 0.82 3E-7 6.522878745280337 1.25 [NR] NR [1,085,772] (Imputed) N 05/08/2013 23571483 Aberg KA 02/01/2013 JAMA Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23571483 A comprehensive family-based replication study of schizophrenia genes. Schizophrenia 11,185 European ancestry cases, 10,768 European ancestry controls 1,262 African American ancestry individuals, 2,740 European ancestry individuals, 2,296 Asian ancestry individuals 10q24.32 10 104662458 AS3MT, CNNM2, NT5C2 100271289 54805 14.49 15.62 rs7897654-T rs7897654 0 7897654 1 0.30 3E-7 6.522878745280337 1.20 [NR] NR [1,085,772] (Imputed) N 05/08/2013 23571483 Aberg KA 02/01/2013 JAMA Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23571483 A comprehensive family-based replication study of schizophrenia genes. Schizophrenia 11,185 European ancestry cases, 10,768 European ancestry controls 1,262 African American ancestry individuals, 2,740 European ancestry individuals, 2,296 Asian ancestry individuals 22q13.33 22 50218611 BRD1 - 23774 rs138880-C rs138880 0 138880 nearGene-5 0 0.78 2E-7 6.698970004336019 1.10 [NR] NR [1,085,772] (Imputed) N 05/08/2013 23571483 Aberg KA 02/01/2013 JAMA Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23571483 A comprehensive family-based replication study of schizophrenia genes. Schizophrenia 11,185 European ancestry cases, 10,768 European ancestry controls 1,262 African American ancestry individuals, 2,740 European ancestry individuals, 2,296 Asian ancestry individuals 1q25.2 1 177722907 SEC16B 57795 89866 471.35 175.34 rs12140439-C rs12140439 0 12140439 1 0.31 1E-6 5.999999999999999 (EA) 1.30 [NR] NR [1,085,772] (Imputed) N 05/08/2013 23571483 Aberg KA 02/01/2013 JAMA Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23571483 A comprehensive family-based replication study of schizophrenia genes. Schizophrenia 11,185 European ancestry cases, 10,768 European ancestry controls 1,262 African American ancestry individuals, 2,740 European ancestry individuals, 2,296 Asian ancestry individuals 2p16.3 2 48047335 FBXO11 - 80204 rs4381823-? rs4381823 0 4381823 intron 0 0.93 6E-6 5.221848749616356 (EA) 1.43 [NR] NR [1,085,772] (Imputed) N 05/08/2013 23571483 Aberg KA 02/01/2013 JAMA Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23571483 A comprehensive family-based replication study of schizophrenia genes. Schizophrenia 11,185 European ancestry cases, 10,768 European ancestry controls 1,262 African American ancestry individuals, 2,740 European ancestry individuals, 2,296 Asian ancestry individuals 3q13.33 3 119084331 ARHGAP31 - 57514 rs17203055-? rs17203055 0 17203055 intron 0 0.87 5E-6 5.301029995663981 (EA) 1.43 [NR] NR [1,085,772] (Imputed) N 05/08/2013 23571483 Aberg KA 02/01/2013 JAMA Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23571483 A comprehensive family-based replication study of schizophrenia genes. Schizophrenia 11,185 European ancestry cases, 10,768 European ancestry controls 1,262 African American ancestry individuals, 2,740 European ancestry individuals, 2,296 Asian ancestry individuals 6p22.1 6 27278020 POM121L2 - 94026 rs16897515-C rs16897515 0 16897515 missense 0 0.16 4E-7 6.397940008672037 (EA) 1.30 [NR] NR [1,085,772] (Imputed) N 05/08/2013 23571483 Aberg KA 02/01/2013 JAMA Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23571483 A comprehensive family-based replication study of schizophrenia genes. Schizophrenia 11,185 European ancestry cases, 10,768 European ancestry controls 1,262 African American ancestry individuals, 2,740 European ancestry individuals, 2,296 Asian ancestry individuals 1p34.3 1 37162352 GRIK3 100462786 2899 65.94 98.78 rs589249-G rs589249 0 589249 1 0.64 3E-7 6.522878745280337 1.20 [NR] NR [1,085,772] (Imputed) N 05/08/2013 23571483 Aberg KA 02/01/2013 JAMA Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23571483 A comprehensive family-based replication study of schizophrenia genes. Schizophrenia 11,185 European ancestry cases, 10,768 European ancestry controls 1,262 African American ancestry individuals, 2,740 European ancestry individuals, 2,296 Asian ancestry individuals 6p21.32 6 32171075 NOTCH4 - 4855 rs3132935-? rs3132935 0 3132935 intron 0 0.82 5E-7 6.30102999566398 (EA) 1.25 [NR] NR [1,085,772] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 6p24.3 6 10176036 Intergenic 728179 442160 56.49 38.05 rs12210761-A rs12210761 0 12210761 1 0.0676606 6E-6 5.221848749616356 (partial response - SSRI treated - 2 weeks) 2.45 [2.06-2.83] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 7p12.3 7 45982460 IGFBP1,IGFBP3 3486 442304 21.59 54.68 rs2462686-C rs2462686 0 2462686 1 0.3509068 9E-6 5.045757490560675 (partial response - SSRI treated - 2 weeks) 1.49 [1.31-1.66] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 4q21.22 4 82462597 RASGEF1B 153020 1330 69.54 378.48 rs1822818-T rs1822818 0 1822818 1 0.87 6E-6 5.221848749616356 (partial response - SSRI treated - 2 weeks) 1.77 [1.53-2.02] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 5q33.3 5 159007778 MIR548D2 3593 147 250.30 335.96 rs10065906-C rs10065906 0 10065906 1 0.3622876 2E-6 5.698970004336018 (partial response - SSRI treated - 2 weeks) 1.53 [1.36-1.7] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 3q25.33 3 159644297 SCHIP1,IL12A 29970 3592 29.14 62.33 rs6799788-G rs6799788 0 6799788 1 0.2476976 1E-6 5.999999999999999 (partial response - SSRI treated - 2 weeks) 1.63 [1.43-1.82] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 3q29 3 193583710 Intergenic 4976 100128023 168.11 127.17 rs604222-A rs604222 0 604222 1 0.1915251 7E-6 5.154901959985742 (% improvement - SSRI treated - 2 weeks) .22 [0.12-0.31] unit increase Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 1p36.32 1 5354844 Intergenic 55966 100616489 510.99 269.29 rs912988-T rs912988 0 912988 1 0.3630374 6E-6 5.221848749616356 (% improvement - SSRI treated - 2 weeks) .18 [0.1-0.26] unit increase Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 9q34.13 9 135632493 C9orf98 - 158067 rs12552369-A rs12552369 0 12552369 intron 0 0.494 8E-6 5.096910013008055 (% improvement - 2 weeks) 1.16 [1.1-1.21] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 5p15.1 5 16812638 MYO10 - 4651 rs17651119-C rs17651119 0 17651119 intron 0 0.99 2E-8 7.698970004336018 (% improvement - 12 weeks) 3.18 [2.77-3.59] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 19q13.11 19 34320854 KCTD15 79047 100271386 14.19 192.62 rs2546057-A rs2546057 0 2546057 1 0.52 3E-7 6.522878745280337 (% improvement - 12 weeks) 1.18 [1.12-1.24] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 1q42.13 1 227667790 Intergenic 503543 391171 45.48 12.76 rs12410462-A rs12410462 0 12410462 1 0.122 4E-7 6.397940008672037 (% improvement - 12 weeks) 1.26 [1.16-1.36] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 19q13.42 19 56265664 RFPL4A 338321 342931 15.90 4.84 rs17634917-A rs17634917 0 17634917 1 0.94 3E-6 5.522878745280337 (% improvement - 12 weeks) 1.37 [1.23-1.51] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 18p11.21 18 10923808 FAM38B - 63895 rs264272-G rs264272 0 264272 intron 0 0.52 4E-6 5.397940008672037 (% improvement - 12 weeks) 1.14 [1.09-1.2] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 13q31.1 13 80169004 NDFIP2 54602 10253 38.79 741.11 rs9601248-C rs9601248 0 9601248 1 0.498 2E-6 5.698970004336018 (remission - 12 weeks) 1.38 [1.25-1.52] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 4q28.1 4 125265313 Intergenic 100271167 391696 597.89 118.60 rs2125000-T rs2125000 0 2125000 1 0.307 3E-6 5.522878745280337 (remission - 12 weeks) 1.43 [1.27-1.58] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 5q32 5 149036976 FLJ41603 389337 494327 22.45 75.41 rs17710780-T rs17710780 0 17710780 1 0.86 4E-6 5.397940008672037 (remission - 12 weeks) 1.66 [1.45-1.88] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 6p22.3 6 23841132 Intergenic 100131805 100874498 737.33 15.66 rs9466930-C rs9466930 0 9466930 1 0.215 4E-6 5.397940008672037 (remission - 12 weeks) 1.50 [1.32-1.68] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 12p13.1 12 13641706 GRIN2B 283422 2904 112.03 72.70 rs1457614-C rs1457614 0 1457614 1 0.181 8E-6 5.096910013008055 (remission - 12 weeks) 1.47 [1.29-1.64] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 15q23 15 68597127 ITGA11 - 22801 rs7174755-T rs7174755 0 7174755 intron 0 0.63 9E-7 6.045757490560675 (% improvement - 2 weeks) 1.17 [1.11-1.23] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 5q33.3 5 159007778 MIR548D2 3593 147 250.30 335.96 rs10065906-C rs10065906 0 10065906 1 0.332 2E-6 5.698970004336018 (% improvement - 2 weeks) 1.17 [1.11-1.22] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 5q23.2 5 123832652 Intergenic 100873892 57507 275.88 139.96 rs12513663-T rs12513663 0 12513663 1 0.268 2E-6 5.698970004336018 (% improvement - 2 weeks) 1.18 [1.11-1.26] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 3q28 3 191818642 FGF12 152138 2257 639.40 38.54 rs4585146-G rs4585146 0 4585146 1 0.65 6E-6 5.221848749616356 (% improvement - 2 weeks) 1.16 [1.11-1.22] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 15q13.3 15 33505067 FMN1 342184 100652857 144.98 23.61 rs974379-C rs974379 0 974379 1 0.075 8E-6 5.096910013008055 (% improvement - 2 weeks) 1.29 [1.17-1.4] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 6p21.1 6 44065311 MRPL14 100131206 64928 7.81 16.06 rs7742824-A rs7742824 0 7742824 1 0.224 9E-6 5.045757490560675 (% improvement - 2 weeks) 1.19 [1.11-1.26] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 5q33.3 5 159007778 Intergenic 3593 147 250.30 335.96 rs10065906-C rs10065906 0 10065906 1 0.308 5E-8 7.30102999566398 (partial response - 2 weeks) 1.47 [1.33-1.61] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 2q32.3 2 193742173 Intergenic 100271070 343981 103.02 1251.85 rs10174573-T rs10174573 0 10174573 1 0.57 2E-6 5.698970004336018 (partial response - 2 weeks) 1.56 [1.39-1.74] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 12p12.3 12 17662235 Intergenic 390297 100616279 124.64 164.00 rs1706631-T rs1706631 0 1706631 1 0.408 6E-6 5.221848749616356 (partial response - 2 weeks) 1.35 [1.22-1.49] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 4p15.2 4 24740958 SOD3 53409 6649 80.91 56.13 rs12500612-G rs12500612 0 12500612 1 0.85 7E-6 5.154901959985742 (partial response - 2 weeks) 1.77 [1.51-2.02] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 22q12.3 22 34823828 ENOX1 9215 91464 507.41 638.30 rs1034394-G rs1034394 0 1034394 1 0.3390146 2E-6 5.698970004336018 (% improvement - SSRI treated - 12 weeks) .21 [0.12-0.3] unit increase Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 18p11.21 18 10923808 FAM38B - 63895 rs264272-T rs264272 0 264272 intron 0 0.4874733 3E-6 5.522878745280337 (% improvement - SSRI treated - 12 weeks) .17 [0.099-0.243] unit decrease Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 19q13.11 19 34321258 CHST8,KCTD15 79047 100271386 14.59 192.21 rs398426-T rs398426 0 398426 1 0.2588456 5E-6 5.301029995663981 (% improvement - SSRI treated - 12 weeks) .25 [0.14-0.36] unit decrease Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 19q13.42 19 56265664 EPN1,NLRP9,RFPL4A,NLRP11 338321 342931 15.90 4.84 rs17634917-G rs17634917 0 17634917 1 0.0573945 6E-6 5.221848749616356 (% improvement - SSRI treated - 12 weeks) .38 [0.21-0.54] unit decrease Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 4q28.1 4 125415534 Intergenic 391696 57182 30.52 169.67 rs6534441-C rs6534441 0 6534441 1 0.3328325 7E-6 5.154901959985742 (% improvement - SSRI treated - 12 weeks) .18 [0.1-0.26] unit decrease Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 12p13.32 12 4416304 CCND2,C12orf5 894 100271361 1.78 17.21 rs4625554-G rs4625554 0 4625554 1 0.2996789 9E-6 5.045757490560675 (% improvement - SSRI treated - 12 weeks) .19 [0.11-0.28] unit increase Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 7q11.22 7 70473005 WBSCR17 26053 100500920 215.12 299.66 rs1525293-C rs1525293 0 1525293 1 0.66 2E-6 5.698970004336018 (remission - SSRI treated - 12 weeks) 1.70 [1.48-1.92] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 9p24.3 9 955794 DMRT1,DMRT3 - 1761 rs364477-C rs364477 0 364477 intron 0 0.2154931 4E-6 5.397940008672037 (remission - SSRI treated - 12 weeks) 1.69 [1.47-1.92] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 14q23.2 14 63322347 KCNH5 - 27133 rs8012941-G rs8012941 0 8012941 intron 0 0.4975174 4E-6 5.397940008672037 (remission - SSRI treated - 12 weeks) 1.54 [1.35-1.72] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 1q41 1 217200883 ESRRG - 2104 rs2377360-G rs2377360 0 2377360 intron 0 0.2632403 9E-6 5.045757490560675 (remission - SSRI treated - 12 weeks) 1.60 [1.39-1.81] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 5p14.1 5 27611431 Intergenic 1007 729862 572.74 1315.55 rs12054895-T rs12054895 0 12054895 1 0.275456 3E-8 7.522878745280337 (% improvement - SSRI treated - 2 weeks) .24 [0.16-0.33] unit increase Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 15q23 15 68597127 PIAS1,CALML4,CLN6,FEM1B,ITGA11 - 22801 rs7174755-C rs7174755 0 7174755 intron 0 0.3690476 3E-7 6.522878745280337 (% improvement - SSRI treated - 2 weeks) .20 [0.13-0.28] unit decrease Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 5q31.3 5 141210753 PCDH1 64411 5097 148.95 21.92 rs166040-G rs166040 0 166040 1 0.87 5E-6 5.301029995663981 (partial response - 2 weeks) 1.61 [1.41-1.8] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 13q14.11 13 43834270 ENOX1 - 55068 rs17538444-T rs17538444 0 17538444 intron 0 0.0698752 4E-7 6.397940008672037 (% improvement - SSRI treated - 12 weeks) .39 [0.24-0.54] unit decrease Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 15q26.3 15 100299239 LYSMD4,C15orf51 145748 196968 25.61 31.12 rs6598266-A rs6598266 0 6598266 1 0.1427493 3E-6 5.522878745280337 (% improvement - SSRI treated - 12 weeks) .25 [0.15-0.36] unit increase Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 13q31.1 13 81357671 Intergenic 100129459 100129023 126.53 98.03 rs11149178-A rs11149178 0 11149178 1 0.3560899 7E-6 5.154901959985742 (% improvement - SSRI treated - 12 weeks) .18 [0.1-0.26] unit decrease Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 12p13.1 12 13519996 C12orf36 2012 283422 150.29 3.61 rs11055387-C rs11055387 0 11055387 1 0.0895145 8E-6 5.096910013008055 (remission - SSRI treated - 12 weeks) 2.19 [1.84-2.53] Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 3q28 3 191818642 FGF12 152138 2257 639.40 38.54 rs4585146-A rs4585146 0 4585146 1 0.362271 3E-7 6.522878745280337 (% improvement - SSRI treated - 2 weeks) .22 [0.14-0.31] unit decrease Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 19q13.11 19 33089431 PDCD5,ANKRD27,RGS9BP,NUDT19 - 84079 rs17692896-A rs17692896 0 17692896 intron 0 0.0739179 7E-7 6.154901959985743 (% improvement - SSRI treated - 2 weeks) .44 [0.27-0.61] unit decrease Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 6p22.3 6 16256043 MYLIP,GMPR,ATXN1 - 2766 rs10484358-T rs10484358 0 10484358 intron 0 0.0827112 1E-6 5.999999999999999 (% improvement - SSRI treated - 2 weeks) .43 [0.25-0.6] unit decrease Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23377640 GENDEP Investigators 02/01/2013 Am J Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23377640 Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. Major depressive disorder Up to 2,256 European ancestry cases NR 5q14.3 5 87034352 RASA1,CCNH 902 153396 325.50 456.67 rs1673101-A rs1673101 0 1673101 1 0.3312154 4E-6 5.397940008672037 (% improvement - SSRI treated - 2 weeks) .19 [0.11-0.27] unit decrease Illumina & Affymetrix [1.2 million] (Imputed) N 05/09/2013 23378610 Xie W 02/01/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23378610 Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Metabolite levels 1,004 European ancestry individuals 339 European ancestry individuals 1p12 1 120255126 PHGDH - 26227 rs478093-G rs478093 0 478093 intron 0 0.71 2E-14 13.69897000433602 (serine) NR NR Affymetrix [909,508] (imputed) N 05/09/2013 23378610 Xie W 02/01/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23378610 Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Metabolite levels 1,004 European ancestry individuals 339 European ancestry individuals 12p13.33 12 320920 SLC6A12, SLC6A13 - 6539 rs499368-A rs499368 0 499368 intron 0 0.51 2E-10 9.698970004336017 (betaine) .36 [0.25-0.46] unit decrease Affymetrix [909,508] (imputed) N 05/09/2013 23378610 Xie W 02/01/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23378610 Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Metabolite levels 1,004 European ancestry individuals 339 European ancestry individuals 5q14.1 5 78341297 BHMT, BHMT2 - 29958 rs17823642-C rs17823642 0 17823642 intron 0 0.89 2E-9 8.698970004336019 (betaine) .38 [0.26-0.51] unit increase Affymetrix [909,508] (imputed) N 05/09/2013 23378610 Xie W 02/01/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23378610 Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Metabolite levels 1,004 European ancestry individuals 339 European ancestry individuals 3q21.3 3 125904165 ALDH1L1, KLF15 - 100862662 rs1107366-G rs1107366 0 1107366 intron 0 0.51 2E-6 5.698970004336018 (glycine/serine) .02 [0.011-0.027] unit increase Affymetrix [909,508] (imputed) N 05/09/2013 23378610 Xie W 02/01/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23378610 Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Metabolite levels 1,004 European ancestry individuals 339 European ancestry individuals 2q34 2 211543055 CPS1 - 1373 rs715-T rs715 0 715 UTR-3 0 0.68 3E-50 49.52287874528033 (glycine) .61 [0.53-0.69] unit decrease Affymetrix [909,508] (imputed) N 05/09/2013 23378610 Xie W 02/01/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23378610 Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Metabolite levels 1,004 European ancestry individuals 339 European ancestry individuals 11q12.2 11 61565908 FADS1, FADS2, FADS3, FEN1 2237 3992 1.19 1.19 rs174541-T rs174541 0 174541 1 0.65 3E-9 8.522878745280337 (adrenate) .28 [0.19-0.37] unit increase Affymetrix [909,508] (imputed) N 05/09/2013 23371916 Dai X 01/31/2013 Genet Epidemiol http://www.ncbi.nlm.nih.gov/pubmed/23371916 A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population. Bilirubin levels 1,452 Han Chinese ancestry individuals 8,830 Han Chinese ancestry individuals 2q37.1 2 234669144 UGT1A1 - 54575;54576;54577;54578;54579;54600;54657;54658;54659 rs4148323-? rs4148323 0 4148323 intron;intron;intron;intron;intron;intron;intron;missense;intron 0 0.20 7E-30 29.15490195998574 (Direct bilirubin) .09 [0.074-0.106] unit increase Affymetrix [658,288] (Imputed) N 05/09/2013 23371916 Dai X 01/31/2013 Genet Epidemiol http://www.ncbi.nlm.nih.gov/pubmed/23371916 A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population. Bilirubin levels 1,452 Han Chinese ancestry individuals 8,830 Han Chinese ancestry individuals 2q37.1 2 234669144 UGT1A1 - 54575;54576;54577;54578;54579;54600;54657;54658;54659 rs4148323-? rs4148323 0 4148323 intron;intron;intron;intron;intron;intron;intron;missense;intron 0 0.20 2E-62 61.69897000433601 (Indirect bilirubin) .12 [0.11-0.13] unit increase Affymetrix [658,288] (Imputed) N 05/09/2013 23371916 Dai X 01/31/2013 Genet Epidemiol http://www.ncbi.nlm.nih.gov/pubmed/23371916 A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population. Bilirubin levels 1,452 Han Chinese ancestry individuals 8,830 Han Chinese ancestry individuals 2q37.1 2 234639310 UGT1A1 - 54575;54576;54577;54578;54579;54600;54657;54659 rs11891311-? rs11891311 0 11891311 intron;intron;intron;intron;intron;intron;intron;intron 0 0.12 1E-41 41 (Direct bilirubin) .14 [0.12-0.16] unit increase Affymetrix [658,288] (Imputed) N 05/09/2013 23371916 Dai X 01/31/2013 Genet Epidemiol http://www.ncbi.nlm.nih.gov/pubmed/23371916 A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population. Bilirubin levels 1,452 Han Chinese ancestry individuals 8,830 Han Chinese ancestry individuals 2q37.1 2 234669144 UGT1A1 - 54575;54576;54577;54578;54579;54600;54657;54658;54659 rs4148323-? rs4148323 0 4148323 intron;intron;intron;intron;intron;intron;intron;missense;intron 0 0.20 5E-69 68.30102999566398 (Total bilirubin) .11 [0.097-0.121] unit increase Affymetrix [658,288] (Imputed) N 05/09/2013 23371916 Dai X 01/31/2013 Genet Epidemiol http://www.ncbi.nlm.nih.gov/pubmed/23371916 A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population. Bilirubin levels 1,452 Han Chinese ancestry individuals 8,830 Han Chinese ancestry individuals 2q37.1 2 234672639 UGT1A1 - 54575;54576;54577;54578;54579;54600;54657;54658;54659 rs6742078-? rs6742078 0 6742078 intron;intron;intron;intron;intron;intron;intron;intron;intron 0 0.12 1E-89 88.99999999999999 (Total bilirubin) .15 [0.14-0.17] unit increase Affymetrix [658,288] (Imputed) N 05/09/2013 23371916 Dai X 01/31/2013 Genet Epidemiol http://www.ncbi.nlm.nih.gov/pubmed/23371916 A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population. Bilirubin levels 1,452 Han Chinese ancestry individuals 8,830 Han Chinese ancestry individuals 2q37.1 2 234672639 UGT1A1 - 54575;54576;54577;54578;54579;54600;54657;54658;54659 rs6742078-? rs6742078 0 6742078 intron;intron;intron;intron;intron;intron;intron;intron;intron 0 0.12 6E-40 39.22184874961636 (Direct bilirubin) .13 [0.11-0.15] unit increase Affymetrix [658,288] (Imputed) N 05/09/2013 23371916 Dai X 01/31/2013 Genet Epidemiol http://www.ncbi.nlm.nih.gov/pubmed/23371916 A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population. Bilirubin levels 1,452 Han Chinese ancestry individuals 8,830 Han Chinese ancestry individuals 2q37.1 2 234672639 UGT1A1 - 54575;54576;54577;54578;54579;54600;54657;54658;54659 rs6742078-? rs6742078 0 6742078 intron;intron;intron;intron;intron;intron;intron;intron;intron 0 0.12 2E-78 77.698970004336 (Indirect bilirubin) .17 [0.15-0.18] unit increase Affymetrix [658,288] (Imputed) N 05/09/2013 23371916 Dai X 01/31/2013 Genet Epidemiol http://www.ncbi.nlm.nih.gov/pubmed/23371916 A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population. Bilirubin levels 1,452 Han Chinese ancestry individuals 8,830 Han Chinese ancestry individuals 12p12.2 12 21017875 SLCO1B3 - 28234 rs2417940-? rs2417940 0 2417940 intron 0 0.16 7E-19 18.15490195998574 (Total bilirubin) .06 [0.045-0.073] unit increase Affymetrix [658,288] (Imputed) N 05/09/2013 23371916 Dai X 01/31/2013 Genet Epidemiol http://www.ncbi.nlm.nih.gov/pubmed/23371916 A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population. Bilirubin levels 1,452 Han Chinese ancestry individuals 8,830 Han Chinese ancestry individuals 12p12.2 12 21017875 SLCO1B3 - 28234 rs2417940-? rs2417940 0 2417940 intron 0 0.16 2E-16 15.69897000433602 (Direct bilirubin) .07 [0.056-0.092] unit increase Affymetrix [658,288] (Imputed) N 05/09/2013 23371916 Dai X 01/31/2013 Genet Epidemiol http://www.ncbi.nlm.nih.gov/pubmed/23371916 A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population. Bilirubin levels 1,452 Han Chinese ancestry individuals 8,830 Han Chinese ancestry individuals 12p12.2 12 21017875 SLCO1B3 - 28234 rs2417940-? rs2417940 0 2417940 intron 0 0.16 5E-13 12.30102999566398 (Indirect bilirubin) .06 [0.04-0.072] unit increase Affymetrix [658,288] (Imputed) N 05/09/2013 23376709 Kerns SL 01/31/2013 J Urol http://www.ncbi.nlm.nih.gov/pubmed/23376709 A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of urinary symptoms after radiotherapy for prostate cancer. Urinary symptoms in response to radiotherapy in prostate cancer 346 European, African, Hispanic and Asian individuals 377 European, African, Hispanic and Asian individuals 9p21.2 9 27488092 IFNK, MOB3B - 79817 rs17779457-? rs17779457 0 17779457 intron 0 0.25 7E-7 6.154901959985743 (at 2-3 yrs) 2.40 [1.1-3.6] unit increase Affymetrix [613,496] N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q25.2 3 153478423 NR 5912 100271162 592.16 263.16 rs6794649-C rs6794649 0 6794649 1 0.159420807120324 1E-6 5.999999999999999 (IGP4) .21 [0.12-0.29] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 33128021 NR - 2683 rs10813951-G rs10813951 0 10813951 intron 0 0.262743396083667 5E-10 9.301029995663981 (IGP40) .22 [0.15-0.29] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9q32 9 115687735 NR 57864 100129193 34.54 33.68 rs10817408-C rs10817408 0 10817408 1 0.149460512683578 7E-6 5.154901959985742 (IGP40) .22 [0.13-0.32] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q11.22 7 69238158 NR - 26053 rs11765886-C rs11765886 0 11765886 intron 0 0.66506290565198 5E-6 5.301029995663981 (IGP40) .16 [0.091-0.228] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q12.3 22 32783904 NR - 51493 rs12530-C rs12530 0 12530 UTR-3 0 0.18432396929239 3E-6 5.522878745280337 (IGP40) .18 [0.11-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10p13 10 13530217 NR - 222389 rs17153352-T rs17153352 0 17153352 intron 0 0.822655938139742 7E-6 5.154901959985742 (IGP40) .20 [0.12-0.29] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q32.2 14 99742187 NR 64919 84193 4.37 121.90 rs2664299-C rs2664299 0 2664299 1 0.404780828660436 9E-6 5.045757490560675 (IGP40) .17 [0.094-0.241] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20p12.1 20 17829280 NR 140836 27131 112.76 92.96 rs2745851-G rs2745851 0 2745851 1 0.639172889630619 4E-6 5.397940008672037 (IGP40) .15 [0.085-0.212] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3p25.3 3 11232779 NR - 3269 rs4684059-C rs4684059 0 4684059 intron 0 0.369267114374722 8E-6 5.096910013008055 (IGP40) .17 [0.095-0.243] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q23.3 14 65775695 FUT8 122888 100616176 27.32 26.14 rs11847263-G rs11847263 0 11847263 1 0.391757509628303 7E-14 13.15490195998574 (IGP11) .24 [0.18-0.3] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q23.3 12 108877541 NR 1240 11153 144.45 31.51 rs918304-C rs918304 0 918304 1 0.00963820126262628 9E-6 5.045757490560675 (IGP13) 1.58 [0.88-2.28] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q22.3 5 115138748 NR 51014 1036 176.87 1.68 rs13174348-G rs13174348 0 13174348 1 0.784686077436582 3E-6 5.522878745280337 (IGP14) .18 [0.11-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3p26.2 3 3231838 NR 51185 57633 10.44 609.28 rs1672743-T rs1672743 0 1672743 1 0.053157 6E-6 5.221848749616356 (IGP16) 1.17 [0.66-1.67] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q15 5 95486940 NR 693168 5122 72.02 239.10 rs4869266-G rs4869266 0 4869266 1 0.664911823953174 3E-6 5.522878745280337 (IGP16) .15 [0.088-0.216] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q12 14 30088138 NR - 5587 rs12431702-C rs12431702 0 12431702 intron 0 0.380447777481086 8E-6 5.096910013008055 (IGP17) .15 [0.082-0.21] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q11.2 5 55322895 IL6ST,ANKRD55 3572 727984 32.07 109.88 rs17348299-C rs17348299 0 17348299 1 0.836731980863373 2E-7 6.698970004336019 (IGP17) .23 [0.14-0.32] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q25.3 17 79218714 NR - 124565 rs2659005-C rs2659005 0 2659005 nearGene-3 0 0.517316186025812 2E-6 5.698970004336018 (IGP17) .15 [0.09-0.217] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10p14 10 7887621 NR - 83860 rs11255400-G rs11255400 0 11255400 intron 0 0.931314253351327 7E-6 5.154901959985742 (IGP2) .29 [0.16-0.41] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 15q22.2 15 62338797 NR - 54832 rs1436958-G rs1436958 0 1436958 intron 0 0.57353197705803 9E-6 5.045757490560675 (IGP2) .14 [0.078-0.2] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 15q13.3 15 33493221 NR 342184 100652857 133.14 35.46 rs6494964-G rs6494964 0 6494964 1 0.686050906432748 6E-6 5.221848749616356 (IGP2) .18 [0.1-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 16q12.2 16 53073788 NR 27324 80205 492.07 15.16 rs10852453-T rs10852453 0 10852453 1 0.502934347747748 1E-6 5.999999999999999 (IGP20) .15 [0.088-0.205] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1q43 1 242522042 NR - 200150 rs2919024-G rs2919024 0 2919024 intron 0 0.012337327027027 7E-6 5.154901959985742 (IGP20) .68 [0.38-0.97] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q14.3 6 87606842 NR 643906 643971 809.95 73.31 rs1853639-G rs1853639 0 1853639 1 0.359453092898615 8E-6 5.096910013008055 (IGP21) .18 [0.099-0.254] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 28181085 NR - 158038 rs1319535-C rs1319535 0 1319535 intron 0 0.345300509585377 9E-6 5.045757490560675 (IGP34) .15 [0.081-0.21] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p21.3 7 12219535 NR 221981 54664 347.71 31.31 rs17594709-G rs17594709 0 17594709 1 0.283855287561302 5E-6 5.301029995663981 (IGP34) .16 [0.09-0.225] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q11.2 5 51173324 NR 100873897 100271072 467.29 405.02 rs17835853-G rs17835853 0 17835853 1 0.956751274008025 6E-6 5.221848749616356 (IGP34) .47 [0.27-0.67] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20q12 20 39478533 NR 9935 7150 160.66 178.93 rs6102185-G rs6102185 0 6102185 1 0.422547655372269 5E-6 5.301029995663981 (IGP34) .14 [0.082-0.204] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20p11.23 20 20634106 NR - 57186 rs6132333-C rs6132333 0 6132333 intron 0 0.0251061037895675 8E-6 5.096910013008055 (IGP34) .49 [0.28-0.71] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8q23.3 8 116330855 NR 100270945 7227 1941.34 89.87 rs6983039-G rs6983039 0 6983039 1 0.971469000267499 9E-6 5.045757490560675 (IGP34) .44 [0.25-0.64] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39859169 SYNGR1,TAB1,MGAT3,CACNA1I - 4248 rs909674-C rs909674 0 909674 intron 0 0.298878222915738 2E-10 9.698970004336017 (IGP34) .21 [0.15-0.28] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q12 12 39253108 NR - 144402 rs11169838-C rs11169838 0 11169838 intron 0 0.680712065091395 8E-6 5.096910013008055 (IGP35) .17 [0.094-0.24] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186725887 ST6GAL1 - 6480 rs11710456-G rs11710456 0 11710456 intron 0 0.699243829246545 5E-44 43.30102999566398 (IGP35) .49 [0.42-0.56] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8q24.23 8 137850011 NR 80327 51059 1211.74 1292.26 rs16906415-G rs16906415 0 16906415 1 0.107695718234507 3E-6 5.522878745280337 (IGP35) .24 [0.14-0.33] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q25.3 17 79168268 NR - 22994 rs2279913-C rs2279913 0 2279913 intron 0 0.439263302273741 4E-7 6.397940008672037 (IGP35) .16 [0.097-0.219] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12p13.2 12 11962573 NR - 2120 rs7314811-C rs7314811 0 7314811 intron 0 0.35010278555506 4E-6 5.397940008672037 (IGP35) .15 [0.083-0.207] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186722944 ST6GAL1 - 6480 rs7652995-G rs7652995 0 7652995 intron 0 0.176986749442711 7E-17 16.15490195998574 (IGP35) .37 [0.28-0.45] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q22 17 56313904 NR - 4025 rs8067912-C rs8067912 0 8067912 nearGene-5 0 0.0305423055728934 1E-6 5.999999999999999 (IGP35) .44 [0.26-0.62] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11q23.2 11 114390106 NR 25996 120400 69.11 2.33 rs9326244-C rs9326244 0 9326244 1 0.878929753455194 5E-7 6.30102999566398 (IGP35) .24 [0.14-0.33] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10p12.2 10 23303253 NR - 219681 rs1054052-T rs1054052 0 1054052 intron 0 0.285274903125 6E-7 6.221848749616355 (IGP36) .17 [0.1-0.24] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11q25 11 134573810 NR 27087 292.00 rs11825685-C rs11825685 0 11825685 1 0.889723712633929 9E-6 5.045757490560675 (IGP36) .23 [0.13-0.33] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 33124872 B4GALT1 - 2683 rs12342831-C rs12342831 0 12342831 intron 0 0.2625544125 1E-10 10 (IGP36) .23 [0.16-0.3] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10q24.1 10 97295589 NR - 10580 rs12772243-G rs12772243 0 12772243 intron 0 0.0871224178571429 5E-6 5.301029995663981 (IGP36) .25 [0.14-0.35] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q31.1 5 135164618 NR 100847082 153328 25.85 5.75 rs13178541-C rs13178541 0 13178541 1 0.811571763392857 5E-6 5.301029995663981 (IGP36) .18 [0.1-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q22 17 54123973 NR 58488 162282 269.23 106.86 rs2060070-G rs2060070 0 2060070 1 0.76230421875 9E-7 6.045757490560675 (IGP36) .18 [0.11-0.25] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11q24.2 11 127110183 NR 283165 2113 234.23 1218.47 rs2514895-C rs2514895 0 2514895 1 0.812138921875 2E-6 5.698970004336018 (IGP36) .19 [0.11-0.26] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q12 6 66178480 NR - 346007 rs4710520-C rs4710520 0 4710520 intron 0 0.00803558 6E-6 5.221848749616356 (IGP36) 2.11 [1.2-3.02] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39841700 NR 10454 4248 8.57 11.63 rs5757676-C rs5757676 0 5757676 1 0.775682419642857 1E-7 7 (IGP36) .20 [0.12-0.27] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2p11.2 2 84444886 NR 100271015 388965 622.52 72.92 rs6547537-G rs6547537 0 6547537 1 0.784824532589286 4E-6 5.397940008672037 (IGP36) .19 [0.11-0.27] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10p12.2 10 23303253 NR - 219681 rs1054052-T rs1054052 0 1054052 intron 0 0.285370675591254 3E-6 5.522878745280337 (IGP37) .16 [0.094-0.231] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10p13 10 13363046 NR - 22929 rs10508459-T rs10508459 0 10508459 intron 0 0.47438586013363 2E-6 5.698970004336018 (IGP9) .14 [0.085-0.204] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4q25 4 110897585 NR - 1950 rs11568995-G rs11568995 0 11568995 intron 0 0.9884981 5E-6 5.301029995663981 (IGP9) 1.62 [0.93-2.32] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q33.3 5 157410278 NR 644198 100421484 51.65 1.37 rs11958404-T rs11958404 0 11958404 1 0.113988281514477 1E-6 5.999999999999999 (IGP9) .25 [0.15-0.35] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4p14 4 37647234 NR - 768211 rs13144232-G rs13144232 0 13144232 intron 0 0.63805114610245 6E-7 6.221848749616355 (IGP9) .16 [0.1-0.228] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 SMARCB1,DERL3 - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.189660889532294 3E-13 12.52287874528034 (IGP9) .30 [0.22-0.39] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p21.1 7 16837454 NR - 10551 rs2280655-C rs2280655 0 2280655 intron 0 0.977065699331849 4E-6 5.397940008672037 (IGP9) .63 [0.36-0.9] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20p12.1 20 17829280 NR 140836 27131 112.76 92.96 rs2745851-G rs2745851 0 2745851 1 0.639296878396437 9E-7 6.045757490560675 (IGP9) .16 [0.096-0.223] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2p11.2 2 88388538 NR - 150572 rs2919856-T rs2919856 0 2919856 intron 0 0.545002280178174 2E-6 5.698970004336018 (IGP9) .15 [0.087-0.208] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.31 22 44561287 NR - 29780 rs5764106-C rs5764106 0 5764106 intron 0 0.229970760801782 5E-6 5.301029995663981 (IGP9) .19 [0.11-0.27] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q21.32 17 47290795 NR - 51225 rs627386-G rs627386 0 627386 0 0.974019461024499 4E-6 5.397940008672037 (IGP9) .55 [0.32-0.78] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 13q14.3 13 51724664 NR - 647166 rs7325564-C rs7325564 0 7325564 nearGene-5 0 0.748729805345211 5E-6 5.301029995663981 (IGP9) .25 [0.14-0.35] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39859169 SYNGR1,TAB1,MGAT3,CACNA1I - 4248 rs909674-C rs909674 0 909674 intron 0 0.299056983073497 3E-9 8.522878745280337 (IGP9) .20 [0.13-0.27] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186725887 ST6GAL1 - 6480 rs11710456-G rs11710456 0 11710456 intron 0 0.698797577867024 8E-17 16.09691001300806 (IGP37) .29 [0.22-0.36] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q22 17 54123973 NR 58488 162282 269.23 106.86 rs2060070-G rs2060070 0 2060070 1 0.761979803659081 2E-6 5.698970004336018 (IGP37) .17 [0.1-0.25] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 33139453 NR - 2683 rs3780486-C rs3780486 0 3780486 intron 0 0.737437251227131 9E-11 10.04575749056067 (IGP37) .23 [0.16-0.3] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q12 6 66178480 NR - 346007 rs4710520-C rs4710520 0 4710520 intron 0 0.00804562 3E-6 5.522878745280337 (IGP37) 2.17 [1.26-3.08] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1p31.1 1 79509109 NR 64123 729779 36.61 11.52 rs6687262-C rs6687262 0 6687262 1 0.553310385988398 4E-7 6.397940008672037 (IGP37) .16 [0.097-0.219] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186722944 ST6GAL1 - 6480 rs7652995-G rs7652995 0 7652995 intron 0 0.176702207496653 5E-8 7.30102999566398 (IGP37) .24 [0.15-0.33] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10p12.2 10 23303253 NR - 219681 rs1054052-T rs1054052 0 1054052 intron 0 0.285116272403032 2E-6 5.698970004336018 (IGP38) .17 [0.098-0.234] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186725887 ST6GAL1 - 6480 rs11710456-G rs11710456 0 11710456 intron 0 0.698840198840838 5E-17 16.30102999566398 (IGP38) .29 [0.23-0.36] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q21.1 5 98715768 NR 100133054 441066 425.06 152.56 rs11745890-C rs11745890 0 11745890 1 0.0301678793134195 4E-6 5.397940008672037 (IGP38) .55 [0.32-0.78] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q22 17 54123973 NR 58488 162282 269.23 106.86 rs2060070-G rs2060070 0 2060070 1 0.761965887650468 2E-6 5.698970004336018 (IGP38) .17 [0.1-0.25] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 33139453 NR - 2683 rs3780486-C rs3780486 0 3780486 intron 0 0.737450810521623 5E-11 10.30102999566398 (IGP38) .23 [0.16-0.3] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q12 6 66178480 NR - 346007 rs4710520-C rs4710520 0 4710520 intron 0 0.00803558 5E-6 5.301029995663981 (IGP38) 2.13 [1.21-3.04] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1p31.1 1 79509109 NR 64123 729779 36.61 11.52 rs6687262-C rs6687262 0 6687262 1 0.553040158270174 5E-7 6.30102999566398 (IGP38) .16 [0.096-0.218] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186722944 ST6GAL1 - 6480 rs7652995-G rs7652995 0 7652995 intron 0 0.176770524297815 5E-8 7.30102999566398 (IGP38) .24 [0.15-0.33] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 33128021 NR - 2683 rs10813951-G rs10813951 0 10813951 intron 0 0.262554376171352 1E-9 8.999999999999998 (IGP39) .22 [0.15-0.29] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10q26.12 10 122043489 NR 100616322 729402 325.39 70.67 rs11199254-C rs11199254 0 11199254 1 0.994452838362069 3E-6 5.522878745280337 (IGP39) 1.56 [0.9-2.21] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q11.22 7 69238158 NR - 26053 rs11765886-C rs11765886 0 11765886 intron 0 0.665165836680053 4E-6 5.397940008672037 (IGP39) .16 [0.094-0.231] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39739638 NR 26807 9145 24.52 6.32 rs137686-C rs137686 0 137686 1 0.24173856626506 1E-11 11 (IGP39) .25 [0.18-0.33] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 SMARCB1,DERL3 - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.189518247657296 1E-10 10 (IGP39) .27 [0.19-0.35] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q32.2 14 99746274 NR 64919 84193 8.45 117.81 rs2614463-T rs2614463 0 2614463 1 0.396310788487282 7E-6 5.154901959985742 (IGP39) .17 [0.098-0.249] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20p12.1 20 17829280 NR 140836 27131 112.76 92.96 rs2745851-G rs2745851 0 2745851 1 0.63954583935743 1E-6 5.999999999999999 (IGP39) .16 [0.093-0.22] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1q23.3 1 161826615 NR - 22926 rs3767633-T rs3767633 0 3767633 intron 0 0.145416417670683 8E-6 5.096910013008055 (IGP39) .21 [0.12-0.3] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39972162 NR - 8911 rs3788556-C rs3788556 0 3788556 intron 0 0.56038034270415 5E-8 7.30102999566398 (IGP39) .18 [0.12-0.24] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39859169 SYNGR1,TAB1,MGAT3,CACNA1I - 4248 rs909674-C rs909674 0 909674 intron 0 0.298476014725569 9E-24 23.04575749056067 (IGP39) .34 [0.27-0.4] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q32.11 14 90227251 NR 317775 90141 22.47 36.22 rs2093746-C rs2093746 0 2093746 1 0.265059655250113 3E-7 6.522878745280337 (IGP4) .29 [0.18-0.4] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 15q25.1 15 79533372 NR - 729911 rs4779031-C rs4779031 0 4779031 intron 0 0.211701583145561 2E-6 5.698970004336018 (IGP4) .18 [0.11-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1p21.3 1 94721660 NR - 100505940 rs12750249-C rs12750249 0 12750249 intron 0 0.256632781737194 4E-6 5.397940008672037 (IGP32) .17 [0.095-0.235] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8q24.23 8 137850011 NR 80327 51059 1211.74 1292.26 rs16906415-G rs16906415 0 16906415 1 0.107822580400891 6E-6 5.221848749616356 (IGP32) .23 [0.13-0.33] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5p14.1 5 25420089 NR 1008 4479 775.00 489.33 rs1904173-G rs1904173 0 1904173 1 0.86006371714922 7E-6 5.154901959985742 (IGP32) .20 [0.11-0.29] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11q23.2 11 114387102 NR 25996 120400 66.10 5.34 rs4466877-G rs4466877 0 4466877 1 0.880799535011136 9E-7 6.045757490560675 (IGP32) .24 [0.15-0.34] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20p11.23 20 20634106 NR - 57186 rs6132333-C rs6132333 0 6132333 intron 0 0.0250837167483296 3E-6 5.522878745280337 (IGP32) .51 [0.29-0.72] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186722944 ST6GAL1 - 6480 rs7652995-G rs7652995 0 7652995 intron 0 0.176843186191537 9E-15 14.04575749056067 (IGP32) .34 [0.25-0.42] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.33 6 30797991 NR - 401247 rs7749924-C rs7749924 0 7749924 intron 0 0.851598582628062 8E-6 5.096910013008055 (IGP32) .22 [0.12-0.32] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3p24.3 3 22171297 NR - 100505836 rs6797769-T rs6797769 0 6797769 intron 0 0.548041472743521 3E-6 5.522878745280337 (IGP74) .17 [0.097-0.235] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2p21 2 46550769 NR - 2034 rs7582701-C rs7582701 0 7582701 intron 0 0.037394344593387 4E-6 5.397940008672037 (IGP74) .43 [0.25-0.62] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.33 6 30666669 NR 100133037 9656 1.36 .92 rs9468811-C rs9468811 0 9468811 1 0.937725588025022 3E-6 5.522878745280337 (IGP74) .33 [0.19-0.46] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 33128021 NR - 2683 rs10813951-G rs10813951 0 10813951 intron 0 0.262766006241641 4E-7 6.397940008672037 (IGP75) .18 [0.11-0.25] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9q32 9 115687735 NR 57864 100129193 34.54 33.68 rs10817408-C rs10817408 0 10817408 1 0.149506685242978 6E-6 5.221848749616356 (IGP75) .23 [0.13-0.33] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 15q24.1 15 73749608 NR - 283677 rs11635553-G rs11635553 0 11635553 intron 0 0.992814619440459 6E-6 5.221848749616356 (IGP75) 1.06 [0.6-1.52] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q23 3 138916393 NR 60467 140464 72.38 35.44 rs11706018-C rs11706018 0 11706018 1 0.934430632634864 7E-6 5.154901959985742 (IGP75) .28 [0.16-0.4] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1q32.1 1 205483595 NR - 5129 rs12127944-C rs12127944 0 12127944 intron 0 0.911226779053085 4E-6 5.397940008672037 (IGP75) .32 [0.18-0.45] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q11.2 5 55322895 IL6ST,ANKRD55 3572 727984 32.07 109.88 rs17348299-C rs17348299 0 17348299 1 0.836657880517164 4E-6 5.397940008672037 (IGP75) .21 [0.12-0.29] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q31.1 7 107592198 LAMB1 - 3912 rs2072209-G rs2072209 0 2072209 intron 0 0.0582759937583593 2E-7 6.698970004336019 (IGP75) .34 [0.21-0.47] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 16q12.1 16 49643566 NR - 23090 rs2080501-G rs2080501 0 2080501 intron 0 0.532295847079804 4E-6 5.397940008672037 (IGP75) .14 [0.082-0.203] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 SMARCB1,DERL3 - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.189826451627285 4E-9 8.397940008672036 (IGP75) .25 [0.16-0.33] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39178375 NR - 10126 rs738144-G rs738144 0 738144 intron 0 0.204838376727597 7E-6 5.154901959985742 (IGP75) .19 [0.11-0.27] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2p21 2 46550769 NR - 2034 rs7582701-C rs7582701 0 7582701 intron 0 0.0373185578689255 2E-6 5.698970004336018 (IGP75) .45 [0.27-0.63] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q12 14 24609147 NR - 51016 rs8010715-C rs8010715 0 8010715 intron 0 0.262775408381632 9E-6 5.045757490560675 (IGP75) .17 [0.093-0.24] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.33 6 30666669 NR 100133037 9656 1.36 .92 rs9468811-C rs9468811 0 9468811 1 0.937641317877842 2E-6 5.698970004336018 (IGP75) .33 [0.19-0.47] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 15q24.1 15 73749608 NR - 283677 rs11635553-G rs11635553 0 11635553 intron 0 0.99282491474212 9E-6 5.045757490560675 (IGP76) 1.04 [0.58-1.49] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q31.1 7 107592198 LAMB1 - 3912 rs2072209-G rs2072209 0 2072209 intron 0 0.0581724966622163 8E-6 5.096910013008055 (IGP76) .29 [0.16-0.42] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 16q12.1 16 49643566 NR - 23090 rs2080501-G rs2080501 0 2080501 intron 0 0.532905723186471 5E-6 5.301029995663981 (IGP76) .14 [0.081-0.201] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 SMARCB1,DERL3 - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.189496820649755 2E-8 7.698970004336018 (IGP76) .23 [0.15-0.31] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q21.31 12 82462226 NR 100312809 29080 199.35 283.86 rs7137515-G rs7137515 0 7137515 1 0.260927853582555 6E-6 5.221848749616356 (IGP76) .16 [0.093-0.235] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2p21 2 46550769 NR - 2034 rs7582701-C rs7582701 0 7582701 intron 0 0.0372783807743658 4E-6 5.397940008672037 (IGP76) .43 [0.25-0.61] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.33 6 30666669 NR 100133037 9656 1.36 .92 rs9468811-C rs9468811 0 9468811 1 0.937308425901202 5E-7 6.30102999566398 (IGP76) .35 [0.21-0.48] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q23.3 14 65775695 FUT8 122888 100616176 27.32 26.14 rs11847263-G rs11847263 0 11847263 1 0.394003751805054 6E-6 5.221848749616356 (IGP77) .14 [0.081-0.204] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p21.1 7 20885095 NR 100271111 340274 1.51 374.50 rs13245023-C rs13245023 0 13245023 1 0.964100804151624 9E-6 5.045757490560675 (IGP77) .42 [0.24-0.61] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q25.1 3 150087008 NR 100270992 9819 218.27 39.78 rs1012583-G rs1012583 0 1012583 1 0.702573039608367 4E-6 5.397940008672037 (IGP8) .16 [0.089-0.221] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3p14.1 3 64173901 NR - 166336;100874243 rs1035275-C rs1035275 0 1035275 intron;intron 0 0.444727228304406 9E-6 5.045757490560675 (IGP8) .14 [0.079-0.204] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4q25 4 111227816 NR 645145 100133103 13.00 93.10 rs13148252-G rs13148252 0 13148252 1 0.745779246105919 6E-6 5.221848749616356 (IGP8) .17 [0.097-0.245] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.2 22 43624765 NR - 80274 rs139014-C rs139014 0 139014 intron 0 0.167018170449488 5E-6 5.301029995663981 (IGP8) .20 [0.11-0.28] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q25.1 3 150697208 NR - 116933 rs16863118-C rs16863118 0 16863118 intron 0 0.836539205162439 8E-6 5.096910013008055 (IGP8) .18 [0.1-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 16q23.3 16 81960958 NR - 5336 rs3813009-C rs3813009 0 3813009 intron 0 0.223729928793947 4E-7 6.397940008672037 (IGP8) .21 [0.13-0.29] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3p24.3 3 20957810 NR 100873800 391518 723.44 489.41 rs6787231-C rs6787231 0 6787231 1 0.900662045838896 5E-6 5.301029995663981 (IGP8) .26 [0.15-0.37] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12p11.22 12 28192989 NR 5744 55297 68.07 217.14 rs7964407-G rs7964407 0 7964407 1 0.620613410769915 6E-6 5.221848749616356 (IGP8) .21 [0.12-0.3] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q23.3 12 104034319 NR - 55576 rs1650123-C rs1650123 0 1650123 intron 0 0.577816124610592 6E-6 5.221848749616356 (IGP8) .15 [0.086-0.218] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2p25.1 2 9259598 NR 100270977 8853 37.67 87.30 rs9636252-C rs9636252 0 9636252 1 0.641289432131731 3E-6 5.522878745280337 (IGP8) .15 [0.087-0.215] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 21q22.13 21 38817812 NR - 1859 rs11700462-G rs11700462 0 11700462 intron 0 0.89698245367811 5E-6 5.301029995663981 (IGP33) .28 [0.16-0.4] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q24.33 12 129646601 NR - 121256 rs12580533-C rs12580533 0 12580533 intron 0 0.014010396137832 8E-6 5.096910013008055 (IGP33) .82 [0.46-1.19] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20q11.23 20 36977970 NR - 3929 rs1739654-G rs1739654 0 1739654 cds-synon 0 0.958833931431119 5E-6 5.301029995663981 (IGP33) .45 [0.26-0.64] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 15q26.3 15 100357435 NR 196968 170691 10.30 154.21 rs1823874-C rs1823874 0 1823874 1 0.428499305840392 3E-6 5.522878745280337 (IGP33) .15 [0.086-0.209] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q32.33 14 105349388 NR - 283638 rs2028414-C rs2028414 0 2028414 cds-synon 0 0.635674106107891 8E-6 5.096910013008055 (IGP33) .14 [0.079-0.201] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10p12.2 10 23303253 NR - 219681 rs1054052-T rs1054052 0 1054052 intron 0 0.28422493357111 6E-6 5.221848749616356 (IGP33) .16 [0.089-0.224] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10q21.3 10 64866912 NR 1959 29982 287.99 26.10 rs10995439-G rs10995439 0 10995439 1 0.500403761034329 1E-7 7 (IGP33) .16 [0.1-0.22] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20p11.23 20 20634106 NR - 57186 rs6132333-C rs6132333 0 6132333 intron 0 0.0251061037895675 7E-7 6.154901959985743 (IGP33) .54 [0.33-0.75] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10q21.3 10 64866912 NR 1959 29982 287.99 26.10 rs10995439-G rs10995439 0 10995439 1 0.500403761034329 3E-6 5.522878745280337 (IGP34) .14 [0.084-0.205] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10p13 10 13361976 NR - 22929 rs1747683-G rs1747683 0 1747683 intron 0 0.414510834817453 4E-7 6.397940008672037 (IGP72) .16 [0.099-0.224] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 SMARCB1,DERL3 - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.189358691006233 9E-17 16.04575749056067 (IGP72) .35 [0.27-0.43] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1p31.2 1 68927513 NR 6121 55635 11.87 12.32 rs435066-C rs435066 0 435066 1 0.195968165182547 8E-6 5.096910013008055 (IGP72) .18 [0.099-0.254] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20q11.22 20 32556777 NR 170555 22913 55.58 24.68 rs6059594-G rs6059594 0 6059594 1 0.962818623864648 7E-6 5.154901959985742 (IGP72) .48 [0.27-0.69] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p12.2 7 50355207 IKZF1 - 10320 rs6421315-C rs6421315 0 6421315 0 0.368120581032947 8E-9 8.096910013008056 (IGP72) .19 [0.12-0.25] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4q12 4 57939863 NR - 3490 rs10049992-G rs10049992 0 10049992 intron 0 0.201848923285199 8E-6 5.096910013008055 (IGP73) .20 [0.11-0.29] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11q13.3 11 69602412 NR 2249 2248 12.24 22.32 rs10796849-C rs10796849 0 10796849 1 0.111934 6E-6 5.221848749616356 (IGP73) .61 [0.35-0.88] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10q24.1 10 97301004 NR - 10580 rs11188352-G rs11188352 0 11188352 intron 0 0.0425983446750903 3E-6 5.522878745280337 (IGP73) .44 [0.25-0.62] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12p13.31 12 5751342 NR - 57101 rs2110166-C rs2110166 0 2110166 intron 0 0.983043627256318 6E-6 5.221848749616356 (IGP73) .56 [0.32-0.81] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q14.1 12 62886123 NR - 23041 rs7301016-G rs7301016 0 7301016 intron 0 0.206214031137184 8E-6 5.096910013008055 (IGP73) .17 [0.095-0.243] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q24.3 6 147759534 NR 442266 389432 30.12 70.29 rs9403856-C rs9403856 0 9403856 1 0.861471281137184 7E-7 6.154901959985743 (IGP73) .34 [0.21-0.48] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 33122645 NR - 2683 rs10113903-C rs10113903 0 10113903 intron 0 0.308537513851653 7E-6 5.154901959985742 (IGP74) .15 [0.086-0.22] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q23 3 138916393 NR 60467 140464 72.38 35.44 rs11706018-C rs11706018 0 11706018 1 0.934284044682752 9E-6 5.045757490560675 (IGP74) .28 [0.15-0.4] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1q32.1 1 205483595 NR - 5129 rs12127944-C rs12127944 0 12127944 intron 0 0.911099744252874 6E-6 5.221848749616356 (IGP74) .31 [0.18-0.45] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 16q12.1 16 49652779 NR - 23090 rs16944158-G rs16944158 0 16944158 intron 0 0.271065156389634 4E-6 5.397940008672037 (IGP74) .16 [0.093-0.231] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q31.1 7 107592198 LAMB1 - 3912 rs2072209-G rs2072209 0 2072209 intron 0 0.0584063163538874 2E-6 5.698970004336018 (IGP74) .31 [0.18-0.44] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4q28.1 4 128466700 NR 132817 27152 980.77 87.39 rs2090104-G rs2090104 0 2090104 1 0.335522302949062 5E-6 5.301029995663981 (IGP74) .15 [0.087-0.219] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 SMARCB1,DERL3 - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.190211496872207 2E-8 7.698970004336018 (IGP74) .24 [0.15-0.32] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q25.3 17 79235788 SLC38A10 - 124565 rs7224668-C rs7224668 0 7224668 intron 0 0.524575415405165 3E-8 7.522878745280337 (IGP31) .17 [0.11-0.23] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186722944 ST6GAL1 - 6480 rs7652995-G rs7652995 0 7652995 intron 0 0.176763000890472 4E-7 6.397940008672037 (IGP31) .22 [0.14-0.31] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q22 17 56313904 NR - 4025 rs8067912-C rs8067912 0 8067912 nearGene-5 0 0.0307230178539626 5E-7 6.30102999566398 (IGP31) .46 [0.28-0.63] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186725887 ST6GAL1 - 6480 rs11710456-G rs11710456 0 11710456 intron 0 0.699319077951002 3E-37 36.52287874528034 (IGP32) .45 [0.38-0.52] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q15 5 95262513 NR - 22936 rs11738945-C rs11738945 0 11738945 intron 0 0.785892907349666 1E-6 5.999999999999999 (IGP32) .18 [0.11-0.25] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q26 6 162314921 NR - 5071 rs12207186-T rs12207186 0 12207186 intron 0 0.0677100908685969 5E-6 5.301029995663981 (IGP32) .29 [0.16-0.41] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q11.2 5 55322895 IL6ST,ANKRD55 3572 727984 32.07 109.88 rs17348299-C rs17348299 0 17348299 1 0.836659126892253 2E-9 8.698970004336019 (IGP3) .27 [0.18-0.35] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q31.1 7 113741105 NR - 93986 rs6466479-G rs6466479 0 6466479 intron 0 0.122476576224399 3E-6 5.522878745280337 (IGP3) .22 [0.13-0.32] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8p22 8 14113816 NR - 137868 rs9886428-G rs9886428 0 9886428 intron 0 0.455031556990205 3E-6 5.522878745280337 (IGP3) .14 [0.083-0.203] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10q21.3 10 64872411 NR 1959 29982 293.48 20.60 rs10822136-C rs10822136 0 10822136 1 0.805344702630406 5E-7 6.30102999566398 (IGP30) .21 [0.13-0.29] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186725887 ST6GAL1 - 6480 rs11710456-G rs11710456 0 11710456 intron 0 0.698844000445832 3E-6 5.522878745280337 (IGP30) .16 [0.095-0.233] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11p15.4 11 5688024 NR - 85363 rs11820502-C rs11820502 0 11820502 intron 0 0.287788676326349 2E-6 5.698970004336018 (IGP30) .18 [0.11-0.26] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 28181085 NR - 158038 rs1319535-C rs1319535 0 1319535 intron 0 0.34574886090058 4E-6 5.397940008672037 (IGP30) .15 [0.087-0.215] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3p22.1 3 39475342 NR 6044 4336 22.64 33.73 rs17038828-C rs17038828 0 17038828 1 0.979741981275078 8E-6 5.096910013008055 (IGP30) .56 [0.31-0.81] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q11.2 5 51173324 NR 100873897 100271072 467.29 405.02 rs17835853-G rs17835853 0 17835853 1 0.956794057690593 4E-6 5.397940008672037 (IGP30) .48 [0.27-0.68] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q32.33 14 105346907 NR - 283638 rs2841233-C rs2841233 0 2841233 intron 0 0.642908958091841 7E-6 5.154901959985742 (IGP30) .15 [0.083-0.212] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 19p13.11 19 19276359 NR - 4207;100271849 rs7249142-G rs7249142 0 7249142 intron;intron 0 0.619273395452519 9E-6 5.045757490560675 (IGP30) .15 [0.085-0.219] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q23.1 5 115733805 NR 100874471 57556 179.81 45.45 rs7734156-C rs7734156 0 7734156 1 0.0499571860008917 7E-6 5.154901959985742 (IGP30) .34 [0.19-0.49] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p14.1 7 42036837 NR - 2737 rs846271-C rs846271 0 846271 intron 0 0.628956223807401 2E-6 5.698970004336018 (IGP30) .15 [0.09-0.218] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39859169 SYNGR1,TAB1,MGAT3,CACNA1I - 4248 rs909674-C rs909674 0 909674 intron 0 0.299100489968792 2E-6 5.698970004336018 (IGP30) .16 [0.095-0.227] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.2 6 37532103 NR 100616413 266727 8.91 68.18 rs9394438-G rs9394438 0 9394438 1 0.713317013374944 7E-6 5.154901959985742 (IGP30) .17 [0.094-0.24] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q31.1 14 81635323 NR 7253 2957 22.68 6.47 rs10131728-C rs10131728 0 10131728 1 0.872444873552983 2E-7 6.698970004336019 (IGP31) .24 [0.15-0.33] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q14.1 12 62818481 NR 9958 23041 14.98 42.12 rs10877839-C rs10877839 0 10877839 1 0.32479838824577 9E-6 5.045757490560675 (IGP31) .15 [0.082-0.21] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q12 12 39253108 NR - 144402 rs11169838-C rs11169838 0 11169838 intron 0 0.680521641139804 2E-6 5.698970004336018 (IGP31) .18 [0.1-0.25] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186725887 ST6GAL1 - 6480 rs11710456-G rs11710456 0 11710456 intron 0 0.699014551202137 6E-17 16.22184874961636 (IGP31) .29 [0.22-0.36] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8p23.3 8 566207 NR 157695 157697 70.43 47.99 rs17666538-C rs17666538 0 17666538 1 0.073151367141585 7E-6 5.154901959985742 (IGP31) .28 [0.16-0.41] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q21 6 107660646 NR - 57107 rs2430457-G rs2430457 0 2430457 intron 0 0.00697800000000004 5E-6 5.301029995663981 (IGP31) 2.60 [1.48-3.73] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q15 5 94653873 NR 79772 153643 33.59 73.18 rs255982-G rs255982 0 255982 1 0.848905209260908 8E-6 5.096910013008055 (IGP31) .21 [0.12-0.3] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 33139453 NR - 2683 rs3780486-C rs3780486 0 3780486 intron 0 0.737357337934105 1E-6 5.999999999999999 (IGP31) .17 [0.1-0.24] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q25.31 3 155267440 NR - 23007 rs3851357-G rs3851357 0 3851357 intron 0 0.805635591718611 9E-6 5.045757490560675 (IGP31) .18 [0.1-0.26] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1p31.1 1 79509109 NR 64123 729779 36.61 11.52 rs6687262-C rs6687262 0 6687262 1 0.552969396260018 2E-6 5.698970004336018 (IGP31) .15 [0.085-0.207] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11p15.4 11 5625603 NR - 117854;445372 rs7108470-G rs7108470 0 7108470 intron;intron 0 0.423505770703473 3E-6 5.522878745280337 (IGP31) .15 [0.088-0.215] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2q23.3 2 153436570 NR - 114793 rs11675841-C rs11675841 0 11675841 intron 0 0.607345676902537 5E-6 5.301029995663981 (IGP70) .15 [0.083-0.208] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10p13 10 13361976 NR - 22929 rs1747683-G rs1747683 0 1747683 intron 0 0.414548764129951 6E-7 6.221848749616355 (IGP70) .16 [0.096-0.22] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 SMARCB1,DERL3 - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.189496820649755 1E-16 16 (IGP70) .35 [0.26-0.43] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20p12.1 20 17829280 NR 140836 27131 112.76 92.96 rs2745851-G rs2745851 0 2745851 1 0.639172889630619 9E-6 5.045757490560675 (IGP70) .14 [0.08-0.207] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 16p13.11 16 16256767 NR - 368 rs3213473-G rs3213473 0 3213473 intron 0 0.851097327102804 7E-6 5.154901959985742 (IGP70) .20 [0.11-0.29] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1p31.2 1 68927513 NR 6121 55635 11.87 12.32 rs435066-C rs435066 0 435066 1 0.196103507788162 5E-6 5.301029995663981 (IGP70) .18 [0.1-0.26] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p12.2 7 50335232 NR 100130988 10320 136.38 9.15 rs4917017-G rs4917017 0 4917017 1 0.70576580729862 1E-8 8 (IGP70) .20 [0.13-0.27] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20q11.22 20 32556777 NR 170555 22913 55.58 24.68 rs6059594-G rs6059594 0 6059594 1 0.962797338540276 5E-6 5.301029995663981 (IGP70) .49 [0.28-0.7] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39859169 NR - 4248 rs909674-C rs909674 0 909674 intron 0 0.299013119715176 4E-16 15.39794000867204 (IGP70) .28 [0.21-0.34] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2q23.3 2 153436570 NR - 114793 rs11675841-C rs11675841 0 11675841 intron 0 0.607345676902537 6E-6 5.221848749616356 (IGP71) .14 [0.082-0.208] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10p13 10 13361976 NR - 22929 rs1747683-G rs1747683 0 1747683 intron 0 0.414548764129951 4E-7 6.397940008672037 (IGP71) .16 [0.099-0.224] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 SMARCB1,DERL3 - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.189496820649755 9E-17 16.04575749056067 (IGP71) .35 [0.27-0.43] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20p12.1 20 17829280 NR 140836 27131 112.76 92.96 rs2745851-G rs2745851 0 2745851 1 0.639172889630619 9E-6 5.045757490560675 (IGP71) .14 [0.08-0.207] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1p31.2 1 68927513 NR 6121 55635 11.87 12.32 rs435066-C rs435066 0 435066 1 0.196103507788162 7E-6 5.154901959985742 (IGP71) .18 [0.1-0.255] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20q11.22 20 32556777 NR 170555 22913 55.58 24.68 rs6059594-G rs6059594 0 6059594 1 0.962797338540276 4E-6 5.397940008672037 (IGP71) .50 [0.29-0.71] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p12.2 7 50355207 IKZF1 - 10320 rs6421315-C rs6421315 0 6421315 0 0.368179075211393 1E-8 8 (IGP71) .18 [0.12-0.25] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39859169 SYNGR1,TAB1,MGAT3,CACNA1I - 4248 rs909674-C rs909674 0 909674 intron 0 0.299013119715176 6E-16 15.22184874961635 (IGP71) .27 [0.21-0.34] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q25.3 17 78060743 NR - 55036 rs1467979-C rs1467979 0 1467979 intron 0 0.823196467468806 3E-6 5.522878745280337 (IGP28) .19 [0.11-0.26] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8q24.12 8 122182310 NR 6641 100271322 358.00 210.02 rs1604897-C rs1604897 0 1604897 1 0.836453155525847 8E-6 5.096910013008055 (IGP28) .19 [0.1-0.27] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8q23.1 8 108281427 NR - 284 rs6993449-C rs6993449 0 6993449 intron 0 0.650415290106952 3E-6 5.522878745280337 (IGP28) .15 [0.088-0.217] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186722944 ST6GAL1 - 6480 rs7652995-G rs7652995 0 7652995 intron 0 0.176683507130125 2E-20 19.69897000433602 (IGP28) .40 [0.32-0.49] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 15q23 15 68718987 NR - 22801 rs16952065-C rs16952065 0 16952065 intron 0 0.937426751336898 1E-6 5.999999999999999 (IGP28) .44 [0.26-0.62] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q12 12 41353749 NR - 1272 rs13328933-C rs13328933 0 13328933 intron 0 0.948348054342984 5E-6 5.301029995663981 (IGP29) .31 [0.18-0.45] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q25.3 17 79218714 NR - 124565 rs2659005-C rs2659005 0 2659005 nearGene-3 0 0.517261684187082 9E-6 5.045757490560675 (IGP29) .14 [0.08-0.208] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20q13.2 20 52701293 NR 100616225 1591 16.27 68.70 rs6064045-C rs6064045 0 6064045 1 0.521164665033408 7E-6 5.154901959985742 (IGP29) .14 [0.077-0.197] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11q22.3 11 108893367 NR 360180 399947 199.99 399.48 rs7101378-G rs7101378 0 7101378 1 0.531881765256125 7E-6 5.154901959985742 (IGP29) .14 [0.079-0.201] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 13q13.1 13 32710520 NR - 10129 rs7331540-C rs7331540 0 7331540 intron 0 0.442209461024499 5E-6 5.301029995663981 (IGP29) .14 [0.08-0.201] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186722944 ST6GAL1 - 6480 rs7652995-G rs7652995 0 7652995 intron 0 0.17684106013363 3E-40 39.52287874528034 (IGP29) .58 [0.49-0.67] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 33124872 B4GALT1 - 2683 rs12342831-C rs12342831 0 12342831 intron 0 0.262517807212823 5E-7 6.30102999566398 (IGP3) .18 [0.11-0.25] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q32 5 147603067 NR 100874442 153218 1.86 45.36 rs1368304-G rs1368304 0 1368304 1 0.915930538379341 9E-6 5.045757490560675 (IGP3) .24 [0.14-0.35] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q11.2 5 58082723 NR - 115827 rs10065350-C rs10065350 0 10065350 intron 0 0.841900657231865 9E-6 5.045757490560675 (IGP67) .20 [0.11-0.29] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1p36.11 1 25402624 NR 100616365 25949 52.55 146.14 rs10903027-C rs10903027 0 10903027 1 0.707795287049399 5E-6 5.301029995663981 (IGP67) .16 [0.091-0.228] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3p13 3 72509271 NR 23429 55164 13.50 289.16 rs11128271-C rs11128271 0 11128271 1 0.93627697952826 6E-7 6.221848749616355 (IGP67) .34 [0.21-0.47] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2q14.3 2 125256736 NR - 129684 rs11899928-C rs11899928 0 11899928 intron 0 0.0215231680017802 3E-6 5.522878745280337 (IGP67) .72 [0.42-1.02] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q27 6 167754975 NR - 83887 rs12528714-G rs12528714 0 12528714 missense 0 0.991049 8E-6 5.096910013008055 (IGP67) 2.43 [1.36-3.49] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.32 6 32915851 NR 3109 3108 7.00 .54 rs16871226-G rs16871226 0 16871226 1 0.0244821228239845 2E-6 5.698970004336018 (IGP67) .52 [0.3-0.73] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 SMARCB1,DERL3 - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.189496820649755 1E-12 12 (IGP67) .29 [0.21-0.38] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 16q24.1 16 86680996 NR 2300 100271519 65.69 620.74 rs300032-G rs300032 0 300032 1 0.146183376056965 3E-7 6.522878745280337 (IGP67) .23 [0.14-0.32] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39835587 NR 10454 4248 2.46 17.74 rs4821897-G rs4821897 0 4821897 1 0.707166482866044 4E-18 17.39794000867204 (IGP67) .30 [0.23-0.36] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q24.2 14 70620642 NR - 6547 rs4899329-C rs4899329 0 4899329 intron 0 0.399541382287494 5E-6 5.301029995663981 (IGP67) .14 [0.081-0.203] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p12.2 7 50355207 IKZF1 - 10320 rs6421315-C rs6421315 0 6421315 0 0.368179075211393 7E-11 10.15490195998574 (IGP67) .21 [0.15-0.27] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12p13.31 12 9546962 NR 5761 440081 153.87 23.33 rs7397814-C rs7397814 0 7397814 1 0.791488588340009 4E-6 5.397940008672037 (IGP67) .19 [0.11-0.27] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9q34.2 9 136679080 NR - 7410 rs756777-G rs756777 0 756777 intron 0 0.208834557187361 1E-6 5.999999999999999 (IGP67) .19 [0.11-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8q13.1 8 66624232 NR 9650 5150 1.43 2.34 rs10504390-G rs10504390 0 10504390 1 0.0802926317898486 8E-6 5.096910013008055 (IGP68) .25 [0.14-0.36] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4q25 4 110897585 NR - 1950 rs11568995-G rs11568995 0 11568995 intron 0 0.9883953 1E-6 5.999999999999999 (IGP68) 1.72 [1.02-2.41] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2q23.3 2 153436570 NR - 114793 rs11675841-C rs11675841 0 11675841 intron 0 0.607171814781834 8E-6 5.096910013008055 (IGP68) .14 [0.08-0.206] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q24.1 6 140139815 NR - 100132735 rs12664111-G rs12664111 0 12664111 intron 0 0.0919615409617097 6E-6 5.221848749616356 (IGP68) .24 [0.14-0.35] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1q31.2 1 191939788 NR 339479 64407 1493.03 187.80 rs17403780-T rs17403780 0 17403780 1 0.910564153517364 7E-6 5.154901959985742 (IGP68) .31 [0.18-0.45] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10p13 10 13361976 NR - 22929 rs1747683-G rs1747683 0 1747683 intron 0 0.414510834817453 1E-7 7 (IGP68) .17 [0.11-0.23] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4p14 4 37651155 NR - 768211 rs2292298-G rs2292298 0 2292298 intron 0 0.360936488423865 4E-6 5.397940008672037 (IGP68) .15 [0.086-0.215] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20p12.1 20 17829280 NR 140836 27131 112.76 92.96 rs2745851-G rs2745851 0 2745851 1 0.639234834372217 6E-7 6.221848749616355 (IGP68) .16 [0.098-0.225] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4q35.1 4 183300614 NR - 55714 rs4862046-G rs4862046 0 4862046 intron 0 0.907650657658059 9E-6 5.045757490560675 (IGP68) .25 [0.14-0.36] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1p36.11 1 25296743 NR 864 100616365 5.24 53.25 rs10751776-C rs10751776 0 10751776 1 0.54112898484173 7E-6 5.154901959985742 (IGP69) .15 [0.084-0.213] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 33128021 NR - 2683 rs10813951-G rs10813951 0 10813951 intron 0 0.262989649130629 7E-8 7.154901959985742 (IGP69) .19 [0.12-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9q32 9 115687735 NR 57864 100129193 34.54 33.68 rs10817408-C rs10817408 0 10817408 1 0.149316170753455 6E-6 5.221848749616356 (IGP69) .23 [0.13-0.33] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8p21.1 8 28181755 NR - 5368 rs11779594-C rs11779594 0 11779594 intron 0 0.930937853767276 9E-6 5.045757490560675 (IGP69) .27 [0.15-0.38] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q31.1 7 107592198 LAMB1 - 3912 rs2072209-G rs2072209 0 2072209 intron 0 0.0582759206419973 1E-8 8 (IGP69) .37 [0.25-0.5] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 SMARCB1,DERL3 - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.189823636647347 2E-8 7.698970004336018 (IGP69) .23 [0.15-0.32] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q21.3 3 128658492 NR - 100132731 rs2933343-G rs2933343 0 2933343 intron 0 0.759492835488185 8E-6 5.096910013008055 (IGP69) .16 [0.091-0.232] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39859169 SYNGR1,TAB1,MGAT3,CACNA1I - 4248 rs909674-C rs909674 0 909674 intron 0 0.299323467231387 9E-6 5.045757490560675 (IGP69) .15 [0.084-0.218] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.33 6 30666669 NR 100133037 9656 1.36 .92 rs9468811-C rs9468811 0 9468811 1 0.937418950958538 3E-6 5.522878745280337 (IGP69) .32 [0.19-0.46] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9q33.1 9 120559011 NR 7099 1620 79.24 1369.90 rs10115586-C rs10115586 0 10115586 1 0.70273622340899 5E-7 6.30102999566398 (IGP7) .17 [0.1-0.23] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1p36.33 1 1079198 NR - 254099 rs11260603-C rs11260603 0 11260603 ncRNA 0 0.217058243435692 4E-7 6.397940008672037 (IGP7) .26 [0.16-0.36] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8q13.3 8 71544748 NR - 286190 rs13272623-G rs13272623 0 13272623 intron 0 0.154915348909657 2E-6 5.698970004336018 (IGP7) .22 [0.13-0.3] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q15 6 90657783 BACH2 - 60468 rs404256-C rs404256 0 404256 intron 0 0.559129675122385 7E-9 8.154901959985743 (IGP7) .21 [0.14-0.28] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20q12 20 40994094 NR - 11122 rs6030171-C rs6030171 0 6030171 intron 0 0.359936573653761 3E-6 5.522878745280337 (IGP7) .15 [0.086-0.21] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10p13 10 13361976 NR - 22929 rs1747683-G rs1747683 0 1747683 intron 0 0.414548764129951 2E-7 6.698970004336019 (IGP66) .17 [0.1-0.23] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 NR - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.189496820649755 9E-17 16.04575749056067 (IGP66) .35 [0.27-0.43] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p12.2 7 50335232 NR 100130988 10320 136.38 9.15 rs4917017-G rs4917017 0 4917017 1 0.70576580729862 2E-7 6.698970004336019 (IGP66) .18 [0.11-0.25] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20q11.22 20 32556777 NR 170555 22913 55.58 24.68 rs6059594-G rs6059594 0 6059594 1 0.962797338540276 9E-6 5.045757490560675 (IGP66) .48 [0.27-0.69] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39859169 SYNGR1,TAB1,MGAT3,CACNA1I - 4248 rs909674-C rs909674 0 909674 intron 0 0.299013119715176 1E-16 16 (IGP66) .28 [0.21-0.35] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q25.3 17 79218714 NR - 124565 rs2659005-C rs2659005 0 2659005 nearGene-3 0 0.517323975066785 4E-7 6.397940008672037 (IGP26) .17 [0.1-0.23] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q31.1 7 113741105 NR - 93986 rs6466479-G rs6466479 0 6466479 intron 0 0.12247588824577 2E-6 5.698970004336018 (IGP26) .23 [0.14-0.32] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4q22.1 4 92917215 NR 401145 100873220 393.85 706.28 rs6853847-C rs6853847 0 6853847 1 0.0304378588601959 5E-6 5.301029995663981 (IGP26) .46 [0.26-0.65] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17p12 17 11250219 NR - 388336 rs8076431-C rs8076431 0 8076431 intron 0 0.851273368210151 2E-6 5.698970004336018 (IGP26) .21 [0.12-0.3] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q33.3 5 156815763 NR - 26999 rs871012-C rs871012 0 871012 intron 0 0.44603092920748 5E-6 5.301029995663981 (IGP26) .15 [0.084-0.21] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8q24.22 8 132330716 NR 114 23167 277.88 585.64 rs10108033-C rs10108033 0 10108033 1 0.990183 1E-6 5.999999999999999 (IGP27) 2.96 [1.76-4.15] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11p15.4 11 5688024 NR - 85363 rs11820502-C rs11820502 0 11820502 intron 0 0.287504188780053 3E-6 5.522878745280337 (IGP27) .18 [0.1-0.25] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q14.1 12 61549081 NR 9194 267005 1365.45 75.64 rs17124610-C rs17124610 0 17124610 1 0.983922182991986 8E-6 5.096910013008055 (IGP27) .67 [0.38-0.97] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20q12 20 39478533 NR 9935 7150 160.66 178.93 rs6102185-G rs6102185 0 6102185 1 0.423097751558326 1E-6 5.999999999999999 (IGP27) .15 [0.09-0.212] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20p11.23 20 20634106 NR - 57186 rs6132333-C rs6132333 0 6132333 intron 0 0.0250725390917186 5E-6 5.301029995663981 (IGP27) .50 [0.29-0.72] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 32422690 NR - 48 rs7032871-T rs7032871 0 7032871 intron 0 0.278857772929653 5E-6 5.301029995663981 (IGP27) .16 [0.09-0.226] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q25.2 3 153350116 NR 5912 100271162 463.85 391.47 rs7623788-G rs7623788 0 7623788 1 0.134195012466607 5E-6 5.301029995663981 (IGP27) .21 [0.12-0.29] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1p31.1 1 71443150 NR - 5733 rs909848-C rs909848 0 909848 intron 0 0.60707254318789 7E-6 5.154901959985742 (IGP27) .14 [0.081-0.206] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186725887 ST6GAL1 - 6480 rs11710456-G rs11710456 0 11710456 intron 0 0.69898246345811 9E-37 36.04575749056067 (IGP28) .44 [0.37-0.51] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3p21.31 3 44333324 NR - 375337 rs13323323-G rs13323323 0 13323323 intron 0 0.732786566399287 4E-6 5.397940008672037 (IGP28) .16 [0.091-0.227] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8q24.22 8 132330716 NR 114 23167 277.88 585.64 rs10108033-C rs10108033 0 10108033 1 0.990183 3E-6 5.522878745280337 (IGP22) 2.85 [1.65-4.05] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 33125804 NR - 2683 rs10758189-C rs10758189 0 10758189 intron 0 0.31099528984862 2E-6 5.698970004336018 (IGP22) .17 [0.099-0.236] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11p14.3 11 25490482 NR 338645 554234 386.30 119.43 rs10834691-G rs10834691 0 10834691 1 0.459134585485307 4E-6 5.397940008672037 (IGP22) .15 [0.085-0.211] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186725887 ST6GAL1 - 6480 rs11710456-G rs11710456 0 11710456 intron 0 0.698789225734639 9E-7 6.045757490560675 (IGP22) .17 [0.1-0.24] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q13 6 70741209 NR - 1310 rs3793039-G rs3793039 0 3793039 intron 0 0.25306153873553 2E-6 5.698970004336018 (IGP22) .24 [0.14-0.34] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20q12 20 39471427 NR 9935 7150 153.55 186.04 rs6072161-C rs6072161 0 6072161 1 0.573146759127338 3E-7 6.522878745280337 (IGP22) .16 [0.098-0.22] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q24.3 14 75327443 NR - 283571 rs722599-C rs722599 0 722599 intron 0 0.4301501460374 8E-6 5.096910013008055 (IGP22) .14 [0.078-0.201] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39859169 SYNGR1,TAB1,MGAT3,CACNA1I - 4248 rs909674-C rs909674 0 909674 intron 0 0.298923567230632 5E-10 9.301029995663981 (IGP22) .21 [0.14-0.28] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4p15.33 4 12579846 NR 9957 9364 1149.31 789.50 rs10002492-G rs10002492 0 10002492 1 0.167227182224207 8E-6 5.096910013008055 (IGP23) .18 [0.1-0.26] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186725887 ST6GAL1 - 6480 rs11710456-G rs11710456 0 11710456 intron 0 0.699064071907101 6E-11 10.22184874961635 (IGP23) .23 [0.16-0.3] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p12.1 7 53127559 NR 285877 653175 22.94 127.27 rs1174864-G rs1174864 0 1174864 1 0.49190341581063 5E-6 5.301029995663981 (IGP23) .14 [0.081-0.203] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q25.1 17 71807713 NR - 283982 rs12451840-C rs12451840 0 12451840 intron 0 0.0417941590759076 3E-6 5.522878745280337 (IGP23) .73 [0.42-1.04] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3p13 3 71414045 NR - 27086 rs13072512-G rs13072512 0 13072512 intron 0 0.576619429209469 6E-6 5.221848749616356 (IGP23) .15 [0.084-0.212] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20p11.23 20 20634106 NR - 57186 rs6132333-C rs6132333 0 6132333 intron 0 0.0251507142920947 1E-6 5.999999999999999 (IGP23) .53 [0.31-0.74] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10q24.1 10 98908733 NR - 6585 rs7072055-C rs7072055 0 7072055 intron 0 0.831620998660116 2E-6 5.698970004336018 (IGP23) .20 [0.12-0.29] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11p15.1 11 19051872 NR 259249 117194 95.32 24.13 rs7111562-C rs7111562 0 7111562 1 0.140150397945511 4E-7 6.397940008672037 (IGP23) .24 [0.15-0.34] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.33 6 31186026 NR 253018 100287272 14.28 57.33 rs9263963-T rs9263963 0 9263963 1 0.113293342563644 1E-6 5.999999999999999 (IGP23) .26 [0.15-0.36] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p14.1 7 39121500 NR - 11281 rs10464366-T rs10464366 0 10464366 intron 0 0.23005360311804 3E-6 5.522878745280337 (IGP24) .17 [0.1-0.25] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186725887 ST6GAL1 - 6480 rs11710456-G rs11710456 0 11710456 intron 0 0.698883767483296 4E-31 30.39794000867203 (IGP24) .40 [0.34-0.47] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 33124872 B4GALT1 - 2683 rs12342831-C rs12342831 0 12342831 intron 0 0.262634642316258 3E-10 9.522878745280336 (IGP24) .22 [0.15-0.29] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10q23.1 10 84419410 NR - 10718 rs2219937-G rs2219937 0 2219937 intron 0 0.984667459331848 4E-6 5.397940008672037 (IGP24) .75 [0.43-1.07] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4q22.1 4 92917215 NR 401145 100873220 393.85 706.28 rs6853847-C rs6853847 0 6853847 1 0.0304513777282851 2E-6 5.698970004336018 (IGP24) .48 [0.28-0.67] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186722944 ST6GAL1 - 6480 rs7652995-G rs7652995 0 7652995 intron 0 0.176834709131403 4E-16 15.39794000867204 (IGP24) .35 [0.27-0.44] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10q21.3 10 64872411 NR 1959 29982 293.48 20.60 rs10822136-C rs10822136 0 10822136 1 0.805465852941177 7E-7 6.154901959985743 (IGP25) .21 [0.13-0.29] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4p15.2 4 21455257 NR - 80333 rs11942476-C rs11942476 0 11942476 intron 0 0.855854377005348 6E-6 5.221848749616356 (IGP25) .21 [0.12-0.31] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q24.33 12 129646572 NR - 121256 rs12580240-G rs12580240 0 12580240 intron 0 0.0139850911701364 2E-6 5.698970004336018 (IGP25) .90 [0.53-1.26] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10p12.1 10 26002248 NR 100422545 53904 20.99 220.75 rs2504183-G rs2504183 0 2504183 1 0.71933817201426 7E-6 5.154901959985742 (IGP25) .19 [0.11-0.28] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20q12 20 39478533 NR 9935 7150 160.66 178.93 rs6102185-G rs6102185 0 6102185 1 0.422812170677362 2E-6 5.698970004336018 (IGP25) .15 [0.088-0.21] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20p11.23 20 20634106 NR - 57186 rs6132333-C rs6132333 0 6132333 intron 0 0.0250948889928699 1E-6 5.999999999999999 (IGP25) .53 [0.31-0.75] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.32 6 32114515 PRRT1 63943 80863 16.45 1.63 rs9296009-T rs9296009 0 9296009 1 0.19676420855615 4E-6 5.397940008672037 (IGP25) .18 [0.1-0.25] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2q32.1 2 186024735 NR 100271293 644935 257.45 385.72 rs11678036-C rs11678036 0 11678036 1 0.390262875779163 6E-6 5.221848749616356 (IGP26) .15 [0.082-0.209] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186725887 ST6GAL1 - 6480 rs11710456-G rs11710456 0 11710456 intron 0 0.698789225734639 2E-13 12.69897000433602 (IGP26) .26 [0.19-0.32] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 33124872 B4GALT1 - 2683 rs12342831-C rs12342831 0 12342831 intron 0 0.262517754229742 3E-11 10.52287874528034 (IGP26) .24 [0.17-0.31] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q21.1 5 100301806 NR 7903 403301 62.82 849.78 rs17161553-C rs17161553 0 17161553 1 0.00759786255756579 1E-6 5.999999999999999 (IGP26) 1.69 [1.01-2.38] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39859169 SYNGR1,TAB1,MGAT3,CACNA1I - 4248 rs909674-C rs909674 0 909674 intron 0 0.299146468388246 2E-10 9.698970004336017 (IGP62) .21 [0.15-0.28] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q21.32 17 45309693 NR 4635 3690 8.65 21.52 rs11079764-G rs11079764 0 11079764 1 0.51337114610245 5E-6 5.301029995663981 (IGP63) .18 [0.1-0.26] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3p13 3 72509271 NR 23429 55164 13.50 289.16 rs11128271-C rs11128271 0 11128271 1 0.936242533184855 6E-6 5.221848749616356 (IGP63) .31 [0.17-0.44] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q23.3 14 65775695 FUT8 122888 100616176 27.32 26.14 rs11847263-G rs11847263 0 11847263 1 0.393668566146993 3E-8 7.522878745280337 (IGP63) .17 [0.11-0.24] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2q14.3 2 125256736 NR - 129684 rs11899928-C rs11899928 0 11899928 intron 0 0.0215184841870824 8E-6 5.096910013008055 (IGP63) .69 [0.39-0.99] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 21q22.3 21 43513480 NR - 89766 rs1475911-C rs1475911 0 1475911 intron 0 0.154651563028953 9E-6 5.045757490560675 (IGP63) .20 [0.11-0.29] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8p23.1 8 12691871 NR 91694 57604 78.88 111.31 rs17120471-C rs17120471 0 17120471 1 0.101965395991091 6E-6 5.221848749616356 (IGP63) .24 [0.13-0.34] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 SMARCB1,DERL3 - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.189663332739421 4E-9 8.397940008672036 (IGP63) .24 [0.16-0.33] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 16q24.1 16 86680996 NR 2300 100271519 65.69 620.74 rs300032-G rs300032 0 300032 1 0.146304785746102 9E-8 7.045757490560674 (IGP63) .24 [0.15-0.33] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1p31.2 1 68927513 NR 6121 55635 11.87 12.32 rs435066-C rs435066 0 435066 1 0.195829321603564 7E-6 5.154901959985742 (IGP63) .18 [0.1-0.253] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39835587 NR 10454 4248 2.46 17.74 rs4821897-G rs4821897 0 4821897 1 0.707128727839644 3E-12 11.52287874528034 (IGP63) .24 [0.17-0.31] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p12.2 7 50355207 IKZF1 - 10320 rs6421315-C rs6421315 0 6421315 0 0.368316756347439 2E-13 12.69897000433602 (IGP63) .24 [0.17-0.3] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9q34.2 9 136676014 NR - 7410 rs7021663-C rs7021663 0 7021663 intron 0 0.209934371046771 3E-6 5.522878745280337 (IGP63) .18 [0.1-0.26] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1q42.3 1 234726356 NR 6894 359948 111.51 13.66 rs11581667-C rs11581667 0 11581667 1 0.745277716510903 4E-6 5.397940008672037 (IGP64) .20 [0.11-0.28] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10p13 10 13361976 NR - 22929 rs1747683-G rs1747683 0 1747683 intron 0 0.414548764129951 3E-7 6.522878745280337 (IGP64) .16 [0.1-0.23] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 SMARCB1,DERL3 - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.189496820649755 2E4 -4.30102999566398 (IGP64) .32 [0.24-0.4] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q11.2 5 52552239 NR 402214 100132049 49.23 157.07 rs27323-G rs27323 0 27323 1 0.421661209612817 9E-6 5.045757490560675 (IGP64) .14 [0.078-0.202] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.33 22 50902390 NR - 6305 rs5771040-G rs5771040 0 5771040 intron 0 0.660043690698709 2E-6 5.698970004336018 (IGP64) .16 [0.093-0.226] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p12.2 7 50355207 IKZF1 - 10320 rs6421315-C rs6421315 0 6421315 0 0.368179075211393 2E-7 6.698970004336019 (IGP64) .17 [0.11-0.23] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39859169 SYNGR1,TAB1,MGAT3,CACNA1I - 4248 rs909674-C rs909674 0 909674 intron 0 0.299013119715176 3E-8 7.522878745280337 (IGP64) .19 [0.12-0.25] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q23.3 14 65775695 FUT8 122888 100616176 27.32 26.14 rs11847263-G rs11847263 0 11847263 1 0.393717723953695 1E-10 10 (IGP65) .20 [0.14-0.26] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 19p13.2 19 11655010 NR - 1264 rs11880637-T rs11880637 0 11880637 intron 0 0.011251 6E-6 5.221848749616356 (IGP65) 3.92 [2.22-5.62] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2p12 2 77223938 NR - 80059 rs1470506-C rs1470506 0 1470506 intron 0 0.595063458147818 4E-7 6.397940008672037 (IGP65) .16 [0.098-0.222] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4p16.1 4 7018185 NR - 57533 rs16839553-G rs16839553 0 16839553 intron 0 0.992978201291118 8E-6 5.096910013008055 (IGP65) 1.14 [0.64-1.64] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q15 6 89253649 NR 68 8732 266.86 66.34 rs2610739-G rs2610739 0 2610739 1 0.187486864203028 4E-6 5.397940008672037 (IGP65) .19 [0.11-0.26] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.33 6 30679628 NR - 9656 rs3094093-T rs3094093 0 3094093 intron 0 0.107712365538735 8E-6 5.096910013008055 (IGP65) .22 [0.12-0.32] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q15 5 95246760 NR - 22936 rs3777193-G rs3777193 0 3777193 intron 0 0.71211365048976 4E-6 5.397940008672037 (IGP65) .16 [0.092-0.227] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2q22.1 2 141741590 NR - 53353 rs4954683-C rs4954683 0 4954683 intron 0 0.172162723953695 9E-6 5.045757490560675 (IGP65) .18 [0.1-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p12.2 7 50355207 IKZF1 - 10320 rs6421315-C rs6421315 0 6421315 0 0.368121119768477 5E-7 6.30102999566398 (IGP65) .16 [0.099-0.224] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2q23.3 2 153436570 NR - 114793 rs11675841-C rs11675841 0 11675841 intron 0 0.607345676902537 6E-6 5.221848749616356 (IGP66) .14 [0.082-0.208] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q23.1 12 97528140 NR 100189509 100302289 37.38 357.55 rs7953959-C rs7953959 0 7953959 1 0.49043844534413 8E-6 5.096910013008055 (IGP2) .14 [0.078-0.2] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4p16.1 4 6183184 NR - 152789 rs10937705-G rs10937705 0 10937705 intron 0 0.779354751351351 4E-6 5.397940008672037 (IGP20) .17 [0.099-0.244] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q13.2 12 55424916 NR 58158 121360 1.12 84.40 rs1386809-C rs1386809 0 1386809 1 0.284827378378378 7E-6 5.154901959985742 (IGP20) .16 [0.089-0.226] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2p24.3 2 14029748 NR 100422986 151354 1152.18 743.06 rs1598106-C rs1598106 0 1598106 1 0.408824843693694 2E-7 6.698970004336019 (IGP20) .16 [0.1-0.23] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q32.12 14 93223990 NR 5641 9950 8.94 36.66 rs7160685-C rs7160685 0 7160685 1 0.700909354954955 8E-6 5.096910013008055 (IGP20) .16 [0.088-0.225] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q23.3 14 65775695 FUT8 122888 100616176 27.32 26.14 rs11847263-G rs11847263 0 11847263 1 0.393609222420723 2E-6 5.698970004336018 (IGP21) .15 [0.089-0.211] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10p14 10 9568910 NR 338591 644495 906.34 194.82 rs17515642-C rs17515642 0 17515642 1 0.855118419830281 2E-6 5.698970004336018 (IGP21) .23 [0.13-0.32] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11q24.1 11 122873076 NR 390259 100271499 20.70 33.50 rs2126200-C rs2126200 0 2126200 1 0.541753456007146 7E-6 5.154901959985742 (IGP21) .14 [0.078-0.2] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q23.3 14 65775695 FUT8 122888 100616176 27.32 26.14 rs11847263-G rs11847263 0 11847263 1 0.393000049217002 1E-22 22 (IGP59) .31 [0.25-0.37] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q21.32 17 45830948 NR 30009 114881 7.46 53.79 rs12950390-C rs12950390 0 12950390 1 0.252525314541387 3E-6 5.522878745280337 (IGP59) .17 [0.098-0.239] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q24.31 12 123414349 NR - 23457 rs2270788-C rs2270788 0 2270788 intron 0 0.0991554951230425 7E-6 5.154901959985742 (IGP59) .24 [0.13-0.34] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.32 6 32697785 NR 404026 3118 23.21 11.38 rs2859113-C rs2859113 0 2859113 1 0.378328302013423 6E-8 7.221848749616355 (IGP59) .18 [0.12-0.25] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.32 6 32953280 NR 6046 3111 4.00 18.68 rs3097645-C rs3097645 0 3097645 1 0.87438328769575 7E-6 5.154901959985742 (IGP59) .21 [0.12-0.3] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p12.2 7 50350267 NR - 10320 rs6583437-G rs6583437 0 6583437 0 0.636650594183445 1E-9 8.999999999999998 (IGP59) .19 [0.13-0.26] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q21.32 17 45351118 NR - 3690 rs7209700-G rs7209700 0 7209700 intron 0 0.308782806263982 4E-7 6.397940008672037 (IGP59) .17 [0.1-0.23] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11p11.2 11 45084531 NR 9537 56981 111.67 31.03 rs7951911-G rs7951911 0 7951911 1 0.0838039874720358 8E-6 5.096910013008055 (IGP59) .27 [0.15-0.39] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 13q34 13 114507239 NR - 348013 rs9329350-G rs9329350 0 9329350 intron 0 0.941389270067114 8E-6 5.096910013008055 (IGP59) .30 [0.17-0.43] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q21.13 7 88695070 NR - 219578 rs10236237-T rs10236237 0 10236237 intron 0 0.267901504028648 7E-6 5.154901959985742 (IGP6) .16 [0.089-0.228] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q23.3 14 65775695 FUT8 122888 100616176 27.32 26.14 rs11847263-G rs11847263 0 11847263 1 0.394040135631155 5E-15 14.30102999566398 (IGP6) .25 [0.19-0.31] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.33 6 31572956 NR 259197 100130756 12.19 5.90 rs2844479-C rs2844479 0 2844479 1 0.393631380483438 4E-6 5.397940008672037 (IGP6) .15 [0.086-0.215] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 18q22.3 18 69379390 NR 342808 147381 1280.99 824.53 rs2887004-G rs2887004 0 2887004 1 0.180826079677708 6E-6 5.221848749616356 (IGP6) .19 [0.11-0.27] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p12.2 7 50350267 NR - 10320 rs6583437-G rs6583437 0 6583437 0 0.637609347358997 1E-8 8 (IGP6) .18 [0.12-0.24] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q21.13 7 88695070 NR - 219578 rs10236237-T rs10236237 0 10236237 intron 0 0.26751565049416 6E-6 5.221848749616356 (IGP60) .16 [0.091-0.229] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q23.3 14 65775695 FUT8 122888 100616176 27.32 26.14 rs11847263-G rs11847263 0 11847263 1 0.393211372416891 3E-14 13.52287874528034 (IGP60) .24 [0.18-0.3] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4q26 4 117849449 NR 100421002 133022 69.32 155.26 rs2389339-G rs2389339 0 2389339 1 0.790576647349506 3E-6 5.522878745280337 (IGP60) .18 [0.1-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.33 6 31572956 NR 259197 100130756 12.19 5.90 rs2844479-C rs2844479 0 2844479 1 0.393698650943396 4E-6 5.397940008672037 (IGP60) .15 [0.087-0.215] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p12.2 7 50350267 NR - 10320 rs6583437-G rs6583437 0 6583437 0 0.637881567834681 5E-9 8.301029995663981 (IGP60) .19 [0.12-0.25] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q15 5 95241222 NR - 22936 rs10069748-C rs10069748 0 10069748 intron 0 0.274419212661614 5E-6 5.301029995663981 (IGP61) .15 [0.088-0.22] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 18q22.3 18 69365300 NR 342808 147381 1266.90 838.62 rs11665307-C rs11665307 0 11665307 1 0.173309217119929 3E-7 6.522878745280337 (IGP61) .21 [0.13-0.29] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q23.3 14 65775695 FUT8 122888 100616176 27.32 26.14 rs11847263-G rs11847263 0 11847263 1 0.393162371823451 3E-17 16.52287874528034 (IGP61) .27 [0.21-0.33] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 19p13.2 19 11655010 NR - 1264 rs11880637-T rs11880637 0 11880637 intron 0 0.011251 6E-6 5.221848749616356 (IGP61) 3.94 [2.24-5.64] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 18q23 18 75638023 NR 724038 27164 488.82 1102.25 rs12455580-C rs12455580 0 12455580 1 0.662638724030317 7E-6 5.154901959985742 (IGP61) .16 [0.091-0.23] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2p12 2 77223938 NR - 80059 rs1470506-C rs1470506 0 1470506 intron 0 0.594972305394561 6E-6 5.221848749616356 (IGP61) .14 [0.081-0.204] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.2 9 27075715 NR 80173 7010 12.78 33.43 rs1577330-G rs1577330 0 1577330 1 0.245380581810076 4E-6 5.397940008672037 (IGP61) .17 [0.1-0.25] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1q42.12 1 225592927 NR - 3930 rs16844846-G rs16844846 0 16844846 intron 0 0.0584601113241195 4E-6 5.397940008672037 (IGP61) .32 [0.18-0.45] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.33 6 31572956 NR 259197 100130756 12.19 5.90 rs2844479-C rs2844479 0 2844479 1 0.393516127507802 9E-6 5.045757490560675 (IGP61) .14 [0.081-0.208] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.32 6 32953280 NR 6046 3111 4.00 18.68 rs3097645-C rs3097645 0 3097645 1 0.873550828800713 6E-6 5.221848749616356 (IGP61) .21 [0.12-0.3] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q22.31 6 123989741 NR 10345 154215 31.50 135.33 rs9490860-C rs9490860 0 9490860 1 0.231696267498885 4E-6 5.397940008672037 (IGP61) .17 [0.098-0.242] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 19p13.2 19 11655010 NR - 1264 rs11880637-T rs11880637 0 11880637 intron 0 0.011251 6E-6 5.221848749616356 (IGP62) 3.87 [2.2-5.54] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 SMARCB1,DERL3 - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.189579642030276 1E-12 12 (IGP62) .29 [0.21-0.38] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1p31.2 1 68927513 NR 6121 55635 11.87 12.32 rs435066-C rs435066 0 435066 1 0.195964786286732 4E-6 5.397940008672037 (IGP62) .18 [0.1-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20q11.22 20 32556777 NR 170555 22913 55.58 24.68 rs6059594-G rs6059594 0 6059594 1 0.962780757212823 3E-6 5.522878745280337 (IGP62) .50 [0.29-0.71] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p12.2 7 50355207 IKZF1 - 10320 rs6421315-C rs6421315 0 6421315 0 0.368343116206589 8E-12 11.09691001300806 (IGP62) .22 [0.16-0.28] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1p31.1 1 79176868 NR 100130630 64123 44.49 178.58 rs4650376-C rs4650376 0 4650376 1 0.126317908441268 2E-6 5.698970004336018 (IGP21) .24 [0.14-0.33] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5p14.3 5 18483651 NR 100271332 100270994 433.63 557.49 rs4866334-C rs4866334 0 4866334 1 0.0883955067200712 4E-6 5.397940008672037 (IGP17) .25 [0.15-0.36] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p13.3 9 36099399 RECK - 8434 rs4878639-C rs4878639 0 4878639 intron 0 0.263725273253227 4E-8 7.397940008672037 (IGP17) .20 [0.13-0.27] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q22.3 5 115138748 NR 51014 1036 176.87 1.68 rs13174348-G rs13174348 0 13174348 1 0.784686077436582 3E-6 5.522878745280337 (IGP54) .18 [0.11-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186732679 NR - 6480 rs17776120-C rs17776120 0 17776120 intron 0 0.636448318202047 2E-6 5.698970004336018 (IGP54) .17 [0.097-0.234] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9q34.3 9 137816459 NR 2219 10439 6.65 150.63 rs2094962-C rs2094962 0 2094962 1 0.901323053404539 5E-6 5.301029995663981 (IGP54) .24 [0.14-0.34] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 SMARCB1,DERL3 - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.189496820649755 2E-7 6.698970004336019 (IGP54) .22 [0.14-0.3] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8q22.1 8 94222945 NR 389676 642924 43.87 135.75 rs278541-C rs278541 0 278541 1 0.97906300623053 4E-8 7.397940008672037 (IGP54) .81 [0.52-1.09] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q31.1 7 113741105 NR - 93986 rs6466479-G rs6466479 0 6466479 intron 0 0.122643248331108 7E-6 5.154901959985742 (IGP54) .22 [0.12-0.31] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 18q21.1 18 46227444 NR - 9811 rs16949825-C rs16949825 0 16949825 intron 0 0.902274750778816 7E-6 5.154901959985742 (IGP55) .25 [0.14-0.35] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q11.2 5 55322895 IL6ST,ANKRD55 3572 727984 32.07 109.88 rs17348299-C rs17348299 0 17348299 1 0.836731980863373 1E-10 10 (IGP55) .29 [0.2-0.37] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q12 17 37332963 NR - 782 rs626657-C rs626657 0 626657 intron 0 0.861032878949711 2E-6 5.698970004336018 (IGP55) .23 [0.14-0.33] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8p22 8 14113816 NR - 137868 rs9886428-G rs9886428 0 9886428 intron 0 0.455051607476636 2E-6 5.698970004336018 (IGP55) .15 [0.087-0.207] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2p23.3 2 27587724 NR - 8890 rs1058065-G rs1058065 0 1058065 cds-synon 0 0.97552739311682 4E-6 5.397940008672037 (IGP56) .54 [0.31-0.77] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1p36.33 1 2205581 NR - 6497 rs12045693-C rs12045693 0 12045693 intron 0 0.573032700580098 3E-6 5.522878745280337 (IGP56) .15 [0.089-0.219] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8q13.3 8 71544748 NR - 286190 rs13272623-G rs13272623 0 13272623 intron 0 0.155110978134761 4E-6 5.397940008672037 (IGP56) .21 [0.12-0.3] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9q21.32 9 84522749 NR 7088 347127 219.15 5.60 rs13295552-C rs13295552 0 13295552 1 0.029172681294964 5E-6 5.301029995663981 (IGP56) .91 [0.52-1.3] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q11.2 5 55322895 IL6ST,ANKRD55 3572 727984 32.07 109.88 rs17348299-C rs17348299 0 17348299 1 0.836660240071397 8E-6 5.096910013008055 (IGP56) .20 [0.11-0.29] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10q25.1 10 110971435 NR 114815 100130409 2046.97 322.98 rs17783561-T rs17783561 0 17783561 1 0.135585937974119 6E-6 5.221848749616356 (IGP56) .27 [0.16-0.39] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.21 22 19565257 NR 7122 5413 52.40 136.73 rs2106139-G rs2106139 0 2106139 1 0.966774019767961 6E-6 5.221848749616356 (IGP56) .44 [0.25-0.62] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q35 7 147615640 NR - 26047 rs2538958-C rs2538958 0 2538958 intron 0 0.436017399375279 8E-6 5.096910013008055 (IGP56) .14 [0.078-0.2] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q12 17 37331345 NR - 782 rs523516-T rs523516 0 523516 UTR-3 0 0.176237627398483 4E-6 5.397940008672037 (IGP56) .19 [0.11-0.27] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1p31.1 1 84868961 NR - 58511 rs604708-C rs604708 0 604708 intron 0 0.970210567603748 8E-6 5.096910013008055 (IGP56) .41 [0.23-0.59] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 33153527 NR - 2683 rs10813957-G rs10813957 0 10813957 intron 0 0.738414638629283 3E-9 8.522878745280337 (IGP57) .21 [0.14-0.28] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q15 12 69581222 NR 1368 11052 224.20 52.10 rs12367448-C rs12367448 0 12367448 1 0.831671480195817 6E-6 5.221848749616356 (IGP57) .25 [0.14-0.35] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2q14.3 2 125291837 NR - 129684 rs13021885-C rs13021885 0 13021885 intron 0 0.932509117935024 8E-6 5.096910013008055 (IGP57) .39 [0.22-0.56] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q11.2 5 55322895 IL6ST,ANKRD55 3572 727984 32.07 109.88 rs17348299-C rs17348299 0 17348299 1 0.836731980863373 1E-10 10 (IGP57) .29 [0.2-0.37] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1p22.3 1 87051201 NR 22802 9629 4.76 48.76 rs1953652-C rs1953652 0 1953652 1 0.653295152202937 9E-6 5.045757490560675 (IGP57) .14 [0.08-0.206] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q31.1 7 113741105 NR - 93986 rs6466479-G rs6466479 0 6466479 intron 0 0.122643248331108 2E-6 5.698970004336018 (IGP57) .23 [0.13-0.32] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3p14.1 3 65398898 NR - 9223 rs7649739-G rs7649739 0 7649739 intron 0 0.358836830440587 6E-6 5.221848749616356 (IGP57) .15 [0.085-0.215] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8p22 8 14113816 NR - 137868 rs9886428-G rs9886428 0 9886428 intron 0 0.455051607476636 2E-6 5.698970004336018 (IGP57) .15 [0.087-0.208] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1q42.12 1 225592927 NR - 3930 rs16844846-G rs16844846 0 16844846 intron 0 0.0583315441465594 6E-6 5.221848749616356 (IGP58) .31 [0.18-0.45] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11q14.1 11 80311671 NR 100847000 729790 1178.40 52.80 rs2140930-G rs2140930 0 2140930 1 0.348471261394102 5E-6 5.301029995663981 (IGP58) .17 [0.095-0.24] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.33 6 31572956 NR 259197 100130756 12.19 5.90 rs2844479-C rs2844479 0 2844479 1 0.393054780607685 7E-6 5.154901959985742 (IGP58) .15 [0.083-0.212] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.32 6 32953280 NR 6046 3111 4.00 18.68 rs3097645-C rs3097645 0 3097645 1 0.873514573726542 3E-6 5.522878745280337 (IGP58) .21 [0.12-0.3] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p12.2 7 50350267 NR - 10320 rs6583437-G rs6583437 0 6583437 0 0.636915159517426 3E-8 7.522878745280337 (IGP58) .18 [0.11-0.24] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q36.1 7 150915071 ABCF2,SMARCD3 - 10061 rs1122979-G rs1122979 0 1122979 intron 0 0.874968858612975 7E-6 5.154901959985742 (IGP59) .22 [0.12-0.32] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8q24.13 8 125721366 NR - 9788 rs11781525-G rs11781525 0 11781525 intron 0 0.97440182935123 6E-6 5.221848749616356 (IGP59) .60 [0.34-0.87] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q31.1 7 113741105 NR - 93986 rs6466479-G rs6466479 0 6466479 intron 0 0.122643248331108 5E-7 6.30102999566398 (IGP17) .24 [0.15-0.34] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39748854 NR - 9145 rs137699-G rs137699 0 137699 intron 0 0.690710359535507 8E-6 5.096910013008055 (IGP18) .16 [0.088-0.225] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q31.3 14 85683053 NR 100151647 26843 2168.07 55.20 rs1550584-C rs1550584 0 1550584 1 0.469772138901295 7E-6 5.154901959985742 (IGP18) .14 [0.078-0.198] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11p12 11 41225433 NR - 57689 rs2862035-C rs2862035 0 2862035 intron 0 0.0246322445734703 8E-6 5.096910013008055 (IGP18) .44 [0.25-0.63] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 16q23.3 16 83771496 NR - 1012 rs444881-C rs444881 0 444881 intron 0 0.585534589548906 4E-6 5.397940008672037 (IGP18) .14 [0.083-0.206] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20q13.12 20 44921631 NR 64405 51006 41.30 56.55 rs6065945-C rs6065945 0 6065945 1 0.470163670388566 5E-6 5.301029995663981 (IGP18) .14 [0.081-0.201] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10q24.1 10 98432703 NR - 118788 rs7895244-T rs7895244 0 7895244 intron 0 0.929057661098705 5E-6 5.301029995663981 (IGP18) .28 [0.16-0.41] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.32 6 32114515 PRRT1 63943 80863 16.45 1.63 rs9296009-T rs9296009 0 9296009 1 0.196796488164359 4E-6 5.397940008672037 (IGP18) .18 [0.1-0.25] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.32 6 32674737 NR 404026 3118 .16 34.43 rs1794265-C rs1794265 0 1794265 1 0.945736455079007 1E-6 5.999999999999999 (IGP19) .33 [0.2-0.46] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3p24.2 3 25343615 NR 100129045 100505919 745.67 22.00 rs322668-G rs322668 0 322668 1 0.285734488487585 4E-6 5.397940008672037 (IGP19) .16 [0.092-0.226] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q35.1 5 169461547 NR - 1794 rs3763048-C rs3763048 0 3763048 cds-synon 0 0.672342024379233 9E-6 5.045757490560675 (IGP19) .14 [0.08-0.205] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.33 6 31802465 NR - 26801;50854 rs4711279-C rs4711279 0 4711279 nearGene-5;nearGene-5 0 0.823257144469526 3E-7 6.522878745280337 (IGP19) .20 [0.12-0.27] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2p13.3 2 71063942 NR - 50489 rs4852708-C rs4852708 0 4852708 nearGene-5 0 0.875251656884876 9E-6 5.045757490560675 (IGP19) .21 [0.11-0.3] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q15 5 95428684 NR 693168 5122 13.77 297.36 rs7734985-G rs7734985 0 7734985 1 0.336041271783296 2E-6 5.698970004336018 (IGP19) .16 [0.093-0.221] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.33 6 30666669 NR 100133037 9656 1.36 .92 rs9468811-C rs9468811 0 9468811 1 0.937946818961625 6E-7 6.221848749616355 (IGP19) .35 [0.21-0.48] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.32 6 32726803 HLA-DQA2, HLA-DQB2 - 3120 rs1049110-C rs1049110 0 1049110 missense 0 0.34601888034188 4E8 -8.602059991327961 (IGP2) .19 [0.12-0.25] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1q32.3 1 214457009 NR - 56950 rs9308433-C rs9308433 0 9308433 intron 0 0.408224476833108 4E-6 5.397940008672037 (IGP2) .15 [0.084-0.207] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q23.2 5 126721853 NR - 84466 rs10519937-C rs10519937 0 10519937 intron 0 0.831854334233018 9E-6 5.045757490560675 (IGP2) .19 [0.11-0.27] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q36.1 7 150915071 ABCF2,SMARCD3 - 10061 rs1122979-G rs1122979 0 1122979 intron 0 0.875182808816914 2E-10 9.698970004336017 (IGP2) .31 [0.22-0.41] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8p12 8 31034275 NR 7486 3084 3.00 462.55 rs11774682-C rs11774682 0 11774682 1 0.96615368329177 1E-6 5.999999999999999 (IGP2) .83 [0.49-1.16] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q23.3 14 65775695 FUT8 122888 100616176 27.32 26.14 rs11847263-G rs11847263 0 11847263 1 0.390847885290148 8E-20 19.09691001300806 (IGP2) .29 [0.23-0.35] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.2 9 27126415 NR - 7010 rs1334809-G rs1334809 0 1334809 intron 0 0.884652631578947 8E-6 5.096910013008055 (IGP2) .22 [0.12-0.32] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.33 6 30679628 NR - 9656 rs3094093-T rs3094093 0 3094093 intron 0 0.107418420152946 8E-6 5.096910013008055 (IGP2) .22 [0.13-0.32] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.32 6 32953280 NR 6046 3111 4.00 18.68 rs3097645-C rs3097645 0 3097645 1 0.874157767431399 5E-6 5.301029995663981 (IGP2) .21 [0.12-0.3] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.33 6 31930441 NR - 6499 rs592229-G rs592229 0 592229 intron 0 0.370283129554656 9E-6 5.045757490560675 (IGP2) .15 [0.083-0.213] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p12.2 7 50350267 NR - 10320 rs6583437-G rs6583437 0 6583437 0 0.63670095951417 2E-9 8.698970004336019 (IGP2) .19 [0.13-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q31.1 5 131721749 NR - 6584 rs7731390-C rs7731390 0 7731390 intron 0 0.947724237786775 3E-6 5.522878745280337 (IGP2) .38 [0.22-0.53] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q23.3 12 108877541 NR 1240 11153 144.45 31.51 rs918304-C rs918304 0 918304 1 0.00963820126262628 8E-6 5.096910013008055 (IGP53) 1.60 [0.9-2.3] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8p22 8 14113816 NR - 137868 rs9886428-G rs9886428 0 9886428 intron 0 0.455051607476636 5E-6 5.301029995663981 (IGP53) .14 [0.08-0.201] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p15.3 7 23480467 NR - 10643 rs11763760-C rs11763760 0 11763760 intron 0 0.797056939029818 2E-6 5.698970004336018 (IGP54) .18 [0.11-0.26] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 21q22.11 21 34262687 NR 56245 10215 76.63 135.53 rs2833991-C rs2833991 0 2833991 1 0.0446738709390298 5E-6 5.301029995663981 (IGP14) .35 [0.2-0.5] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 15q11.2 15 23817721 NR 7681 54551 4.55 70.98 rs2900-G rs2900 0 2900 1 0.860145730752114 4E-6 5.397940008672037 (IGP14) .20 [0.12-0.29] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1p36.12 1 22573942 NR 54361 100616433 104.42 18.79 rs909814-C rs909814 0 909814 1 0.57460965776591 7E-6 5.154901959985742 (IGP14) .14 [0.08-0.204] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 13q21.32 13 66212020 NR 6771 387933 326.73 149.66 rs11619878-G rs11619878 0 11619878 1 0.510985562333036 1E-7 7 (IGP15) .16 [0.1-0.22] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186725887 ST6GAL1 - 6480 rs11710456-G rs11710456 0 11710456 intron 0 0.699014551202137 2E-45 44.69897000433601 (IGP15) .50 [0.43-0.57] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q25.3 17 78060743 NR - 55036 rs1467979-C rs1467979 0 1467979 intron 0 0.82313228539626 2E-6 5.698970004336018 (IGP15) .19 [0.11-0.27] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 15q23 15 68718987 NR - 22801 rs16952065-C rs16952065 0 16952065 intron 0 0.93746857524488 6E-6 5.221848749616356 (IGP15) .41 [0.23-0.59] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2q11.2 2 99876244 NR 254773 129530 4.67 24.46 rs2200578-C rs2200578 0 2200578 1 0.788386317008014 4E-7 6.397940008672037 (IGP15) .19 [0.12-0.26] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q23.2 6 131355864 NR - 2037 rs6908917-C rs6908917 0 6908917 intron 0 0.751956642030276 2E-6 5.698970004336018 (IGP15) .17 [0.098-0.236] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20q13.12 20 43773737 NR 128488 5266 20.63 29.80 rs7361168-C rs7361168 0 7361168 1 0.758153525448028 3E-6 5.522878745280337 (IGP15) .36 [0.21-0.51] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186722944 ST6GAL1 - 6480 rs7652995-G rs7652995 0 7652995 intron 0 0.176763000890472 5E-19 18.30102999566398 (IGP15) .39 [0.31-0.48] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4q21.23 4 86129616 NR 23001 100616349 242.07 514.01 rs7691216-G rs7691216 0 7691216 1 0.155663414959929 7E-6 5.154901959985742 (IGP15) .19 [0.11-0.27] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q24.31 12 124316876 NR - 196385 rs7978454-G rs7978454 0 7978454 intron 0 0.409630410507569 7E-6 5.154901959985742 (IGP15) .15 [0.083-0.212] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q15 5 95301463 NR 22936 100288964 3.69 7.21 rs918629-G rs918629 0 918629 1 0.745524385574354 1E-6 5.999999999999999 (IGP15) .17 [0.1-0.24] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 32870068 NR 401498 392302 80.87 75.82 rs10971170-G rs10971170 0 10971170 1 0.969529949122017 9E-6 5.045757490560675 (IGP16) .41 [0.23-0.6] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1q43 1 242531654 NR - 200150 rs1439523-C rs1439523 0 1439523 intron 0 0.983777045475011 4E-6 5.397940008672037 (IGP16) .61 [0.35-0.87] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.32 6 32953280 NR 6046 3111 4.00 18.68 rs3097645-C rs3097645 0 3097645 1 0.873857556055831 6E-6 5.221848749616356 (IGP16) .21 [0.12-0.29] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3p22.3 3 32264991 NR 645326 729211 31.80 35.38 rs4376071-C rs4376071 0 4376071 1 0.313983692931112 8E-6 5.096910013008055 (IGP16) .16 [0.09-0.231] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1q43 1 237598416 NR - 6262 rs7529251-C rs7529251 0 7529251 intron 0 0.907539242683476 3E-7 6.522878745280337 (IGP16) .28 [0.17-0.38] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11q22.3 11 107347277 NR 100271884 91801 71.91 26.18 rs11212260-C rs11212260 0 11212260 1 0.0281428517133956 5E-6 5.301029995663981 (IGP17) .46 [0.26-0.65] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186725887 ST6GAL1 - 6480 rs11710456-G rs11710456 0 11710456 intron 0 0.698919993324432 1E-8 8 (IGP17) .20 [0.13-0.27] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 33124872 B4GALT1 - 2683 rs12342831-C rs12342831 0 12342831 intron 0 0.262623398308856 3E-11 10.52287874528034 (IGP17) .24 [0.17-0.31] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2q32.1 2 186184030 NR 100271293 644935 416.74 226.42 rs1364477-G rs1364477 0 1364477 1 0.178595763239875 6E-6 5.221848749616356 (IGP17) .18 [0.1-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q21.1 5 100301806 NR 7903 403301 62.82 849.78 rs17161553-C rs17161553 0 17161553 1 0.00759162019720625 6E-6 5.221848749616356 (IGP17) 1.60 [0.9-2.29] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q24.21 12 116211863 NR 100128617 23389 181.08 184.52 rs17719439-G rs17719439 0 17719439 1 0.96234668518024 1E-6 5.999999999999999 (IGP17) .40 [0.24-0.57] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p24.1 9 7518656 NR 158345 90871 40.28 277.83 rs2381628-C rs2381628 0 2381628 1 0.816537394303516 6E-6 5.221848749616356 (IGP17) .18 [0.1-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p14.3 7 34697060 NR - 387129;404744 rs2530544-G rs2530544 0 2530544 nearGene-5;intron 0 0.768357767245216 8E-7 6.096910013008056 (IGP17) .20 [0.12-0.28] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q21.11 7 86348999 NR - 2913 rs2189812-C rs2189812 0 2189812 intron 0 0.258550537841469 6E-6 5.221848749616356 (IGP11) .16 [0.092-0.233] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2p24.1 2 23592145 NR 338 114818 2325.20 16.15 rs2577704-G rs2577704 0 2577704 1 0.900847768293775 3E-6 5.522878745280337 (IGP11) .24 [0.14-0.34] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q15 12 71289556 NR - 5801 rs4760854-G rs4760854 0 4760854 intron 0 0.270106625167935 9E-6 5.045757490560675 (IGP11) .16 [0.088-0.227] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8p23.2 8 2819809 NR - 64478 rs4875857-C rs4875857 0 4875857 intron 0 0.177865535602329 5E-6 5.301029995663981 (IGP11) .18 [0.11-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q31.1 7 112649414 NR 154743 54329 69.48 71.05 rs6969802-G rs6969802 0 6969802 1 0.0792205338110166 5E-6 5.301029995663981 (IGP11) .26 [0.15-0.37] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 13q21.31 13 62930300 NR 100133193 283491 27.77 1381.27 rs9563960-G rs9563960 0 9563960 1 0.296353501567398 7E-6 5.154901959985742 (IGP11) .15 [0.087-0.222] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10q24.1 10 97301004 NR - 10580 rs11188352-G rs11188352 0 11188352 intron 0 0.042712513900135 6E-6 5.221848749616356 (IGP12) .42 [0.24-0.6] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186725887 ST6GAL1 - 6480 rs11710456-G rs11710456 0 11710456 intron 0 0.699626190283401 5E-6 5.301029995663981 (IGP12) .16 [0.09-0.227] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186732679 NR - 6480 rs17776120-C rs17776120 0 17776120 intron 0 0.637453049482681 2E-6 5.698970004336018 (IGP12) .16 [0.097-0.233] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 15q25.1 15 80013422 NR 23251 646985 248.78 30.59 rs2692194-G rs2692194 0 2692194 1 0.626112833558255 9E-6 5.045757490560675 (IGP12) .15 [0.084-0.217] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p21.3 7 11291400 NR 9678 10836 82.15 5.60 rs4720952-G rs4720952 0 4720952 1 0.419193108861898 3E-7 6.522878745280337 (IGP12) .16 [0.098-0.219] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20p13 20 4387134 NR 146 128668 157.48 184.45 rs586446-C rs586446 0 586446 1 0.118161679262258 2E-6 5.698970004336018 (IGP12) .23 [0.13-0.33] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q24.3 6 147759534 NR 442266 389432 30.12 70.29 rs9403856-C rs9403856 0 9403856 1 0.86167473954116 4E-7 6.397940008672037 (IGP12) .35 [0.21-0.48] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 13q31.1 13 79382101 NR - 100874126 rs9574309-C rs9574309 0 9574309 0 0.432876341880342 2E-6 5.698970004336018 (IGP12) .16 [0.093-0.226] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 33153527 NR - 2683 rs10813957-G rs10813957 0 10813957 intron 0 0.738414638629283 5E-8 7.30102999566398 (IGP13) .20 [0.13-0.27] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q11.2 5 55322895 IL6ST,ANKRD55 3572 727984 32.07 109.88 rs17348299-C rs17348299 0 17348299 1 0.836731980863373 1E-10 10 (IGP13) .29 [0.2-0.38] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1p22.3 1 87051201 NR 22802 9629 4.76 48.76 rs1953652-C rs1953652 0 1953652 1 0.653295152202937 5E-6 5.301029995663981 (IGP13) .15 [0.084-0.21] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186732725 NR - 6480 rs3821819-G rs3821819 0 3821819 intron 0 0.632029343569203 3E-6 5.522878745280337 (IGP13) .16 [0.095-0.231] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p13.3 9 36099399 RECK - 8434 rs4878639-C rs4878639 0 4878639 intron 0 0.263725273253227 6E-6 5.221848749616356 (IGP13) .16 [0.092-0.231] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8q13.1 8 66624232 NR 9650 5150 1.43 2.34 rs10504390-G rs10504390 0 10504390 1 0.0804795064530485 1E-7 7 (IGP14) .30 [0.19-0.4] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186725887 ST6GAL1 - 6480 rs11710456-G rs11710456 0 11710456 intron 0 0.698919993324432 9E-7 6.045757490560675 (IGP14) .17 [0.1-0.24] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2q14.3 2 125256736 NR - 129684 rs11899928-C rs11899928 0 11899928 intron 0 0.0215231680017802 9E-6 5.045757490560675 (IGP14) .69 [0.38-0.99] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8q12.1 8 59508580 NR - 8439 rs11994937-C rs11994937 0 11994937 intron 0 0.978061912475822 5E-6 5.301029995663981 (IGP14) .50 [0.29-0.72] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 SMARCB1,DERL3 - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.189496820649755 3E-8 7.522878745280337 (IGP14) .23 [0.15-0.31] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8q22.1 8 94222945 NR 389676 642924 43.87 135.75 rs278541-C rs278541 0 278541 1 0.97906300623053 4E-8 7.397940008672037 (IGP14) .80 [0.52-1.09] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2p16.1 2 59789705 NR 400955 100616473 498.80 824.79 rs10203166-C rs10203166 0 10203166 1 0.974135912544803 4E-6 5.397940008672037 (IGP5) .80 [0.46-1.14] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4p15.31 4 21206490 NR - 80333 rs1023721-T rs1023721 0 1023721 intron 0 0.941465292386465 1E-6 5.999999999999999 (IGP5) .31 [0.19-0.44] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q36.1 7 150915071 ABCF2,SMARCD3 - 10061 rs1122979-G rs1122979 0 1122979 intron 0 0.875342207034728 2E-9 8.698970004336019 (IGP5) .29 [0.2-0.39] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8q11.21 8 51384987 NR - 54212 rs13272236-G rs13272236 0 13272236 intron 0 0.0365154950657895 2E-6 5.698970004336018 (IGP5) .79 [0.46-1.11] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9q22.32 9 98816484 NR 375748 100128771 85.36 91.81 rs1547201-C rs1547201 0 1547201 1 0.530244325912734 4E-6 5.397940008672037 (IGP5) .14 [0.083-0.206] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q11.2 5 55324802 NR 3572 727984 33.98 107.97 rs16884711-C rs16884711 0 16884711 1 0.189044272039181 2E-6 5.698970004336018 (IGP5) .19 [0.11-0.27] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q21.3 14 48054159 NR - 161357 rs4143912-G rs4143912 0 4143912 intron 0 0.416787130454141 6E-6 5.221848749616356 (IGP5) .14 [0.081-0.206] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p12.2 7 50355207 IKZF1 - 10320 rs6421315-C rs6421315 0 6421315 0 0.368136455031166 7E-6 5.154901959985742 (IGP5) .14 [0.081-0.208] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10q21.2 10 63695048 NR - 84159 rs6479779-C rs6479779 0 6479779 intron 0 0.345369661175423 2E-6 5.698970004336018 (IGP5) .19 [0.11-0.27] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39859169 SYNGR1,TAB1,MGAT3,CACNA1I - 4248 rs909674-C rs909674 0 909674 intron 0 0.298923567230632 1E-10 10 (IGP5) .22 [0.15-0.28] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5p15.1 5 16038102 NR 100126347 441061 102.73 29.37 rs1039443-C rs1039443 0 1039443 1 0.105031482310793 8E-6 5.096910013008055 (IGP50) .22 [0.12-0.32] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 SMARCB1,DERL3 - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.189640669950739 5E-10 9.301029995663981 (IGP50) .26 [0.18-0.34] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10q25.3 10 117824888 NR - 2674 rs2302105-C rs2302105 0 2302105 intron 0 0.768104532915361 4E-6 5.397940008672037 (IGP50) .17 [0.097-0.24] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q23.3 12 105458797 NR - 160428 rs10861342-C rs10861342 0 10861342 intron 0 0.099068749529359 2E-6 5.698970004336018 (IGP51) .25 [0.14-0.35] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q21.32 17 45835278 NR 30009 114881 11.79 49.46 rs11651000-G rs11651000 0 11651000 1 0.840144331241596 8E-6 5.096910013008055 (IGP51) .19 [0.11-0.27] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q23.3 14 65775695 FUT8 122888 100616176 27.32 26.14 rs11847263-G rs11847263 0 11847263 1 0.392332365307037 2E-13 12.69897000433602 (IGP51) .23 [0.17-0.29] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2p24.1 2 23592145 NR 338 114818 2325.20 16.15 rs2577704-G rs2577704 0 2577704 1 0.900979990049305 5E-6 5.301029995663981 (IGP51) .24 [0.14-0.34] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q31.1 7 112649414 NR 154743 54329 69.48 71.05 rs6969802-G rs6969802 0 6969802 1 0.0788437633348274 3E-6 5.522878745280337 (IGP51) .27 [0.16-0.38] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 15q26.1 15 93564972 NR - 1106 rs7179432-C rs7179432 0 7179432 intron 0 0.455903207978485 4E-6 5.397940008672037 (IGP51) .16 [0.09-0.224] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 13q21.31 13 62930300 NR 100133193 283491 27.77 1381.27 rs9563960-G rs9563960 0 9563960 1 0.296508162707306 4E-6 5.397940008672037 (IGP51) .16 [0.092-0.226] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11q13.3 11 69602412 NR 2249 2248 12.24 22.32 rs10796849-C rs10796849 0 10796849 1 0.111934 6E-6 5.221848749616356 (IGP52) .61 [0.35-0.88] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10q24.1 10 97301004 NR - 10580 rs11188352-G rs11188352 0 11188352 intron 0 0.0425983854693141 5E-6 5.301029995663981 (IGP52) .43 [0.24-0.61] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 13q31.1 13 79380816 NR - 100874126 rs2184180-G rs2184180 0 2184180 0 0.362504259025271 5E-6 5.301029995663981 (IGP52) .16 [0.093-0.234] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q36.2 7 153578416 NR 57180 1804 1025.95 6.00 rs38989-G rs38989 0 38989 1 0.405296777978339 7E-6 5.154901959985742 (IGP52) .15 [0.086-0.219] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p21.3 7 11291400 NR 9678 10836 82.15 5.60 rs4720952-G rs4720952 0 4720952 1 0.419614749097473 7E-7 6.154901959985743 (IGP52) .15 [0.093-0.214] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4p16.1 4 6736365 NR 55330 9778 16.98 48.09 rs7661864-G rs7661864 0 7661864 1 0.699190685672515 5E-6 5.301029995663981 (IGP52) .33 [0.19-0.47] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q24.3 6 147759534 NR 442266 389432 30.12 70.29 rs9403856-C rs9403856 0 9403856 1 0.861277425090253 2E-6 5.698970004336018 (IGP52) .33 [0.19-0.46] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 33153527 NR - 2683 rs10813957-G rs10813957 0 10813957 intron 0 0.738414638629283 2E-9 8.698970004336019 (IGP53) .22 [0.15-0.29] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q11.2 5 55322895 IL6ST,ANKRD55 3572 727984 32.07 109.88 rs17348299-C rs17348299 0 17348299 1 0.836731980863373 7E-11 10.15490195998574 (IGP53) .29 [0.2-0.38] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1p22.3 1 87051201 NR 22802 9629 4.76 48.76 rs1953652-C rs1953652 0 1953652 1 0.653295152202937 4E-6 5.397940008672037 (IGP53) .15 [0.086-0.212] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p13.3 9 36099399 RECK - 8434 rs4878639-C rs4878639 0 4878639 intron 0 0.263725273253227 6E-7 6.221848749616355 (IGP53) .18 [0.11-0.25] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q31.1 7 113741105 NR - 93986 rs6466479-G rs6466479 0 6466479 intron 0 0.122643248331108 4E-6 5.397940008672037 (IGP53) .22 [0.13-0.32] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2q12.1 2 103388594 NR - 130827 rs12465996-C rs12465996 0 12465996 intron 0 0.864479920980926 5E-6 5.301029995663981 (IGP1) .24 [0.14-0.35] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17p11.2 17 17142896 NR 201163 8533 2.39 7.04 rs12600635-G rs12600635 0 12600635 1 0.145264718437784 2E-7 6.698970004336019 (IGP1) .23 [0.14-0.31] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12p13.31 12 7335217 PEX5 9746 5830 23.68 6.54 rs12828421-C rs12828421 0 12828421 1 0.513425077202543 9E-7 6.045757490560675 (IGP1) .16 [0.096-0.223] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.32 6 32674737 NR 404026 3118 .16 34.43 rs1794265-C rs1794265 0 1794265 1 0.945894807901907 8E-6 5.096910013008055 (IGP1) .30 [0.17-0.43] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 21q22.3 21 42793791 NR - 4599 rs459482-C rs459482 0 459482 UTR-5 0 0.594937723887375 2E-6 5.698970004336018 (IGP1) .15 [0.089-0.213] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.33 6 31802465 NR - 26801;50854 rs4711279-C rs4711279 0 4711279 nearGene-5;nearGene-5 0 0.824401248864668 4E-6 5.397940008672037 (IGP1) .18 [0.1-0.25] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11q13.2 11 67931761 SUV420H1 - 51111 rs4930561-G rs4930561 0 4930561 intron 0 0.510670339237057 1E-8 8 (IGP1) .17 [0.11-0.23] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17p11.2 17 16960978 NR - 23164 rs6502557-G rs6502557 0 6502557 intron 0 0.861939099364214 6E-6 5.221848749616356 (IGP1) .22 [0.12-0.31] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 18q22.3 18 72897161 NR 55628 284273 119.53 12.12 rs9948784-G rs9948784 0 9948784 1 0.9873089 1E-6 5.999999999999999 (IGP1) 1.81 [1.08-2.54] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1q41 1 216056348 NR - 7399 rs17025548-G rs17025548 0 17025548 intron 0 0.165189309375 8E-6 5.096910013008055 (IGP10) .20 [0.11-0.28] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1q31.2 1 191939788 NR 339479 64407 1493.03 187.80 rs17403780-T rs17403780 0 17403780 1 0.910622742901786 1E-6 5.999999999999999 (IGP10) .34 [0.2-0.47] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20p12.1 20 17825143 NR 140836 27131 108.63 97.10 rs2077147-C rs2077147 0 2077147 1 0.336549315178571 3E-6 5.522878745280337 (IGP10) .16 [0.091-0.223] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 SMARCB1,DERL3 - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.189377544642857 9E-10 9.045757490560675 (IGP10) .26 [0.17-0.34] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9q21.2 9 80320365 NR 9630 2776 57.13 14.82 rs4745661-G rs4745661 0 4745661 1 0.684846625 3E-6 5.522878745280337 (IGP10) .16 [0.094-0.23] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10p11.22 10 33405087 NR 401640 8829 57.73 61.33 rs7902627-C rs7902627 0 7902627 1 0.135378764285714 8E-6 5.096910013008055 (IGP10) .20 [0.11-0.29] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q23.3 12 105452442 NR - 160428 rs10861337-G rs10861337 0 10861337 intron 0 0.900366844872369 2E-7 6.698970004336019 (IGP11) .27 [0.16-0.37] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q21.32 17 45835278 NR 30009 114881 11.79 49.46 rs11651000-G rs11651000 0 11651000 1 0.840287136139722 8E-6 5.096910013008055 (IGP11) .19 [0.11-0.27] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1q42.12 1 225590675 NR - 3930 rs16844841-C rs16844841 0 16844841 UTR-3 0 0.0583146565158979 4E-6 5.397940008672037 (IGP11) .32 [0.18-0.45] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q21.3 14 48054159 NR - 161357 rs4143912-G rs4143912 0 4143912 intron 0 0.417046732532265 7E-6 5.154901959985742 (IGP45) .14 [0.08-0.205] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20p13 20 549918 NR 1457 6939 25.44 34.72 rs6084946-C rs6084946 0 6084946 1 0.233844371161549 5E-6 5.301029995663981 (IGP45) .22 [0.12-0.31] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10q21.2 10 63695048 NR - 84159 rs6479779-C rs6479779 0 6479779 intron 0 0.345248463284379 1E-6 5.999999999999999 (IGP45) .19 [0.12-0.27] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p12.2 7 50346134 NR - 10320 rs7781977-C rs7781977 0 7781977 0 0.695324747663551 5E7 -7.698970004336018 (IGP45) .17 [0.1-0.23] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.31 22 44204319 NR - 64800 rs8140172-C rs8140172 0 8140172 intron 0 0.985708288681948 6E-6 5.221848749616356 (IGP45) .88 [0.5-1.26] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39859169 SYNGR1,TAB1,MGAT3,CACNA1I - 4248 rs909674-C rs909674 0 909674 intron 0 0.299013119715176 3E-13 12.52287874528034 (IGP45) .25 [0.18-0.31] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q21.13 7 88695070 NR - 219578 rs10236237-T rs10236237 0 10236237 intron 0 0.267777818671454 5E-6 5.301029995663981 (IGP46) .16 [0.092-0.23] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q21.32 17 45835278 NR 30009 114881 11.79 49.46 rs11651000-G rs11651000 0 11651000 1 0.83992863016158 9E-6 5.045757490560675 (IGP46) .19 [0.11-0.27] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q23.3 14 65775695 NR 122888 100616176 27.32 26.14 rs11847263-G rs11847263 0 11847263 1 0.393307344254937 2E-13 12.69897000433602 (IGP46) .23 [0.17-0.29] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4q26 4 117849449 NR 100421002 133022 69.32 155.26 rs2389339-G rs2389339 0 2389339 1 0.790110045780969 2E-6 5.698970004336018 (IGP46) .18 [0.11-0.26] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p12.2 7 50350267 NR - 10320 rs6583437-G rs6583437 0 6583437 0 0.637533007630161 4E-8 7.397940008672037 (IGP46) .17 [0.11-0.24] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186725887 ST6GAL1 - 6480 rs11710456-G rs11710456 0 11710456 intron 0 0.698919993324432 5E-6 5.301029995663981 (IGP47) .16 [0.092-0.23] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q13.2 3 113430599 NR 205717 80218 15.11 4.71 rs11711311-G rs11711311 0 11711311 1 0.396079672452158 4E-7 6.397940008672037 (IGP47) .16 [0.1-0.227] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2q36.3 2 230349989 NR - 92737 rs11890081-C rs11890081 0 11890081 intron 0 0.0172129438807299 8E-6 5.096910013008055 (IGP47) .68 [0.38-0.98] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8q13.3 8 71544748 NR - 286190 rs13272623-G rs13272623 0 13272623 intron 0 0.154915348909657 2E-6 5.698970004336018 (IGP47) .22 [0.13-0.31] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q13.11 3 103513436 NR 100616336 100189440 270.48 366.09 rs1673866-C rs1673866 0 1673866 1 0.63878196306186 7E-6 5.154901959985742 (IGP47) .14 [0.081-0.206] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10q21.1 10 53262633 NR - 5592 rs1952138-C rs1952138 0 1952138 intron 0 0.766987149087672 3E-6 5.522878745280337 (IGP47) .17 [0.1-0.24] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2q31.1 2 177012578 NR 100506783 406903 10.75 2.45 rs4972806-C rs4972806 0 4972806 1 0.635161429906542 8E-6 5.096910013008055 (IGP47) .14 [0.08-0.205] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12q23.3 12 104034319 NR - 55576 rs1650123-C rs1650123 0 1650123 intron 0 0.577816124610592 1E-6 5.999999999999999 (IGP48) .16 [0.097-0.229] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q25.1 3 150697208 NR - 116933 rs16863118-C rs16863118 0 16863118 intron 0 0.836539205162439 7E-7 6.154901959985743 (IGP48) .20 [0.12-0.29] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2p16.1 2 55973732 NR 87178 2202 52.72 119.37 rs2163237-C rs2163237 0 2163237 1 0.671727695594125 5E-6 5.301029995663981 (IGP48) .15 [0.087-0.217] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p22.1 7 5880377 NR - 401303 rs308097-G rs308097 0 308097 ncRNA 0 0.966564075211393 2E-6 5.698970004336018 (IGP48) .43 [0.25-0.61] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 16q23.3 16 81960958 NR - 5336 rs3813009-C rs3813009 0 3813009 intron 0 0.223729928793947 4E-6 5.397940008672037 (IGP48) .19 [0.11-0.27] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3p24.3 3 20957810 NR 100873800 391518 723.44 489.41 rs6787231-C rs6787231 0 6787231 1 0.900662045838896 5E-6 5.301029995663981 (IGP48) .26 [0.15-0.37] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 16p12.3 16 18062136 NR 146110 353512 34.93 366.12 rs7194356-C rs7194356 0 7194356 1 0.895432401869159 7E-6 5.154901959985742 (IGP48) .23 [0.13-0.32] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q23.1 6 130886437 NR 114801 100507203 122.23 262.11 rs9492645-G rs9492645 0 9492645 1 0.947434826924789 7E-6 5.154901959985742 (IGP48) .33 [0.19-0.47] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10p13 10 13355131 NR 5264 22929 13.00 4.31 rs1095368-C rs1095368 0 1095368 1 0.437467493541203 7E-7 6.154901959985743 (IGP49) .15 [0.092-0.213] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4q25 4 110897585 NR - 1950 rs11568995-G rs11568995 0 11568995 intron 0 0.9884981 4E-7 6.397940008672037 (IGP49) 1.80 [1.11-2.5] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q33.3 5 157410278 NR 644198 100421484 51.65 1.37 rs11958404-T rs11958404 0 11958404 1 0.113988281514477 8E-6 5.096910013008055 (IGP49) .23 [0.13-0.33] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1q43 1 239397104 NR 100129952 1131 180.85 395.27 rs1339738-C rs1339738 0 1339738 1 0.0857549797772829 7E-6 5.154901959985742 (IGP49) .29 [0.16-0.42] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 SMARCB1,DERL3 - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.189660889532294 7E-16 15.15490195998574 (IGP49) .34 [0.25-0.42] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4p14 4 37645389 NR - 768211 rs4832928-C rs4832928 0 4832928 intron 0 0.701397954120267 2E-6 5.698970004336018 (IGP49) .16 [0.096-0.229] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4q35.1 4 183300614 NR - 55714 rs4862046-G rs4862046 0 4862046 intron 0 0.907610376436526 6E-7 6.221848749616355 (IGP49) .28 [0.17-0.39] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.31 22 44561287 NR - 29780 rs5764106-C rs5764106 0 5764106 intron 0 0.229970760801782 2E-6 5.698970004336018 (IGP49) .20 [0.12-0.28] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39859169 SYNGR1,TAB1,MGAT3,CACNA1I - 4248 rs909674-C rs909674 0 909674 intron 0 0.299056983073497 3E-9 8.522878745280337 (IGP49) .20 [0.13-0.27] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q23.1 6 130886437 NR 114801 100507203 122.23 262.11 rs9492645-G rs9492645 0 9492645 1 0.947434826924789 5E-6 5.301029995663981 (IGP8) .34 [0.19-0.48] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186725887 ST6GAL1 - 6480 rs11710456-G rs11710456 0 11710456 intron 0 0.698889241071429 2E-6 5.698970004336018 (IGP36) .17 [0.099-0.237] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10p12.1 10 25880459 NR - 57512 rs17558301-C rs17558301 0 17558301 intron 0 0.961067 7E-6 5.154901959985742 (IGP36) 1.59 [0.9-2.28] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3p14.2 3 62782468 NR - 8618 rs304172-G rs304172 0 304172 intron 0 0.956126387053571 8E-6 5.096910013008055 (IGP36) .33 [0.19-0.48] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11p15.1 11 19051872 NR 259249 117194 95.32 24.13 rs7111562-C rs7111562 0 7111562 1 0.139875874553571 2E-6 5.698970004336018 (IGP36) .23 [0.13-0.32] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q16.3 6 104663778 NR 10837 57531 189.04 512.19 rs2744203-C rs2744203 0 2744203 1 0.0959963838018742 7E-6 5.154901959985742 (IGP39) .23 [0.13-0.33] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q22.1 6 115069717 NR 728614 2444 397.90 1192.98 rs6928844-C rs6928844 0 6928844 1 0.828187721552878 4E-6 5.397940008672037 (IGP39) .29 [0.16-0.41] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11p15.4 11 7464372 NR - 143425;100506258 rs4076555-C rs4076555 0 4076555 intron;intron 0 0.336591107706174 7E-6 5.154901959985742 (IGP4) .16 [0.09-0.229] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10q26.12 10 122043489 NR 100616322 729402 325.39 70.67 rs11199254-C rs11199254 0 11199254 1 0.994468962750716 2E-6 5.698970004336018 (IGP40) 1.56 [0.91-2.21] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 SMARCB1,DERL3 - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.189496820649755 1E-10 10 (IGP40) .27 [0.18-0.35] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q22.1 6 115069717 NR 728614 2444 397.90 1192.98 rs6928844-C rs6928844 0 6928844 1 0.828248277703605 7E-6 5.154901959985742 (IGP40) .28 [0.16-0.4] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q21.3 5 107731958 NR 64839 6225 14.16 197.23 rs1001579-G rs1001579 0 1001579 1 0.167464012461059 7E-6 5.154901959985742 (IGP43) .18 [0.1-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q11.2 5 55322895 IL6ST,ANKRD55 3572 727984 32.07 109.88 rs17348299-C rs17348299 0 17348299 1 0.836731980863373 3E-10 9.522878745280336 (IGP43) .28 [0.19-0.37] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 19q13.42 19 53780026 NR 317703 646508 9.11 5.52 rs2965260-C rs2965260 0 2965260 1 0.898395713962946 9E-6 5.045757490560675 (IGP44) .23 [0.13-0.33] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8q11.21 8 51384987 NR - 54212 rs13272236-G rs13272236 0 13272236 intron 0 0.0367158118323747 6E-7 6.221848749616355 (IGP45) .84 [0.51-1.17] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1q31.2 1 191939788 NR 339479 64407 1493.03 187.80 rs17403780-T rs17403780 0 17403780 1 0.910603886426346 6E-6 5.221848749616356 (IGP45) .31 [0.18-0.45] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q31.1 7 107443386 NR - 1811 rs4730268-C rs4730268 0 4730268 intron 0 0.783243083222074 5E-6 5.301029995663981 (IGP48) .17 [0.096-0.24] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8q24.3 8 143020731 NR 100302147 100616268 153.06 236.97 rs7845056-C rs7845056 0 7845056 1 0.409235014686248 9E-6 5.045757490560675 (IGP48) .18 [0.099-0.256] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 21q22.11 21 33296113 NR - 30811 rs11910494-G rs11910494 0 11910494 intron 0 0.288747077060134 8E-6 5.096910013008055 (IGP49) .15 [0.083-0.213] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q25.3 17 76311991 NR 390816 9021 59.73 40.87 rs4789580-G rs4789580 0 4789580 1 0.203878510467706 9E-6 5.045757490560675 (IGP49) .23 [0.13-0.33] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1q41 1 216504269 NR - 7399 rs7532570-G rs7532570 0 7532570 intron 0 0.0626114699331849 6E-6 5.221848749616356 (IGP49) .29 [0.17-0.42] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12p13.31 12 5751342 NR - 57101 rs2110166-C rs2110166 0 2110166 intron 0 0.983043522563177 5E-6 5.301029995663981 (IGP52) .57 [0.32-0.81] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20p13 20 4387134 NR 146 128668 157.48 184.45 rs586446-C rs586446 0 586446 1 0.118307047833935 5E-6 5.301029995663981 (IGP52) .22 [0.13-0.32] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11q22.3 11 107347277 NR 100271884 91801 71.91 26.18 rs11212260-C rs11212260 0 11212260 1 0.0281428517133956 9E-6 5.045757490560675 (IGP53) .44 [0.25-0.64] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p14.3 7 34697140 NR - 387129;404744 rs2530545-C rs2530545 0 2530545 nearGene-5;intron 0 0.806018537605697 7E-6 5.154901959985742 (IGP53) .19 [0.11-0.27] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8q13.1 8 66624232 NR 9650 5150 1.43 2.34 rs10504390-G rs10504390 0 10504390 1 0.0804795064530485 2E-7 6.698970004336019 (IGP54) .29 [0.18-0.4] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11q22.3 11 107347277 NR 100271884 91801 71.91 26.18 rs11212260-C rs11212260 0 11212260 1 0.0281428517133956 7E-6 5.154901959985742 (IGP57) .45 [0.25-0.65] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p13.3 9 36099399 RECK - 8434 rs4878639-C rs4878639 0 4878639 intron 0 0.263725273253227 1E-6 5.999999999999999 (IGP57) .17 [0.1-0.24] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q23.3 14 65775695 FUT8 122888 100616176 27.32 26.14 rs11847263-G rs11847263 0 11847263 1 0.39336899642538 2E-19 18.69897000433602 (IGP58) .29 [0.22-0.35] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 18q22.3 18 69379390 NR 342808 147381 1280.99 824.53 rs2887004-G rs2887004 0 2887004 1 0.181545600983021 2E-6 5.698970004336018 (IGP58) .19 [0.11-0.27] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8p12 8 31034275 NR 7486 3084 3.00 462.55 rs11774682-C rs11774682 0 11774682 1 0.966250893300248 1E-6 5.999999999999999 (IGP59) .83 [0.49-1.16] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p12.2 7 50350267 NR - 10320 rs6583437-G rs6583437 0 6583437 0 0.636609333927775 7E-6 5.154901959985742 (IGP61) .14 [0.081-0.205] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q13.11 3 103450591 NR 100616336 100189440 207.63 428.93 rs2677247-C rs2677247 0 2677247 1 0.602245139804096 9E-6 5.045757490560675 (IGP62) .14 [0.079-0.204] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q23.3 14 65758642 NR 122888 100616176 10.27 43.19 rs7159888-G rs7159888 0 7159888 1 0.550559034728406 2E-6 5.698970004336018 (IGP62) .15 [0.086-0.207] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 18q23 18 75638023 NR 724038 27164 488.82 1102.25 rs12455580-C rs12455580 0 12455580 1 0.662723558771149 2E-6 5.698970004336018 (IGP65) .17 [0.1-0.24] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.32 6 32953280 NR 6046 3111 4.00 18.68 rs3097645-C rs3097645 0 3097645 1 0.872971129118433 6E-7 6.221848749616355 (IGP65) .23 [0.14-0.31] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q21.2 7 91240297 NR 100132321 7978 289.79 261.72 rs2540552-C rs2540552 0 2540552 1 0.58104074197861 8E-6 5.096910013008055 (IGP25) .14 [0.078-0.199] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11p12 11 41225954 NR - 57689 rs980952-G rs980952 0 980952 intron 0 0.975374875668449 5E-6 5.301029995663981 (IGP25) .45 [0.26-0.64] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8q21.11 8 76036444 NR 83690 100874436 89.65 178.09 rs1531590-C rs1531590 0 1531590 1 0.227292733303651 3E-6 5.522878745280337 (IGP26) .18 [0.1-0.25] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q25.3 17 78066617 NR - 55036 rs2361701-G rs2361701 0 2361701 intron 0 0.823049887254902 4E-6 5.397940008672037 (IGP28) .19 [0.11-0.26] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q27.3 3 186725887 ST6GAL1 - 6480 rs11710456-G rs11710456 0 11710456 intron 0 0.699317446770601 6E-75 74.22184874961634 (IGP29) .64 [0.57-0.71] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q14.1 5 78943648 NR - 167153 rs6859704-C rs6859704 0 6859704 intron 0 0.0769240376391982 8E-6 5.096910013008055 (IGP29) .26 [0.15-0.37] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2p25.3 2 1557927 NR 7173 7837 11.43 77.73 rs10206020-C rs10206020 0 10206020 1 0.188020994657168 4E-6 5.397940008672037 (IGP3) .18 [0.1-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10q26.2 10 130233808 NR 4288 4255 309.34 1031.65 rs10764775-C rs10764775 0 10764775 1 0.340436585930543 6E-6 5.221848749616356 (IGP31) .14 [0.081-0.206] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 10q26.12 10 121821538 NR 100616322 729402 103.43 292.62 rs17621444-C rs17621444 0 17621444 1 0.722329589937667 3E-6 5.522878745280337 (IGP31) .16 [0.095-0.233] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1q25.3 1 181655752 NR - 777 rs3845441-C rs3845441 0 3845441 intron 0 0.127711492920748 7E-6 5.154901959985742 (IGP31) .21 [0.12-0.3] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p14.2 7 37067395 NR - 9844 rs10488029-G rs10488029 0 10488029 intron 0 0.10578790637539 4E-6 5.397940008672037 (IGP35) .23 [0.13-0.33] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q12.1 22 27041283 NR - 100287193 rs16982515-C rs16982515 0 16982515 0 0.919024750334374 3E-6 5.522878745280337 (IGP35) .31 [0.18-0.44] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 1,848 European ancestry individuals 3q27.3 3 186725887 ST6GAL1 - 6480 rs11710456-G rs11710456 0 11710456 intron 0 0.6936 8E-7 6.096910013008056 (IgG1G2) .04 [0.027-0.061] unit decrease Illumina [~ 2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 1,848 European ancestry individuals 9p21.1 9 33124872 B4GALT1 - 2683 rs12342831-T rs12342831 0 12342831 intron 0 0.73755 5E-8 7.30102999566398 (IgG1G2) .05 [0.032-0.068] unit increase Illumina [~ 2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 1,848 European ancestry individuals 22q13.1 22 39859169 SYNGR1, TAB1, MGAT3, CACNA1I - 4248 rs909674-C rs909674 0 909674 intron 0 0.29096 3E-8 7.522878745280337 (IgG1G0N) .08 [0.054-0.112] unit increase Illumina [~ 2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 1,848 European ancestry individuals 22q11.23 22 24170996 SMARCB1, DERL3 - 6598 rs2186369-T rs2186369 0 2186369 intron 0 0.81823 2E-7 6.698970004336019 (IgG1G1N) .07 [0.042-0.092] unit increase Illumina [~ 2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 1,848 European ancestry individuals 22q13.1 22 39859169 SYNGR1, TAB1, MGAT3, CACNA1I - 4248 rs909674-C rs909674 0 909674 intron 0 0.29096 2E-10 9.698970004336017 (IgG1G1N) .07 [0.050-0.094] unit increase Illumina [~ 2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 1,848 European ancestry individuals 22q13.1 22 39859169 SYNGR1, TAB1, MGAT3, CACNA1I - 4248 rs909674-C rs909674 0 909674 intron 0 0.29096 9E-6 5.045757490560675 (IgG1G2N) .07 [0.036-0.094] unit increase Illumina [~ 2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q15 5 95273410 NR - 22936 rs7700895-T rs7700895 0 7700895 intron 0 0.783746748105216 1E-6 5.999999999999999 (IGP35) .18 [0.11-0.25] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17p12 17 13708861 NR 9955 94158 203.62 218.95 rs7215286-C rs7215286 0 7215286 1 0.961960845948353 3E-6 5.522878745280337 (IGP65) .40 [0.23-0.57] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 20p12.1 20 17829280 NR 140836 27131 112.76 92.96 rs2745851-G rs2745851 0 2745851 1 0.639172889630619 2E-6 5.698970004336018 (IGP66) .15 [0.089-0.216] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3p13 3 72518040 NR 23429 55164 22.27 280.39 rs9832314-G rs9832314 0 9832314 1 0.055934898976413 9E-6 5.045757490560675 (IGP66) .30 [0.17-0.43] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 SMARCB1,DERL3 - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.189580990204809 8E-15 14.09691001300805 (IGP68) .32 [0.24-0.41] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39859169 SYNGR1,TAB1,MGAT3,CACNA1I - 4248 rs909674-C rs909674 0 909674 intron 0 0.298923976402493 6E-10 9.221848749616356 (IGP68) .21 [0.14-0.28] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q11.2 5 55322895 IL6ST,ANKRD55 3572 727984 32.07 109.88 rs17348299-C rs17348299 0 17348299 1 0.836804684351315 2E-6 5.698970004336018 (IGP69) .21 [0.12-0.3] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2p21 2 46550769 NR - 2034 rs7582701-C rs7582701 0 7582701 intron 0 0.0373370440481498 1E-6 5.999999999999999 (IGP69) .45 [0.27-0.64] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3p12.3 3 76725903 NR - 6092 rs10511052-G rs10511052 0 10511052 intron 0 0.950688225100133 6E-6 5.221848749616356 (IGP7) .36 [0.2-0.52] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5p13.2 5 36473237 NR 202151 100271028 171.23 115.37 rs2937550-C rs2937550 0 2937550 1 0.537253260908281 9E-6 5.045757490560675 (IGP72) .18 [0.1-0.26] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39859169 SYNGR1,TAB1,MGAT3,CACNA1I - 4248 rs909674-C rs909674 0 909674 intron 0 0.299146275601069 2E-15 14.69897000433602 (IGP72) .27 [0.2-0.34] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p21.3 7 11291400 NR 9678 10836 82.15 5.60 rs4720952-G rs4720952 0 4720952 1 0.419614954873646 4E-7 6.397940008672037 (IGP73) .16 [0.096-0.217] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 15q24.1 15 73749608 NR - 283677 rs11635553-G rs11635553 0 11635553 intron 0 0.992804206752874 4E-6 5.397940008672037 (IGP74) 1.08 [0.62-1.54] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q11.2 5 55322895 IL6ST,ANKRD55 3572 727984 32.07 109.88 rs17348299-C rs17348299 0 17348299 1 0.836669484361037 2E-6 5.698970004336018 (IGP74) .21 [0.13-0.3] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q12.1 5 61025082 NR 285668 3796 22.72 576.91 rs4699982-T rs4699982 0 4699982 1 0.158658866845398 9E-6 5.045757490560675 (IGP74) .19 [0.11-0.28] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 33128021 NR - 2683 rs10813951-G rs10813951 0 10813951 intron 0 0.262743396083667 3E-6 5.522878745280337 (IGP76) .17 [0.097-0.237] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2p12 2 77246331 NR - 80059 rs6547115-G rs6547115 0 6547115 intron 0 0.391438525144637 8E-6 5.096910013008055 (IGP76) .14 [0.08-0.206] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2q35 2 220864654 NR 100422959 2043 93.37 1418.09 rs10198756-C rs10198756 0 10198756 1 0.139068532490975 3E-6 5.522878745280337 (IGP77) .21 [0.12-0.29] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4q34.2 4 176648332 NR - 2823 rs9284954-C rs9284954 0 9284954 intron 0 0.444965493231047 5E-6 5.301029995663981 (IGP77) .14 [0.081-0.203] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q25.3 6 156657842 NR 100302259 100189513 389.83 211.20 rs12213468-G rs12213468 0 12213468 1 0.655773469069871 7E-6 5.154901959985742 (IGP8) .15 [0.082-0.209] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1p31.1 1 78987302 NR - 5737 rs672561-C rs672561 0 672561 intron 0 0.257740490431687 9E-6 5.045757490560675 (IGP8) .17 [0.094-0.242] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17p11.2 17 17142896 NR 201163 8533 2.39 7.04 rs12600635-G rs12600635 0 12600635 1 0.145679882058288 4E-7 6.397940008672037 (IGP41) .22 [0.14-0.31] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.32 6 32674737 NR 404026 3118 .16 34.43 rs1794265-C rs1794265 0 1794265 1 0.945425811930783 3E-7 6.522878745280337 (IGP41) .34 [0.21-0.48] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 16p12.3 16 20031205 NR 51704 124274 135.05 11.84 rs2764743-T rs2764743 0 2764743 1 0.936472894262295 8E-7 6.096910013008056 (IGP41) .35 [0.21-0.48] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 21q22.3 21 42793791 NR - 4599 rs459482-C rs459482 0 459482 UTR-5 0 0.594327337431694 3E-7 6.522878745280337 (IGP41) .16 [0.1-0.22] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.33 6 31802465 NR - 26801;50854 rs4711279-C rs4711279 0 4711279 nearGene-5;nearGene-5 0 0.824607758652095 1E-6 5.999999999999999 (IGP41) .19 [0.11-0.26] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11q13.2 11 67931761 SUV420H1 - 51111 rs4930561-G rs4930561 0 4930561 intron 0 0.511382618397086 9E-10 9.045757490560675 (IGP41) .19 [0.13-0.24] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 12p13.31 12 7334813 NR 9746 5830 23.27 6.95 rs7973719-C rs7973719 0 7973719 1 0.487491611566485 4E-8 7.397940008672037 (IGP41) .18 [0.11-0.24] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 18q21.1 18 46240711 NR - 9811 rs9947954-C rs9947954 0 9947954 intron 0 0.425160203096539 8E-6 5.096910013008055 (IGP41) .14 [0.078-0.201] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 18q22.3 18 72897161 NR 55628 284273 119.53 12.12 rs9948784-G rs9948784 0 9948784 1 0.9873229 2E-6 5.698970004336018 (IGP41) 1.77 [1.04-2.5] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.32 6 32726803 HLA-DQA2, HLA-DQB2 - 3120 rs1049110-C rs1049110 0 1049110 missense 0 0.346381764494382 2E-8 7.698970004336018 (IGP42) .19 [0.12-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q36.1 7 150915071 ABCF2,SMARCD3 - 10061 rs1122979-G rs1122979 0 1122979 intron 0 0.874862054831461 1E-9 8.999999999999998 (IGP42) .30 [0.2-0.39] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8p12 8 31034275 NR 7486 3084 3.00 462.55 rs11774682-C rs11774682 0 11774682 1 0.966180189368771 3E-6 5.522878745280337 (IGP42) .80 [0.47-1.14] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q23.3 14 65775695 FUT8 122888 100616176 27.32 26.14 rs11847263-G rs11847263 0 11847263 1 0.391170597752809 3E-21 20.52287874528034 (IGP42) .30 [0.24-0.37] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.33 6 30679628 NR - 9656 rs3094093-T rs3094093 0 3094093 intron 0 0.107325880449438 3E-6 5.522878745280337 (IGP42) .23 [0.14-0.33] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.32 6 32953280 NR 6046 3111 4.00 18.68 rs3097645-C rs3097645 0 3097645 1 0.874270331235955 2E-6 5.698970004336018 (IGP42) .22 [0.13-0.3] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.33 6 31930441 NR - 6499 rs592229-G rs592229 0 592229 intron 0 0.370399655280899 4E-6 5.397940008672037 (IGP42) .15 [0.088-0.219] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q13.1 22 39859169 SYNGR1,TAB1,MGAT3,CACNA1I - 4248 rs909674-C rs909674 0 909674 intron 0 0.299013119715176 1E-24 24 (IGP40) .34 [0.28-0.41] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2q12.1 2 103388594 NR - 130827 rs12465996-C rs12465996 0 12465996 intron 0 0.864380324681238 5E-6 5.301029995663981 (IGP41) .24 [0.14-0.35] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 15q13.3 15 33493221 NR 342184 100652857 133.14 35.46 rs6494964-G rs6494964 0 6494964 1 0.685883860674157 8E-6 5.096910013008055 (IGP42) .18 [0.1-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7p12.2 7 50350267 NR - 10320 rs6583437-G rs6583437 0 6583437 0 0.636802753258427 7E-10 9.154901959985741 (IGP42) .20 [0.13-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q31.1 5 131721749 NR - 6584 rs7731390-C rs7731390 0 7731390 intron 0 0.947771454651685 2E-6 5.698970004336018 (IGP42) .38 [0.23-0.54] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 1q32.3 1 214457009 NR - 56950 rs9308433-C rs9308433 0 9308433 intron 0 0.408306478651685 2E-6 5.698970004336018 (IGP42) .15 [0.088-0.211] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 2p25.3 2 1557927 NR 7173 7837 11.43 77.73 rs10206020-C rs10206020 0 10206020 1 0.188382478860703 3E-6 5.522878745280337 (IGP43) .18 [0.1-0.26] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9p21.1 9 33153527 NR - 2683 rs10813957-G rs10813957 0 10813957 intron 0 0.738414638629283 7E-6 5.154901959985742 (IGP43) .16 [0.09-0.23] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 18q21.1 18 46227444 NR - 9811 rs16949825-C rs16949825 0 16949825 intron 0 0.902274750778816 3E-6 5.522878745280337 (IGP43) .25 [0.15-0.36] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q31.1 7 113741105 NR - 93986 rs6466479-G rs6466479 0 6466479 intron 0 0.122643248331108 6E-6 5.221848749616356 (IGP43) .22 [0.12-0.31] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 8p22 8 14113816 NR - 137868 rs9886428-G rs9886428 0 9886428 intron 0 0.455051607476636 1E-6 5.999999999999999 (IGP43) .15 [0.088-0.208] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 14q32.11 14 90227251 NR 317775 90141 22.47 36.22 rs2093746-C rs2093746 0 2093746 1 0.265047574785359 2E-7 6.698970004336019 (IGP44) .29 [0.18-0.4] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6q15 6 90657783 BACH2 - 60468 rs404256-C rs404256 0 404256 intron 0 0.55888563217352 5E-6 5.301029995663981 (IGP44) .17 [0.095-0.237] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 3q25.2 3 153478423 NR 5912 100271162 592.16 263.16 rs6794649-C rs6794649 0 6794649 1 0.159404027112517 2E-6 5.698970004336018 (IGP44) .20 [0.12-0.28] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 4p15.31 4 21206490 NR - 80333 rs1023721-T rs1023721 0 1023721 intron 0 0.941491348153093 1E-6 5.999999999999999 (IGP45) .31 [0.19-0.44] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 7q36.1 7 150915071 ABCF2,SMARCD3 - 10061 rs1122979-G rs1122979 0 1122979 intron 0 0.875396395193591 6E-10 9.221848749616356 (IGP45) .30 [0.21-0.4] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 9q22.32 9 98816484 NR 375748 100128771 85.36 91.81 rs1547201-C rs1547201 0 1547201 1 0.530022081441923 7E-6 5.154901959985742 (IGP45) .14 [0.08-0.203] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 5q11.2 5 55324802 NR 3572 727984 33.98 107.97 rs16884711-C rs16884711 0 16884711 1 0.188959846461949 3E-6 5.522878745280337 (IGP45) .19 [0.11-0.27] unit increase Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 22q11.23 22 24170996 SMARCB1,DERL3 - 6598 rs2186369-G rs2186369 0 2186369 intron 0 0.189496820649755 4E-6 5.397940008672037 (IGP45) .19 [0.11-0.27] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 6p21.32 6 32114515 PRRT1 63943 80863 16.45 1.63 rs9296009-T rs9296009 0 9296009 1 0.196432337204109 4E-8 7.397940008672037 (IGP23) .21 [0.14-0.29] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 17q25.3 17 79218714 NR - 124565 rs2659005-C rs2659005 0 2659005 nearGene-3 0 0.517358149665924 3E-7 6.522878745280337 (IGP24) .16 [0.1-0.23] unit decrease Illumina [~2.5 Million] (Imputed) N 06/14/2013 23382691 Lauc G 01/31/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23382691 Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. IgG glycosylation 2,247 European ancestry individuals 11p15.4 11 5688024 NR - 85363 rs11820502-C rs11820502 0 11820502 intron 0 0.287492850713013 1E-6 5.999999999999999 (IGP25) .18 [0.11-0.26] unit decrease Illumina [~2.5 Million] (Imputed) N 05/01/2013 23364394 Lee JY 01/31/2013 J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23364394 A genome-wide association study of a coronary artery disease risk variant. Coronary heart disease 2,123 Korean ancestry cases; 3,591 Korean ancestry controls 3,052 Japanese ancestry cases; 4,976 Japanese ancestry controls 9p21.3 9 22103813 CDKN2A/2B - 100048912 rs1333042-? rs1333042 0 1333042 intron 0 NR 1E-9 8.999999999999998 1.30 [1.19-1.41] Affymetrix [521,786] N 05/01/2013 23364394 Lee JY 01/31/2013 J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23364394 A genome-wide association study of a coronary artery disease risk variant. Coronary heart disease 2,123 Korean ancestry cases; 3,591 Korean ancestry controls 3,052 Japanese ancestry cases; 4,976 Japanese ancestry controls 12q24.12 12 112168009 ACAD10, ALDH2, C12orf51, RPL6-PTPN11 - 80724 rs11066015-A rs11066015 0 11066015 intron 0 NR 5E-11 10.30102999566398 1.41 [1.27-1.56] Affymetrix [521,786] N 05/01/2013 23364394 Lee JY 01/31/2013 J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23364394 A genome-wide association study of a coronary artery disease risk variant. Coronary heart disease 2,123 Korean ancestry cases; 3,591 Korean ancestry controls 3,052 Japanese ancestry cases; 4,976 Japanese ancestry controls 13q12.3 13 28984063 FLT1 - 2321 rs9508025-C rs9508025 0 9508025 intron 0 0.50 6E-7 6.221848749616355 1.14 [1.08-1.20] Affymetrix [521,786] N 05/01/2013 23364394 Lee JY 01/31/2013 J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23364394 A genome-wide association study of a coronary artery disease risk variant. Coronary heart disease 2,123 Korean ancestry cases; 3,591 Korean ancestry controls 3,052 Japanese ancestry cases; 4,976 Japanese ancestry controls 12q24.11 12 111350655 MYL2 - 4633 rs3782889-C rs3782889 0 3782889 intron 0 0.21 4E-14 13.39794000867204 1.26 [1.19-1.34] Affymetrix [521,786] N 05/01/2013 23364394 Lee JY 01/31/2013 J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23364394 A genome-wide association study of a coronary artery disease risk variant. Coronary heart disease 2,123 Korean ancestry cases; 3,591 Korean ancestry controls 3,052 Japanese ancestry cases; 4,976 Japanese ancestry controls 12q24.11 12 111679214 CUX2 - 23316 rs886126-T rs886126 0 886126 intron 0 0.66 1E-6 5.999999999999999 1.14 [1.08-1.20] Affymetrix [521,786] N 05/01/2013 23372041 Chu AY 01/30/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23372041 Novel locus including FGF21 is associated with dietary macronutrient intake. Dietary macronutrient intake 33,533 European ancestry individuuals 38,360 European ancestry individuuals 2q24.2 2 161894663 TANK 100616364 10010 630.27 98.80 rs197273-A rs197273 0 197273 1 0.48 1E-7 7 (Carbohydrates - model 2) .23 [0.15-0.31] percent increase Illumina and Affymetrix [~2.6 million] (Imputed) N 05/01/2013 23372041 Chu AY 01/30/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23372041 Novel locus including FGF21 is associated with dietary macronutrient intake. Dietary macronutrient intake 33,533 European ancestry individuuals 38,360 European ancestry individuuals 1q32.3 1 214261350 PROXI 5629 56950 46.50 193.22 rs1440620-T rs1440620 0 1440620 1 0.65 1E-6 5.999999999999999 (Protein - model 2) .12 [0.069-0.163] percent decrease Illumina and Affymetrix [~2.6 million] (Imputed) N 05/01/2013 23372041 Chu AY 01/30/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23372041 Novel locus including FGF21 is associated with dietary macronutrient intake. Dietary macronutrient intake 33,533 European ancestry individuuals 38,360 European ancestry individuuals 19q13.33 19 49259529 FGF21, FUT1, FUT2, IZUMO1, RASIP1 - 2523;26291 rs838133-A rs838133 0 838133 nearGene-5;cds-synon 0 0.45 8E-9 8.096910013008056 (Protein - model 2) .11 [0.071-0.149] percent decrease Illumina and Affymetrix [~2.6 million] (Imputed) N 05/16/2013 23386860 Pasquale LR 01/30/2013 Front Genet http://www.ncbi.nlm.nih.gov/pubmed/23386860 Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes. Type 2 diabetes (dietary heme iron intake interaction) 1,806 European ancestry cases, 2,965 European ancestry controls NR 9q31.3 9 113419759 MUSK, SVEP1 79987 100271236 77.60 69.97 rs10980508-? rs10980508 0 10980508 1 NR 1E-6 5.999999999999999 .64 [NR] unit increase Affymetrix [681,770] N 05/16/2013 23386860 Pasquale LR 01/30/2013 Front Genet http://www.ncbi.nlm.nih.gov/pubmed/23386860 Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes. Type 2 diabetes (dietary heme iron intake interaction) 1,806 European ancestry cases, 2,965 European ancestry controls NR 22q13.31 22 44248504 SULT4A1 - 25830 rs470089-? rs470089 0 470089 intron 0 NR 9E-6 5.045757490560675 .55 [NR] unit decrease Affymetrix [681,770] N 05/16/2013 23386860 Pasquale LR 01/30/2013 Front Genet http://www.ncbi.nlm.nih.gov/pubmed/23386860 Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes. Type 2 diabetes (dietary heme iron intake interaction) 1,806 European ancestry cases, 2,965 European ancestry controls NR 16p12.1 16 24810681 TNRC6A - 27327 rs17177078-? rs17177078 0 17177078 intron 0 NR 5E-6 5.301029995663981 .83 [NR] unit increase Affymetrix [681,770] N 05/16/2013 23386860 Pasquale LR 01/30/2013 Front Genet http://www.ncbi.nlm.nih.gov/pubmed/23386860 Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes. Type 2 diabetes (dietary heme iron intake interaction) 1,806 European ancestry cases, 2,965 European ancestry controls NR 7p21.1 7 16889812 AGR2, AGR3 - 100287613 rs1525739-? rs1525739 0 1525739 0 NR 6E-6 5.221848749616356 .44 [NR] unit decrease Affymetrix [681,770] N 05/02/2013 23364009 Yang X 01/30/2013 Am J Clin Nutr http://www.ncbi.nlm.nih.gov/pubmed/23364009 Common variants at 12q24 are associated with drinking behavior in Han Chinese. Drinking behavior 1,420 Han Chinese cases, 3,590 Han Chinese controls 4,896 Han Chinese cases, 13,293 Han Chinese controls 12q24.13 12 112817783 C12orf51, CCDC63, MYL2, ALDH2 - 283450 rs11066280-T rs11066280 0 11066280 intron 0 0.84 3E-215 214.5228787452803 3.33 [3.23-3.45] Affymetrix [~2.2 Million] (Imputed) N 04/27/2013 23358156 Benyamin B 01/29/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23358156 Childhood intelligence is heritable, highly polygenic and associated with FNBP1L. Intelligence (childhood) 12,441 European ancestry children 5,548 European ancestry children 1q32.3 1 212392163 NR 100422947 728134 141.14 90.23 rs6540731-A rs6540731 0 6540731 1 0.415 9E-6 5.045757490560675 .05 [0.028-0.072] unit decrease Illumina & Affymetrix [138,093] (Imputed) N 04/27/2013 23358156 Benyamin B 01/29/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23358156 Childhood intelligence is heritable, highly polygenic and associated with FNBP1L. Intelligence (childhood) 12,441 European ancestry children 5,548 European ancestry children 8q23.1 8 107844447 NR 137735 100419978 61.98 340.98 rs2981205-T rs2981205 0 2981205 1 0.226 5E-6 5.301029995663981 .06 [0.035-0.085] unit decrease Illumina & Affymetrix [138,093] (Imputed) N 04/27/2013 23358156 Benyamin B 01/29/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23358156 Childhood intelligence is heritable, highly polygenic and associated with FNBP1L. Intelligence (childhood) 12,441 European ancestry children 5,548 European ancestry children 20p12.1 20 13696129 NR - 51575 rs6042314-C rs6042314 0 6042314 intron 0 0.748 7E-6 5.154901959985742 .06 [0.033-0.083] unit increase Illumina & Affymetrix [138,093] (Imputed) N 04/27/2013 23358156 Benyamin B 01/29/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23358156 Childhood intelligence is heritable, highly polygenic and associated with FNBP1L. Intelligence (childhood) 12,441 European ancestry children 5,548 European ancestry children 4q32.1 4 160282718 NR 9693 100271065 1.42 1456.86 rs6536413-A rs6536413 0 6536413 1 0.13 6E-6 5.221848749616356 .08 [0.042-0.108] unit decrease Illumina & Affymetrix [138,093] (Imputed) N 04/27/2013 23358156 Benyamin B 01/29/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23358156 Childhood intelligence is heritable, highly polygenic and associated with FNBP1L. Intelligence (childhood) 12,441 European ancestry children 5,548 European ancestry children 2p21 2 44135314 NR - 10128 rs13387221-A rs13387221 0 13387221 intron 0 0.187 9E-6 5.045757490560675 .06 [0.035-0.093] unit increase Illumina & Affymetrix [138,093] (Imputed) N 04/27/2013 23358156 Benyamin B 01/29/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23358156 Childhood intelligence is heritable, highly polygenic and associated with FNBP1L. Intelligence (childhood) 12,441 European ancestry children 5,548 European ancestry children 12p13.32 12 5131553 NR - 100507560 rs16932667-T rs16932667 0 16932667 nearGene-5 0 0.66 8E-6 5.096910013008055 .05 [0.028-0.076] unit increase Illumina & Affymetrix [138,093] (Imputed) N 05/02/2013 23358160 Borglum AD 01/29/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23358160 Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci. Schizophrenia 888 European ancestry cases, 882 European ancestry controls 2539 European ancestry cases, 5486 European ancestry controls 16p13.13 16 12077632 RUNDC2A - 92017 rs12922317-G rs12922317 0 12922317 intron 0 0.339 9E-7 6.045757490560675 1.17 Illumina [541,148] N 05/02/2013 23358160 Borglum AD 01/29/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23358160 Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci. Schizophrenia 888 European ancestry cases, 882 European ancestry controls 2539 European ancestry cases, 5486 European ancestry controls 11p15.2 11 13331226 ARNTL - 406 rs4757144-G rs4757144 0 4757144 intron 0 0.418 5E-6 5.301029995663981 1.15 Illumina [541,148] N 05/02/2013 23358160 Borglum AD 01/29/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23358160 Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci. Schizophrenia 888 European ancestry cases, 882 European ancestry controls 2539 European ancestry cases, 5486 European ancestry controls 16q23.3 16 82692812 CDH13 - 1012 rs8057927-C rs8057927 0 8057927 intron 0 0.069 1E-6 5.999999999999999 1.34 Illumina [541,148] N 05/02/2013 23358160 Borglum AD 01/29/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23358160 Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci. Schizophrenia (cytomegalovirus infection interaction) 888 European ancestry cases, 882 European ancestry controls 2539 European ancestry cases, 5486 European ancestry controls 10q21.3 10 68598292 CTNNA3 - 29119 rs7902091-A rs7902091 0 7902091 intron 0 NR 7E-7 6.154901959985743 5.33 [NR] Illumina [541,148] N 05/02/2013 23374588 Martinelli-Boneschi F 01/29/2013 Neurobiol Aging http://www.ncbi.nlm.nih.gov/pubmed/23374588 Pharmacogenomics in Alzheimer's disease: a genome-wide association study of response to cholinesterase inhibitors. Response to cholinesterase inhibitors in Alzheimer's disease 92 European ancestry cases, 77 European ancestry controls 94 European ancestry cases, 74 European ancestry controls 3q24 3 143005029 SLC9A9 - 285195 rs17636071-G rs17636071 0 17636071 intron 0 0.09 2E-6 5.698970004336018 (MMSE) 4.74 [NR] unit decrease Illumina [522,109] N 05/02/2013 23374588 Martinelli-Boneschi F 01/29/2013 Neurobiol Aging http://www.ncbi.nlm.nih.gov/pubmed/23374588 Pharmacogenomics in Alzheimer's disease: a genome-wide association study of response to cholinesterase inhibitors. Response to cholinesterase inhibitors in Alzheimer's disease 92 European ancestry cases, 77 European ancestry controls 94 European ancestry cases, 74 European ancestry controls 13q13.2[rs17798800]; 13q13.2[rs492452] Intergenic - rs17798800-? rs17798800, rs492452 0.71 7E-6 (cases vs. controls) 2.63 [1.72-4] Illumina [522,109] N 05/02/2013 23374588 Martinelli-Boneschi F 01/29/2013 Neurobiol Aging http://www.ncbi.nlm.nih.gov/pubmed/23374588 Pharmacogenomics in Alzheimer's disease: a genome-wide association study of response to cholinesterase inhibitors. Response to cholinesterase inhibitors in Alzheimer's disease 92 European ancestry cases, 77 European ancestry controls 94 European ancestry cases, 74 European ancestry controls 8q24.22[rs2270875]; 8q24.22[rs7832443] EFR3A - rs2270875-G rs2270875, rs7832443 0.16 9E-6 (MMSE) 2.84 [NR] unit decrease Illumina [522,109] N 06/05/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Oleic acid (18:1n-9) plasma levels 8,961 European ancestry individuals 6p21.32 6 32127477 PPT2, EGFL8, AGPAT1 - 9374;100532746 rs3134950-A rs3134950 0 3134950 intron;intron 0 NR 1E-6 5.999999999999999 .09 unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/05/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Oleic acid (18:1n-9) plasma levels 8,961 European ancestry individuals 13q14.12 13 45493881 NUFIP1 400129 26747 323.60 19.50 rs17648246-A rs17648246 0 17648246 1 NR 1E-6 5.999999999999999 .28 unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/05/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Oleic acid (18:1n-9) plasma levels 8,961 European ancestry individuals 10q11.23 10 50500459 C10orf71 100506733 100462986 140.87 148.40 rs17774576-C rs17774576 0 17774576 1 NR 5E-6 5.301029995663981 .39 unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 06/05/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Oleic acid (18:1n-9) plasma levels 8,961 European ancestry individuals 10q21.1 10 61146582 FAM13C1 220965 359751 23.92 164.58 rs11006464-T rs11006464 0 11006464 1 NR 5E-6 5.301029995663981 .38 unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 06/05/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Oleic acid (18:1n-9) plasma levels 8,961 European ancestry individuals 6q16.1 6 98462501 C6orf167 253714 100302164 731.45 9.91 rs12529874-A rs12529874 0 12529874 1 NR 3E-7 6.522878745280337 .48 unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/05/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Oleic acid (18:1n-9) plasma levels 8,961 European ancestry individuals 3p26.2 3 3130221 IL5RA - 3568 rs334809-A rs334809 0 334809 intron 0 NR 1E-6 5.999999999999999 .33 unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 06/05/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Oleic acid (18:1n-9) plasma levels 8,961 European ancestry individuals 7q32.3 7 132325309 PLXNA4 - 91584 rs4731889-A rs4731889 0 4731889 intron 0 NR 5E-6 5.301029995663981 .09 unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/05/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Oleic acid (18:1n-9) plasma levels 8,961 European ancestry individuals 11q12.2 11 61557803 C11orf10, C11orf9, FADS1, FADS2, FADS3, FEN1, RAB3IL1 - 746 rs102275-C rs102275 0 102275 intron 0 0.328 2E-32 31.69897000433602 .23 [0.192-0.268] unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 06/05/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Oleic acid (18:1n-9) plasma levels 8,961 European ancestry individuals 11q24.1 11 123751828 PMP22CD 79321 338661 18.60 1.81 rs12280105-A rs12280105 0 12280105 1 NR 3E-6 5.522878745280337 .71 unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitic acid (16:0) plasma levels 8,961 European ancestry individuals 10q24.31 10 102075479 PKD2L1, SCD - 9033 rs603424-A rs603424 0 603424 intron 0 NR 2E-7 6.698970004336019 .19 unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitic acid (16:0) plasma levels 8,961 European ancestry individuals 1p21.3 1 95485825 ALG14, RWDD3, CNN3, TMEM56 - 199857 rs2391388-C rs2391388 0 2391388 intron 0 0.451 3E-11 10.52287874528034 .18 [0.125-0.23] unit incease Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitic acid (16:0) plasma levels 8,961 European ancestry individuals 2p23.3 2 27742603 GCKR - 2646 rs780093-T rs780093 0 780093 intron 0 NR 3E-6 5.522878745280337 .13 unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitic acid (16:0) plasma levels 8,961 European ancestry individuals 2q14.3 2 129504351 HS6ST1 100130549 100129819 227.52 1193.07 rs7561966-A rs7561966 0 7561966 1 NR 3E-6 5.522878745280337 .68 unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitic acid (16:0) plasma levels 8,961 European ancestry individuals 7p14.3 7 32376748 LSM5 5137 442525 38.37 134.29 rs10237735-T rs10237735 0 10237735 1 NR 1E-6 5.999999999999999 .71 unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitic acid (16:0) plasma levels 8,961 European ancestry individuals 19q13.41 19 51796299 FLJ40235 114196 402665 11.86 18.80 rs10414689-T rs10414689 0 10414689 1 NR 9E-7 6.045757490560675 .78 unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitic acid (16:0) plasma levels 8,961 European ancestry individuals 12q24.32 12 128736522 SLC15A4 100616298 100500817 7.40 42.12 rs12297524-T rs12297524 0 12297524 1 NR 5E-6 5.301029995663981 .13 unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitic acid (16:0) plasma levels 8,961 European ancestry individuals 6q16.3 6 103799046 GRIK2 2898 100129694 1281.09 666.46 rs994988-T rs994988 0 994988 1 NR 2E-7 6.698970004336019 .14 unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitic acid (16:0) plasma levels 8,961 European ancestry individuals 9p23 9 11402319 PTPRD 5789 7306 789.60 1291.07 rs10809457-T rs10809457 0 10809457 1 NR 9E-7 6.045757490560675 .14 unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitic acid (16:0) plasma levels 8,961 European ancestry individuals 7q36.1 7 152387869 XRCC2 7516 644333 14.62 58.19 rs10234749-T rs10234749 0 10234749 1 NR 4E-6 5.397940008672037 .18 unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitic acid (16:0) plasma levels 8,961 European ancestry individuals 3p24.3 3 21718841 ZNF659 - 79750 rs9816269-T rs9816269 0 9816269 intron 0 NR 5E-6 5.301029995663981 .37 unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitic acid (16:0) plasma levels 8,961 European ancestry individuals 20q13.13 20 48344311 B4GALT5 9334 170550 13.89 1.82 rs1980946-C rs1980946 0 1980946 1 NR 4E-6 5.397940008672037 .30 unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitoleic acid (16:1n-7) plasma levels 8,961 European ancestry individuals 1q32.1 1 204274519 PLEKHA6 - 22874 rs7534537-T rs7534537 0 7534537 intron 0 NR 3E-6 5.522878745280337 .06 unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitoleic acid (16:1n-7) plasma levels 8,961 European ancestry individuals 14q31.1 14 81405922 C14orf45 - 145508 rs12587252-T rs12587252 0 12587252 nearGene-5 0 NR 2E-6 5.698970004336018 .08 unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitoleic acid (16:1n-7) plasma levels 8,961 European ancestry individuals 10p12.1 10 29336849 LYZL1 653665 84569 148.40 241.14 rs788076-A rs788076 0 788076 1 NR 2E-6 5.698970004336018 .04 unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitoleic acid (16:1n-7) plasma levels 8,961 European ancestry individuals 1p22.1 1 94533014 ABCA4 - 24 rs1931575-T rs1931575 0 1931575 intron 0 NR 2E-6 5.698970004336018 .02 unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitoleic acid (16:1n-7) plasma levels 8,961 European ancestry individuals 16p13.12 16 13154878 FLJ1111 - 729993 rs4465599-A rs4465599 0 4465599 intron 0 NR 4E-7 6.397940008672037 .03 unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitoleic acid (16:1n-7) plasma levels 8,961 European ancestry individuals 17q24.3 17 67850901 KCNJ16 5608 3773 312.43 220.47 rs2366017-A rs2366017 0 2366017 1 NR 3E-7 6.522878745280337 .09 unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitoleic acid (16:1n-7) plasma levels 8,961 European ancestry individuals 2q21.2 2 134529091 NAP5 344148 100500878 203.06 355.61 rs6722456-A rs6722456 0 6722456 1 0.023 4E-8 7.397940008672037 .05 [0.031-0.065] unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitoleic acid (16:1n-7) plasma levels 8,961 European ancestry individuals 10q24.31 10 102302457 HIF1AN, SEC31B, NDUFB8, WNT8B, SCD - 55662 rs11190604-A rs11190604 0 11190604 intron 0 0.782 6E-9 8.221848749616356 .02 unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitoleic acid (16:1n-7) plasma levels 8,961 European ancestry individuals 2p23.3 2 27742603 GCKR, C2orf16, ZNF512, XAB1 - 2646 rs780093-T rs780093 0 780093 intron 0 0.41 1E-9 8.999999999999998 .02 [0.014-0.027] unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitoleic acid (16:1n-7) plasma levels 8,961 European ancestry individuals 2q31.1 2 171318894 MY03B - 140469 rs2118674-A rs2118674 0 2118674 intron 0 NR 4E-7 6.397940008672037 .05 unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitoleic acid (16:1n-7) plasma levels 8,961 European ancestry individuals 16p11.1 16 35088131 LOC729355 100130059 100129627 15.97 58.26 rs12599426-T rs12599426 0 12599426 1 NR 3E-6 5.522878745280337 .02 unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitoleic acid (16:1n-7) plasma levels 8,961 European ancestry individuals 10q24.31 10 102075479 PKD2L1 - 9033 rs603424-A rs603424 0 603424 intron 0 0.193 6E-15 14.22184874961635 .03 [0.024-0.041] unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitoleic acid (16:1n-7) plasma levels 8,961 European ancestry individuals 13q13.3 13 37762637 CSNK1A1L 122011 100271551 82.84 32.36 rs2323397-A rs2323397 0 2323397 1 NR 3E-6 5.522878745280337 .04 unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitoleic acid (16:1n-7) plasma levels 8,961 European ancestry individuals 2p13.3 2 69985435 ANXA4 - 307 rs7597155-A rs7597155 0 7597155 intron 0 NR 5E-6 5.301029995663981 .01 unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Palmitoleic acid (16:1n-7) plasma levels 8,961 European ancestry individuals 11q12.2 11 61557803 C11orf0, C11orf9, FADS1, FADS2, FEN1 - 746 rs102275-T rs102275 0 102275 intron 0 0.329 7E-13 12.15490195998574 .02 [0.017-0.03] unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Stearic acid (18:0) plasma levels 8,961 European ancestry individuals 1p36.31 1 7113112 CAMTA1 - 23261;100129476 rs11120822-C rs11120822 0 11120822 intron;nearGene-5 0 NR 1E-6 5.999999999999999 .09 unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Stearic acid (18:0) plasma levels 8,961 European ancestry individuals 1q32.3 1 211918244 LPGAT1 - 9926 rs11119805-A rs11119805 0 11119805 UTR-3 0 0.123 3E-9 8.522878745280337 .17 [0.113-0.223] unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Stearic acid (18:0) plasma levels 8,961 European ancestry individuals 11q12.2 11 61557803 C11orf10, FADS1, FADS2, FEN1, FADS3 - 746 rs102275-C rs102275 0 102275 intron 0 0.322 1E-20 20 .18 [0.142-0.218] unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Stearic acid (18:0) plasma levels 8,961 European ancestry individuals 1p13.3 1 110082886 GPR61 - 83873 rs7550711-T rs7550711 0 7550711 intron 0 NR 5E-6 5.301029995663981 .27 unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Stearic acid (18:0) plasma levels 8,961 European ancestry individuals 1p21.3 1 95515637 ALG14, TMEM56 - 199857 rs6675668-T rs6675668 0 6675668 intron 0 0.49 2E-18 17.69897000433602 .17 [0.128-0.202] unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Stearic acid (18:0) plasma levels 8,961 European ancestry individuals 1p21.3 1 95697529 RWDD3 - 100527978 rs6671200-A rs6671200 0 6671200 intron 0 NR 2E-15 14.69897000433602 .25 unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Stearic acid (18:0) plasma levels 8,961 European ancestry individuals 1p21.3 1 95387208 CNN3 - 1266 rs860873-A rs860873 0 860873 intron 0 NR 2E-14 13.69897000433602 .15 unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Stearic acid (18:0) plasma levels 8,961 European ancestry individuals 20q11.22 20 32482632 CHMP4B - 170555 rs742614-A rs742614 0 742614 0 NR 3E-7 6.522878745280337 .10 unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Stearic acid (18:0) plasma levels 8,961 European ancestry individuals 10q23.1 10 86953327 GRID1 439992 100507470 632.27 384.16 rs12098564-A rs12098564 0 12098564 1 NR 4E-7 6.397940008672037 .44 unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Stearic acid (18:0) plasma levels 8,961 European ancestry individuals 15q26.2 15 95318767 MCTP2 55784 7026 291.59 1550.39 rs16949516-T rs16949516 0 16949516 1 NR 4E-6 5.397940008672037 .20 unit decrease Affymetrix & Illumina [~2.5 million] (imputed) N 06/06/2013 23362303 Wu JH 01/29/2013 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23362303 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. Stearic acid (18:0) plasma levels 8,961 European ancestry individuals 5q13.3 5 74302658 GCNT4 100271300 51301 16.20 20.63 rs4555772-A rs4555772 0 4555772 1 NR 4E-6 5.397940008672037 .09 unit increase Affymetrix & Illumina [~2.5 million] (imputed) N 05/01/2013 23382809 Xu C 01/29/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23382809 BCL9 and C9orf5 are associated with negative symptoms in schizophrenia: meta-analysis of two genome-wide association studies. Schizophrenia (negative symptoms) 1,774 European ancestry cases, 2,726 European ancestry controls 9q31.3 9 111799563 C9orf5 - 23731 rs643410-A rs643410 0 643410 intron 0 0.05 1E-6 5.999999999999999 1.60 [NR] Affymetrix [729,454] N 05/01/2013 23382809 Xu C 01/29/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23382809 BCL9 and C9orf5 are associated with negative symptoms in schizophrenia: meta-analysis of two genome-wide association studies. Schizophrenia (negative symptoms) 1,774 European ancestry cases, 2,726 European ancestry controls 1q21.2 1 147083114 BCL9 - 607 rs583583-A rs583583 0 583583 intron 0 0.28 6E-7 6.221848749616355 1.30 [NR] Affymetrix [729,454] N 05/01/2013 23382809 Xu C 01/29/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23382809 BCL9 and C9orf5 are associated with negative symptoms in schizophrenia: meta-analysis of two genome-wide association studies. Schizophrenia (negative symptoms) 1,774 European ancestry cases, 2,726 European ancestry controls 8q24.22 8 134668677 ST3Gal1 6482 100873179 84.49 98.31 rs2860223-C rs2860223 0 2860223 1 0.35 2E-6 5.698970004336018 1.26 [NR] Affymetrix [729,454] N 04/23/2013 23350875 Fernandez-Rozadilla C 01/26/2013 BMC Genomics http://www.ncbi.nlm.nih.gov/pubmed/23350875 A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12. Colorectal cancer 882 European ancestry cases, 473 European ancestry controls 1,436 European ancestry cases, 1,780 European ancestry controls 3p21.31 3 47388947 NR 23276 25930 .64 33.54 rs8180040-? rs8180040 0 8180040 1 NR 2E-6 5.698970004336018 1.28 [1.15-1.41] Affymetrix [674,718] N 04/23/2013 23350875 Fernandez-Rozadilla C 01/26/2013 BMC Genomics http://www.ncbi.nlm.nih.gov/pubmed/23350875 A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12. Colorectal cancer 882 European ancestry cases, 473 European ancestry controls 1,436 European ancestry cases, 1,780 European ancestry controls 8q22.1 8 96595736 NR - 100616530 rs3104964-? rs3104964 0 3104964 intron 0 NR 4E-6 5.397940008672037 1.27 [1.144-1.398] Affymetrix [674,718] N 04/23/2013 23350875 Fernandez-Rozadilla C 01/26/2013 BMC Genomics http://www.ncbi.nlm.nih.gov/pubmed/23350875 A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12. Colorectal cancer 882 European ancestry cases, 473 European ancestry controls 1,436 European ancestry cases, 1,780 European ancestry controls 8p12 8 29344462 NR 1846 646909 136.20 145.11 rs12548021-? rs12548021 0 12548021 1 NR 3E-6 5.522878745280337 1.28 [1.155-1.418] Affymetrix [674,718] N 04/24/2013 23354978 Rinella ES 01/25/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23354978 Genetic variants associated with breast cancer risk for Ashkenazi Jewish women with strong family histories but no identifiable BRCA1/2 mutation. Breast cancer 477 Ashkenazi Jewish cases, 524 Ashkenazi Jewish controls 203 Ashkenazi Jewish cases, 263 Ashkenazi Jewish contols 10q26.13 10 123338975 FGFR2 - 2263 rs1078806-C rs1078806 0 1078806 intron 0 0.39 2E-6 5.698970004336018 (Pooled P value) 1.43 [NR] Affymetrix [435,632] N 04/24/2013 23354978 Rinella ES 01/25/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23354978 Genetic variants associated with breast cancer risk for Ashkenazi Jewish women with strong family histories but no identifiable BRCA1/2 mutation. Breast cancer 477 Ashkenazi Jewish cases, 524 Ashkenazi Jewish controls 203 Ashkenazi Jewish cases, 263 Ashkenazi Jewish contols 15q24.3 15 78269472 Intergenic 400403 23102 65.51 17.86 rs12906542-? rs12906542 0 12906542 1 0.93 7E-7 6.154901959985743 (Meta P value) 2.00 [NR] Affymetrix [435,632] N 04/24/2013 23354978 Rinella ES 01/25/2013 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23354978 Genetic variants associated with breast cancer risk for Ashkenazi Jewish women with strong family histories but no identifiable BRCA1/2 mutation. Breast cancer 477 Ashkenazi Jewish cases, 524 Ashkenazi Jewish controls 203 Ashkenazi Jewish cases, 263 Ashkenazi Jewish contols 6p22.3 6 19443935 Intergenic 100131913 441133 94.59 168.98 rs16882214-? rs16882214 0 16882214 1 0.81 2E-6 5.698970004336018 (Meta P value) 1.43 [NR] Affymetrix [435,632] N 04/18/2013 23349225 Hwang JY 01/24/2013 J Med Genet http://www.ncbi.nlm.nih.gov/pubmed/23349225 Meta-analysis identifies a MECOM gene as a novel predisposing factor of osteoporotic fracture. Osteoporosis 288 Korean ancestry cases, 1,139 Korean ancestry controls 831 East Asian ancestry cases, 2305 East Asian ancestry controls 3q26.2 3 168971231 MECOM - 2122 rs784288-A rs784288 0 784288 intron 0 0.23 4E-8 7.397940008672037 1.39 [1.24-1.56] Affymetrix [1,573,409] (Imputed) N 04/18/2013 23337944 Haghighi A 01/22/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23337944 Opioid receptor mu 1 gene, fat intake and obesity in adolescence. Fat intake 598 European ancestry adolescents 490 European ancestry young adults NR NR - NR NR NR NS NS NR NR Illumina [530,011] N 04/17/2013 23337848 Posti JP 01/18/2013 Pharmacogenet Genomics http://www.ncbi.nlm.nih.gov/pubmed/23337848 A polymorphism in the protein kinase C gene PRKCB is associated with α2-adrenoceptor-mediated vasoconstriction. Vascular constriction 64 European ancestry individuals 68 individuals NR NR - NR NR NR NS NS NR NR Illumina [433,378] N 04/17/2013 23341777 Dong J 01/17/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23341777 Genome-wide association study identifies a novel susceptibility locus at 12q23.1 for lung squamous cell carcinoma in han chinese. Squamous cell carcinoma 833 Han Chinese cases, 3,094 Han Chinese controls 2,223 Han Chinese cases, 6,409 Han Chinese controls 12q23.1 12 100820085 SLC17A8, NR1H4, SCYL2, GAS2L3 246213 9971 4.25 47.47 rs12296850-A rs12296850 0 12296850 1 0.744 1E-10 10 1.28 [1.19-1.39] Affymetrix [570,009] N 04/17/2013 23349640 Vijai J 01/17/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23349640 Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Lymphoma 275 Follicular non-Hodgkin’s Lymphoma cases, 269 diffuse large B-cell non-Hodgkin’s Lymphoma cases, 198 other non-Hodgkin’s Lymphoma cases, 202 Hodgkin’s Lymphoma cases, 4,044 controls 202 European ancestry Follicular non-Hodgkin’s Lymphoma cases, 367 European ancestry diffuse large B-cell non-Hodgkin’s Lymphoma cases, 577 European ancestry other non-Hodgkin’s Lymphoma cases, 99 European ancestry Hodgkin’s Lymphoma cases, 2,596 European ancestry controls 11q12.1 11 58347765 ZFP91-CNTF - 80829;386607 rs948562-G rs948562 0 948562 intron;intron 0 NR 3E-7 6.522878745280337 (NHL) 1.32 [1.18-1.46] Affymetrix [530,583] N 04/17/2013 23349640 Vijai J 01/17/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23349640 Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Lymphoma 275 Follicular non-Hodgkin’s Lymphoma cases, 269 diffuse large B-cell non-Hodgkin’s Lymphoma cases, 198 other non-Hodgkin’s Lymphoma cases, 202 Hodgkin’s Lymphoma cases, 4,044 controls 202 European ancestry Follicular non-Hodgkin’s Lymphoma cases, 367 European ancestry diffuse large B-cell non-Hodgkin’s Lymphoma cases, 577 European ancestry other non-Hodgkin’s Lymphoma cases, 99 European ancestry Hodgkin’s Lymphoma cases, 2,596 European ancestry controls 6p21.32 6 32730012 HLA-DQB2 - 3120 rs7453920-? rs7453920 0 7453920 intron 0 NR 5E-6 5.301029995663981 (LYM) 1.19 [1.11-1.3] Affymetrix [530,583] N 04/17/2013 23349640 Vijai J 01/17/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23349640 Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Lymphoma 275 Follicular non-Hodgkin’s Lymphoma cases, 269 diffuse large B-cell non-Hodgkin’s Lymphoma cases, 198 other non-Hodgkin’s Lymphoma cases, 202 Hodgkin’s Lymphoma cases, 4,044 controls 202 European ancestry Follicular non-Hodgkin’s Lymphoma cases, 367 European ancestry diffuse large B-cell non-Hodgkin’s Lymphoma cases, 577 European ancestry other non-Hodgkin’s Lymphoma cases, 99 European ancestry Hodgkin’s Lymphoma cases, 2,596 European ancestry controls 6p21.32 6 32581889 HLA-DRB5, HLA-DQA1 3123 3117 24.28 23.29 rs4530903-T rs4530903 0 4530903 1 NR 3E-12 11.52287874528034 (FL) 1.93 [NR] Affymetrix [530,583] N 04/17/2013 23349640 Vijai J 01/17/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23349640 Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Lymphoma 275 Follicular non-Hodgkin’s Lymphoma cases, 269 diffuse large B-cell non-Hodgkin’s Lymphoma cases, 198 other non-Hodgkin’s Lymphoma cases, 202 Hodgkin’s Lymphoma cases, 4,044 controls 202 European ancestry Follicular non-Hodgkin’s Lymphoma cases, 367 European ancestry diffuse large B-cell non-Hodgkin’s Lymphoma cases, 577 European ancestry other non-Hodgkin’s Lymphoma cases, 99 European ancestry Hodgkin’s Lymphoma cases, 2,596 European ancestry controls 6p21.32 6 32429643 HLA-DRA, HLA-DRB5, HLA-DRB1, BTLN2 3132 3127 1.78 55.51 rs9268853-C rs9268853 0 9268853 1 NR 2E-10 9.698970004336017 (FL) 1.56 [NR] Affymetrix [530,583] N 04/17/2013 23349640 Vijai J 01/17/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23349640 Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Lymphoma 275 Follicular non-Hodgkin’s Lymphoma cases, 269 diffuse large B-cell non-Hodgkin’s Lymphoma cases, 198 other non-Hodgkin’s Lymphoma cases, 202 Hodgkin’s Lymphoma cases, 4,044 controls 202 European ancestry Follicular non-Hodgkin’s Lymphoma cases, 367 European ancestry diffuse large B-cell non-Hodgkin’s Lymphoma cases, 577 European ancestry other non-Hodgkin’s Lymphoma cases, 99 European ancestry Hodgkin’s Lymphoma cases, 2,596 European ancestry controls 6p21.32 6 32668100 HLA-DQB1, HLA-DQA2 3119 404026 33.63 5.82 rs2647045-? rs2647045 0 2647045 1 NR 4E-10 9.397940008672037 (FL) 1.69 [NR] Affymetrix [530,583] N 04/17/2013 23349640 Vijai J 01/17/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23349640 Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Lymphoma 275 Follicular non-Hodgkin’s Lymphoma cases, 269 diffuse large B-cell non-Hodgkin’s Lymphoma cases, 198 other non-Hodgkin’s Lymphoma cases, 202 Hodgkin’s Lymphoma cases, 4,044 controls 202 European ancestry Follicular non-Hodgkin’s Lymphoma cases, 367 European ancestry diffuse large B-cell non-Hodgkin’s Lymphoma cases, 577 European ancestry other non-Hodgkin’s Lymphoma cases, 99 European ancestry Hodgkin’s Lymphoma cases, 2,596 European ancestry controls 6p23 6 14636963 RNF182, JARID2 9308 100131229 499.81 466.21 rs707824-T rs707824 0 707824 1 NR 6E-7 6.221848749616355 (NHL) 1.33 [1.17-1.47] Affymetrix [530,583] N 04/17/2013 23349640 Vijai J 01/17/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23349640 Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Lymphoma 275 Follicular non-Hodgkin’s Lymphoma cases, 269 diffuse large B-cell non-Hodgkin’s Lymphoma cases, 198 other non-Hodgkin’s Lymphoma cases, 202 Hodgkin’s Lymphoma cases, 4,044 controls 202 European ancestry Follicular non-Hodgkin’s Lymphoma cases, 367 European ancestry diffuse large B-cell non-Hodgkin’s Lymphoma cases, 577 European ancestry other non-Hodgkin’s Lymphoma cases, 99 European ancestry Hodgkin’s Lymphoma cases, 2,596 European ancestry controls 6p21.32 6 32581889 HLA-DRB5, HLA-DQA1 3123 3117 24.28 23.29 rs4530903-T rs4530903 0 4530903 1 NR 3E-6 5.522878745280337 (LYM) 1.29 [1.16-1.43] Affymetrix [530,583] N 04/17/2013 23349640 Vijai J 01/17/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23349640 Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Lymphoma 275 Follicular non-Hodgkin’s Lymphoma cases, 269 diffuse large B-cell non-Hodgkin’s Lymphoma cases, 198 other non-Hodgkin’s Lymphoma cases, 202 Hodgkin’s Lymphoma cases, 4,044 controls 202 European ancestry Follicular non-Hodgkin’s Lymphoma cases, 367 European ancestry diffuse large B-cell non-Hodgkin’s Lymphoma cases, 577 European ancestry other non-Hodgkin’s Lymphoma cases, 99 European ancestry Hodgkin’s Lymphoma cases, 2,596 European ancestry controls 6p21.32 6 32581889 HLA-DRB5, HLA-DQA1 3123 3117 24.28 23.29 rs4530903-T rs4530903 0 4530903 1 NR 2E-8 7.698970004336018 (NHL) 1.37 [1.23-1.54] Affymetrix [530,583] N 04/17/2013 23349640 Vijai J 01/17/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23349640 Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Lymphoma 275 Follicular non-Hodgkin’s Lymphoma cases, 269 diffuse large B-cell non-Hodgkin’s Lymphoma cases, 198 other non-Hodgkin’s Lymphoma cases, 202 Hodgkin’s Lymphoma cases, 4,044 controls 202 European ancestry Follicular non-Hodgkin’s Lymphoma cases, 367 European ancestry diffuse large B-cell non-Hodgkin’s Lymphoma cases, 577 European ancestry other non-Hodgkin’s Lymphoma cases, 99 European ancestry Hodgkin’s Lymphoma cases, 2,596 European ancestry controls 11q12.1 11 58060192 LPXN - 81345 rs12289961-T rs12289961 0 12289961 0 NR 1E-7 7 (NHL) 1.29 [1.17-1.42] Affymetrix [530,583] N 04/17/2013 23349640 Vijai J 01/17/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23349640 Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Lymphoma 275 Follicular non-Hodgkin’s Lymphoma cases, 269 diffuse large B-cell non-Hodgkin’s Lymphoma cases, 198 other non-Hodgkin’s Lymphoma cases, 202 Hodgkin’s Lymphoma cases, 4,044 controls 202 European ancestry Follicular non-Hodgkin’s Lymphoma cases, 367 European ancestry diffuse large B-cell non-Hodgkin’s Lymphoma cases, 577 European ancestry other non-Hodgkin’s Lymphoma cases, 99 European ancestry Hodgkin’s Lymphoma cases, 2,596 European ancestry controls 11q12.1 11 58347765 ZFP91-CNTF - 80829;386607 rs948562-G rs948562 0 948562 intron;intron 0 NR 6E-7 6.221848749616355 (LYM) 1.29 [1.16-1.43] Affymetrix [530,583] N 04/17/2013 23349640 Vijai J 01/17/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23349640 Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Lymphoma 275 Follicular non-Hodgkin’s Lymphoma cases, 269 diffuse large B-cell non-Hodgkin’s Lymphoma cases, 198 other non-Hodgkin’s Lymphoma cases, 202 Hodgkin’s Lymphoma cases, 4,044 controls 202 European ancestry Follicular non-Hodgkin’s Lymphoma cases, 367 European ancestry diffuse large B-cell non-Hodgkin’s Lymphoma cases, 577 European ancestry other non-Hodgkin’s Lymphoma cases, 99 European ancestry Hodgkin’s Lymphoma cases, 2,596 European ancestry controls 6p21.32 6 32668336 HLA-DQB1, HLA-DQA2 3119 404026 33.87 5.59 rs2647046-? rs2647046 0 2647046 1 NR 2E-6 5.698970004336018 (NHL) 1.25 [1.14-1.37] Affymetrix [530,583] N 04/17/2013 23349640 Vijai J 01/17/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23349640 Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Lymphoma 275 Follicular non-Hodgkin’s Lymphoma cases, 269 diffuse large B-cell non-Hodgkin’s Lymphoma cases, 198 other non-Hodgkin’s Lymphoma cases, 202 Hodgkin’s Lymphoma cases, 4,044 controls 202 European ancestry Follicular non-Hodgkin’s Lymphoma cases, 367 European ancestry diffuse large B-cell non-Hodgkin’s Lymphoma cases, 577 European ancestry other non-Hodgkin’s Lymphoma cases, 99 European ancestry Hodgkin’s Lymphoma cases, 2,596 European ancestry controls 11q12.1 11 58060192 LPXN - 81345 rs12289961-T rs12289961 0 12289961 0 NR 4E-8 7.397940008672037 (LYM) 1.29 [1.17-1.40] Affymetrix [530,583] N 04/17/2013 23349640 Vijai J 01/17/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23349640 Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. Lymphoma 275 Follicular non-Hodgkin’s Lymphoma cases, 269 diffuse large B-cell non-Hodgkin’s Lymphoma cases, 198 other non-Hodgkin’s Lymphoma cases, 202 Hodgkin’s Lymphoma cases, 4,044 controls 202 European ancestry Follicular non-Hodgkin’s Lymphoma cases, 367 European ancestry diffuse large B-cell non-Hodgkin’s Lymphoma cases, 577 European ancestry other non-Hodgkin’s Lymphoma cases, 99 European ancestry Hodgkin’s Lymphoma cases, 2,596 European ancestry controls 6p21.32 6 32741868 HLA-DQB2, TAP2 3120 3112 10.54 38.67 rs2621416-G rs2621416 0 2621416 1 NR 2E-9 8.698970004336019 (FL) 1.57 [NR] Affymetrix [530,583] N 04/04/2013 23328707 Tin A 01/16/2013 Nephrol Dial Transplant http://www.ncbi.nlm.nih.gov/pubmed/23328707 Genome-wide significant locus of beta-trace protein, a novel kidney function biomarker, identified in European and African Americans. Beta-trace protein levels 6,720 European ancestry individuals 1,734 African American individuals 9q34.3 9 139862633 PTGDS 286256 5730 12.68 9.32 rs57024841-A rs57024841 0 57024841 1 0.58 1E-23 23 (EA) .05 [0.040-0.060] unit increase Affymetrix [~2.5 Million] (Imputed) N 05/10/2013 23322567 Lopes MC 01/15/2013 Invest Ophthalmol Vis Sci http://www.ncbi.nlm.nih.gov/pubmed/23322567 Identification of a candidate gene for astigmatism. Corneal astigmatism 22,100 European ancestry individuals 4q26 4 120187611 NR - 54532 rs11098499-C rs11098499 0 11098499 intron 0 NR 9E-6 5.045757490560675 .05 [NR] unit increase Illumina & Affymetrix [2.8 million] (Imputed) N 05/10/2013 23322567 Lopes MC 01/15/2013 Invest Ophthalmol Vis Sci http://www.ncbi.nlm.nih.gov/pubmed/23322567 Identification of a candidate gene for astigmatism. Corneal astigmatism 22,100 European ancestry individuals 2p13.3 2 71133014 VAX2 - 25806 rs3771395-G rs3771395 0 3771395 intron 0 0.16 2E-7 6.698970004336019 .08 [NR] unit decrease Illumina & Affymetrix [2.8 million] (Imputed) N 05/10/2013 23322567 Lopes MC 01/15/2013 Invest Ophthalmol Vis Sci http://www.ncbi.nlm.nih.gov/pubmed/23322567 Identification of a candidate gene for astigmatism. Corneal astigmatism 22,100 European ancestry individuals 16p12.3 16 17739692 XYLT1 64131 146110 174.95 286.88 rs12445126-G rs12445126 0 12445126 1 0.09 2E-6 5.698970004336018 .09 [NR] unit decrease Illumina & Affymetrix [2.8 million] (Imputed) N 05/10/2013 23322567 Lopes MC 01/15/2013 Invest Ophthalmol Vis Sci http://www.ncbi.nlm.nih.gov/pubmed/23322567 Identification of a candidate gene for astigmatism. Corneal astigmatism 22,100 European ancestry individuals 6q12 6 67248410 Intergenic 89761 577 443.57 2097.22 rs9445732-G rs9445732 0 9445732 1 0.05 2E-6 5.698970004336018 1.28 [NR] unit increase Illumina & Affymetrix [2.8 million] (Imputed) N 05/10/2013 23322567 Lopes MC 01/15/2013 Invest Ophthalmol Vis Sci http://www.ncbi.nlm.nih.gov/pubmed/23322567 Identification of a candidate gene for astigmatism. Corneal astigmatism 22,100 European ancestry individuals 16q24.1 16 86485131 FOXF1 3394 400550 528.92 23.00 rs11644988-G rs11644988 0 11644988 1 0.12 2E-6 5.698970004336018 .13 [NR] unit increase Illumina & Affymetrix [2.8 million] (Imputed) N 05/10/2013 23322567 Lopes MC 01/15/2013 Invest Ophthalmol Vis Sci http://www.ncbi.nlm.nih.gov/pubmed/23322567 Identification of a candidate gene for astigmatism. Corneal astigmatism 22,100 European ancestry individuals 11q21 11 96023214 MAML2 - 84441 rs485842-A rs485842 0 485842 intron 0 0.261 2E-6 5.698970004336018 .06 [NR] unit increase Illumina & Affymetrix [2.8 million] (Imputed) N 05/10/2013 23322567 Lopes MC 01/15/2013 Invest Ophthalmol Vis Sci http://www.ncbi.nlm.nih.gov/pubmed/23322567 Identification of a candidate gene for astigmatism. Corneal astigmatism 22,100 European ancestry individuals 1p35.3 1 28262409 NR - 27293 rs4409675-T rs4409675 0 4409675 0 NR 2E-6 5.698970004336018 .06 [NR] unit decrease Illumina & Affymetrix [2.8 million] (Imputed) N 05/10/2013 23322567 Lopes MC 01/15/2013 Invest Ophthalmol Vis Sci http://www.ncbi.nlm.nih.gov/pubmed/23322567 Identification of a candidate gene for astigmatism. Corneal astigmatism 22,100 European ancestry individuals 10p14 10 10388195 NR 100126596 207107 88.86 438.21 rs7092703-C rs7092703 0 7092703 1 NR 3E-6 5.522878745280337 .05 [NR] unit increase Illumina & Affymetrix [2.8 million] (Imputed) N 05/10/2013 23322567 Lopes MC 01/15/2013 Invest Ophthalmol Vis Sci http://www.ncbi.nlm.nih.gov/pubmed/23322567 Identification of a candidate gene for astigmatism. Corneal astigmatism 22,100 European ancestry individuals 10q21.1 10 60318897 NR - 80114 rs1658442-A rs1658442 0 1658442 intron 0 NR 3E-6 5.522878745280337 .06 [NR] unit decrease Illumina & Affymetrix [2.8 million] (Imputed) N 05/10/2013 23322567 Lopes MC 01/15/2013 Invest Ophthalmol Vis Sci http://www.ncbi.nlm.nih.gov/pubmed/23322567 Identification of a candidate gene for astigmatism. Corneal astigmatism 22,100 European ancestry individuals 14q32.31 14 101539384 NR - 100507257 rs7147503-C rs7147503 0 7147503 intron 0 NR 5E-6 5.301029995663981 .05 [NR] unit increase Illumina & Affymetrix [2.8 million] (Imputed) N 05/10/2013 23322567 Lopes MC 01/15/2013 Invest Ophthalmol Vis Sci http://www.ncbi.nlm.nih.gov/pubmed/23322567 Identification of a candidate gene for astigmatism. Corneal astigmatism 22,100 European ancestry individuals 3p14.1 3 65326882 NR 100507098 100421506 329.74 346.05 rs6764388-T rs6764388 0 6764388 1 NR 6E-6 5.221848749616356 .05 [NR] unit increase Illumina & Affymetrix [2.8 million] (Imputed) N 05/10/2013 23322567 Lopes MC 01/15/2013 Invest Ophthalmol Vis Sci http://www.ncbi.nlm.nih.gov/pubmed/23322567 Identification of a candidate gene for astigmatism. Corneal astigmatism 22,100 European ancestry individuals 1q25.1 1 175715606 NR 7143 100271124 2.85 175.48 rs17312292-C rs17312292 0 17312292 1 NR 7E-6 5.154901959985742 .88 [NR] unit increase Illumina & Affymetrix [2.8 million] (Imputed) N 05/10/2013 23322567 Lopes MC 01/15/2013 Invest Ophthalmol Vis Sci http://www.ncbi.nlm.nih.gov/pubmed/23322567 Identification of a candidate gene for astigmatism. Corneal astigmatism 22,100 European ancestry individuals 15q26.3 15 101721892 NR - 22856 rs12593811-T rs12593811 0 12593811 intron 0 NR 7E-6 5.154901959985742 .23 [NR] unit increase Illumina & Affymetrix [2.8 million] (Imputed) N 05/10/2013 23322567 Lopes MC 01/15/2013 Invest Ophthalmol Vis Sci http://www.ncbi.nlm.nih.gov/pubmed/23322567 Identification of a candidate gene for astigmatism. Corneal astigmatism 22,100 European ancestry individuals 8p22 8 15197417 NR 494332 7991 486.40 200.18 rs12676170-A rs12676170 0 12676170 1 NR 8E-6 5.096910013008055 .05 [NR] unit decrease Illumina & Affymetrix [2.8 million] (Imputed) N 05/10/2013 23322567 Lopes MC 01/15/2013 Invest Ophthalmol Vis Sci http://www.ncbi.nlm.nih.gov/pubmed/23322567 Identification of a candidate gene for astigmatism. Corneal astigmatism 22,100 European ancestry individuals 9p22.2 9 16970809 NR 54796 100271197 100.02 137.49 rs4961511-G rs4961511 0 4961511 1 NR 9E-6 5.045757490560675 .05 [NR] unit increase Illumina & Affymetrix [2.8 million] (Imputed) N 05/10/2013 23322567 Lopes MC 01/15/2013 Invest Ophthalmol Vis Sci http://www.ncbi.nlm.nih.gov/pubmed/23322567 Identification of a candidate gene for astigmatism. Corneal astigmatism 22,100 European ancestry individuals 7q36.3 7 155837295 SHH 6469 64433 232.33 495.89 rs10226930-C rs10226930 0 10226930 1 0.07 8E-7 6.096910013008056 1.38 [NR] unit decrease Illumina & Affymetrix [2.8 million] (Imputed) N 05/10/2013 23322567 Lopes MC 01/15/2013 Invest Ophthalmol Vis Sci http://www.ncbi.nlm.nih.gov/pubmed/23322567 Identification of a candidate gene for astigmatism. Corneal astigmatism 22,100 European ancestry individuals 5p15.2 5 13798559 DNAH5 - 1767 rs795544-? rs795544 0 795544 intron 0 0.17 1E-6 5.999999999999999 .06 [NR] unit increase Illumina & Affymetrix [2.8 million] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA) up to 398 European individuals NR 2p22.3 2 35662797 Intergenic 344371 100616475 1596.99 33.67 rs13402855-C rs13402855 0 13402855 1 NR 2E-6 5.698970004336018 .23 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA) up to 398 European individuals NR 6q27 6 168388928 KIF25, HGC6.3, HGC6.1.1, MLLT4 100128124 3834 11.31 29.63 rs2843012-A rs2843012 0 2843012 1 NR 6E-6 5.221848749616356 .22 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA) up to 398 European individuals NR 8p23.2 8 5227102 Intergenic 100129861 100271466 296.66 106.93 rs77265424-G rs77265424 0 77265424 1 NR 4E-6 5.397940008672037 .22 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA) up to 398 European individuals NR 8p23.2 8 6152919 Intergenic 100271466 79648 818.43 111.19 rs6559140-A rs6559140 0 6559140 1 NR 7E-6 5.154901959985742 .22 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA) up to 398 European individuals NR 8q24.13 8 122706291 Intergenic 594842 347704 48.73 397.42 rs279612-G rs279612 0 279612 1 NR 7E-6 5.154901959985742 .21 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA) up to 398 European individuals NR 9q21.13 9 78665776 PCSK5 - 5125 rs7047865-G rs7047865 0 7047865 intron 0 NR 5E-6 5.301029995663981 .22 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA) up to 398 European individuals NR 16q23.1 16 78335044 WWOX - 51741 rs78867184-G rs78867184 0 78867184 intron 0 NR 9E-6 5.045757490560675 .21 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA) up to 398 European individuals NR 1q31.1 1 187412042 Intergenic 5321 343332 453.93 120.15 rs2244067-T rs2244067 0 2244067 1 NR 7E-6 5.154901959985742 .21 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA) up to 398 European individuals NR 11q24.3 11 128816221 TP53AIP1, ARHGAP32, 5S_rRNA 63970 9743 2.93 18.73 rs11221522-A rs11221522 0 11221522 1 NR 5E-7 6.30102999566398 .24 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA) up to 398 European individuals NR 13q31.3 13 91732770 Intergenic 100874492 100874150 56.57 47.10 rs61970269-T rs61970269 0 61970269 1 NR 3E-6 5.522878745280337 .22 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA) up to 398 European individuals NR 1q32.3 1 213834643 Intergenic 100270983 100861504 232.24 263.45 rs4655303-T rs4655303 0 4655303 1 NR 5E-6 5.301029995663981 .22 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA) up to 398 European individuals NR 17p13.3 17 2145193 SRR, SMG6, AJ276246 - 23293 rs11078884-C rs11078884 0 11078884 intron 0 NR 3E-6 5.522878745280337 .22 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA) up to 398 European individuals NR 1p35.2 1 31315593 Intergenic 7805 9672 84.91 26.72 rs4949316-G rs4949316 0 4949316 1 NR 9E-6 5.045757490560675 .21 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA/ MHPG Ratio) up to 398 European individuals NR 14q21.1 14 38683261 SSTR1, CLEC14A 6751 161198 .99 39.94 rs11622412-T rs11622412 0 11622412 1 NR 5E-8 7.30102999566398 .32 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA/ MHPG Ratio) up to 398 European individuals NR 18p11.22 18 10766425 PIEZO2 - 63895 rs2865126-A rs2865126 0 2865126 intron 0 NR 8E-6 5.096910013008055 .27 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA/ MHPG Ratio) up to 398 European individuals NR Xp21.3 23 26369899 Intergenic 158809 139538 156.14 206.56 rs6526555-C rs6526555 0 6526555 1 NR 5E-6 5.301029995663981 .28 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA/ MHPG Ratio) up to 398 European individuals NR Xq24 23 116869914 Intergenic 100128536 90293 772.27 161.86 rs5910235-G rs5910235 0 5910235 1 NR 7E-6 5.154901959985742 .28 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA/ MHPG Ratio) up to 398 European individuals NR 2q36.3 2 228092035 COL4A3, BC035052, AK056332 - 1285 rs35212277-A rs35212277 0 35212277 intron 0 NR 9E-6 5.045757490560675 .27 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA/ MHPG Ratio) up to 398 European individuals NR 3p12.3 3 77652742 ROBO2 - 6092 rs73114594-A rs73114594 0 73114594 intron 0 NR 7E-6 5.154901959985742 .27 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA/ MHPG Ratio) up to 398 European individuals NR 4p13 4 43320507 Intergenic 389207 441013 287.83 91.51 rs2006970-C rs2006970 0 2006970 1 NR 9E-6 5.045757490560675 .27 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA/ MHPG Ratio) up to 398 European individuals NR 6p21.1 6 41962671 CCND3 - 896 rs9357377-A rs9357377 0 9357377 intron 0 NR 5E-6 5.301029995663981 .27 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA/ MHPG Ratio) up to 398 European individuals NR 9p22.3 9 16000235 Intergenic 100873746 54796 223.95 409.27 rs79156074-T rs79156074 0 79156074 1 NR 2E-6 5.698970004336018 .28 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA/ MHPG Ratio) up to 398 European individuals NR 11q23.3 11 115398746 Intergenic 23705 441623 23.51 10.84 rs7483296-T rs7483296 0 7483296 1 NR 8E-7 6.096910013008056 .29 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (5-HIAA/ MHPG Ratio) up to 398 European individuals NR 10q26.2 10 127823151 ADAM12 - 8038 rs1278329-G rs1278329 0 1278329 intron 0 NR 8E-6 5.096910013008055 .27 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA) up to 398 European individuals NR 4q34.3 4 181229200 Intergenic 391719 728081 2020.68 756.04 rs17834666-A rs17834666 0 17834666 1 NR 8E-6 5.096910013008055 .22 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA) up to 398 European individuals NR 4q22.1 4 91401611 FAM190A - 401145 rs187200046-T rs187200046 0 187200046 intron 0 NR 2E-6 5.698970004336018 .24 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA) up to 398 European individuals NR 3p24.1 3 29275646 Intergenic 131572 100271053 144.54 156.66 rs4680719-A rs4680719 0 4680719 1 NR 3E-6 5.522878745280337 .23 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA) up to 398 European individuals NR 3p25.3 3 11625414 VGLL4 - 9686 rs6802119-C rs6802119 0 6802119 intron 0 NR 2E-6 5.698970004336018 .23 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA) up to 398 European individuals NR 2p23.3 2 26667130 CCDC164, OTOF - 92749 rs3795958-G rs3795958 0 3795958 missense 0 NR 2E-6 5.698970004336018 .24 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA) up to 398 European individuals NR 2p23.3 2 26249899 U6, RAB10 729769 391358 31.76 1.00 rs68184094-A rs68184094 0 68184094 1 NR 2E-6 5.698970004336018 .24 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA) up to 398 European individuals NR 21q22.2 21 39721764 ERG 3772 100874428 48.02 152.61 rs2836326-G rs2836326 0 2836326 1 NR 3E-6 5.522878745280337 .23 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA) up to 398 European individuals NR 21q21.3 21 28146189 Intergenic 116159 9510 200.61 62.42 rs2830487-A rs2830487 0 2830487 1 NR 2E-7 6.698970004336019 .25 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA) up to 398 European individuals NR 9q33.3 9 130110411 GARNL3, SLC2A8 - 84253 rs7029536-T rs7029536 0 7029536 intron 0 NR 5E-6 5.301029995663981 .23 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA) up to 398 European individuals NR 9p22.1 9 19213634 DQ572382 100270865 55667 12.58 17.13 rs141215807-T rs141215807 0 141215807 1 NR 9E-6 5.045757490560675 .22 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA) up to 398 European individuals NR 8q22.1 8 96106037 C8orf38 100500907 79666 20.81 39.91 rs4590408-G rs4590408 0 4590408 1 NR 6E-6 5.221848749616356 .22 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA) up to 398 European individuals NR 6q16.1 6 93197300 Intergenic 100270906 100128159 472.94 399.69 rs13207034-A rs13207034 0 13207034 1 NR 4E-6 5.397940008672037 .23 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA) up to 398 European individuals NR 8p12 8 29106059 KIF13B - 23303 rs2954793-T rs2954793 0 2954793 intron 0 NR 3E-6 5.522878745280337 .23 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA-5-HIAA Factor score) up to 398 European individuals NR 21q21.3 21 28146189 Intergenic 116159 9510 200.61 62.42 rs2830487-A rs2830487 0 2830487 1 NR 5E-7 6.30102999566398 .25 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA-5-HIAA Factor score) up to 398 European individuals NR 20q12 20 39439483 Intergenic 9935 7150 121.61 217.98 rs4812466-T rs4812466 0 4812466 1 NR 6E-6 5.221848749616356 .23 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA-5-HIAA Factor score) up to 398 European individuals NR 8q22.1 8 96106037 C8orf38 100500907 79666 20.81 39.91 rs4590408-G rs4590408 0 4590408 1 NR 6E-6 5.221848749616356 .23 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA-5-HIAA Factor score) up to 398 European individuals NR 8q13.3 8 71139330 NCOA2 - 10499 rs72663955-G rs72663955 0 72663955 intron 0 NR 6E-6 5.221848749616356 .22 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA-5-HIAA Factor score) up to 398 European individuals NR 8p12 8 28995022 KIF13B, AF086219 - 23303 rs13251954-A rs13251954 0 13251954 intron 0 NR 2E-6 5.698970004336018 .24 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA-5-HIAA Factor score) up to 398 European individuals NR 22q12.3 22 35371248 Intergenic 9215 91464 1054.83 90.88 rs9619497-A rs9619497 0 9619497 1 NR 5E-6 5.301029995663981 .23 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA-5-HIAA Factor score) up to 398 European individuals NR 6q16.1 6 93197300 Intergenic 100270906 100128159 472.94 399.69 rs13207034-A rs13207034 0 13207034 1 NR 1E-6 5.999999999999999 .24 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA-5-HIAA Factor score) up to 398 European individuals NR 4q22.1 4 91401611 FAM190A - 401145 rs187200046-T rs187200046 0 187200046 intron 0 NR 4E-6 5.397940008672037 .23 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA-5-HIAA Factor score) up to 398 European individuals NR 3p25.3 3 11625414 VGLL4 - 9686 rs6802119-C rs6802119 0 6802119 intron 0 NR 8E-6 5.096910013008055 .22 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA-5-HIAA Factor score) up to 398 European individuals NR 2p23.3 2 26249899 U6, RAB10 729769 391358 31.76 1.00 rs68184094-A rs68184094 0 68184094 1 NR 4E-6 5.397940008672037 .23 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA-5-HIAA Factor score) up to 398 European individuals NR 1q41 1 222245258 Intergenic 11221 100422330 329.74 189.92 rs10863681-G rs10863681 0 10863681 1 NR 6E-6 5.221848749616356 .23 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA-5-HIAA Factor score) up to 398 European individuals NR 6p22.3 6 21455153 Intergenic 54901 6659 222.52 138.82 rs9460635-C rs9460635 0 9460635 1 NR 7E-6 5.154901959985742 .22 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/5-HIAA ratio) up to 398 European individuals NR 6q25.1 6 150380884 ULBP3 5246 79465 15.45 4.86 rs78546022-G rs78546022 0 78546022 1 NR 4E-6 5.397940008672037 .22 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/5-HIAA ratio) up to 398 European individuals NR 9q34.11 9 132349597 BC037833 414318 375759 264.72 24.91 rs73628692-T rs73628692 0 73628692 1 NR 7E-6 5.154901959985742 .21 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/5-HIAA ratio) up to 398 European individuals NR 11p13 11 31884919 RCN1, DKFZp686K1684 - 440034 rs11031492-G rs11031492 0 11031492 intron 0 NR 4E-6 5.397940008672037 .22 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/5-HIAA ratio) up to 398 European individuals NR 12q13.11 12 47814972 Intergenic 100616478 79657 56.92 240.74 rs1881744-A rs1881744 0 1881744 1 NR 2E-6 5.698970004336018 .23 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/5-HIAA ratio) up to 398 European individuals NR 12q23.1 12 99904540 ANKS1B - 56899 rs1961649-T rs1961649 0 1961649 intron 0 NR 3E-6 5.522878745280337 .22 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/5-HIAA ratio) up to 398 European individuals NR 16p13.3 16 3769581 TRAP1, CREBBP - 10131 rs56240109-G rs56240109 0 56240109 nearGene-5 0 NR 5E-6 5.301029995663981 .22 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/5-HIAA ratio) up to 398 European individuals NR 3p14.2 3 62112141 PTPRG, ID2B - 5793 rs35593266-A rs35593266 0 35593266 intron 0 NR 5E-6 5.301029995663981 .22 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/5-HIAA ratio) up to 398 European individuals NR 3q21.2 3 125592857 Intergenic 729150 100125556 78.09 42.59 rs71327718-G rs71327718 0 71327718 1 NR 7E-6 5.154901959985742 .22 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/5-HIAA ratio) up to 398 European individuals NR 5p13.2 5 35461200 Intergenic 5618 79925 230.38 156.79 rs284737-C rs284737 0 284737 1 NR 8E-6 5.096910013008055 .21 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 2p23.3 2 26228207 U6, RAB10 729769 391358 10.07 22.70 rs112288323-T rs112288323 0 112288323 1 NR 2E-6 5.698970004336018 .30 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 2p23.3 2 26667130 CCDC164,OTOF - 92749 rs3795958-G rs3795958 0 3795958 missense 0 NR 4E-6 5.397940008672037 .30 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR Xp21.2 23 30119777 Intergenic 100847047 4113 527.30 113.90 rs6628506-A rs6628506 0 6628506 1 NR 1E-6 5.999999999999999 .33 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR Xp21.3 23 26369899 VENTXP1 158809 139538 156.14 206.56 rs6526555-C rs6526555 0 6526555 1 NR 4E-6 5.397940008672037 .30 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 22q12.1 22 27435820 AK055980 100130624 4330 152.28 708.45 rs742004-A rs742004 0 742004 1 NR 3E-6 5.522878745280337 .30 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 16p13.3 16 5003074 SEC14L5, PPL 5493 9717 15.94 5.24 rs34924084-A rs34924084 0 34924084 1 NR 2E-6 5.698970004336018 .30 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 15q23 15 72169466 SENP8, NR2E3, MYO9A, GRAMD2 - 4649 rs12050794-G rs12050794 0 12050794 intron 0 NR 2E-6 5.698970004336018 .30 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 14q32.11 14 90298275 BX247991, EFCAB11 - 90141 rs8021963-C rs8021963 0 8021963 intron 0 NR 2E-6 5.698970004336018 .30 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 13q12.3 13 32125315 Intergenic 100873882 122042 238.25 188.36 rs1902272-C rs1902272 0 1902272 1 NR 1E-6 5.999999999999999 .31 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 11q23.3 11 115398746 Intergenic 23705 441623 23.51 10.84 rs7483296-T rs7483296 0 7483296 1 NR 5E-7 6.30102999566398 .32 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 10p12.33 10 18525170 CACNB2 - 783 rs2482109-G rs2482109 0 2482109 intron 0 NR 3E-6 5.522878745280337 .30 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 9p13.1 9 38750579 Intergenic 253650 100033392 130.22 276.07 rs184891496-C rs184891496 0 184891496 1 NR 7E-6 5.154901959985742 .28 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 2p25.1 2 11255340 C2orf50, AX746649, FLJ33534 - 285150 rs12692432-C rs12692432 0 12692432 intron 0 NR 6E-6 5.221848749616356 .29 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 1p35.1 1 33983019 CSMD2 - 114784 rs10798959-T rs10798959 0 10798959 intron 0 NR 8E-6 5.096910013008055 .28 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 8q21.13 8 80985035 TPD52 - 7163 rs181166265-C rs181166265 0 181166265 intron 0 NR 3E-6 5.522878745280337 .30 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 8p23.2 8 5373540 Intergenic 100271466 79648 39.05 890.57 rs62494762-C rs62494762 0 62494762 1 NR 2E-6 5.698970004336018 .31 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 7p14.3 7 32460724 Intergenic 5137 442525 122.34 50.32 rs62458065-T rs62458065 0 62458065 1 NR 1E-6 5.999999999999999 .31 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 6p23 6 14597982 Intergenic 9308 100131229 460.83 505.20 rs9296949-T rs9296949 0 9296949 1 NR 2E-6 5.698970004336018 .30 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 6p25.3 6 1524570 BC087858, DD413621 260335 2296 8.75 86.11 rs2569872-C rs2569872 0 2569872 1 NR 8E-6 5.096910013008055 .28 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 5p15.2 5 10512697 Intergenic 100270979 651746 23.40 51.74 rs111426949-T rs111426949 0 111426949 1 NR 6E-6 5.221848749616356 .29 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 5p15.2 5 10159541 Intergenic 50834 134145 529.08 66.08 rs2009501-C rs2009501 0 2009501 1 NR 2E-6 5.698970004336018 .30 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 2p22.2 2 37957480 Intergenic 10602 151393 57.80 194.98 rs13012266-C rs13012266 0 13012266 1 NR 7E-6 5.154901959985742 .28 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 2p16.3 2 50760503 NRXN1 - 9378 rs6750634-A rs6750634 0 6750634 intron 0 NR 4E-6 5.397940008672037 .29 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 4q28.2 4 131026488 Intergenic 360170 100421146 82.45 389.34 rs114646238-C rs114646238 0 114646238 1 NR 9E-6 5.045757490560675 .28 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (HVA/MHPG ratio) up to 398 European individuals NR 4q34.3 4 181229200 Intergenic 391719 728081 2020.68 756.04 rs17834666-A rs17834666 0 17834666 1 NR 1E-6 5.999999999999999 .31 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (MHPG) up to 398 European individuals NR 12q24.11 12 110398145 GIT2, TCHP, ANKRD13A - 9815 rs4766646-T rs4766646 0 4766646 intron 0 NR 4E-7 6.397940008672037 .32 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (MHPG) up to 398 European individuals NR Xq25 23 121967359 Intergenic 100131358 286423 293.99 282.60 rs4559365-A rs4559365 0 4559365 1 NR 9E-6 5.045757490560675 .30 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (MHPG) up to 398 European individuals NR 10q26.2 10 128267640 C10orf90 118611 642938 57.63 666.05 rs11245052-A rs11245052 0 11245052 1 NR 2E-6 5.698970004336018 .30 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (MHPG) up to 398 European individuals NR 10q26.11 10 119604938 Intergenic 2018 22841 295.88 159.49 rs1925265-G rs1925265 0 1925265 1 NR 5E-6 5.301029995663981 .29 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (MHPG) up to 398 European individuals NR 10q25.1 10 108254464 Intergenic 86123 100271618 804.98 55.40 rs2039964-A rs2039964 0 2039964 1 NR 7E-6 5.154901959985742 .29 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (MHPG) up to 398 European individuals NR 9q31.1 9 106369944 Intergenic 1539 10592 589.17 486.60 rs144649413-A rs144649413 0 144649413 1 NR 9E-6 5.045757490560675 .28 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (MHPG) up to 398 European individuals NR 6q13 6 75158266 AF086303 135228 1303 620.23 635.78 rs72960926-A rs72960926 0 72960926 1 NR 2E-6 5.698970004336018 .31 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (MHPG) up to 398 European individuals NR 6q13 6 71726539 Intergenic 135152 157713 59.75 148.14 rs1158058-T rs1158058 0 1158058 1 NR 5E-6 5.301029995663981 .29 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (MHPG) up to 398 European individuals NR 4q23 4 100444684 C4orf17 - 84103 rs13126513-C rs13126513 0 13126513 intron 0 NR 8E-6 5.096910013008055 .29 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (MHPG) up to 398 European individuals NR 4p15.33 4 12111549 Intergenic 9957 9364 681.01 1257.80 rs187075894-C rs187075894 0 187075894 1 NR 8E-7 6.096910013008056 .31 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (MHPG) up to 398 European individuals NR 3q26.31 3 175103614 NAALADL2, MIR4789 - 254827 rs62287976-T rs62287976 0 62287976 intron 0 NR 1E-6 5.999999999999999 .31 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (MHPG) up to 398 European individuals NR 2q35 2 218314253 DIRC3 - 729582 rs11689435-T rs11689435 0 11689435 intron 0 NR 4E-6 5.397940008672037 .29 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (MHPG) up to 398 European individuals NR 2q22.1 2 139399354 Intergenic 339745 11249 68.55 27.37 rs58938945-A rs58938945 0 58938945 1 NR 8E-6 5.096910013008055 .28 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (MHPG) up to 398 European individuals NR 1q32.1 1 203492720 OPTC 26254 493 14.64 103.20 rs13303128-C rs13303128 0 13303128 1 NR 9E-6 5.045757490560675 .28 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (MHPG) up to 398 European individuals NR 1p36.31 1 5707816 AK125078 100616489 100616421 83.61 214.92 rs4845812-T rs4845812 0 4845812 1 NR 5E-6 5.301029995663981 .29 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (MHPG) up to 398 European individuals NR 20q13.33 20 58946489 AK309218 693231 140909 62.86 42.97 rs55681231-A rs55681231 0 55681231 1 NR 7E-7 6.154901959985743 .31 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (MHPG) up to 398 European individuals NR 18q21.31 18 55496305 Intergenic 342776 284288 64.86 9.40 rs62094879-T rs62094879 0 62094879 1 NR 6E-6 5.221848749616356 .29 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (MHPG) up to 398 European individuals NR 16p13.13 16 10630777 EMP2 - 2013 rs6498068-C rs6498068 0 6498068 intron 0 NR 6E-6 5.221848749616356 .29 unit decrease Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (MHPG) up to 398 European individuals NR 16p13.2 16 7903609 Intergenic 100271576 283953 726.97 715.89 rs12446289-C rs12446289 0 12446289 1 NR 6E-6 5.221848749616356 .29 unit increase Illumina [5,767,231] (Imputed) N 04/04/2013 23319000 Luykx JJ 01/15/2013 Mol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23319000 Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. Metabolite levels (MHPG) up to 398 European individuals NR 11p12 11 38278950 Intergenic 100271536 100129670 530.91 904.04 rs5004866-T rs5004866 0 5004866 1 NR 2E-6 5.698970004336018 .30 unit decrease Illumina [5,767,231] (Imputed) N 03/26/2013 23319801 Rafiq S 01/14/2013 Cancer Res http://www.ncbi.nlm.nih.gov/pubmed/23319801 Identification of inherited genetic variations influencing prognosis in early-onset breast cancer. Breast cancer (prognosis) 536 early-onset cases 1,516 early-onset cases 5q14.3 5 91275313 ARRDC3 100131236 100129283 134.97 901.23 rs421379-? rs421379 0 421379 1 0.05 1E-6 5.999999999999999 1.61 [1.33-1.96] Illumina [487,496] N 03/26/2013 23319801 Rafiq S 01/14/2013 Cancer Res http://www.ncbi.nlm.nih.gov/pubmed/23319801 Identification of inherited genetic variations influencing prognosis in early-onset breast cancer. Breast cancer (prognosis) 536 early-onset cases 1,516 early-onset cases 15q22.2 15 61702779 RORa 6095 54832 181.28 441.81 rs3884558-? rs3884558 0 3884558 1 0.07 4E-6 5.397940008672037 1.46 [1.24-1.72] Illumina [487,496] N 03/26/2013 23319801 Rafiq S 01/14/2013 Cancer Res http://www.ncbi.nlm.nih.gov/pubmed/23319801 Identification of inherited genetic variations influencing prognosis in early-onset breast cancer. Breast cancer (prognosis) 536 early-onset cases 1,516 early-onset cases 1q23.3 1 164689762 PBX1 - 5087 rs1387389-? rs1387389 0 1387389 intron 0 0.36 4E-6 5.397940008672037 1.28 [1.16-1.43] Illumina [487,496] N 03/26/2013 23319801 Rafiq S 01/14/2013 Cancer Res http://www.ncbi.nlm.nih.gov/pubmed/23319801 Identification of inherited genetic variations influencing prognosis in early-onset breast cancer. Breast cancer (prognosis) 536 early-onset cases 1,516 early-onset cases 1p13.2 1 114670969 SYT6 - 148281 rs2774307-? rs2774307 0 2774307 intron 0 0.26 8E-6 5.096910013008055 1.30 [1.16-1.47] Illumina [487,496] N 03/26/2013 23319801 Rafiq S 01/14/2013 Cancer Res http://www.ncbi.nlm.nih.gov/pubmed/23319801 Identification of inherited genetic variations influencing prognosis in early-onset breast cancer. Breast cancer (prognosis) 536 early-onset cases 1,516 early-onset cases 17p13.1 17 9090224 NTN1 - 9423 rs3785982-? rs3785982 0 3785982 intron 0 0.12 8E-6 5.096910013008055 1.40 [1.21-1.62] Illumina [487,496] N 03/26/2013 23321320 Urabe Y 01/12/2013 J Hepatol http://www.ncbi.nlm.nih.gov/pubmed/23321320 A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region. Hepatitis C induced liver cirrhosis 682 Japanese ancestry cases, 1,045 Japanese ancestry controls 936 Japanese ancestry cases, 3,809 Japanese ancestry controls 6p21.32 6 32315727 C6orf10 - 10665 rs910049-A rs910049 0 910049 intron 0 0.142 9E-11 10.04575749056067 1.46 [1.28-1.62] Illumina [431,618] N 03/26/2013 23321320 Urabe Y 01/12/2013 J Hepatol http://www.ncbi.nlm.nih.gov/pubmed/23321320 A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region. Hepatitis C induced liver cirrhosis 682 Japanese ancestry cases, 1,045 Japanese ancestry controls 936 Japanese ancestry cases, 3,809 Japanese ancestry controls 6p21.32 6 32368087 BTNL2 - 56244 rs3817963-A rs3817963 0 3817963 intron 0 0.315 1E-8 8 1.30 [1.18-1.42] Illumina [431,618] N 03/26/2013 23321320 Urabe Y 01/12/2013 J Hepatol http://www.ncbi.nlm.nih.gov/pubmed/23321320 A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region. Hepatitis C induced liver cirrhosis 682 Japanese ancestry cases, 1,045 Japanese ancestry controls 936 Japanese ancestry cases, 3,809 Japanese ancestry controls 6p21.32 6 32401079 Intergenic 56244 3122 26.18 6.54 rs3129860-A rs3129860 0 3129860 1 0.231 1E-9 8.999999999999998 1.36 [1.22-1.49] Illumina [431,618] N 03/26/2013 23321320 Urabe Y 01/12/2013 J Hepatol http://www.ncbi.nlm.nih.gov/pubmed/23321320 A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region. Hepatitis C induced liver cirrhosis 682 Japanese ancestry cases, 1,045 Japanese ancestry controls 936 Japanese ancestry cases, 3,809 Japanese ancestry controls 6p21.32 6 32389648 Intergenic 56244 3122 14.75 17.97 rs3135363-C rs3135363 0 3135363 1 0.702 1E-10 10 1.37 [1.24-1.51] Illumina [431,618] N 03/26/2013 23321320 Urabe Y 01/12/2013 J Hepatol http://www.ncbi.nlm.nih.gov/pubmed/23321320 A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region. Hepatitis C induced liver cirrhosis 682 Japanese ancestry cases, 1,045 Japanese ancestry controls 936 Japanese ancestry cases, 3,809 Japanese ancestry controls 6p21.32 6 32379736 Intergenic 56244 3122 4.84 27.88 rs9405098-A rs9405098 0 9405098 1 0.253 1E-10 10 1.37 [1.24-1.51] Illumina [431,618] N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 10q26.13 10 124219275 ARMS2,HTRA1 - 5654 rs3793917-? rs3793917 0 3793917 nearGene-5 0 0.2 4E-24 23.39794000867204 (EA) 1.45 [1.35-1.56] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 1q25.2 1 177568799 Intergenic 57795 89866 317.24 329.44 rs16851585-? rs16851585 0 16851585 1 0.08 5E-6 5.301029995663981 (EA) 1.30 [1.16-1.45] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 1q31.3 1 196654324 CFH - 3075 rs1061147-A rs1061147 0 1061147 cds-synon 0 0.37 7E-32 31.15490195998574 1.40 [1.32-1.48] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 4q13.1 4 63342270 Intergenic 100271164 644534 227.78 33.81 rs6819266-? rs6819266 0 6819266 1 0.62 8E-6 5.096910013008055 1.15 [1.09-1.22] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 8q24.21 8 127332657 Intergenic 100420058 157638 145.32 232.03 rs11986011-T rs11986011 0 11986011 1 0.02 5E-6 5.301029995663981 2.50 [1.68-3.71] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 11q14.3 11 88891114 TYR 2915 7299 94.30 19.93 rs10830228-A rs10830228 0 10830228 1 0.42 9E-6 5.045757490560675 1.12 [1.06-1.18] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 19p13.3 19 3944240 ITGB1BP3, DAPK3 27231 693222 1.83 17.17 rs10406174-A rs10406174 0 10406174 1 0.11 7E-6 5.154901959985742 1.24 [1.12-1.36] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 1q32.2 1 208039471 CD34, CD46 407025 947 63.60 20.41 rs1967689-? rs1967689 0 1967689 1 0.75 5E-6 5.301029995663981 (EA) 1.18 [1.1-1.25] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 2q14.2 2 121301911 GLI2, INHBB 3625 2736 192.53 252.96 rs6721654-T rs6721654 0 6721654 1 0.08 7E-6 5.154901959985742 (EA) 1.26 [1.14-1.40] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 4q26 4 116924184 Intergenic 132391 645368 81.00 40.35 rs17586843-T rs17586843 0 17586843 1 0.78 2E-6 5.698970004336018 (EA) 1.18 [1.10-1.27] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 6q21 6 106260128 Intergenic 5550 639 409.13 274.07 rs7750345-A rs7750345 0 7750345 1 0.75 7E-6 5.154901959985742 (EA) 1.16 [1.09-1.24] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 7p14.1 7 42176282 GLI3 - 2737 rs2049622-? rs2049622 0 2049622 intron 0 0.51 9E-6 5.045757490560675 (EA) 1.15 [1.08-1.2] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 8q24.21 8 127332657 FAM84B 100420058 157638 145.32 232.03 rs11986011-T rs11986011 0 11986011 1 0.02 5E-6 5.301029995663981 (EA) 2.50 [1.68-3.71] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 10q21.1 10 54574996 MBL2 4153 100874423 43.54 223.05 rs6480975-C rs6480975 0 6480975 1 0.84 3E-6 5.522878745280337 (EA) 1.21 [1.12-1.32] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 11q14.1 11 82821382 PCF11, RAB30 1333 100127960 3.36 21.70 rs4293143-? rs4293143 0 4293143 1 0.31 8E-6 5.096910013008055 (EA) 1.18 [1.1-1.27] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 11q14.3 11 88913663 TYR - 7299 rs621313-? rs621313 0 621313 intron 0 0.49 4E-6 5.397940008672037 (EA) 1.15 [1.09-1.2] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 13q13.3 13 38065446 POSTN, TRPC4 100271551 400121 270.06 43.63 rs9646096-? rs9646096 0 9646096 1 0.05 6E-6 5.221848749616356 (EA) 1.35 [1.19-1.54] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 19q13.32 19 45392254 PVRL2 - 5819 rs6857-? rs6857 0 6857 UTR-3 0 0.85 1E-6 5.999999999999999 (EA) 1.23 [1.14-1.35] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 19q13.32 19 45395619 APOE, TOMM40 - 10452 rs2075650-A rs2075650 0 2075650 intron 0 0.86 1E-6 5.999999999999999 (EA) 1.23 [1.13-1.34] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 1q32.2 1 208039471 CD34, CD46 407025 947 63.60 20.41 rs1967689-? rs1967689 0 1967689 1 0.75 5E-6 5.301029995663981 1.18 [1.1-1.25] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 2q14.2 2 121282630 GLI2, INHBB 3625 2736 173.25 272.24 rs17050244-? rs17050244 0 17050244 1 0.11 5E-7 6.30102999566398 1.28 [1.16-1.41] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 4q26 4 116934079 Intergenic 132391 645368 90.89 30.45 rs7676999-? rs7676999 0 7676999 1 0.79 1E-6 5.999999999999999 1.19 [1.11-1.28] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 6p21.1 6 45885061 Intergenic - 53405 rs4714888-T rs4714888 0 4714888 intron 0 0.05 8E-6 5.096910013008055 1.30 [1.16-1.47] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 6q21 6 106252999 Intergenic 5550 639 402.00 281.20 rs1355023-T rs1355023 0 1355023 1 0.69 6E-6 5.221848749616356 1.13 [1.07-1.20] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 10q21.1 10 54574996 MBL2 4153 100874423 43.54 223.05 rs6480975-C rs6480975 0 6480975 1 0.84 2E-6 5.698970004336018 1.21 [1.12-1.32] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 10q26.13 10 124219275 ARMS2, HTRA1 - 5654 rs3793917-? rs3793917 0 3793917 nearGene-5 0 0.26 1E-25 25 1.39 [1.32-1.49] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 13q13.3 13 38065446 POSTN, TRPC4 100271551 400121 270.06 43.63 rs9646096-? rs9646096 0 9646096 1 0.05 6E-6 5.221848749616356 1.35 [1.19-1.54] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 19q13.32 19 45392254 PVRL2,APOE,TOMM40 - 5819 rs6857-? rs6857 0 6857 UTR-3 0 0.85 1E-6 5.999999999999999 1.23 [1.14-1.35] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 1q31.3[rs1329424]; CFH - rs1329424-T rs1329424 0.38 NS NS 1.41 [1.33-1.49] Illumina & Affymetrix [~2.5 million] Imputed N 04/19/2013 23326517 Holliday EG 01/11/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326517 Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. Age-related macular degeneration 3,772 European ancestry cases, 16,033 European ancestry controls 264 Asian ancestry cases, 3,926 Asian ancestry controls 19p13.3 19 3944240 ITGB1BP3, DAPK3 27231 693222 1.83 17.17 rs10406174-A rs10406174 0 10406174 1 0.11 6E-6 5.221848749616356 (EA) 1.24 [1.13-1.36] Illumina & Affymetrix [~2.5 million] Imputed N 04/12/2013 23326512 Greenwood TA 01/10/2013 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23326512 Genome-wide association study of irritable vs. elated mania suggests genetic differences between clinical subtypes of bipolar disorder. Bipolar disorder (mania) 117 irritable mania European ancestry cases, 843 elated mania European ancestry cases, 1033 European ancestry controls 121 irritable mania European ancestry cases, 1026 elated mania European ancestry cases 13q31.1 13 85665879 SLITRK1, SLITRK6 100873210 100874137 567.84 271.86 rs17079247-T rs17079247 0 17079247 1 NR 8E-6 5.096910013008055 (IM vs. EM) 1.75 Affymetrix [703,012] N 03/22/2013 23303382 Hong KW 01/10/2013 J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23303382 Genome-wide association study of serum albumin:globulin ratio in Korean populations. Hematology traits 4,637 East Asian ancestry individuals 4,205 East Asian ancestry individuals 6p25.3 6 252145 IRF4 26685 56940 145.29 39.96 rs6927090-A rs6927090 0 6927090 1 0.282 4E-6 5.397940008672037 (ALB/GLB) .02 [0.0091-0.0209] unit increase Affymetrix [290,659] N 03/22/2013 23303382 Hong KW 01/10/2013 J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23303382 Genome-wide association study of serum albumin:globulin ratio in Korean populations. Hematology traits 4,637 East Asian ancestry individuals 4,205 East Asian ancestry individuals 1q42.13 1 230388989 GALNT2 - 2590 rs3761944-C rs3761944 0 3761944 intron 0 0.224 8E-6 5.096910013008055 (ALB/GLB) .02 [0.0082-0.0238] unit increase Affymetrix [290,659] N 03/22/2013 23303382 Hong KW 01/10/2013 J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23303382 Genome-wide association study of serum albumin:globulin ratio in Korean populations. Hematology traits 4,637 East Asian ancestry individuals 4,205 East Asian ancestry individuals 9q32 9 115997249 SLC31A1 - 1317 rs6477998-C rs6477998 0 6477998 intron 0 0.467 8E-6 5.096910013008055 (ALB/GLB) .01 [0.0071-0.0189] unit increase Affymetrix [290,659] N 03/22/2013 23303382 Hong KW 01/10/2013 J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23303382 Genome-wide association study of serum albumin:globulin ratio in Korean populations. Hematology traits 4,637 East Asian ancestry individuals 4,205 East Asian ancestry individuals 17p11.2 17 16848750 TNFRSF13B - 23495 rs4561508-T rs4561508 0 4561508 intron 0 0.335 8E-24 23.09691001300805 (ALB/GLB) .03 [0.025-0.037] unit increase Affymetrix [290,659] N 03/22/2013 23303382 Hong KW 01/10/2013 J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23303382 Genome-wide association study of serum albumin:globulin ratio in Korean populations. Hematology traits 4,637 East Asian ancestry individuals 4,205 East Asian ancestry individuals 11q12.2 11 61571348 FADS1 - 3992 rs174548-G rs174548 0 174548 intron 0 0.319 4E-8 7.397940008672037 (ALB/GLB) .02 [0.011-0.023] unit increase Affymetrix [290,659] N 05/01/2013 23326239 Rubicz R 01/10/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23326239 A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1). Epstein-Barr virus immune response (EBNA-1) 1,367 Mexican American indivduals 589 Mexican American indivduals 6p21.32 6 32569691 HLA-DRB1 3123 3117 12.08 35.49 rs477515-T rs477515 0 477515 1 0.32 3E-13 12.52287874528034 (Quantitative) .28 [NR] unit decrease Illumina [944,565] N 05/01/2013 23326239 Rubicz R 01/10/2013 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23326239 A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1). Epstein-Barr virus immune response (EBNA-1) 1,367 Mexican American indivduals 589 Mexican American indivduals 6p21.32 6 32628428 HLA-DQB1, C6orf15, PSORS1C1, HLA-B, BAT2, BAT4, EHMT2, PRRT1, NOTCH4, - 3119 rs2854275-T rs2854275 0 2854275 intron 0 0.064 2E-10 9.698970004336017 (Conditional on rs477515 - Quantitative) .45 [NR] unit decrease Illumina [944,565] N 04/17/2013 23307926 Perry JR 01/09/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23307926 A genome-wide association study of early menopause and the combined impact of identified variants. Menopause (age at onset) 3,493 European ancestry cases, 13,598 European ancestry controls 3,412 European ancestry cases, 4,928 European ancestry controls 1p31.3 1 67046126 SGIP1 - 84251 rs1867631-A rs1867631 0 1867631 intron 0 0.2892 5E-6 5.301029995663981 .11 [0.060-0.154] years decrease NR N 04/17/2013 23307926 Perry JR 01/09/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23307926 A genome-wide association study of early menopause and the combined impact of identified variants. Menopause (age at onset) 3,493 European ancestry cases, 13,598 European ancestry controls 3,412 European ancestry cases, 4,928 European ancestry controls 19q13.42 19 55833664 NR - 284417 rs11668344-A rs11668344 0 11668344 intron 0 0.636 5E-26 25.30102999566398 .30 [0.25-0.36] years decrease NR N 04/17/2013 23307926 Perry JR 01/09/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23307926 A genome-wide association study of early menopause and the combined impact of identified variants. Menopause (age at onset) 3,493 European ancestry cases, 13,598 European ancestry controls 3,412 European ancestry cases, 4,928 European ancestry controls 20p12.3 20 5948227 NR - 84515 rs16991615-A rs16991615 0 16991615 missense 0 0.0785 5E-12 11.30102999566398 .46 [0.33-0.59] years decrease NR N 04/17/2013 23307926 Perry JR 01/09/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23307926 A genome-wide association study of early menopause and the combined impact of identified variants. Menopause (age at onset) 3,493 European ancestry cases, 13,598 European ancestry controls 3,412 European ancestry cases, 4,928 European ancestry controls 2q36.3 2 226225623 NYAP2 100616207 57624 350.37 39.98 rs1473307-T rs1473307 0 1473307 1 0.5715 3E-7 6.522878745280337 .14 [0.089-0.199] years decrease NR N 04/17/2013 23307926 Perry JR 01/09/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23307926 A genome-wide association study of early menopause and the combined impact of identified variants. Menopause (age at onset) 3,493 European ancestry cases, 13,598 European ancestry controls 3,412 European ancestry cases, 4,928 European ancestry controls 16p13.13 16 12016919 NR 9384 608 18.87 42.05 rs10852344-T rs10852344 0 10852344 1 0.5835 5E-8 7.30102999566398 .16 [0.10-0.21] years increase NR N 04/17/2013 23307926 Perry JR 01/09/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23307926 A genome-wide association study of early menopause and the combined impact of identified variants. Menopause (age at onset) 3,493 European ancestry cases, 13,598 European ancestry controls 3,412 European ancestry cases, 4,928 European ancestry controls 19q13.43 19 56320663 NR - 204801 rs12461110-A rs12461110 0 12461110 missense 0 0.3594 9E-8 7.045757490560674 .16 [0.098-0.212] years increase NR N 04/17/2013 23307926 Perry JR 01/09/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23307926 A genome-wide association study of early menopause and the combined impact of identified variants. Menopause (age at onset) 3,493 European ancestry cases, 13,598 European ancestry controls 3,412 European ancestry cases, 4,928 European ancestry controls 8p11.23 8 37977732 NR - 9070 rs2517388-T rs2517388 0 2517388 intron 0 0.8234 1E-7 7 .21 [0.13-0.29] years increase NR N 04/17/2013 23307926 Perry JR 01/09/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23307926 A genome-wide association study of early menopause and the combined impact of identified variants. Menopause (age at onset) 3,493 European ancestry cases, 13,598 European ancestry controls 3,412 European ancestry cases, 4,928 European ancestry controls 6p21.33 6 31602967 NR - 7916 rs1046089-A rs1046089 0 1046089 missense 0 0.3492 4E-11 10.39794000867204 .19 [0.13-0.25] years increase NR N 03/27/2013 23300278 Saxena R 01/08/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23300278 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Type 2 diabetes 842 Punjabi Sikh cases, 774 Punjabi Sikh controls up to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls; up to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls; up to 13,559 other South Asian cases and 20,822 other South Asian controls; up to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls; up to 8,130 European ancestry cases and 38,987 European ancestry controls 10q25.2 10 114758349 TCF7L2 - 6934 rs7903146-T rs7903146 0 7903146 intron 0 0.31 3E-19 18.52287874528033 (Punjabi Sikhs) 1.44 [1.33 - 1.56] Illumina [1,232,008] (imputed) N 03/27/2013 23300278 Saxena R 01/08/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23300278 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Type 2 diabetes 842 Punjabi Sikh cases, 774 Punjabi Sikh controls up to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls; up to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls; up to 13,559 other South Asian cases and 20,822 other South Asian controls; up to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls; up to 8,130 European ancestry cases and 38,987 European ancestry controls 3q27.2 3 185529080 IGF2BP2 - 10644 rs1470579-C rs1470579 0 1470579 intron 0 0.5 2E-19 18.69897000433602 (South Asian, East Asian, Europeans) 1.08 [1.05-1.09] Illumina [1,232,008] (imputed) N 03/27/2013 23300278 Saxena R 01/08/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23300278 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Type 2 diabetes 842 Punjabi Sikh cases, 774 Punjabi Sikh controls up to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls; up to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls; up to 13,559 other South Asian cases and 20,822 other South Asian controls; up to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls; up to 8,130 European ancestry cases and 38,987 European ancestry controls 5q33.2 5 155394230 Intergenic 100131033 6444 520.86 359.54 rs17053082-T rs17053082 0 17053082 1 0.1 4E-7 6.397940008672037 (Punjabi Sikhs) 1.49 [1.28 - 1.73] Illumina [1,232,008] (imputed) N 03/27/2013 23300278 Saxena R 01/08/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23300278 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Type 2 diabetes 842 Punjabi Sikh cases, 774 Punjabi Sikh controls up to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls; up to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls; up to 13,559 other South Asian cases and 20,822 other South Asian controls; up to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls; up to 8,130 European ancestry cases and 38,987 European ancestry controls 1q42.13 1 228880115 RHOU - 58480 rs6426514-A rs6426514 0 6426514 ncRNA 0 0.06 2E-6 5.698970004336018 (Punjabi Sikhs) 1.51 [1.27 - 1.78] Illumina [1,232,008] (imputed) N 03/27/2013 23300278 Saxena R 01/08/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23300278 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Type 2 diabetes 842 Punjabi Sikh cases, 774 Punjabi Sikh controls up to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls; up to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls; up to 13,559 other South Asian cases and 20,822 other South Asian controls; up to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls; up to 8,130 European ancestry cases and 38,987 European ancestry controls 8q24.22 8 134196849 WISP1 6503 8840 81.54 6.43 rs4527850-T rs4527850 0 4527850 1 0.75 2E-6 5.698970004336018 (Punjabi Sikhs) 1.23 [1.13 - 1.34] Illumina [1,232,008] (imputed) N 03/27/2013 23300278 Saxena R 01/08/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23300278 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Type 2 diabetes 842 Punjabi Sikh cases, 774 Punjabi Sikh controls up to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls; up to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls; up to 13,559 other South Asian cases and 20,822 other South Asian controls; up to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls; up to 8,130 European ancestry cases and 38,987 European ancestry controls 17p13.3 17 700020 NXN 55178 64359 4.28 2.53 rs623323-T rs623323 0 623323 1 0.15 4E-6 5.397940008672037 (Punjabi Sikhs) 1.28 [1.15 - 1.42] Illumina [1,232,008] (imputed) N 03/27/2013 23300278 Saxena R 01/08/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23300278 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Type 2 diabetes 842 Punjabi Sikh cases, 774 Punjabi Sikh controls up to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls; up to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls; up to 13,559 other South Asian cases and 20,822 other South Asian controls; up to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls; up to 8,130 European ancestry cases and 38,987 European ancestry controls 3q27.2 3 185529080 IGF2BP2 - 10644 rs1470579-C rs1470579 0 1470579 intron 0 0.41 5E-6 5.301029995663981 (Punjabi Sikhs) 1.19 [1.11-1.28] Illumina [1,232,008] (imputed) N 03/27/2013 23300278 Saxena R 01/08/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23300278 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Type 2 diabetes 842 Punjabi Sikh cases, 774 Punjabi Sikh controls up to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls; up to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls; up to 13,559 other South Asian cases and 20,822 other South Asian controls; up to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls; up to 8,130 European ancestry cases and 38,987 European ancestry controls 10q25.2 10 114758349 TCF7L2 - 6934 rs7903146-T rs7903146 0 7903146 intron 0 0.31 6E-22 21.22184874961636 (All Punjabi) 1.30 [1.23 - 1.37] Illumina [1,232,008] (imputed) N 03/27/2013 23300278 Saxena R 01/08/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23300278 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Type 2 diabetes 842 Punjabi Sikh cases, 774 Punjabi Sikh controls up to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls; up to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls; up to 13,559 other South Asian cases and 20,822 other South Asian controls; up to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls; up to 8,130 European ancestry cases and 38,987 European ancestry controls 5q33.2 5 155394230 Intergenic 100131033 6444 520.86 359.54 rs17053082-T rs17053082 0 17053082 1 0.1 4E-7 6.397940008672037 (All Punjabi) 1.49 [1.28 - 1.73] Illumina [1,232,008] (imputed) N 03/27/2013 23300278 Saxena R 01/08/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23300278 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Type 2 diabetes 842 Punjabi Sikh cases, 774 Punjabi Sikh controls up to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls; up to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls; up to 13,559 other South Asian cases and 20,822 other South Asian controls; up to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls; up to 8,130 European ancestry cases and 38,987 European ancestry controls 3q27.2 3 185529080 IGF2BP2 - 10644 rs1470579-C rs1470579 0 1470579 intron 0 0.41 4E-7 6.397940008672037 (All Punjabi) .88 [0.83 - 0.92] Illumina [1,232,008] (imputed) N 03/27/2013 23300278 Saxena R 01/08/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23300278 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Type 2 diabetes 842 Punjabi Sikh cases, 774 Punjabi Sikh controls up to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls; up to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls; up to 13,559 other South Asian cases and 20,822 other South Asian controls; up to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls; up to 8,130 European ancestry cases and 38,987 European ancestry controls 10q25.2 10 114758349 TCF7L2 - 6934 rs7903146-T rs7903146 0 7903146 intron 0 0.3 3E-35 34.52287874528033 (South Asians) 1.15 [1.13 - 1.18] Illumina [1,232,008] (imputed) N 03/27/2013 23300278 Saxena R 01/08/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23300278 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Type 2 diabetes 842 Punjabi Sikh cases, 774 Punjabi Sikh controls up to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls; up to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls; up to 13,559 other South Asian cases and 20,822 other South Asian controls; up to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls; up to 8,130 European ancestry cases and 38,987 European ancestry controls 3q27.2 3 185529080 IGF2BP2 - 10644 rs1470579-C rs1470579 0 1470579 intron 0 0.45 4E-9 8.397940008672036 (South Asians) 1.06 [1.04-1.09] Illumina [1,232,008] (imputed) N 03/27/2013 23300278 Saxena R 01/08/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23300278 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Type 2 diabetes 842 Punjabi Sikh cases, 774 Punjabi Sikh controls up to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls; up to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls; up to 13,559 other South Asian cases and 20,822 other South Asian controls; up to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls; up to 8,130 European ancestry cases and 38,987 European ancestry controls 20q13.31 20 56029604 HMG1L1, CTCFL, RBM38, PCK1 55544 10357 45.22 33.39 rs328506-C rs328506 0 328506 1 0.8 2E-6 5.698970004336018 (South Asians) 1.11 [1.06-1.15] Illumina [1,232,008] (imputed) N 03/27/2013 23300278 Saxena R 01/08/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23300278 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Type 2 diabetes 842 Punjabi Sikh cases, 774 Punjabi Sikh controls up to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls; up to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls; up to 13,559 other South Asian cases and 20,822 other South Asian controls; up to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls; up to 8,130 European ancestry cases and 38,987 European ancestry controls 10q25.2 10 114758349 TCF7L2 - 6934 rs7903146-T rs7903146 0 7903146 intron 0 0.3 2E-38 37.69897000433602 (South Asians, East Asians) 1.15 [1.12 - 1.17] Illumina [1,232,008] (imputed) N 03/27/2013 23300278 Saxena R 01/08/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23300278 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Type 2 diabetes 842 Punjabi Sikh cases, 774 Punjabi Sikh controls up to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls; up to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls; up to 13,559 other South Asian cases and 20,822 other South Asian controls; up to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls; up to 8,130 European ancestry cases and 38,987 European ancestry controls 3q27.2 3 185529080 IGF2BP2 - 10644 rs1470579-C rs1470579 0 1470579 intron 0 0.45 2E-13 12.69897000433602 (South Asians, East Asians) 1.06 [1.04-1.08] Illumina [1,232,008] (imputed) N 03/27/2013 23300278 Saxena R 01/08/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23300278 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Type 2 diabetes 842 Punjabi Sikh cases, 774 Punjabi Sikh controls up to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls; up to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls; up to 13,559 other South Asian cases and 20,822 other South Asian controls; up to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls; up to 8,130 European ancestry cases and 38,987 European ancestry controls 10q25.2 10 114758349 TCF7L2 - 6934 rs7903146-T rs7903146 0 7903146 intron 0 0.5 9E-75 74.04575749056066 (South Asian, East Asian, Europeans) 1.19 [1.17 - 1.21] Illumina [1,232,008] (imputed) N 03/27/2013 23300278 Saxena R 01/08/2013 Diabetes http://www.ncbi.nlm.nih.gov/pubmed/23300278 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Type 2 diabetes 842 Punjabi Sikh cases, 774 Punjabi Sikh controls up to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls; up to 2,569 non-Sikh Punjabi cases and 3,024 non-Sikh Punjabi controls; up to 13,559 other South Asian cases and 20,822 other South Asian controls; up to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls; up to 8,130 European ancestry cases and 38,987 European ancestry controls 13q12.12 13 23864657 SGCG, SACS - 6445 rs9552911-G rs9552911 0 9552911 intron 0 0.93 2E-8 7.698970004336018 (Punjabi Sikhs) 1.49 [1.3-1.72] Illumina [1,232,008] (imputed) N 04/17/2013 23297363 Cordell HJ 01/07/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23297363 Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot. Tetralogy of Fallot 835 European ancestry cases, 5,159 European ancestry controls 798 European ancestry cases and 2,931 European ancestry controls 16q12.2 16 52831462 Intergenic 27324 80205 249.75 257.48 rs6499100-A rs6499100 0 6499100 1 0.519 1E-6 5.999999999999999 1.26 [1.14-1.4] Illumina [516,131] N 04/17/2013 23297363 Cordell HJ 01/07/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23297363 Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot. Tetralogy of Fallot 835 European ancestry cases, 5,159 European ancestry controls 798 European ancestry cases and 2,931 European ancestry controls 10p11.22 10 33475282 NRP1 - 8829 rs2228638-A rs2228638 0 2228638 missense 0 0.096 2E-7 6.698970004336019 1.45 [1.239-1.69] Illumina [516,131] N 04/17/2013 23297363 Cordell HJ 01/07/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23297363 Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot. Tetralogy of Fallot 835 European ancestry cases, 5,159 European ancestry controls 798 European ancestry cases and 2,931 European ancestry controls 10p14 10 8954224 Intergenic 338591 644495 291.65 809.50 rs2388896-G rs2388896 0 2388896 1 0.599 9E-8 7.045757490560674 1.28 [1.15-1.43] Illumina [516,131] N 04/17/2013 23297363 Cordell HJ 01/07/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23297363 Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot. Tetralogy of Fallot 835 European ancestry cases, 5,159 European ancestry controls 798 European ancestry cases and 2,931 European ancestry controls 13q31.3 13 92988323 GPC5 - 2262 rs7982677-A rs7982677 0 7982677 intron 0 0.281 3E-9 8.522878745280337 1.29 [1.152-1.441] Illumina [516,131] N 04/17/2013 23297363 Cordell HJ 01/07/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23297363 Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot. Tetralogy of Fallot 835 European ancestry cases, 5,159 European ancestry controls 798 European ancestry cases and 2,931 European ancestry controls 3q25.32 3 158453279 Intergenic - 100287290 rs7646881-A rs7646881 0 7646881 0 0.168 2E-6 5.698970004336018 1.39 [1.224-1.581] Illumina [516,131] N 04/17/2013 23297363 Cordell HJ 01/07/2013 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23297363 Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot. Tetralogy of Fallot 835 European ancestry cases, 5,159 European ancestry controls 798 European ancestry cases and 2,931 European ancestry controls 12q24.12 12 112072424 PTPN11 6311 8315 34.94 7.53 rs11065987-G rs11065987 0 11065987 1 0.418 8E-11 10.09691001300805 1.34 [1.208-1.496] Illumina [516,131] N 04/11/2013 23300138 He M 01/07/2013 Gut http://www.ncbi.nlm.nih.gov/pubmed/23300138 A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk. Tumor biomarkers 3,451 Han Chinese individuals 10,326 Chinese ancestry individuals 19q13.33 19 49206631 FUT2 - 2524 rs1047781-T rs1047781 0 1047781 missense 0 0.46 6E-209 208.2218487496163 (CEA) .24 [0.21-0.26] ng/ml increase Illumina & Affymetrix [NR] imputed N 04/11/2013 23300138 He M 01/07/2013 Gut http://www.ncbi.nlm.nih.gov/pubmed/23300138 A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk. Tumor biomarkers 3,451 Han Chinese individuals 10,326 Chinese ancestry individuals 21q22.3 21 42698907 FAM3B - 54097 rs441810-G rs441810 0 441810 intron 0 0.24 3E-22 21.52287874528033 (CEA) .07 [0.040-0.098] ng/ml increase Illumina & Affymetrix [NR] imputed N 04/11/2013 23300138 He M 01/07/2013 Gut http://www.ncbi.nlm.nih.gov/pubmed/23300138 A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk. Tumor biomarkers 3,451 Han Chinese individuals 10,326 Chinese ancestry individuals 4q13.3 4 74319283 AFP - 174 rs12506899-G rs12506899 0 12506899 intron 0 0.32 3E-18 17.52287874528034 (AFP) .07 [0.032-0.098] ng/ml decrease Illumina & Affymetrix [NR] imputed N 04/11/2013 23300138 He M 01/07/2013 Gut http://www.ncbi.nlm.nih.gov/pubmed/23300138 A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk. Tumor biomarkers 3,451 Han Chinese individuals 10,326 Chinese ancestry individuals 15q15.3 15 43836478 HISPPD2A - 9677 rs2251844-C rs2251844 0 2251844 intron 0 0.42 1E-14 14 (AFP) .09 [0.056-0.118] ng/ml increase Illumina & Affymetrix [NR] imputed N 04/11/2013 23300138 He M 01/07/2013 Gut http://www.ncbi.nlm.nih.gov/pubmed/23300138 A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk. Tumor biomarkers 3,451 Han Chinese individuals 10,326 Chinese ancestry individuals 9q34.2 9 136131188 ABO - 28 rs8176749-T rs8176749 0 8176749 cds-synon 0 0.18 7E-105 104.1549019599857 (CEA) .21 [0.18-0.23] ng/ml increase Illumina & Affymetrix [NR] imputed N 04/11/2013 23300138 He M 01/07/2013 Gut http://www.ncbi.nlm.nih.gov/pubmed/23300138 A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk. Tumor biomarkers 3,451 Han Chinese individuals 10,326 Chinese ancestry individuals 19p13.11 19 17902334 B3GNT3 23149 10331 2.96 3.59 rs265548-C rs265548 0 265548 1 0.26 1E-13 13 (CA19-9) .07 [0.029-0.115] U/ml decrease Illumina & Affymetrix [NR] imputed N 04/11/2013 23300138 He M 01/07/2013 Gut http://www.ncbi.nlm.nih.gov/pubmed/23300138 A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk. Tumor biomarkers 3,451 Han Chinese individuals 10,326 Chinese ancestry individuals 19p13.3 19 5841356 FUT6 - 2528 rs3760775-T rs3760775 0 3760775 nearGene-5 0 0.33 3E-290 289.5228787452803 (CA19-9) .48 [0.44-0.52] U/ml decrease Illumina & Affymetrix [NR] imputed N 04/11/2013 23300138 He M 01/07/2013 Gut http://www.ncbi.nlm.nih.gov/pubmed/23300138 A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk. Tumor biomarkers 3,451 Han Chinese individuals 10,326 Chinese ancestry individuals 19p13.3 19 5841356 FUT6 - 2528 rs3760775-T rs3760775 0 3760775 nearGene-5 0 0.33 1E-35 35 (CEA) .07 [0.048-0.098] ng/ml increase Illumina & Affymetrix [NR] imputed N 04/11/2013 23300138 He M 01/07/2013 Gut http://www.ncbi.nlm.nih.gov/pubmed/23300138 A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk. Tumor biomarkers 3,451 Han Chinese individuals 10,326 Chinese ancestry individuals 19p13.3 19 5839746 FUT6 - 2528 rs3760776-T rs3760776 0 3760776 nearGene-5 0 0.20 2E-56 55.69897000433601 (CA19-9) .17 [0.11-0.22] U/ml decrease Illumina & Affymetrix [NR] imputed N 04/11/2013 23300138 He M 01/07/2013 Gut http://www.ncbi.nlm.nih.gov/pubmed/23300138 A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk. Tumor biomarkers 3,451 Han Chinese individuals 10,326 Chinese ancestry individuals 19q13.33 19 49206631 FUT2, CA11 - 2524 rs1047781-T rs1047781 0 1047781 missense 0 0.46 8E-176 175.0969100130081 (CA19-9) .44 [0.41-0.48] U/ml increase Illumina & Affymetrix [NR] imputed N 04/11/2013 23300138 He M 01/07/2013 Gut http://www.ncbi.nlm.nih.gov/pubmed/23300138 A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and α fetoprotein and their associations with cancer risk. Tumor biomarkers 3,451 Han Chinese individuals 10,326 Chinese ancestry individuals 19p13.3 19 5834212 FUT6 - 2528 rs17271883-G rs17271883 0 17271883 intron 0 0.38 5E-132 131.301029995664 (CA19-9) .28 [0.20-0.37] U/ml increase Illumina & Affymetrix [NR] imputed N 03/27/2013 23291587 Kirino Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291587 Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. Behcet's disease 435 Turkish cases with uveitis, 780 Turkish cases without uveitis, 1,278 Turkish controls 355 Turkish cases with uveitis, 483 Turkish cases without uveitis, 601 Turkish controls, up to 612 Japanese ancestry cases, up to 740 Japanese ancestry controls 5q15 5 96118866 ERAP1 - 51752 rs17482078-T rs17482078 0 17482078 missense 0 0.02 5E-11 10.30102999566398 (Turkish cases with Uveitis - Recessive Model) 4.56 [2.88-7.22] Illumina [779,465] (imputed) N 03/27/2013 23291587 Kirino Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291587 Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. Behcet's disease 435 Turkish cases with uveitis, 780 Turkish cases without uveitis, 1,278 Turkish controls 355 Turkish cases with uveitis, 483 Turkish cases without uveitis, 601 Turkish controls, up to 612 Japanese ancestry cases, up to 740 Japanese ancestry controls 3q25.33 3 159665050 IL12A 29970 3592 49.90 41.57 rs17810546-A rs17810546 0 17810546 1 0.05 6E-7 6.221848749616355 (All Turkish cases) 1.55 [1.30-1.85] Illumina [779,465] (imputed) N 03/27/2013 23291587 Kirino Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291587 Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. Behcet's disease 435 Turkish cases with uveitis, 780 Turkish cases without uveitis, 1,278 Turkish controls 355 Turkish cases with uveitis, 483 Turkish cases without uveitis, 601 Turkish controls, up to 612 Japanese ancestry cases, up to 740 Japanese ancestry controls 12p13.2 12 10560957 KLRC4 - 8302;100528032 rs2617170-T rs2617170 0 2617170 missense;UTR-5 0 0.63 1E-9 8.999999999999998 1.28 [1.18-1.39] Illumina [779,465] (imputed) N 03/27/2013 23291587 Kirino Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291587 Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. Behcet's disease 435 Turkish cases with uveitis, 780 Turkish cases without uveitis, 1,278 Turkish controls 355 Turkish cases with uveitis, 483 Turkish cases without uveitis, 601 Turkish controls, up to 612 Japanese ancestry cases, up to 740 Japanese ancestry controls 2q32.3 2 192010488 STAT4 - 6775 rs7574070-A rs7574070 0 7574070 intron 0 0.421 1E-9 8.999999999999998 1.27 [1.17-1.37] Illumina [779,465] (imputed) N 03/27/2013 23291587 Kirino Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291587 Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. Behcet's disease 435 Turkish cases with uveitis, 780 Turkish cases without uveitis, 1,278 Turkish controls 355 Turkish cases with uveitis, 483 Turkish cases without uveitis, 601 Turkish controls, up to 612 Japanese ancestry cases, up to 740 Japanese ancestry controls 3p21.31 3 46205686 CCR1, CCR3 391533 1230 20.40 37.51 rs7616215-C rs7616215 0 7616215 1 0.654 4E-13 12.39794000867204 1.39 [1.27-1.52] Illumina [779,465] (imputed) N 03/27/2013 23291587 Kirino Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291587 Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. Behcet's disease 435 Turkish cases with uveitis, 780 Turkish cases without uveitis, 1,278 Turkish controls 355 Turkish cases with uveitis, 483 Turkish cases without uveitis, 601 Turkish controls, up to 612 Japanese ancestry cases, up to 740 Japanese ancestry controls 5q15 5 96118866 ERAP1 - 51752 rs17482078-T rs17482078 0 17482078 missense 0 0.02 4E-8 7.397940008672037 (All Turkish cases - Recessive Model) 3.08 [2.04-4.65] Illumina [779,465] (imputed) N 03/21/2013 23291585 LeishGEN Consortium 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291585 Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis. Leishmaniasis (visceral) 889 Indian ancestry cases, 977 Indian ancestry controls, 357 Brazilian ancestry cases, and 1,615 Brazilian ancestry unaffected relatives 889 Indian ancestry cases, 948 Indian ancestry controls. 6p21.32 6 32595223 HLA-DRB1, HLA-DQA1, HLA 3123 3117 37.61 9.96 rs9271858-G rs9271858 0 9271858 1 0.39 3E-17 16.52287874528034 1.41 [1.30-1.52] Illumina [521,134] N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 7q11.21 7 66421446 C7orf42 - 55069 rs4718428-T rs4718428 0 4718428 UTR-3 0 0.65 3E-10 9.522878745280336 .05 [0.03-0.07] unit increase Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 9p23 9 13557491 MPDZ, NF1B 401492 347193 126.16 428.63 rs1324183-A rs1324183 0 1324183 1 0.2 8E-9 8.096910013008056 .05 [0.011-0.089] unit decrease Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 9q31.3 9 113662681 LPAR1 - 1902 rs1007000-T rs1007000 0 1007000 intron 0 0.22 5E-12 11.30102999566398 .07 [0.031-0.109] unit increase Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 9q34.3 9 137440528 RXRA, COL5A1 6256 1289 108.10 93.12 rs1536482-A rs1536482 0 1536482 1 0.34 3E-22 21.52287874528033 .12 [0.1-0.14] unit decrease Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 9q34.3 9 137568051 COL5A1 - 1289 rs7044529-T rs7044529 0 7044529 intron 0 0.15 5E-12 11.30102999566398 .13 [0.091-0.169] unit decrease Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 9q34.3 9 139860264 LCN12, PTGDS 286256 5730 10.32 11.69 rs11145951-T rs11145951 0 11145951 1 0.49 6E-12 11.22184874961635 .09 [0.07-0.11] unit increase Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 10q21.2 10 63830286 ARID5B - 84159 rs7090871-T rs7090871 0 7090871 intron 0 0.59 6E-10 9.221848749616356 .06 [0.04-0.08] unit increase Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 11q23.1 11 110913240 ARHGAP20, POU2AF1 57569 100271363 329.33 63.05 rs4938174-A rs4938174 0 4938174 1 0.31 4E-9 8.397940008672036 .06 [0.04-0.08] unit increase Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 12q23.3 12 104445742 GLT8D2 - 83468 rs1564892-A rs1564892 0 1564892 nearGene-5 0 0.76 2E-10 9.698970004336017 .08 [0.041-0.119] unit decrease Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 13q12.11 13 23228691 FGF9, SGCG 100873208 2500 541.21 41.31 rs1034200-A rs1034200 0 1034200 1 0.23 4E-9 8.397940008672036 .10 [0.061-0.139] unit increase Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 13q14.11 13 41110884 FOXO1 - 100289058 rs2721051-T rs2721051 0 2721051 0 0.11 4E-14 13.39794000867204 .17 [0.13-0.21] unit decrease Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 15q13.1 15 30173885 TJP1 7082 283698 59.18 162.76 rs785422-T rs785422 0 785422 1 0.11 3E-11 10.52287874528034 .14 [0.1-0.18] unit decrease Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 15q22.33 15 67467507 SMAD3 - 4088 rs12913547-T rs12913547 0 12913547 intron 0 0.77 5E-10 9.301029995663981 .08 [0.041-0.119] unit decrease Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 15q25.3 15 85825567 AKAP13 100216542 100151676 29.08 107.49 rs6496932-A rs6496932 0 6496932 1 0.2 7E-13 12.15490195998574 .11 [0.071-0.149] unit decrease Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 15q26.3 15 101558562 LRRK1 - 79705 rs930847-T rs930847 0 930847 intron 0 0.77 6E-19 18.22184874961635 .11 [0.071-0.149] unit decrease Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 15q26.3 15 101781934 CHSY1 - 22856 rs752092-A rs752092 0 752092 intron 0 0.66 2E-9 8.698970004336019 .08 [0.06-0.1] unit decrease Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 16q24.2 16 88331640 BANP, ZNF469 54971 84627 220.72 162.24 rs9938149-A rs9938149 0 9938149 1 0.62 2E-49 48.69897000433601 .17 [0.15-0.19] unit increase Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 17p12 17 14561016 HS3ST3B1, PMP22 9953 388339 311.52 47.34 rs12940030-T rs12940030 0 12940030 1 0.71 7E-10 9.154901959985741 .08 [0.06-0.1] unit increase Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 7q11.21 7 65326821 VKORC1L1 643253 154807 98.16 11.44 rs11763147-A rs11763147 0 11763147 1 0.45 4E-9 8.397940008672036 .07 [0.05-0.09] unit increase Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 6q14.1 6 82794594 FAM46A, IBTK 55603 25998 332.17 85.36 rs1538138-T rs1538138 0 1538138 1 0.25 1E-12 12 .07 [0.031-0.109] unit decrease Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 5q12.3 5 64625512 ADAMTS6 - 11174 rs2307121-T rs2307121 0 2307121 intron 0 0.34 6E-11 10.22184874961635 .09 [0.07-0.11] unit increase Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 4q31.23 4 149079497 NR3C2 - 4306 rs3931397-T rs3931397 0 3931397 intron 0 0.07 4E-8 7.397940008672037 .12 [0.061-0.179] unit decrease Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 3q26.32 3 177304298 TBL1XR1, KCNMB2 - 100505566 rs7620503-T rs7620503 0 7620503 intron 0 0.39 1E-8 8 .06 [0.04-0.08] unit decrease Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 3q26.31 3 171995605 FNDC3B - 64778 rs4894535 -T rs4894535 0 4894535 intron 0 0.17 5E-12 11.30102999566398 .10 [0.061-0.139] unit decrease Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 1p34.3 1 36571920 COL8A2 1296 27095 6.07 30.25 rs96067-A rs96067 0 96067 1 0.8 3E-11 10.52287874528034 .03 [-0.0092-0.0692] unit increase Illumina & Affymetrix [~1 Million] (Imputed) N 03/28/2013 23291589 Lu Y 01/06/2013 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23291589 Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. Corneal structure 13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals NR 2q36.3 2 228135180 COL4A3 - 1285;654841 rs7606754-A rs7606754 0 7606754 intron;intron 0 0.35 1E-9 8.999999999999998 .07 [0.05-0.09] unit decrease Illumina & Affymetrix [~1 Million] (Imputed) N 03/20/2013 23401653 Guggenheim JA 01/03/2013 Mol Vis http://www.ncbi.nlm.nih.gov/pubmed/23401653 A genome-wide association study for corneal curvature identifies the platelet-derived growth factor receptor alpha gene as a quantitative trait locus for eye size in white Europeans. Corneal curvature 2,023 European ancestry children 2,008 Chinese ancestry adults, 2,281 Malay ancestry adults, 2,142 Indian ancestry adults, 929 Chinese ancestry children 4q12 4 55087581 PDGFRA - 442108 rs17084051-A rs17084051 0 17084051 0 NR 5E-14 13.30102999566398 .13 [0.093-0.159] (unit decrease) Illumina [2,543,887] (Imputed) N 03/19/2013 23279374 Athanasiadis G 01/02/2013 J Thromb Haemost http://www.ncbi.nlm.nih.gov/pubmed/23279374 Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain. β2-Glycoprotein I (β2-GPI) plasma levels 306 European ancestry individuals NR 11p15.4 11 9111558 SCUBE2 - 57758;100847015 rs963167-C rs963167 0 963167 intron;nearGene-3 0 0.15 1E-7 7 .65 (unit increase) Illumina [283,437] N 03/19/2013 23279374 Athanasiadis G 01/02/2013 J Thromb Haemost http://www.ncbi.nlm.nih.gov/pubmed/23279374 Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain. β2-Glycoprotein I (β2-GPI) plasma levels 306 European ancestry individuals NR 10q24.2 10 101365313 SLC25A28 159296 81894 69.03 4.96 rs11190179-G rs11190179 0 11190179 1 0.12 2E-6 5.698970004336018 .65 (unit increase) Illumina [283,437] N 03/19/2013 23279374 Athanasiadis G 01/02/2013 J Thromb Haemost http://www.ncbi.nlm.nih.gov/pubmed/23279374 Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain. β2-Glycoprotein I (β2-GPI) plasma levels 306 European ancestry individuals NR 5p14.1 5 25692973 CDH10, CDH9 1008 4479 1047.89 216.44 rs193741-A rs193741 0 193741 1 0.14 2E-6 5.698970004336018 .64 (unit decrease) Illumina [283,437] N 03/19/2013 23279374 Athanasiadis G 01/02/2013 J Thromb Haemost http://www.ncbi.nlm.nih.gov/pubmed/23279374 Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain. β2-Glycoprotein I (β2-GPI) plasma levels 306 European ancestry individuals NR 20q13.33 20 60381799 CDH4 - 1002 rs4925295-A rs4925295 0 4925295 intron 0 0.16 2E-6 5.698970004336018 .52 (unit decrease) Illumina [283,437] N 03/19/2013 23279374 Athanasiadis G 01/02/2013 J Thromb Haemost http://www.ncbi.nlm.nih.gov/pubmed/23279374 Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain. β2-Glycoprotein I (β2-GPI) plasma levels 306 European ancestry individuals NR 17q24.1 17 64098545 CEP112 - 201134 rs2319125-C rs2319125 0 2319125 intron 0 0.46 1E-6 5.999999999999999 .42 (unit increase) Illumina [283,437] N 03/19/2013 23279374 Athanasiadis G 01/02/2013 J Thromb Haemost http://www.ncbi.nlm.nih.gov/pubmed/23279374 Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain. β2-Glycoprotein I (β2-GPI) plasma levels 306 European ancestry individuals NR 17q24.2 17 64236318 APOH 350 5578 10.76 62.61 rs10048158-C rs10048158 0 10048158 1 0.5 1E-6 5.999999999999999 .41 (unit decrease) Illumina [283,437] N 03/19/2013 23279374 Athanasiadis G 01/02/2013 J Thromb Haemost http://www.ncbi.nlm.nih.gov/pubmed/23279374 Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain. β2-Glycoprotein I (β2-GPI) plasma levels 306 European ancestry individuals NR 17q24.1 17 64133726 CEP112 - 201134 rs7209395-T rs7209395 0 7209395 intron 0 0.34 7E-7 6.154901959985743 .44 (unit increase) Illumina [283,437] N 03/19/2013 23279374 Athanasiadis G 01/02/2013 J Thromb Haemost http://www.ncbi.nlm.nih.gov/pubmed/23279374 Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain. β2-Glycoprotein I (β2-GPI) plasma levels 306 European ancestry individuals NR 11p15.4 11 9109287 SCUBE2 - 57758 rs2647528-C rs2647528 0 2647528 intron 0 0.17 3E-7 6.522878745280337 .59 (unit increase) Illumina [283,437] N 03/19/2013 23279374 Athanasiadis G 01/02/2013 J Thromb Haemost http://www.ncbi.nlm.nih.gov/pubmed/23279374 Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain. β2-Glycoprotein I (β2-GPI) plasma levels 306 European ancestry individuals NR 11p13 11 34555191 ELF5 2001 26298 19.84 87.40 rs836132-C rs836132 0 836132 1 0.15 5E-8 7.30102999566398 .65 (unit increase) Illumina [283,437] N 04/09/2013 23290196 Hek K 01/02/2013 Biol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23290196 A genome-wide association study of depressive symptoms. Depression (quantitative trait) up to 34,549 European ancestry individuals up to 16,709 European ancestry individuals 14q23.3 14 67453858 GPHN - 10243 rs8020095-A rs8020095 0 8020095 intron 0 0.17 3E-6 5.522878745280337 NR NR Illumina & Affymetrix [2,391,896] (Imputed) N 04/09/2013 23290196 Hek K 01/02/2013 Biol Psychiatry http://www.ncbi.nlm.nih.gov/pubmed/23290196 A genome-wide association study of depressive symptoms. Depression (quantitative trait) up to 34,549 European ancestry individuals up to 16,709 European ancestry individuals 5q21.2 5 104069917 NUDT12 83594 9366 1171.43 365.26 rs161645-A rs161645 0 161645 1 0.34 8E-8 7.096910013008055 NR NR Illumina & Affymetrix [2,391,896] (Imputed) N 06/18/2013 23703922 Li WD 01/02/2013 Obesity (Silver Spring) http://www.ncbi.nlm.nih.gov/pubmed/23703922 A genome wide association study of plasma uric acid levels in obese cases and never-overweight controls. Uric acid levels 487 European ancestry obese individuals, 472 non-obese individuals NR 4p16.1 4 10286301 SLC2A9 348910 85460 28.02 155.20 rs4698014-? rs4698014 0 4698014 1 NR 8E-13 12.09691001300806 (Non-obese) NR NR Illumina [~550,000] N 06/18/2013 23703922 Li WD 01/02/2013 Obesity (Silver Spring) http://www.ncbi.nlm.nih.gov/pubmed/23703922 A genome wide association study of plasma uric acid levels in obese cases and never-overweight controls. Uric acid levels 487 European ancestry obese individuals, 472 non-obese individuals NR 4p16.1 4 9994215 SLC2A9 - 56606 rs6449213-? rs6449213 0 6449213 intron 0 NR 2E-7 6.698970004336019 (Obese) NR NR Illumina [~550,000] N 06/18/2013 23703922 Li WD 01/02/2013 Obesity (Silver Spring) http://www.ncbi.nlm.nih.gov/pubmed/23703922 A genome wide association study of plasma uric acid levels in obese cases and never-overweight controls. Uric acid levels 487 European ancestry obese individuals, 472 non-obese individuals NR 10p15.3 10 771532 DIP2C 100847086 23185 83.81 83.95 rs877282-? rs877282 0 877282 1 NR 5E-8 7.30102999566398 (Obese) NR NR Illumina [~550,000] N 06/18/2013 23703922 Li WD 01/02/2013 Obesity (Silver Spring) http://www.ncbi.nlm.nih.gov/pubmed/23703922 A genome wide association study of plasma uric acid levels in obese cases and never-overweight controls. Uric acid levels 487 European ancestry obese individuals, 472 non-obese individuals NR 4q21.21 4 79079757 FRAS1 - 80144 rs17002988-? rs17002988 0 17002988 intron 0 NR 6E-6 5.221848749616356 (Obese) NR NR Illumina [~550,000] N 06/18/2013 23703922 Li WD 01/02/2013 Obesity (Silver Spring) http://www.ncbi.nlm.nih.gov/pubmed/23703922 A genome wide association study of plasma uric acid levels in obese cases and never-overweight controls. Uric acid levels 487 European ancestry obese individuals, 472 non-obese individuals NR 1q24.2 1 169498975 F5 - 2153 rs6030-? rs6030 0 6030 missense 0 NR 3E-6 5.522878745280337 (Obese) NR NR Illumina [~550,000] N 06/18/2013 23703922 Li WD 01/02/2013 Obesity (Silver Spring) http://www.ncbi.nlm.nih.gov/pubmed/23703922 A genome wide association study of plasma uric acid levels in obese cases and never-overweight controls. Uric acid levels 487 European ancestry obese individuals, 472 non-obese individuals NR 4p16.1 4 9994215 SLC2A9 - 56606 rs6449213-? rs6449213 0 6449213 intron 0 NR 3E-12 11.52287874528034 NR NR Illumina [~550,000] N 03/27/2013 23359319 Jin G 01/01/2013 Neoplasia http://www.ncbi.nlm.nih.gov/pubmed/23359319 Genome-wide association study identifies loci at ATF7IP and KLK2 associated with percentage of circulating free PSA. Prostate-specific antigen levels 3,192 European ancestry individuals 1,722 European ancestry individuals 12p13.1 12 14587301 ATF7IP - 55729 rs3213764-G rs3213764 0 3213764 missense 0 0.467 2E-9 8.698970004336019 .05 % increase Illumina [642,584] N 03/27/2013 23359319 Jin G 01/01/2013 Neoplasia http://www.ncbi.nlm.nih.gov/pubmed/23359319 Genome-wide association study identifies loci at ATF7IP and KLK2 associated with percentage of circulating free PSA. Prostate-specific antigen levels 3,192 European ancestry individuals 1,722 European ancestry individuals 19q13.33 19 51393118 KLK2, KLKP1 - 606293 rs1354774-G rs1354774 0 1354774 intron 0 0.343 6E-20 19.22184874961636 .06 % increase Illumina [642,584] N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 13q34 13 113793849 F7/F10 - 2159 rs3211770-G rs3211770 0 3211770 intron 0 0.879 3E-19 18.52287874528033 (FVII:C) .53 [0.42-0.65] unit increase Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 1q31.3 1 197155021 CFHR4 - 360023 rs7410943-A rs7410943 0 7410943 intron 0 0.531 3E-19 18.52287874528033 (FXIIIB) .30 [0.23-0.37] unit increase Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 1q31.3 1 196886770 CFHR4 - 10877 rs4915559-T rs4915559 0 4915559 intron 0 0.759 7E-19 18.15490195998574 (FXIIIA) .34 [0.26-0.41] unit increase Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 6p25.1 6 6337506 F13A1 2162 100750245 16.58 9.81 rs11243081-C rs11243081 0 11243081 1 0.676 5E-18 17.30102999566398 (FXIIIA) .30 [0.23-0.37] unit decrease Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 6p25.1 6 6341287 F13A1 2162 100750245 20.36 6.03 rs17142067-A rs17142067 0 17142067 1 0.67 1E-17 17 (FXIIIA) .30 [0.23-0.37] unit decrease Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 9q34.2 9 136131415 ABO - 28 rs8176743-C rs8176743 0 8176743 missense 0 0.939 2E-17 16.69897000433602 (vWF) .58 [0.45-0.72] unit decrease Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 6p25.1 6 6331936 F13A1 2162 100750245 11.01 15.38 rs1318606-T rs1318606 0 1318606 1 0.569 4E-17 16.39794000867203 (FXIIIA) .27 [0.21-0.34] unit decrease Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 13q34 13 113756540 F7/F10 23263 2155 2.49 3.56 rs555212-G rs555212 0 555212 1 0.768 1E-15 15 (FVII:C) .37 [0.28-0.46] unit decrease Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 9q32 9 117088064 ORM1 - 5004 rs10982156-T rs10982156 0 10982156 intron 0 0.939 2E-10 9.698970004336017 (FX) .46 [0.31-0.6] unit increase Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 5p15.31 5 6324293 FLJ33360 - 401172 rs12518614-A rs12518614 0 12518614 intron 0 0.954 2E-9 8.698970004336019 (vWF) .46 [0.31-0.61] unit decrease Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 13q14.11 13 43770474 ENOX1 100420520 100873855 16.33 198.19 rs9533425-G rs9533425 0 9533425 1 0.801 2E-9 8.698970004336019 (Fibrin lag time) .31 [0.21-0.41] unit decrease Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 6p25.1 6 6318795 F13A1 - 2162 rs5985-C rs5985 0 5985 missense 0 0.741 3E-186 185.5228787452803 (FXIII activity) 1.08 [1-1.15] unit decrease Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 6p25.1 6 6318126 F13A1 - 2162 rs3024321-A rs3024321 0 3024321 intron 0 0.679 8E-142 141.0969100130081 (FXIII activity) .89 [0.82-0.96] unit decrease Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 9q34.2 9 136149229 ABO - 28 rs505922-T rs505922 0 505922 intron 0 0.68 5E-57 56.30102999566398 (vWF) .56 [0.49-0.63] unit decrease Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 9q34.2 9 136142355 ABO - 28 rs643434-G rs643434 0 643434 intron 0 0.656 1E-49 48.99999999999999 (vWF) .51 [0.44-0.58] unit decrease Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 13q34 13 113752831 F7/F10 - 23263 rs10665-A rs10665 0 10665 UTR-3 0 0.878 2E-47 46.69897000433602 (FVII:C) .85 [0.73-0.96] unit increase Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 13q34 13 113753164 F7/F10 - 23263 rs2181540-T rs2181540 0 2181540 UTR-3 0 0.876 1E-46 45.99999999999999 (FVII:C) .83 [0.72-0.95] unit increase Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 13q34 13 113772707 F7/F10 - 2155 rs6041-G rs6041 0 6041 intron 0 0.892 2E-45 44.69897000433601 (FVII:C) .88 [0.76-1] unit increase Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 1q31.3 1 196696933 CFHR4 - 3075 rs1410996-G rs1410996 0 1410996 intron 0 0.585 1E-9 8.999999999999998 (FXIIIA) .20 [0.14-0.27] unit increase Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 1p21.3 1 95052476 F3 2152 100421182 45.06 86.00 rs2022309-G rs2022309 0 2022309 1 0.701 4E-8 7.397940008672037 (D-dimer) .24 [0.16-0.33] unit decrease Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 9q34.2 9 136153875 ABO 28 653163 3.25 30.57 rs651007-C rs651007 0 651007 1 0.81 2E-25 24.69897000433602 (FVIII) .46 [0.37-0.55] unit decrease Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 1q31.3 1 197070776 CFHR4 - 259266 rs10922162-C rs10922162 0 10922162 cds-synon 0 0.839 2E-30 29.69897000433602 (FXIIIA) .52 [0.43-0.61] unit increase Illumina [NR] (imputed) N 03/20/2013 23381943 Williams FM 01/01/2013 Ann Neurol http://www.ncbi.nlm.nih.gov/pubmed/23381943 Ischemic stroke is associated with the ABO locus: the EuroCLOT study. End-stage coagulation 2,100 European ancestry individuals NR 1q31.3 1 196973183 CFHR4 - 81494 rs12116643-T rs12116643 0 12116643 intron 0 0.84 5E-30 29.30102999566398 (FXIIIA) .52 [0.43-0.6] unit increase Illumina [NR] (imputed) N 02/23/2013 23275298 Fox ER 12/28/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23275298 Genome-wide association study of cardiac structure and systolic function in African Americans: the Candidate Gene Association Resource (CARe) study. Cardiac structure and function 6,765 African American individuals 2,468 African American individuals, 12,612 European ancestry individuals NR NR - NR NR NR NS NS NR NR Affymetrix [~2.5 Million] (imputed) N 03/22/2013 23269536 Sun J 12/27/2012 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23269536 Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population. Prostate-specific antigen levels 1,999 Chinese ancestry men 1,496 Chinese ancestry men 1q32.1 1 205638222 SLC45A3, NUCKS1, RAB7L1, SLC41A1, FLJ32569 - 85414 rs12409639-A rs12409639 0 12409639 intron 0 0.11 2E-19 18.69897000433602 .20 [NR] % higher levels Illumina [>709,211] (imputed) N 03/22/2013 23269536 Sun J 12/27/2012 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23269536 Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population. Prostate-specific antigen levels 1,999 Chinese ancestry men 1,496 Chinese ancestry men 19q13.33 19 51364623 KLK3 354 3817 .60 12.07 rs2735839-G rs2735839 0 2735839 1 0.58 6E-37 36.22184874961636 .19 [NR] % higher levels Illumina [>709,211] (imputed) N 03/22/2013 23269536 Sun J 12/27/2012 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23269536 Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population. Prostate-specific antigen levels 1,999 Chinese ancestry men 1,496 Chinese ancestry men 10q11.23 10 51549496 MSMB - 4477 rs10993994-T rs10993994 0 10993994 nearGene-5 0 0.50 5E-17 16.30102999566398 .12 [NR] % higher levels Illumina [>709,211] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 6q23.3 6 138196066 TNFAIP3 - 7128 rs2230926-G rs2230926 0 2230926 missense 0 0.02 1E-13 13 2.71 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 1q25.1 1 173191475 TNFSF4 7292 730070 15.00 123.52 rs2205960-T rs2205960 0 2205960 1 0.25 3E-12 11.52287874528034 1.36 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 10q11.23 10 50042951 WDFY4 - 57705 rs877819-A rs877819 0 877819 intron 0 0.18 8E-9 8.096910013008056 1.46 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 11q24.3 11 128311059 ETS1 283165 2113 1435.11 17.60 rs6590330-A rs6590330 0 6590330 1 0.35 3E-8 7.522878745280337 1.51 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 12q24.33 12 129300694 SLC15A4 - 121260 rs1385374-A rs1385374 0 1385374 intron 0 0.17 8E-8 7.096910013008055 1.41 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 13q14.11 13 41558110 ELF1 - 1997 rs7329174-G rs7329174 0 7329174 intron 0 0.21 6E-6 5.221848749616356 1.45 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 2p22.3 2 33701890 RASGRP3 - 25780 rs13385731-A rs13385731 0 13385731 intron 0 0.83 4E-6 5.397940008672037 1.39 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 5q33.1 5 150458146 TNIP1 - 10318 rs10036748-T rs10036748 0 10036748 intron 0 0.74 3E-6 5.522878745280337 1.25 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 22q11.21 22 21939675 UBE2L3 - 7332 rs5754217-T rs5754217 0 5754217 intron 0 0.56 5E-6 5.301029995663981 1.12 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 6p21.31 6 34823187 UHRF1BP1 - 54887 rs3734266-G rs3734266 0 3734266 intron 0 0.13 1E-12 12 1.56 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 16p13.13 16 11189888 CLEC16A - 23274 rs12599402-A rs12599402 0 12599402 intron 0 0.56 5E-7 6.30102999566398 1.28 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 16p11.2 16 31298939 ITGAM - 3684 rs9937837-G rs9937837 0 9937837 intron 0 0.02 7E-6 5.154901959985742 1.86 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 10q21.2 10 63805617 ARID5B, RTKN2 - 84159 rs4948496-C rs4948496 0 4948496 intron 0 0.63 5E-11 10.30102999566398 1.18 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 12p13.2 12 12773521 CREBL2 - 1389 rs12822507-A rs12822507 0 12822507 0 0.57 2E-8 7.698970004336018 1.16 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 12p13.1 12 12834894 GPR19 - 2842 rs10845606-C rs10845606 0 10845606 0 0.71 4E-17 16.39794000867203 1.27 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 12p13.1 12 12870695 CDKN1B - 1027 rs34330-C rs34330 0 34330 UTR-5 0 0.52 5E-12 11.30102999566398 1.19 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 12q23.2 12 102321935 DRAM1 55332 100271045 4.53 8.06 rs4622329-A rs4622329 0 4622329 1 0.56 9E-12 11.04575749056067 1.19 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 1q25.3 1 183616884 APOBEC4 - 23179;403314 rs10911390-T rs10911390 0 10911390 intron;missense 0 0.06 6E-6 5.221848749616356 1.13 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 3p22.2 3 38843647 SCN10A 6336 11280 8.15 43.61 rs11717455-T rs11717455 0 11717455 1 0.93 7E-6 5.154901959985742 1.41 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 6q15 6 91015039 BACH2 60468 100616109 8.41 7.42 rs12529935-C rs12529935 0 12529935 1 0.91 9E-6 5.045757490560675 1.35 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 10q22.1 10 73115942 SLC29A3 - 55315 rs2252996-A rs2252996 0 2252996 missense 0 0.68 3E-6 5.522878745280337 1.22 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 16p11.2 16 29882490 SEZ6L2 - 26470 rs12917712-T rs12917712 0 12917712 UTR-3 0 0.29 7E-6 5.154901959985742 1.07 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 19p13.11 19 17420289 DDA1 - 79016 rs2303745-A rs2303745 0 2303745 nearGene-5 0 0.39 1E-6 5.999999999999999 1.07 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 4q24 4 102715888 BANK1 - 55024 rs4522865-A rs4522865 0 4522865 intron 0 0.54 5E-6 5.301029995663981 1.35 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 8p23.1 8 11343680 BLK 83648 640 19.40 7.84 rs2254546-G rs2254546 0 2254546 1 0.73 2E-13 12.69897000433602 1.49 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 7p12.2 7 50313352 IKZF1 100130988 10320 114.50 31.03 rs10276619-G rs10276619 0 10276619 1 0.63 6E-6 5.221848749616356 1.18 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 7q32.1 7 128568960 IRF5 375616 3663 18.19 9.03 rs729302-A rs729302 0 729302 1 0.66 1E-9 8.999999999999998 1.47 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 2q32.3 2 191964633 STAT4 - 6775 rs7574865-T rs7574865 0 7574865 intron 0 0.34 1E-21 21 1.63 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 2p13.1 2 74208362 TET3, DGUOK - 100874048 rs6705628-C rs6705628 0 6705628 ncRNA 0 0.78 7E-17 16.15490195998574 1.33 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 2p13.1 2 74202578 TET3, DGUOK - 100874048 rs4852324-T rs4852324 0 4852324 intron 0 0.76 6E-14 13.22184874961636 1.27 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 6q21 6 106582920 PRDM1, ATG5 639 9474 25.11 49.43 rs742108-T rs742108 0 742108 1 0.34 4E-6 5.397940008672037 1.24 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 3q13.33 3 119260944 CD80 - 941 rs6804441-A rs6804441 0 6804441 intron 0 0.61 3E-16 15.52287874528034 1.27 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 11p13 11 35093070 CD44 8050 960 75.40 67.35 rs2785197-C rs2785197 0 2785197 1 0.74 2E-7 6.698970004336019 1.23 Illumina [2,100,739] (imputed) N 02/21/2013 23273568 Yang W 12/27/2012 Am J Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23273568 Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. Systemic lupus erythematosus 1,656 Han Chinese cases, 3,394 Han Chinese controls 3,256 Han Chinese cases, 5,667 Han Chinese controls, 453 Thai ancestry cases, 963 Thai ancestry controls 6p21.32 6 32573991 HLA-DRB1 3123 3117 16.38 31.19 rs9270984-T rs9270984 0 9270984 1 0.18 5E-24 23.30102999566398 1.73 Illumina [2,100,739] (imputed) N 04/05/2013 23300701 Jiao S 12/26/2012 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23300701 Genome-wide search for gene-gene interactions in colorectal cancer. Colorectal cancer 8,380 European ancestry cases and 10,558 European ancestry controls 2,527 European ancestry cases and 2,628 European ancestry controls 6q25.3 6 158435572 Intergenic - 8871 rs9365723-? rs9365723 0 9365723 intron 0 0.57 4E-6 5.397940008672037 (rs6687758, known) 1.27 [1.15-1.41] Illumina [2,011,668] N 04/05/2013 23300701 Jiao S 12/26/2012 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23300701 Genome-wide search for gene-gene interactions in colorectal cancer. Colorectal cancer 8,380 European ancestry cases and 10,558 European ancestry controls 2,527 European ancestry cases and 2,628 European ancestry controls 7p15.3 7 25133849 Intergenic 26031 54205 114.09 24.42 rs39453-? rs39453 0 39453 1 0.63 2E-6 5.698970004336018 (rs6687758, known) 1.28 [1.16-1.43] Illumina [2,011,668] N 04/05/2013 23300701 Jiao S 12/26/2012 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23300701 Genome-wide search for gene-gene interactions in colorectal cancer. Colorectal cancer 8,380 European ancestry cases and 10,558 European ancestry controls 2,527 European ancestry cases and 2,628 European ancestry controls 4q13.2 4 67357454 Intergenic 100271091 1060 60.22 980.54 rs17730929-? rs17730929 0 17730929 1 0.90 3E-6 5.522878745280337 (rs7136702, known) 1.47 [1.25-1.72] Illumina [2,011,668] N 04/05/2013 23300701 Jiao S 12/26/2012 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23300701 Genome-wide search for gene-gene interactions in colorectal cancer. Colorectal cancer 8,380 European ancestry cases and 10,558 European ancestry controls 2,527 European ancestry cases and 2,628 European ancestry controls 12q21.1 12 72414563 Intergenic - 121278 rs10879357-? rs10879357 0 10879357 intron 0 0.62 3E-6 5.522878745280337 (rs1571218, novel) 1.25 [1.14-1.39] Illumina [2,011,668] N 04/05/2013 23300701 Jiao S 12/26/2012 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23300701 Genome-wide search for gene-gene interactions in colorectal cancer. Colorectal cancer 8,380 European ancestry cases and 10,558 European ancestry controls 2,527 European ancestry cases and 2,628 European ancestry controls 5q21.3 5 108948937 Intergenic 391819 4124 23.58 76.22 rs367615-? rs367615 0 367615 1 0.73 4E-8 7.397940008672037 (rs10795668) 1.35 [1.20-1.49] Illumina [2,011,668] N 04/05/2013 23300701 Jiao S 12/26/2012 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23300701 Genome-wide search for gene-gene interactions in colorectal cancer. Colorectal cancer 8,380 European ancestry cases and 10,558 European ancestry controls 2,527 European ancestry cases and 2,628 European ancestry controls 9q22.32 9 96631134 CRAC1 100422927 56033 49.43 82.78 rs10114408-? rs10114408 0 10114408 1 0.76 3E-6 5.522878745280337 (rs4779584, known) 1.37 [1.20-1.56] Illumina [2,011,668] N 04/05/2013 23300701 Jiao S 12/26/2012 PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23300701 Genome-wide search for gene-gene interactions in colorectal cancer. Colorectal cancer 8,380 European ancestry cases and 10,558 European ancestry controls 2,527 European ancestry cases and 2,628 European ancestry controls 3p24.3 3 23143047 Intergenic 100130785 100270963 109.98 32.76 rs4591517-? rs4591517 0 4591517 1 0.28 3E-6 5.522878745280337 (rs4925386, known) 1.06 [0.88-1.29] Illumina [2,011,668] N 02/21/2013 23267103 Desch KC 12/24/2012 Proc Natl Acad Sci U S A http://www.ncbi.nlm.nih.gov/pubmed/23267103 Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association. Coagulation factor levels 3,250 European ancestry individuals, up to 212 individuals NR 9q34.2 9 136135552 ABO, LOC653163, ADAMTS13, OBP2B, OBP2A, C9orf96, LOC286310, SURF6, SURF5 - 28 rs8176704-A rs8176704 0 8176704 intron 0 NR 4E-34 33.39794000867203 (Conditioned on rs687289) .34 [NR] lU/dL decrease Illumina [723,716] N 02/21/2013 23267103 Desch KC 12/24/2012 Proc Natl Acad Sci U S A http://www.ncbi.nlm.nih.gov/pubmed/23267103 Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association. Coagulation factor levels 3,250 European ancestry individuals, up to 212 individuals NR 9q34.2[rs687289]; 9q34.2[rs8176704] ABO - 3-SNP Haplotype rs687289, rs8176704, rs8176749 0.155 4E-98 (rs687289-A, rs8176704-G, rs8176749-C) .36 [NR] lU/dL increase Illumina [723,716] N 02/21/2013 23267103 Desch KC 12/24/2012 Proc Natl Acad Sci U S A http://www.ncbi.nlm.nih.gov/pubmed/23267103 Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association. Coagulation factor levels 3,250 European ancestry individuals, up to 212 individuals NR 12p13.31[rs1063856]; 12p13.31[rs1063857] VWF - 2-SNP Haplotype rs1063856, rs1063857 NR 6E-7 NR NR Illumina [723,716] N 02/21/2013 23267103 Desch KC 12/24/2012 Proc Natl Acad Sci U S A http://www.ncbi.nlm.nih.gov/pubmed/23267103 Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association. Coagulation factor levels 3,250 European ancestry individuals, up to 212 individuals NR 9q34.2[rs687289]; 9q34.2[rs8176704] ABO - 3-SNP Haplotype rs687289, rs8176704, rs8176749 0.0722 7E-50 (rs687289-A, rs8176704-G, rs8176749-T) .36 [NR] lU/dL increase Illumina [723,716] N 02/21/2013 23267103 Desch KC 12/24/2012 Proc Natl Acad Sci U S A http://www.ncbi.nlm.nih.gov/pubmed/23267103 Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association. Coagulation factor levels 3,250 European ancestry individuals, up to 212 individuals NR 12p13.31 12 6153534 VWF - 7450 rs1063856-A rs1063856 0 1063856 missense 0 0.395 5E-16 15.30102999566398 .12 [0.091-0.149] lU/dL decrease Illumina [723,716] N 02/21/2013 23267103 Desch KC 12/24/2012 Proc Natl Acad Sci U S A http://www.ncbi.nlm.nih.gov/pubmed/23267103 Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association. Coagulation factor levels 3,250 European ancestry individuals, up to 212 individuals NR 9q34.2[rs687289]; 9q34.2[rs8176704] ABO - 3-SNP Haplotype rs687289, rs8176704, rs8176749 0.720 2E-138 (rs687289-G, rs8176704-G, rs8176749-C) .34 [NR] lU/dL decrease Illumina [723,716] N 02/21/2013 23267103 Desch KC 12/24/2012 Proc Natl Acad Sci U S A http://www.ncbi.nlm.nih.gov/pubmed/23267103 Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association. Coagulation factor levels 3,250 European ancestry individuals, up to 212 individuals NR 9q34.2 9 136137106 ABO, LOC653163, ADAMTS13, OBP2B, OBP2A, C9orf96, LOC286310, SURF6, SURF5 - 28 rs687289-T rs687289 0 687289 intron 0 0.751 1E-128 128 .33 [0.30-0.36] lU/dL increase Illumina [723,716] N 03/05/2013 23263487 Jia WH 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263487 Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. Colorectal cancer 2,098 East Asian ancestry cases, 5,749 East Asian ancestry controls 5,358 East Asian ancestry cases, 5,922 East Asian ancestry controls, 26,060 European ancestry individuals 20p12.3 20 7812350 HAO1, PLCB1 - 171472 rs2423279-C rs2423279 0 2423279 0 0.302 2E-7 6.698970004336019 (East Asian) 1.14 [1.08-1.19] Illumina & Affymetrix (1,636,380) imputed N 03/05/2013 23263487 Jia WH 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263487 Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. Colorectal cancer 2,098 East Asian ancestry cases, 5,749 East Asian ancestry controls 5,358 East Asian ancestry cases, 5,922 East Asian ancestry controls, 26,060 European ancestry individuals 5q31.1 5 134499092 PITX1, CATSPER3, PCBD2, MIR4461 and H2AFY - 100996485 rs647161-A rs647161 0 647161 intron 0 0.667 1E-10 10 1.11 [1.08-1.15] Illumina & Affymetrix (1,636,380) imputed N 03/05/2013 23263487 Jia WH 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263487 Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. Colorectal cancer 2,098 East Asian ancestry cases, 5,749 East Asian ancestry controls 5,358 East Asian ancestry cases, 5,922 East Asian ancestry controls, 26,060 European ancestry individuals 20p12.3 20 7812350 HAO1, PLCB1 - 171472 rs2423279-C rs2423279 0 2423279 0 0.252 7E-9 8.154901959985743 1.10 [1.06-1.14] Illumina & Affymetrix (1,636,380) imputed N 03/05/2013 23263487 Jia WH 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263487 Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. Colorectal cancer 2,098 East Asian ancestry cases, 5,749 East Asian ancestry controls 5,358 East Asian ancestry cases, 5,922 East Asian ancestry controls, 26,060 European ancestry individuals 12p13.32 12 4368352 CCND2, PARP11, FGF23, FGF6, C12orf5, RAD51AP1 100129645 894 139.23 14.55 rs10774214-T rs10774214 0 10774214 1 0.379 3E-8 7.522878745280337 1.09 [1.06-1.13] Illumina & Affymetrix (1,636,380) imputed N 03/05/2013 23263487 Jia WH 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263487 Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. Colorectal cancer 2,098 East Asian ancestry cases, 5,749 East Asian ancestry controls 5,358 East Asian ancestry cases, 5,922 East Asian ancestry controls, 26,060 European ancestry individuals 12p13.32 12 4368352 CCND2, PARP11, FGF23, FGF6, C12orf5, RAD51AP1 100129645 894 139.23 14.55 rs10774214-T rs10774214 0 10774214 1 0.352 5E-10 9.301029995663981 (East Asian) 1.17 [1.11-1.23] Illumina & Affymetrix (1,636,380) imputed N 03/05/2013 23263487 Jia WH 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263487 Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. Colorectal cancer 2,098 East Asian ancestry cases, 5,749 East Asian ancestry controls 5,358 East Asian ancestry cases, 5,922 East Asian ancestry controls, 26,060 European ancestry individuals 10q25.3 10 118487100 HSPA12A - 259217 rs1665650-T rs1665650 0 1665650 intron 0 0.315 9E-7 6.045757490560675 (East Asian) 1.13 [1.08-1.19] Illumina & Affymetrix (1,636,380) imputed N 03/05/2013 23263487 Jia WH 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263487 Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. Colorectal cancer 2,098 East Asian ancestry cases, 5,749 East Asian ancestry controls 5,358 East Asian ancestry cases, 5,922 East Asian ancestry controls, 26,060 European ancestry individuals 5q31.1 5 134499092 PITX1, CATSPER3, PCBD2, MIR4461 and H2AFY - 100996485 rs647161-A rs647161 0 647161 intron 0 0.313 4E-10 9.397940008672037 (East Asian) 1.17 [1.11-1.22] Illumina & Affymetrix (1,636,380) imputed N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Gout 2,115 European ancestry cases, 67,259 European ancestry controls 1,036 European ancestry cases 4q22.1 4 89039082 ABCG2 - 9429 rs1481012-A rs1481012 0 1481012 intron 0 0.8903 2E-32 31.69897000433602 .55 [0.46-0.64] unit decrease Affymetrix, Illumina [2,538,056] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Gout 2,115 European ancestry cases, 67,259 European ancestry controls 1,036 European ancestry cases 9q31.1 9 107324200 NR 138803 138802 25.11 7.25 rs13287980-A rs13287980 0 13287980 1 0.1271 1E-6 5.999999999999999 .24 [0.14-0.33] unit increase Affymetrix, Illumina [2,538,056] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Gout 2,115 European ancestry cases, 67,259 European ancestry controls 1,036 European ancestry cases 10q26.13 10 123280658 NR - 2263 rs3135753-T rs3135753 0 3135753 intron 0 0.9897 9E-7 6.045757490560675 1.07 [0.65-1.49] unit decrease Affymetrix, Illumina [2,538,056] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Gout 2,115 European ancestry cases, 67,259 European ancestry controls 1,036 European ancestry cases 4q35.1 4 184278131 NR 100132463 55602 34.55 87.66 rs17074636-T rs17074636 0 17074636 1 0.9862 7E-7 6.154901959985743 .71 [0.43-0.99] unit decrease Affymetrix, Illumina [2,538,056] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Gout 2,115 European ancestry cases, 67,259 European ancestry controls 1,036 European ancestry cases 4p16.1 4 9946656 SLC2A9 - 56606 rs4475146-A rs4475146 0 4475146 intron 0 0.2237 4E-26 25.39794000867203 .47 [0.38-0.55] unit decrease Affymetrix, Illumina [2,538,056] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Gout 2,115 European ancestry cases, 67,259 European ancestry controls 1,036 European ancestry cases 18q21.32 18 58375934 NR 359797 728111 188.53 85.91 rs2168303-A rs2168303 0 2168303 1 0.9953 2E-7 6.698970004336019 1.94 [1.21-2.67] unit decrease Affymetrix, Illumina [2,538,056] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 17q22 17 53364788 HLF - 3131 rs7224610-A rs7224610 0 7224610 intron 0 0.58 5E-17 16.30102999566398 .04 [0.032-0.052] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 10q11.23 10 52646093 A1CF, ASAH2 - 29974 rs10821905-A rs10821905 0 10821905 nearGene-5 0 0.18 7E-17 16.15490195998574 .06 [0.043-0.071] mg/dl increase Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 3p21.1 3 53100214 SFMBT1, MUSTN1 553148 91869 1.11 22.29 rs6770152-T rs6770152 0 6770152 1 0.58 3E-16 15.52287874528034 .04 [0.034-0.054] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 6p21.1 6 43804571 VEGFA 7422 221416 50.35 163.77 rs729761-T rs729761 0 729761 1 0.30 8E-16 15.09691001300805 .05 [0.036-0.058] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 2q23.1 2 148716428 ORC4L, ACVR2A - 5000 rs2307394-T rs2307394 0 2307394 missense 0 0.68 2E-8 7.698970004336018 .03 [0.019-0.039] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 15q24.2 15 76158983 UBE2Q2, NRG4 - 92912 rs1394125-A rs1394125 0 1394125 intron 0 0.34 3E-13 12.52287874528034 .04 [0.031-0.055] mg/dl increase Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 11q13.1 11 65560620 OVOL1, LTBP3 - 5017 rs642803-T rs642803 0 642803 intron 0 0.46 3E-13 12.52287874528034 .04 [0.026-0.045] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 7q11.23 7 72857049 BAZ1B, MLXIPL - 9031 rs1178977-A rs1178977 0 1178977 intron 0 0.81 1E-12 12 .05 [0.034-0.06] unit increase Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 12q24.12 12 112007756 ATXN2, PTPN11 - 6311 rs653178-T rs653178 0 653178 intron 0 0.51 7E-12 11.15490195998574 .04 [0.025-0.045] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 5q13.2 5 72431482 TMEM171 134285 134288 3.84 37.54 rs17632159-C rs17632159 0 17632159 1 0.31 4E-11 10.39794000867204 .04 [0.027-0.051] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 11q13.1 11 64478063 NRXN2, SLC22A12 - 9379 rs478607-A rs478607 0 478607 intron 0 0.84 4E-11 10.39794000867204 .05 [0.033-0.061] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 2q14.2 2 121306440 INHBB 3625 2736 197.06 248.43 rs17050272-A rs17050272 0 17050272 1 0.43 2E-10 9.698970004336017 .04 [0.023-0.047] mg/dl increase Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 16q22.1 16 69563890 NFAT5 80777 100302119 63.72 35.82 rs7193778-T rs7193778 0 7193778 1 0.86 8E-10 9.096910013008054 .05 [0.030-0.062] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 7q36.1 7 151406005 PRKAG2 - 51422 rs10480300-T rs10480300 0 10480300 intron 0 0.28 4E-9 8.397940008672036 .04 [0.023-0.047] mg/dl increase Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 17q23.2 17 59465697 BCAS3, C17orf82 - 54828 rs2079742-T rs2079742 0 2079742 intron 0 0.85 1E-8 8 .04 [0.027-0.059] mg/dl increase Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 8p21.2 8 23777006 STC1 6781 10863 64.69 374.57 rs17786744-A rs17786744 0 17786744 1 0.58 1E-8 8 .03 [0.019-0.039] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 12q24.31 12 122625992 B3GNT4 22877 386653 108.82 30.59 rs7953704-A rs7953704 0 7953704 1 0.47 3E-8 7.522878745280337 (network) .03 [0.019-0.039] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 12q24.31 12 121416988 HNF1A - 6927 rs2244608-A rs2244608 0 2244608 intron 0 0.68 8E-8 7.096910013008055 (women) .04 [0.023-0.049] mg/dl increase Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 1q21.3 1 150950062 ARNT 29956 8416 2.58 4.44 rs4970988-A rs4970988 0 4970988 1 0.36 1E-7 7 (network) .03 [0.018-0.038] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 19p13.2 19 7199803 INSR - 3643 rs1035942-A rs1035942 0 1035942 intron 0 0.27 1E-7 7 .03 [0.017-0.041] mg/dl increase Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 15q24.1 15 73082366 ADPGK - 100287559 rs4777542-T rs4777542 0 4777542 intron 0 0.32 2E-7 6.698970004336019 .03 [0.017-0.041] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 9p21.1 9 33180362 B4GALT1 2683 27290 13.01 59.83 rs10813960-T rs10813960 0 10813960 1 0.29 4E-7 6.397940008672037 .03 [0.018-0.042] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 6q22.1 6 116310287 FRK - 2444 rs1933737-T rs1933737 0 1933737 intron 0 0.69 7E-7 6.154901959985743 (women) .03 [0.02-0.047] mg/dl increase Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 6p21.1 6 43272188 SLC22A7 - 10864 rs4149178-A rs4149178 0 4149178 0 0.84 1E-6 5.999999999999999 (candidate) .03 [0.02-0.048] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 18q21.32 18 57872989 MC4R 400652 4160 55.35 165.58 rs12955983-A rs12955983 0 12955983 1 0.73 2E-6 5.698970004336018 (women) .04 [0.022-0.051] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 11q23.3 11 119235404 USP2 - 9099 rs2195525-T rs2195525 0 2195525 intron 0 0.52 2E-6 5.698970004336018 .03 [0.015-0.035] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 2q33.2 2 203337001 BMPR2 - 659 rs12468226-A rs12468226 0 12468226 intron 0 0.88 3E-6 5.522878745280337 (network) .04 [0.023-0.055] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 5p13.1 5 39902365 DAB2 285634 5734 180.75 777.67 rs11954519-A rs11954519 0 11954519 1 0.73 4E-6 5.397940008672037 (women) .03 [0.019-0.047] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 16q23.2 16 79734987 MAF 4094 83657 100.37 839.87 rs7188445-A rs7188445 0 7188445 1 0.33 2E-9 8.698970004336019 .03 [0.022-0.042] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 17q25.1 17 74283669 QRICH2, PRPSAP1 - 84074 rs164009-A rs164009 0 164009 intron 0 0.61 2E-7 6.698970004336019 .03 [0.018-0.038] mg/dl increase Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 4q21.21 4 81169912 FGF5 56978 2250 44.43 17.83 rs11099098-T rs11099098 0 11099098 1 0.29 7E-7 6.154901959985743 .03 [0.017-0.041] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 5q11.2 5 55811092 ANKRD55 441073 4214 10.15 299.81 rs456867-T rs456867 0 456867 1 0.17 3E-6 5.522878745280337 (women) .04 [0.022-0.054] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 12q13.13 12 52251272 ACVR1B, ACVRL1 401720 341405 25.57 30.52 rs7976059-T rs7976059 0 7976059 1 0.35 2E-9 8.698970004336019 (network) .03 [0.022-0.042] mg/dl increase Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 8q21.11 8 76478768 HNF4G - 3174 rs2941484-T rs2941484 0 2941484 UTR-3 0 0.44 4E-17 16.39794000867203 .04 [0.034-0.054] mg/dl increase Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 1q22 1 155151493 TRIM46, PKLR - 80128 rs11264341-T rs11264341 0 11264341 intron 0 0.43 6E-19 18.22184874961635 .05 [0.038-0.062] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 6p24.3 6 7102084 RREB1 652960 6239 306.35 5.75 rs675209-T rs675209 0 675209 1 0.27 1E-23 23 .06 [0.049-0.073] mg/dl increase Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 12q13.3 12 57844049 INHBC, INHBE - 3626 rs3741414-T rs3741414 0 3741414 UTR-3 0 0.24 2E-25 24.69897000433602 .07 [0.058-0.085] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 10q21.2 10 61469538 SLC16A9 - 220963 rs1171614-T rs1171614 0 1171614 UTR-5 0 0.22 2E-28 27.69897000433602 .08 [0.065-0.093] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 1q21.1 1 145723739 PDZK1 11126 5174 8.17 3.93 rs1471633-A rs1471633 0 1471633 1 0.46 1E-29 28.99999999999999 .06 [0.049-0.069] mg/dl increase Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 11q13.1 11 64334114 SLC22A11 - 55867 rs2078267-T rs2078267 0 2078267 intron 0 0.51 9E-38 37.04575749056067 .07 [0.061-0.085] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 2p23.3 2 27730940 GCKR - 2646 rs1260326-T rs1260326 0 1260326 missense 0 0.41 1E-44 44 .07 [0.063-0.084] mg/dl increase Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 6p22.2 6 25821616 SLC17A1, SLC17A3 - 6568 rs1165151-T rs1165151 0 1165151 intron 0 0.47 7E-70 69.15490195998574 .09 [0.081-0.101] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 4q22.1 4 89052323 ABCG2 - 9429 rs2231142-T rs2231142 0 2231142 missense 0 0.11 1E-134 134 .22 [0.20-0.23] mg/dl increase Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 13q21.33 13 72345505 DACH1 - 1602 rs584480-T rs584480 0 584480 intron 0 0.40 9E-6 5.045757490560675 .02 [0.013-0.033] mg/dl decrease Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 12q13.11 12 48173352 HDAC7 - 55652 rs4760636-T rs4760636 0 4760636 intron 0 0.23 6E-6 5.221848749616356 (network) .03 [0.015-0.039] mg/dl increase Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 4p16.1 4 9944052 SLC2A9 - 56606 rs12498742-A rs12498742 0 12498742 intron 0 0.77 1E-700 700 .37 [0.36-0.38] mg/dl increase Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/15/2013 23263486 Kottgen A 12/23/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23263486 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Urate levels 49,825 European ancestry men, 60,522 European ancestry women Up to 32,813 European ancestry individuals 15q26.3 15 99271135 IGF1R - 3480 rs6598541-A rs6598541 0 6598541 intron 0 0.36 5E-15 14.30102999566398 .04 [0.031-0.055] mg/dl increase Affymetrix, Illumina, Perlegen [2,450,547] (imputed) N 03/21/2013 23263445 Lawrance-Owen AJ 12/22/2012 Hum Genet http://www.ncbi.nlm.nih.gov/pubmed/23263445 Genetic association suggests that SMOC1 mediates between prenatal sex hormones and digit ratio. Digit length ratio 979 European ancestry individuals (see Medland, 2010) 14q24.2 14 70347348 SMOC - 64093 rs11158820-? rs11158820 0 11158820 intron 0 NR 2E-11 10.69897000433602 NR NR Illumina [642,758] N 02/19/2013 23266556 Peters U 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 12,696 European ancestry colorectal tumor cases, and 15,113 European ancestry controls 958 European ancestry colorectal tumor cases, up to 2,098 East Asian ancestry colorectal tumor cases, 909 European ancestry controls, up to 5,749 East Asian ancestry controls 8q24.21 8 130820039 Intergenic 56169 100131958 20.91 56.69 rs2128382-? rs2128382 0 2128382 1 0.82 8E-6 5.096910013008055 1.11 [1.06-1.16] Illumina & Affymetrix [2,708,280] imputed N 02/19/2013 23266556 Peters U 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 12,696 European ancestry colorectal tumor cases, and 15,113 European ancestry controls 958 European ancestry colorectal tumor cases, up to 2,098 East Asian ancestry colorectal tumor cases, 909 European ancestry controls, up to 5,749 East Asian ancestry controls 8q24.21 8 128413305 MYC 401475 5462 312.53 14.55 rs6983267-G rs6983267 0 6983267 1 0.5 1E-11 11 1.13 [1.09-1.18] Illumina & Affymetrix [2,708,280] imputed N 02/19/2013 23266556 Peters U 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 12,696 European ancestry colorectal tumor cases, and 15,113 European ancestry controls 958 European ancestry colorectal tumor cases, up to 2,098 East Asian ancestry colorectal tumor cases, 909 European ancestry controls, up to 5,749 East Asian ancestry controls 6q22.1 6 117819357 GOPC, DCBLD1 - 285761 rs2057314-? rs2057314 0 2057314 intron 0 0.50 3E-6 5.522878745280337 1.08 [1.04-1.11] Illumina & Affymetrix [2,708,280] imputed N 02/19/2013 23266556 Peters U 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 12,696 European ancestry colorectal tumor cases, and 15,113 European ancestry controls 958 European ancestry colorectal tumor cases, up to 2,098 East Asian ancestry colorectal tumor cases, 909 European ancestry controls, up to 5,749 East Asian ancestry controls 4q22.2 4 94887031 Intergenic 474 644429 135.89 230.06 rs13130787-? rs13130787 0 13130787 1 0.43 3E-7 6.522878745280337 1.09 [1.06-1.13] Illumina & Affymetrix [2,708,280] imputed N 02/19/2013 23266556 Peters U 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 12,696 European ancestry colorectal tumor cases, and 15,113 European ancestry controls 958 European ancestry colorectal tumor cases, up to 2,098 East Asian ancestry colorectal tumor cases, 909 European ancestry controls, up to 5,749 East Asian ancestry controls 1q23.3 1 162821291 C1orf110 51478 339512 38.68 2.80 rs1912453-? rs1912453 0 1912453 1 0.41 9E-6 5.045757490560675 1.07 [1.04-1.11] Illumina & Affymetrix [2,708,280] imputed N 02/19/2013 23266556 Peters U 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 12,696 European ancestry colorectal tumor cases, and 15,113 European ancestry controls 958 European ancestry colorectal tumor cases, up to 2,098 East Asian ancestry colorectal tumor cases, 909 European ancestry controls, up to 5,749 East Asian ancestry controls 12q24.21 12 115116352 TBX3 - 6926 rs59336-T rs59336 0 59336 intron 0 0.48 4E-7 6.397940008672037 1.09 [1.06-1.13] Illumina & Affymetrix [2,708,280] imputed N 02/19/2013 23266556 Peters U 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 12,696 European ancestry colorectal tumor cases, and 15,113 European ancestry controls 958 European ancestry colorectal tumor cases, up to 2,098 East Asian ancestry colorectal tumor cases, 909 European ancestry controls, up to 5,749 East Asian ancestry controls 12p13.32 12 4405389 CCND2 - 894 rs3217901-G rs3217901 0 3217901 intron 0 0.41 3E-7 6.522878745280337 1.10 [1.06-1.14] Illumina & Affymetrix [2,708,280] imputed N 02/19/2013 23266556 Peters U 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 12,696 European ancestry colorectal tumor cases, and 15,113 European ancestry controls 958 European ancestry colorectal tumor cases, up to 2,098 East Asian ancestry colorectal tumor cases, 909 European ancestry controls, up to 5,749 East Asian ancestry controls 12p13.32 12 4388271 CCND2 - 894 rs3217810-T rs3217810 0 3217810 intron 0 0.16 6E-8 7.221848749616355 1.20 [1.12-1.28] Illumina & Affymetrix [2,708,280] imputed N 02/19/2013 23266556 Peters U 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 12,696 European ancestry colorectal tumor cases, and 15,113 European ancestry controls 958 European ancestry colorectal tumor cases, up to 2,098 East Asian ancestry colorectal tumor cases, 909 European ancestry controls, up to 5,749 East Asian ancestry controls 1q25.3 1 183081194 LAMC1 - 3915 rs10911251-A rs10911251 0 10911251 intron 0 0.57 9E-8 7.045757490560674 1.09 [1.06-1.13] Illumina & Affymetrix [2,708,280] imputed N 02/19/2013 23266556 Peters U 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 12,696 European ancestry colorectal tumor cases, and 15,113 European ancestry controls 958 European ancestry colorectal tumor cases, up to 2,098 East Asian ancestry colorectal tumor cases, 909 European ancestry controls, up to 5,749 East Asian ancestry controls 2q32.3 2 192587204 NABP1 64859 8436 33.96 111.83 rs11903757-C rs11903757 0 11903757 1 0.16 4E-8 7.397940008672037 1.16 [1.10-1.22] Illumina & Affymetrix [2,708,280] imputed N 02/19/2013 23266556 Peters U 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 12,696 European ancestry colorectal tumor cases, and 15,113 European ancestry controls 958 European ancestry colorectal tumor cases, up to 2,098 East Asian ancestry colorectal tumor cases, 909 European ancestry controls, up to 5,749 East Asian ancestry controls 20p12.3 20 6699595 BMP2 100462816 650 498.20 49.15 rs4813802-G rs4813802 0 4813802 1 0.34 7E-6 5.154901959985742 1.10 [1.05-1.14] Illumina & Affymetrix [2,708,280] imputed N 02/19/2013 23266556 Peters U 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 12,696 European ancestry colorectal tumor cases, and 15,113 European ancestry controls 958 European ancestry colorectal tumor cases, up to 2,098 East Asian ancestry colorectal tumor cases, 909 European ancestry controls, up to 5,749 East Asian ancestry controls 18q21.1 18 46453463 SMAD7 - 4092 rs4939827-? rs4939827 0 4939827 intron 0 0.52 2E-10 9.698970004336017 1.12 [1.09-1.16] Illumina & Affymetrix [2,708,280] imputed N 02/19/2013 23266556 Peters U 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 12,696 European ancestry colorectal tumor cases, and 15,113 European ancestry controls 958 European ancestry colorectal tumor cases, up to 2,098 East Asian ancestry colorectal tumor cases, 909 European ancestry controls, up to 5,749 East Asian ancestry controls 15q13.3 15 32994756 CRAC1, HMPS, GREM1 6447 26585 5.46 15.45 rs4779584-? rs4779584 0 4779584 1 0.18 5E-7 6.30102999566398 1.12 [1.08-1.19] Illumina & Affymetrix [2,708,280] imputed N 02/19/2013 23266556 Peters U 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 12,696 European ancestry colorectal tumor cases, and 15,113 European ancestry controls 958 European ancestry colorectal tumor cases, up to 2,098 East Asian ancestry colorectal tumor cases, 909 European ancestry controls, up to 5,749 East Asian ancestry controls 11q23.1 11 111171709 Intergenic - 120376;399948 rs3802842-? rs3802842 0 3802842 intron;nearGene-5 0 0.29 4E-7 6.397940008672037 1.11 [1.06-1.15] Illumina & Affymetrix [2,708,280] imputed N 02/19/2013 23266556 Peters U 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266556 Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Colorectal cancer 12,696 European ancestry colorectal tumor cases, and 15,113 European ancestry controls 958 European ancestry colorectal tumor cases, up to 2,098 East Asian ancestry colorectal tumor cases, 909 European ancestry controls, up to 5,749 East Asian ancestry controls 14q23.1 14 59189361 Intergenic 51339 729646 74.32 71.99 rs17094983-? rs17094983 0 17094983 1 0.13 3E-6 5.522878745280337 1.13 [1.08-1.20] Illumina & Affymetrix [2,708,280] imputed N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 20q13.33 20 62297802 RTEL1 - 51750;100533107 rs6011002-? rs6011002 0 6011002 intron;intron 0 NR 3E-6 5.522878745280337 (Comparatively Younger) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 1q42.13 1 229285858 RHOU 100288517 5867 107.52 121.02 rs9793739-? rs9793739 0 9793739 1 NR 5E-7 6.30102999566398 (Comparatively Older) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 7p21.1 7 20791998 ABCB5 - 340273 rs2108258-? rs2108258 0 2108258 intron 0 NR 2E-6 5.698970004336018 (Comparatively Older) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 7q21.13 7 90915354 LOC644727, FZD1, HOXA10 8321 100132321 17.22 33.96 rs2888830-? rs2888830 0 2888830 1 NR 7E-6 5.154901959985742 (Comparatively Older) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 12q21.31 12 81337458 LIN7A 693203 100616133 7.85 214.71 rs1163656-? rs1163656 0 1163656 1 NR 9E-6 5.045757490560675 (Comparatively Older) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 3p24.1 3 30372053 RBMS3 27303 7048 320.17 275.94 rs7634533-? rs7634533 0 7634533 1 NR 5E-6 5.301029995663981 NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 4q13.3 4 73417524 ADAMTS3 - 9508 rs1383934-? rs1383934 0 1383934 intron 0 NR 3E-7 6.522878745280337 NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 14q22.2 14 54876184 CDKN3, CNIH, GMFB, CGRRF1, BMP4 - 1033 rs4251631-? rs4251631 0 4251631 intron 0 NR 2E-6 5.698970004336018 NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 7q21.13 7 90915354 LOC644727, FZD1, HOXA10 8321 100132321 17.22 33.96 rs2888830-? rs2888830 0 2888830 1 NR 4E-6 5.397940008672037 NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 19p12 19 22608374 ZNF98 148198 441843 3.23 38.35 rs10404998-? rs10404998 0 10404998 1 NR 3E-6 5.522878745280337 (Comparatively Younger) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 18q11.2 18 24687324 CHST9 - 83539 rs9961915-? rs9961915 0 9961915 intron 0 NR 5E-6 5.301029995663981 (Comparatively Younger) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 16q23.2 16 79431853 LOC729251 645957 4094 571.87 195.89 rs4888966-? rs4888966 0 4888966 1 NR 5E-6 5.301029995663981 (Comparatively Younger) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 14q22.2 14 54876184 CDKN3, CNIH, GMFB, CGRRF1, BMP4 - 1033 rs4251631-? rs4251631 0 4251631 intron 0 NR 2E-7 6.698970004336019 (Comparatively Younger) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 8p21.3 8 20301437 LZTS1 11178 26844 188.63 170.93 rs4922199-? rs4922199 0 4922199 1 NR 8E-6 5.096910013008055 (Comparatively Younger) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 8q21.3 8 90211100 LOC100129100 4325 8767 871.38 558.88 rs2046315-? rs2046315 0 2046315 1 NR 3E-6 5.522878745280337 (Comparatively Younger) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 8p21.1 8 27416801 EPHX2, PTK2B 2053 2989 14.36 18.33 rs17057381-? rs17057381 0 17057381 1 NR 4E-7 6.397940008672037 (Comparatively Younger) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 7q21.13 7 89060733 ZNF804B 219578 442523 94.39 687.98 rs6973392-? rs6973392 0 6973392 1 NR 7E-6 5.154901959985742 (Comparatively Younger) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 6q27 6 167177422 RPS6KA2 - 6196 rs635808-? rs635808 0 635808 intron 0 NR 1E-7 7 (Comparatively Younger) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 6q23.2 6 134720067 LOC442261 100874507 114182 5.42 204.21 rs9402592-? rs9402592 0 9402592 1 NR 3E-6 5.522878745280337 (Comparatively Younger) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 5q11.2 5 50928810 ISL1 100873897 100271072 222.77 649.54 rs4865673-? rs4865673 0 4865673 1 NR 9E-6 5.045757490560675 (Comparatively Younger) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 4p14 4 40973527 APBB2 - 323 rs4466078-? rs4466078 0 4466078 intron 0 NR 8E-6 5.096910013008055 (Comparatively Younger) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 3q13.2 3 113290468 SIDT1 - 54847 rs13092825-? rs13092825 0 13092825 intron 0 NR 2E-6 5.698970004336018 (Comparatively Younger) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 3q13.2 3 112995074 BOC - 91653 rs775227-? rs775227 0 775227 intron 0 NR 2E-6 5.698970004336018 (Comparatively Younger) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 1p21.3 1 99386293 PAP2D, SNX7 - 163404 rs1571500-? rs1571500 0 1571500 intron 0 NR 2E-6 5.698970004336018 (Comparatively Younger) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 2q24.3 2 167177359 SCN9A - 6335 rs4438497-? rs4438497 0 4438497 intron 0 NR 7E-6 5.154901959985742 (Comparatively Younger) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 8q23.1 8 107909009 ABRA 137735 100419978 126.54 276.42 rs4269515-? rs4269515 0 4269515 1 NR 4E-6 5.397940008672037 NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 1q42.13 1 229285858 LOC648390, RHOU 100288517 5867 107.52 121.02 rs9793739-? rs9793739 0 9793739 1 NR 4E-6 5.397940008672037 NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 17q25.3 17 79682051 SLC25A10 - 1468 rs3204270-? rs3204270 0 3204270 cds-synon 0 NR 5E-6 5.301029995663981 (Comparatively Older) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 10p14 10 10073544 LOC644495 644495 644540 307.08 142.57 rs10905651-? rs10905651 0 10905651 1 NR 8E-6 5.096910013008055 (Comparatively Older) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 4q13.3 4 73417524 ADAMTS3 - 9508 rs1383934-? rs1383934 0 1383934 intron 0 NR 2E-6 5.698970004336018 (Comparatively Older) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 21q21.3 21 30489300 C21orf7 - 56911 rs2832191-? rs2832191 0 2832191 intron 0 NR 5E-6 5.301029995663981 (Comparatively Younger) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 19p12 19 22554854 LOC342994 342994 148198 2.96 19.05 rs1865075-? rs1865075 0 1865075 1 NR 6E-6 5.221848749616356 (Comparatively Younger) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 18p11.21 18 11282319 C18orf58 63895 2774 133.56 406.70 rs7243066-? rs7243066 0 7243066 1 NR 9E-6 5.045757490560675 (Comparatively Younger) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/26/2013 23259602 Wang X 12/21/2012 BMC Oral Health http://www.ncbi.nlm.nih.gov/pubmed/23259602 Genome-wide association scan of dental caries in the permanent dentition. Dental caries 1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals 14q22.2 14 54652479 ATP5C2 645560 1033 193.74 211.19 rs1953743-? rs1953743 0 1953743 1 NR 2E-6 5.698970004336018 (Comparatively younger) NR NR Illumina and Affymetrix [~ 1.4 Million] (imputed) N 02/27/2013 23266558 Yamazaki K 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266558 A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. Crohn's disease 372 Japanese ancestry cases and 3,389 Japanese ancestry controls Up to 1,151 Japanese ancestry cases and up to 15,800 Japanese ancestry controls 6p21.32 6 32680928 HLA-DQA2, HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DOB, PSMB9 404026 3118 6.35 28.24 rs7765379-G rs7765379 0 7765379 1 NR 9E-59 58.04575749056067 1.93 [1.78-2.09] Illumina [4,929,034] (imputed) N 02/27/2013 23266558 Yamazaki K 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266558 A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. Crohn's disease 372 Japanese ancestry cases and 3,389 Japanese ancestry controls Up to 1,151 Japanese ancestry cases and up to 15,800 Japanese ancestry controls 6p21.32 6 32205110 PBX2, NOTCH4 4855 100131609 13.27 88.07 rs9267911-T rs9267911 0 9267911 1 0.479 3E-7 6.522878745280337 1.50 [1.29-1.76] Illumina [4,929,034] (imputed) N 02/27/2013 23266558 Yamazaki K 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266558 A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. Crohn's disease 372 Japanese ancestry cases and 3,389 Japanese ancestry controls Up to 1,151 Japanese ancestry cases and up to 15,800 Japanese ancestry controls 6p21.33 6 31142245 PSORS1C3 - 100130889 rs3094188-C rs3094188 0 3094188 intron 0 0.280 7E-7 6.154901959985743 1.61 [1.33-1.94] Illumina [4,929,034] (imputed) N 02/27/2013 23266558 Yamazaki K 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266558 A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. Crohn's disease 372 Japanese ancestry cases and 3,389 Japanese ancestry controls Up to 1,151 Japanese ancestry cases and up to 15,800 Japanese ancestry controls 9p24.1 9 4985879 JAK2 - 3717 rs2274471-A rs2274471 0 2274471 intron 0 NR 5E-6 5.301029995663981 1.27 [1.15-1.41] Illumina [4,929,034] (imputed) N 02/27/2013 23266558 Yamazaki K 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266558 A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. Crohn's disease 372 Japanese ancestry cases and 3,389 Japanese ancestry controls Up to 1,151 Japanese ancestry cases and up to 15,800 Japanese ancestry controls 11q13.4 11 72670900 ATG16L2, FCHSD2 - 9873 rs72981516-T rs72981516 0 72981516 intron 0 0.12 4E-7 6.397940008672037 1.28 [1.27-1.29] Illumina [4,929,034] (imputed) N 02/27/2013 23266558 Yamazaki K 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266558 A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. Crohn's disease 372 Japanese ancestry cases and 3,389 Japanese ancestry controls Up to 1,151 Japanese ancestry cases and up to 15,800 Japanese ancestry controls 9q32 9 117545666 TNFSF15, LOC100129633, LOC645266, TNFSF8 203197 9966 136.96 1.25 rs6478106-T rs6478106 0 6478106 1 NR 5E-46 45.30102999566397 1.73 [1.60-1.86] Illumina [4,929,034] (imputed) N 02/27/2013 23266558 Yamazaki K 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266558 A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. Crohn's disease 372 Japanese ancestry cases and 3,389 Japanese ancestry controls Up to 1,151 Japanese ancestry cases and up to 15,800 Japanese ancestry controls 17q21.2 17 40507980 STAT3 - 6774 rs9891119-A rs9891119 0 9891119 intron 0 NR 2E-15 14.69897000433602 1.37 [1.27-1.48] Illumina [4,929,034] (imputed) N 02/27/2013 23266558 Yamazaki K 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266558 A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. Crohn's disease 372 Japanese ancestry cases and 3,389 Japanese ancestry controls Up to 1,151 Japanese ancestry cases and up to 15,800 Japanese ancestry controls 13q14.11 13 41558110 ELF1, microRNA2276, SLC25A15, WBP4 - 1997 rs7329174-G rs7329174 0 7329174 intron 0 NR 8E-9 8.096910013008056 1.27 [1.17-1.38] Illumina [4,929,034] (imputed) N 02/27/2013 23266558 Yamazaki K 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266558 A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. Crohn's disease 372 Japanese ancestry cases and 3,389 Japanese ancestry controls Up to 1,151 Japanese ancestry cases and up to 15,800 Japanese ancestry controls 4p14 4 38335823 TBC1D1 23216 79667 195.03 278.50 rs1487630-T rs1487630 0 1487630 1 NR 1E-11 11 1.33 [1.22-1.44] Illumina [4,929,034] (imputed) N 02/27/2013 23266558 Yamazaki K 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266558 A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. Crohn's disease 372 Japanese ancestry cases and 3,389 Japanese ancestry controls Up to 1,151 Japanese ancestry cases and up to 15,800 Japanese ancestry controls 1p36.11 1 25273200 RUNX3 - 864 rs7551188-T rs7551188 0 7551188 intron 0 NR 9E-6 5.045757490560675 1.18 [1.10-1.28] Illumina [4,929,034] (imputed) N 02/27/2013 23266558 Yamazaki K 12/21/2012 Gastroenterology http://www.ncbi.nlm.nih.gov/pubmed/23266558 A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. Crohn's disease 372 Japanese ancestry cases and 3,389 Japanese ancestry controls Up to 1,151 Japanese ancestry cases and up to 15,800 Japanese ancestry controls 2p25.2 2 5664008 SOX11 100240713 6664 1927.36 168.79 rs11894081-T rs11894081 0 11894081 1 0.55 4E-9 8.397940008672036 1.22 [1.2-1.22] Illumina [4,929,034] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 1p36.13 1 17306675 MFAP2 - 4237 rs2284746-? rs2284746 0 2284746 intron 0 NR 2E-11 10.69897000433602 (FEV1/FVC, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 1p36.13 1 17591679 PADI3 - 51702 rs3003429-T rs3003429 0 3003429 intron 0 NR 4E-7 6.397940008672037 (FEV1, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 6p21.32 6 32151443 AGER - 177 rs2070600-? rs2070600 0 2070600 missense 0 NR 1E-21 21 (FEV1/FVC, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 6q24.1 6 142750516 GPR126 - 57211 rs3817928-? rs3817928 0 3817928 intron 0 NR 3E-12 11.52287874528034 (FEV1/FVC, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 10q22.3 10 78315224 C10orf11 - 83938 rs11001819-? rs11001819 0 11001819 intron 0 NR 5E-8 7.30102999566398 (FEV1, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 15q23 15 71645120 THSD4 - 79875 rs12899618-? rs12899618 0 12899618 intron 0 NR 4E-21 20.39794000867204 (FEV1/FVC, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 16q23.1 16 75390316 CFDP1 - 10428 rs2865531-? rs2865531 0 2865531 intron 0 NR 2E-8 7.698970004336018 (FEV1/FVC, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 15q25.1 15 78911181 CHRNA3 - 1136 rs8040868-T rs8040868 0 8040868 cds-synon 0 NR 7E-7 6.154901959985743 (FEV1, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 6p21.33 6 30938883 DPCR1 , MUC21 135656 394263 16.89 12.60 rs9368649-A rs9368649 0 9368649 1 NR 1E-7 7 (FEV1/FVC, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 6p22.3 6 22017738 SOX4 , PRL - 401237 rs1928168-T rs1928168 0 1928168 intron 0 NR 2E-7 6.698970004336019 (FEV1/FVC, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 5q11.2 5 52179790 ITGA1 - 3672 rs2456203-T rs2456203 0 2456203 intron 0 NR 2E-7 6.698970004336019 (FEV1/FVC, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 18p11.22 18 10078071 TXNDC2 , VAPA 9218 147495 118.05 376.55 rs8089099-A rs8089099 0 8089099 1 NR 4E-7 6.397940008672037 (FEV1/FVC, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 11q13.4 11 73312252 FAM168A , PLEKHB 100874482 58473 20.65 44.97 rs10751226-T rs10751226 0 10751226 1 NR 3E-7 6.522878745280337 (FEV1/FVC, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 11q13.4 11 73036481 ARHGEF - 9828 rs2027760-A rs2027760 0 2027760 intron 0 NR 1E-6 5.999999999999999 (FEV1/FVC, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 6q25.1 6 150570867 PPP1R1 - 81706 rs3734729-A rs3734729 0 3734729 UTR-3 0 NR 4E-7 6.397940008672037 (FEV1, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 6p21.31 6 35404354 PPARD , FANCE 5467 23610 8.39 9.63 rs2206030-T rs2206030 0 2206030 1 NR 5E-7 6.30102999566398 (FEV1/FVC, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 12q21.33 12 91473798 KERA , LUM 11081 4060 21.67 23.43 rs10777288-A rs10777288 0 10777288 1 NR 5E-7 6.30102999566398 (FEV1/FVC, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 6p21.32 6 32680576 HLA-DQB1, HLA-DQA2 404026 3118 6.00 28.59 rs7764819-T rs7764819 0 7764819 1 0.89 4E-9 8.397940008672036 (FEV1/FVC, Ever-smoking) .00 [-0.04016-0.04216] unit decrease NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 2q35 2 218683154 TNS1 - 7145 rs2571445-? rs2571445 0 2571445 missense 0 NR 8E-9 8.096910013008056 (FEV1, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 2q37.3 2 239877148 HDAC4 401039 100616397 29.18 113.37 rs12477314-? rs12477314 0 12477314 1 NR 2E-7 6.698970004336019 (FEV1/FVC, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 3p24.2 3 25520582 RARB - 5915 rs1529672-? rs1529672 0 1529672 intron 0 NR 7E-11 10.15490195998574 (FEV1/FVC, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 3q26.2 3 169300219 MECOM - 2122 rs1344555-? rs1344555 0 1344555 intron 0 NR 4E-6 5.397940008672037 (FEV1, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 4q22.1 4 89869332 FAM13A - 10144 rs2869967-? rs2869967 0 2869967 intron 0 NR 5E-11 10.30102999566398 (FEV1/FVC, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 4q24 4 106808107 INTS12, GSTCD, NPNT 79807 255743 39.23 8.49 rs17331332-? rs17331332 0 17331332 1 NR 1E-16 16 (FEV1, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 4q31.21 4 145485738 HHIP 2993 391703 423.83 7.65 rs1980057-? rs1980057 0 1980057 1 NR 5E-18 17.30102999566398 (FEV1/FVC, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 5q32 5 147842353 HTR4 - 3360 rs11168048-? rs11168048 0 11168048 intron 0 NR 5E-17 16.30102999566398 (FEV1/FVC, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 5q33.3 5 156932376 ADAM19 - 8728 rs2277027-? rs2277027 0 2277027 intron 0 NR 2E-11 10.69897000433602 (FEV1/FVC, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 6p21.33 6 31568469 NCR3 259197 100130756 7.71 10.39 rs2857595-? rs2857595 0 2857595 1 NR 8E-8 7.096910013008055 (FEV1/FVC, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 6q21 6 109268050 ARMC2 - 84071 rs2798641-? rs2798641 0 2798641 intron 0 NR 2E-7 6.698970004336019 (FEV1, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 10p13 10 12277992 CDC123 - 8872 rs7068966-? rs7068966 0 7068966 intron 0 NR 2E-11 10.69897000433602 (FEV1/FVC, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 12q13.3 12 57527283 LRP1 - 4035 rs11172113-? rs11172113 0 11172113 intron 0 NR 8E-6 5.096910013008055 (FEV1/FVC, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 12q23.1 12 96271428 CCDC38 - 120935 rs1036429-? rs1036429 0 1036429 intron 0 NR 1E-7 7 (FEV1/FVC, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 16q21 16 58075282 MMP15 - 4324 rs12447804-? rs12447804 0 12447804 intron 0 NR 4E-8 7.397940008672037 (FEV1/FVC, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 16q23.1 16 78188496 WWOX - 51741 rs8056446-A rs8056446 0 8056446 intron 0 NR 8E-8 7.096910013008055 (FEV1, Pack-years NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 15q25.1 15 78911181 CHRNA3 - 1136 rs8040868-T rs8040868 0 8040868 cds-synon 0 NR 9E-8 7.045757490560674 (FEV1/FVC, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 16q23.1 16 78187903 WWOX - 51741 rs12716850-A rs12716850 0 12716850 intron 0 NR 1E-7 7 (FEV1, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 6p21.33 6 30938883 DPCR1 , MUC21 135656 394263 16.89 12.60 rs9368649-A rs9368649 0 9368649 1 NR 1E-7 7 (FEV1/FVC, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 6q25.1 6 150570867 PPP1R1 - 81706 rs3734729-A rs3734729 0 3734729 UTR-3 0 NR 7E-7 6.154901959985743 (FEV1, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 6p22.1 6 29626321 MOG - 4340 rs2252711-T rs2252711 0 2252711 intron 0 NR 4E-7 6.397940008672037 (FEV1/FVC, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 3q27.3 3 187543342 RTP2 , BCL6 604 339929 79.83 325.65 rs10513821-A rs10513821 0 10513821 1 NR 5E-7 6.30102999566398 (FEV1/FVC, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 9q33.1 9 119314217 ASTN2 - 23245;100128505 rs13290997-A rs13290997 0 13290997 intron;intron 0 NR 5E-7 6.30102999566398 (FEV1, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 2q36.3 2 230224031 DNER - 92737 rs7594321-T rs7594321 0 7594321 intron 0 0.35 3E-9 8.522878745280337 (FEV1/FVC, Ever-smoking) .02 [-0.01048-0.04048] unit decrease NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 2q36.3 2 230224031 DNER - 92737 rs7594321-T rs7594321 0 7594321 intron 0 0.35 5E-11 10.30102999566398 (FEV1/FVC, Pack-years) .00 [0.00005-0.00035] unit decrease NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 6p21.32 6 32680576 HLA-DQB1, HLA-DQA2 404026 3118 6.00 28.59 rs7764819-T rs7764819 0 7764819 1 0.89 4E-9 8.397940008672036 (FEV1/FVC, Pack-years) .00 [-0.00014-0.00025] unit decrease NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 17q24.3 17 69125606 KCNJ2, SOX9 100128390 6662 887.09 991.56 rs11654749-T rs11654749 0 11654749 1 0.39 1E-8 8 (FEV1, Ever-smoking) .02 [-0.00848-0.04248] unit decrease NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 17q24.3 17 69125606 KCNJ2, SOX9 100128390 6662 887.09 991.56 rs11654749-T rs11654749 0 11654749 1 0.39 7E-8 7.154901959985742 (FEV1, Pack-years) .00 [-0.00008-0.00018] unit increase NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 9q22.32 9 98231008 PTCH1 - 5727;100507346 rs16909898-? rs16909898 0 16909898 intron;ncRNA 0 NR 8E-12 11.09691001300806 (FEV1/FVC, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 6p22.3 6 21996860 SOX4 , PRL - 401237 rs2078543-A rs2078543 0 2078543 intron 0 NR 2E-7 6.698970004336019 (FEV1/FVC, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 2p24.3 2 15926168 DDX1 , MYCN 1653 130678 154.93 83.77 rs2544527-T rs2544527 0 2544527 1 NR 2E-7 6.698970004336019 (FEV1/FVC, Pack-years) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 18p11.22 18 10078071 TXNDC2 , VAPA 9218 147495 118.05 376.55 rs8089099-A rs8089099 0 8089099 1 NR 3E-7 6.522878745280337 (FEV1/FVC, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 11q13.4 11 73312252 FAM168A , PLEKHB 100874482 58473 20.65 44.97 rs10751226-T rs10751226 0 10751226 1 NR 4E-7 6.397940008672037 (FEV1/FVC, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 11q13.4 11 73036481 ARHGEF - 9828 rs2027760-A rs2027760 0 2027760 intron 0 NR 4E-7 6.397940008672037 (FEV1/FVC, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 02/27/2013 23284291 Hancock DB 12/20/2012 PLoS Genet http://www.ncbi.nlm.nih.gov/pubmed/23284291 Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Pulmonary function (interaction) 50,047 European ancestry individuals NR 2q36.3 2 229510929 PID1 80309 100270941 464.57 357.67 rs1435867-? rs1435867 0 1435867 1 NR 2E-9 8.698970004336019 (FEV1/FVC, Ever-smoking) NR NR NR [~2.5 Million] (imputed) N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Hematology traits 7,943 African American children, 6,234 European ancestry children NR 6q23.3 6 135419018 HBS1L, MYB 10767 4602 42.98 83.44 rs9399137-T rs9399137 0 9399137 1 NR 3E-6 5.522878745280337 (RBC) .04 [0.021-0.051] unit increase Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Hematology traits 7,943 African American children, 6,234 European ancestry children NR 6p21.33 6 31058340 MUC21, HCG22, C6orf15, CDSN, PSORS1C1, PSORS1C2, CCHCR1 285834 29113 30.67 20.66 rs3130544-A rs3130544 0 3130544 1 NR 5E-7 6.30102999566398 (WBC) .02 [0.011-0.026] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Hematology traits 7,943 African American children, 6,234 European ancestry children NR 1q23.3 1 161946727 DARC 22926 25903 12.87 6.26 rs2340727-A rs2340727 0 2340727 1 NR 2E-23 22.69897000433602 (WBC) .02 [0.018-0.027] unit increase Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Hematology traits 7,943 African American children, 6,234 European ancestry children NR 6p22.2 6 26093141 HFE - 3077 rs1800562-A rs1800562 0 1800562 missense 0 NR 2E-6 5.698970004336018 (HGB) .19 [0.11-0.27] unit increase Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Hematology traits 7,943 African American children, 6,234 European ancestry children NR 11p15.4 11 5303063 HBE1, HBB, HBD, HBBP1, HBG1 3046 403265 11.69 9.63 rs2213169-T rs2213169 0 2213169 1 0.1362 5E-11 10.30102999566398 (AA, HCT) .45 [0.31-0.58] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Hematology traits 7,943 African American children, 6,234 European ancestry children NR 16p13.3 16 240280 Alpha-globin cluster - 55692 rs1211375-A rs1211375 0 1211375 intron 0 NR 7E-14 13.15490195998574 (RBC) .04 [0.031-0.053] unit increase Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Hematology traits 7,943 African American children, 6,234 European ancestry children NR 16p13.3 16 184390 Alpha-globin cluster - 8131 rs7203560-G rs7203560 0 7203560 intron 0 0.06801 2E-23 22.69897000433602 (AA, RBC) .15 [0.12-0.17] unit increase Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Hematology traits 7,943 African American children, 6,234 European ancestry children NR Xq28 23 154014107 MPP1 - 4354 rs5987027-T rs5987027 0 5987027 intron 0 0.2462 1E-11 11 (AA, RBC) .07 [0.053-0.096] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Hematology traits 7,943 African American children, 6,234 European ancestry children NR 1q23.1 1 158971086 DARC 149628 3428 24.24 8.60 rs4657616-G rs4657616 0 4657616 1 0.099 5E-47 46.30102999566398 (AA, WBC) .06 [0.053-0.07] unit increase Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Hematology traits 7,943 African American children, 6,234 European ancestry children NR 6p21.33 6 31940897 ZBTB12, CFB, STK19 - 1797;8859 rs389884-C rs389884 0 389884 nearGene-5;intron 0 0.0953 2E-8 7.698970004336018 (EA, WBC) .03 [0.017-0.034] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Hematology traits 7,943 African American children, 6,234 European ancestry children NR 22q12.3 22 37462936 TMPRSS6 - 164656 rs855791-T rs855791 0 855791 missense 0 0.4408 3E-8 7.522878745280337 (HGB) .09 [0.058-0.121] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Hematology traits 7,943 African American children, 6,234 European ancestry children NR 16p13.3 16 184390 Alpha-globin cluster - 8131 rs7203560-G rs7203560 0 7203560 intron 0 0.06801 2E-8 7.698970004336018 (AA, HGB) .20 [0.13-0.27] unit decrease Illumina [544,917] N 03/20/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular hemoglobin 7,943 African American children, 6,234 European ancestry children NR 16p13.3 16 240280 Alpha-globin cluster - 55692 rs1211375-A rs1211375 0 1211375 intron 0 NR 3E-17 16.52287874528034 .21 [0.16-0.26] unit decrease Illumina [544,917] N 03/20/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular hemoglobin 7,943 African American children, 6,234 European ancestry children NR 6q23.3 6 135419018 HBS1L, MYB 10767 4602 42.98 83.44 rs9399137-T rs9399137 0 9399137 1 NR 4E-15 14.39794000867204 .25 [0.19-0.31] unit decrease Illumina [544,917] N 03/20/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular hemoglobin 7,943 African American children, 6,234 European ancestry children NR 6p22.2 6 26093141 HFE - 3077 rs1800562-A rs1800562 0 1800562 missense 0 NR 7E-9 8.154901959985743 .36 [0.24-0.48] unit increase Illumina [544,917] N 03/20/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular hemoglobin 7,943 African American children, 6,234 European ancestry children NR 6q24.1 6 139835689 CITED2 10370 645440 139.90 99.89 rs668459-T rs668459 0 668459 1 NR 9E-9 8.045757490560675 .14 [0.092-0.186] unit decrease Illumina [544,917] N 03/20/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular hemoglobin 7,943 African American children, 6,234 European ancestry children NR 9p24.1 9 4845520 RCL1 - 10171 rs10815094-A rs10815094 0 10815094 intron 0 NR 5E-6 5.301029995663981 .15 [0.083-0.209] unit increase Illumina [544,917] N 03/20/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular hemoglobin 7,943 African American children, 6,234 European ancestry children NR 22q12.3 22 37462936 TMPRSS6 - 164656 rs855791-T rs855791 0 855791 missense 0 NR 2E-6 5.698970004336018 (AA) NR NR Illumina [544,917] N 03/20/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular hemoglobin 7,943 African American children, 6,234 European ancestry children NR 16p13.3 16 184390 Alpha-globin cluster - 8131 rs7203560-G rs7203560 0 7203560 intron 0 0.06801 5E-62 61.30102999566397 (AA) 1.26 [1.11-1.4] unit decrease Illumina [544,917] N 03/20/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular hemoglobin 7,943 African American children, 6,234 European ancestry children NR 22q12.3 22 37462936 TMPRSS6 - 164656 rs855791-T rs855791 0 855791 missense 0 0.4408 5E-14 13.30102999566398 (EA) .23 [0.17-0.3] unit decrease Illumina [544,917] N 03/20/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular hemoglobin 7,943 African American children, 6,234 European ancestry children NR 6q23.3 6 135418635 HBS1L, MYB 10767 4602 42.60 83.82 rs7775698-T rs7775698 0 7775698 1 0.2615 4E-13 12.39794000867204 (EA) .25 [0.19-0.32] unit increase Illumina [544,917] N 03/20/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular hemoglobin 7,943 African American children, 6,234 European ancestry children NR 22q12.3 22 37462936 TMPRSS6 - 164656 rs855791-T rs855791 0 855791 missense 0 0.4408 7E-19 18.15490195998574 .23 [0.18-0.28] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular hemoglobin concentration 7,943 African American children, 6,234 European ancestry children NR 6q23.3 6 135426573 HBS1L, MYB 10767 4602 50.54 75.88 rs4895441-A rs4895441 0 4895441 1 NR 3E-6 5.522878745280337 .09 [0.054-0.132] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular hemoglobin concentration 7,943 African American children, 6,234 European ancestry children NR 22q12.3 22 37462936 TMPRSS6 - 164656 rs855791-T rs855791 0 855791 missense 0 0.4408 4E-7 6.397940008672037 .09 [0.054-0.121] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular hemoglobin concentration 7,943 African American children, 6,234 European ancestry children NR 11p15.4 11 5303063 HBE1, HBB, HBD, HBBP1, HBG1 3046 403265 11.69 9.63 rs2213169-T rs2213169 0 2213169 1 0.1362 1E-13 13 (AA) .22 [0.16-0.28] unit increase Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular hemoglobin concentration 7,943 African American children, 6,234 European ancestry children NR 16p13.3 16 184390 Alpha-globin cluster - 8131 rs7203560-G rs7203560 0 7203560 intron 0 0.06801 1E-33 32.99999999999999 (AA) .53 [0.45-0.62] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular hemoglobin concentration 7,943 African American children, 6,234 European ancestry children NR 1q32.1 1 203651927 ATP2B4 - 493 rs1541252-? rs1541252 0 1541252 UTR-5 0 NR 9E-8 7.045757490560674 NR NR Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular hemoglobin concentration 7,943 African American children, 6,234 European ancestry children NR 16p13.3 16 580124 Alpha-globin cluster - 6650 rs2266928-A rs2266928 0 2266928 intron 0 NR 3E-11 10.52287874528034 .12 [0.083-0.152] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular volume 7,943 African American children, 6,234 European ancestry children NR Xq28 23 154014107 MPP1 - 4354 rs5987027-T rs5987027 0 5987027 intron 0 0.2462 4E-10 9.397940008672037 (AA) .92 [0.63-1.2] unit increase Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular volume 7,943 African American children, 6,234 European ancestry children NR 9p24.1 9 4844265 RCL1 - 10171 rs2236496-T rs2236496 0 2236496 intron 0 NR 2E-7 6.698970004336019 .42 [0.26-0.57] unit increase Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular volume 7,943 African American children, 6,234 European ancestry children NR 6p21.1 6 41905275 USP49, MED20, BYSL, CCND3 - 896 rs3218097-T rs3218097 0 3218097 intron 0 NR 9E-8 7.045757490560674 .42 [0.27-0.58] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular volume 7,943 African American children, 6,234 European ancestry children NR 6q24.1 6 139835689 CITED2 10370 645440 139.90 99.89 rs668459-T rs668459 0 668459 1 NR 4E-8 7.397940008672037 .34 [0.22-0.46] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular volume 7,943 African American children, 6,234 European ancestry children NR 6q23.3 6 135419018 HBS1L, MYB 10767 4602 42.98 83.44 rs9399137-T rs9399137 0 9399137 1 NR 1E-11 11 .55 [0.39-0.71] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular volume 7,943 African American children, 6,234 European ancestry children NR 22q12.3 22 37462936 TMPRSS6 - 164656 rs855791-T rs855791 0 855791 missense 0 0.4408 7E-12 11.15490195998574 .46 [0.33-0.59] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular volume 7,943 African American children, 6,234 European ancestry children NR 22q12.3 22 37462936 TMPRSS6 - 164656 rs855791-T rs855791 0 855791 missense 0 0.4408 2E-9 8.698970004336019 (EA) .48 [0.32-0.64] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular volume 7,943 African American children, 6,234 European ancestry children NR 6q23.3 6 135418635 HBS1L, MYB 10767 4602 42.60 83.82 rs7775698-T rs7775698 0 7775698 1 0.2615 2E-9 8.698970004336019 (EA) .54 [0.37-0.72] unit increase Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular volume 7,943 African American children, 6,234 European ancestry children NR 16p13.3 16 184390 Alpha-globin cluster - 8131 rs7203560-G rs7203560 0 7203560 intron 0 0.06801 8E-43 42.09691001300805 (AA) 2.56 [2.19-2.92] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Mean corpuscular volume 7,943 African American children, 6,234 European ancestry children NR 16p13.3 16 240280 Alpha-globin cluster - 55692 rs1211375-A rs1211375 0 1211375 intron 0 NR 1E-16 16 .53 [0.4-0.65] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Platelet counts 7,943 African American children, 6,234 European ancestry children NR 6p21.31 6 33540209 BAK1 - 578 rs210134-A rs210134 0 210134 nearGene-3 0 0.2675 2E-8 7.698970004336018 (AA) 8.92 [5.82-12.02] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Platelet counts 7,943 African American children, 6,234 European ancestry children NR 3p14.3 3 56849749 ARHGEF3 - 50650 rs1354034-T rs1354034 0 1354034 intron 0 0.4092 4E-9 8.397940008672036 (EA) 9.44 [6.3-12.59] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Platelet counts 7,943 African American children, 6,234 European ancestry children NR 3p14.3 3 56849749 ARHGEF3 - 50650 rs1354034-T rs1354034 0 1354034 intron 0 NR 1E-19 19 10.44 [8.18-12.69] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Platelet counts 7,943 African American children, 6,234 European ancestry children NR 12q13.13 12 54736470 COPZ1 - 22818 rs4326844-A rs4326844 0 4326844 intron 0 0.4493 5E-8 7.30102999566398 (EA) 8.68 [5.57-11.79] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Platelet counts 7,943 African American children, 6,234 European ancestry children NR 3p14.3 3 56849749 ARHGEF3 - 50650 rs1354034-C rs1354034 0 1354034 intron 0 0.27 9E-13 12.04575749056067 (AA) 11.44 [8.31-14.57] unit increase Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Platelet counts 7,943 African American children, 6,234 European ancestry children NR 6p21.31 6 33541719 BAK1 - 578 rs513349-A rs513349 0 513349 intron 0 NR 2E-12 11.69897000433602 7.75 [5.59-9.92] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Platelet counts 7,943 African American children, 6,234 European ancestry children NR 9p24.1 9 4834394 RCL1 - 10171 rs457287-A rs457287 0 457287 intron 0 NR 1E-6 5.999999999999999 5.99 [3.55-8.42] unit decrease Illumina [544,917] N 03/15/2013 23263863 Li J 12/20/2012 Hum Mol Genet http://www.ncbi.nlm.nih.gov/pubmed/23263863 GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children. Platelet counts 7,943 African American children, 6,234 European ancestry children NR 10q21.3 10 64963449 JMJD1C - 221037 rs4379723-T rs4379723 0 4379723 intron 0 NR 7E-7 6.154901959985743 5.43 [3.28-7.58] unit decrease Illumina [544,917] N 02/23/2013 23255317 Wooten EC 12/19/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23255317 Formin homology 2 domain containing 3 variants associated with hypertrophic cardiomyopathy. Hypertrophic cardiomyopathy 174 European ancestry cases, 823 European ancestry controls 1,012 European ancestry cases, 1,326 European ancestry controls NR NR - NR NR NR NS NS NR NR Illumina [311,399] N 03/06/2013 23247145 Makela KM 12/17/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23247145 Genome-wide association study pinpoints a new functional apolipoprotein B variant influencing oxidized low-density lipoprotein levels but not cardiovascular events: AtheroRemo Consortium. LDL (oxidized) 2,080 European ancestry individuals 4,238 European ancestry individuals 2p24.1 2 21231524 apoB - 338 rs676210-G rs676210 0 676210 missense 0 0.77 3E-47 46.52287874528033 10.50 (U/L increase) Illumina [2,543,887] (imputed) N 03/11/2013 23242368 Jiang DK 12/16/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23242368 Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. Hepatocellular carcinoma (hepatitis B virus related) 1,161 Chinese ancestry cases, 1,353 Chinese ancestry controls 4,319 Chinese ancestry cases, 4,966 Chinese ancestry controls 6p21.32 6 32666295 HLA-DQ 3119 404026 31.83 7.63 rs9275319-A rs9275319 0 9275319 1 0.88 3E-17 16.52287874528034 1.49 [1.36-1.63] Illumina (1,672,517) imputed N 03/11/2013 23242368 Jiang DK 12/16/2012 Nat Genet http://www.ncbi.nlm.nih.gov/pubmed/23242368 Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. Hepatocellular carcinoma (hepatitis B virus related) 1,161 Chinese ancestry cases, 1,353 Chinese ancestry controls 4,319 Chinese ancestry cases, 4,966 Chinese ancestry controls 2q32.3 2 191964633 STAT4 - 6775 rs7574865-G rs7574865 0 7574865 intron 0 0.67 2E-10 9.698970004336017 1.21 [1.14-1.28] Illumina (1,672,517) imputed N 02/27/2013 23247143 Yu B 12/16/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23247143 Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Cardiac Troponin-T levels 9,491 European ancestry individuals, up to 2,053 African American individuals NR 8q13.3 8 71386904 NCOA2, TRAM1 100271077 100130225 50.05 31.59 rs10091374-A rs10091374 0 10091374 1 NR 9E-9 8.045757490560675 (Continous Variable) .04 [0.027-0.059] ug/L decrease Affymetrix and Illumina [~2.5 Million] (imputed) N 02/27/2013 23247143 Yu B 12/16/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23247143 Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Cardiac Troponin-T levels 9,491 European ancestry individuals, up to 2,053 African American individuals NR 2p16.3 2 52713807 LOC129656 100419682 100616431 409.23 215.85 rs1526687-T rs1526687 0 1526687 1 NR 5E-6 5.301029995663981 (Continous Variable) .04 [0.02-0.06] ug/L increase Affymetrix and Illumina [~2.5 Million] (imputed) N 02/27/2013 23247143 Yu B 12/16/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23247143 Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Cardiac Troponin-T levels 9,491 European ancestry individuals, up to 2,053 African American individuals NR 18q22.1 18 62884918 CDH7 100271410 1005 1145.03 532.57 rs605920-C rs605920 0 605920 1 NR 6E-6 5.221848749616356 (Continous Variable) .04 [0.02-0.05] ug/L decrease Affymetrix and Illumina [~2.5 Million] (imputed) N 02/27/2013 23247143 Yu B 12/16/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23247143 Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Cardiac Troponin-T levels 9,491 European ancestry individuals, up to 2,053 African American individuals NR 18q21.33 18 60859321 BCL2 - 596 rs899967-C rs899967 0 899967 intron 0 NR 7E-6 5.154901959985742 (Continous Variable) .04 [0.02-0.05] ug/L decrease Affymetrix and Illumina [~2.5 Million] (imputed) N 02/27/2013 23247143 Yu B 12/16/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23247143 Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Cardiac Troponin-T levels 9,491 European ancestry individuals, up to 2,053 African American individuals NR 1q32.1 1 201345487 TNNT2 - 7139 rs12564445-A rs12564445 0 12564445 intron 0 NR 5E-8 7.30102999566398 (Dichotomous variable) 2.33 [1.72-3.16] Affymetrix and Illumina [~2.5 Million] (imputed) N 02/27/2013 23247143 Yu B 12/16/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23247143 Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Cardiac Troponin-T levels 9,491 European ancestry individuals, up to 2,053 African American individuals NR 1p31.1 1 74054060 LRRIQ3 126811 127255 481.89 437.64 rs2341260-T rs2341260 0 2341260 1 NR 4E-6 5.397940008672037 (Continous Variable) .05 [0.03-0.07] ug/L decrease Affymetrix and Illumina [~2.5 Million] (imputed) N 02/27/2013 23247143 Yu B 12/16/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23247143 Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Cardiac Troponin-T levels 9,491 European ancestry individuals, up to 2,053 African American individuals NR NR NRG1 - rs74733271-A rs74733271 NR 5E-6 5.301029995663981 (Continous Variable) .04 [0.02-0.06] ug/L increase Affymetrix and Illumina [~2.5 Million] (imputed) N 02/27/2013 23247143 Yu B 12/16/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23247143 Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Cardiac Troponin-T levels 9,491 European ancestry individuals, up to 2,053 African American individuals NR 1q32.1 1 201345487 TNNT2 - 7139 rs12564445-A rs12564445 0 12564445 intron 0 NR 5E-8 7.30102999566398 (Dichotomous variable) 2.33 [1.72-3.16] Affymetrix and Illumina [~2.5 Million] (imputed) N 02/27/2013 23247143 Yu B 12/16/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23247143 Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Cardiac Troponin-T levels 9,491 European ancestry individuals, up to 2,053 African American individuals NR 11q25 11 131807171 HNT - 50863 rs12098973-G rs12098973 0 12098973 intron 0 NR 1E-6 5.999999999999999 (Dichotomous variable) 2.17 [1.59-3.03] Affymetrix and Illumina [~2.5 Million] (imputed) N 02/27/2013 23247143 Yu B 12/16/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23247143 Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Cardiac Troponin-T levels 9,491 European ancestry individuals, up to 2,053 African American individuals NR 2p25.1 2 10903412 ATP6V1C2 - 245973 rs1198872-T rs1198872 0 1198872 intron 0 NR 2E-6 5.698970004336018 (Dichotomous variable) 2.04 [1.51-2.74] Affymetrix and Illumina [~2.5 Million] (imputed) N 02/27/2013 23247143 Yu B 12/16/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23247143 Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Cardiac Troponin-T levels 9,491 European ancestry individuals, up to 2,053 African American individuals NR 1p36.21 1 16080171 FBLIM1 388595 54751 5.69 5.08 rs12725198-A rs12725198 0 12725198 1 NR 3E-6 5.522878745280337 (Dichotomous variable) 1.85 [1.43-2.39] Affymetrix and Illumina [~2.5 Million] (imputed) N 02/27/2013 23247143 Yu B 12/16/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23247143 Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Cardiac Troponin-T levels 9,491 European ancestry individuals, up to 2,053 African American individuals NR 3q21.1 3 122014566 CASR 846 100130002 9.22 21.89 rs13083990-T rs13083990 0 13083990 1 NR 4E-6 5.397940008672037 (Dichotomous variable) 2.66 [1.76-4.02] Affymetrix and Illumina [~2.5 Million] (imputed) N 02/27/2013 23247143 Yu B 12/16/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23247143 Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Cardiac Troponin-T levels 9,491 European ancestry individuals, up to 2,053 African American individuals NR 4q23 4 100163873 CXCL13 - 100507053 rs2201728-G rs2201728 0 2201728 intron 0 NR 5E-6 5.301029995663981 (Dichotomous variable) 3.13 [1.92-5] Affymetrix and Illumina [~2.5 Million] (imputed) N 02/27/2013 23247143 Yu B 12/16/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23247143 Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Cardiac Troponin-T levels 9,491 European ancestry individuals, up to 2,053 African American individuals NR 6q23.3 6 138266685 TNFAIP3 7128 100270919 62.23 49.72 rs9321637-C rs9321637 0 9321637 1 NR 8E-6 5.096910013008055 (Dichotomous variable) 2.17 [1.56-3.13] Affymetrix and Illumina [~2.5 Million] (imputed) N 02/27/2013 23247143 Yu B 12/16/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23247143 Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Cardiac Troponin-T levels 9,491 European ancestry individuals, up to 2,053 African American individuals NR 18p11.31 18 3512216 DLGAP1 - 9229 rs17724172-C rs17724172 0 17724172 intron 0 NR 9E-6 5.045757490560675 (Dichotomous variable) 2.04 [1.49-2.78] Affymetrix and Illumina [~2.5 Million] (imputed) N 02/27/2013 23247143 Yu B 12/16/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23247143 Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Cardiac Troponin-T levels 9,491 European ancestry individuals, up to 2,053 African American individuals NR 10q26.13 10 125207501 GPR26 100128168 2849 275.34 218.37 rs17666963-T rs17666963 0 17666963 1 NR 9E-6 5.045757490560675 (Dichotomous variable) 2.28 [1.58-3.28] Affymetrix and Illumina [~2.5 Million] (imputed) N 02/27/2013 23247143 Yu B 12/16/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23247143 Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Cardiac Troponin-T levels 9,491 European ancestry individuals, up to 2,053 African American individuals NR 6p22.1 6 28020820 OR2B7P 81695 65944 5.67 .09 rs172166-C rs172166 0 172166 1 NR 5E-6 5.301029995663981 (Continous Variable) .04 [0.04-0.06] ug/L decrease Affymetrix and Illumina [~2.5 Million] (imputed) N 02/27/2013 23247143 Yu B 12/16/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23247143 Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Cardiac Troponin-T levels 9,491 European ancestry individuals, up to 2,053 African American individuals NR 2q11.2 2 96841793 STARD7 1844 56910 30.61 8.80 rs11886999-T rs11886999 0 11886999 1 NR 8E-6 5.096910013008055 (Continous Variable) .04 [0.02-0.06] ug/L increase Affymetrix and Illumina [~2.5 Million] (imputed) N 02/27/2013 23247143 Yu B 12/16/2012 Circ Cardiovasc Genet http://www.ncbi.nlm.nih.gov/pubmed/23247143 Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Cardiac Troponin-T levels 9,491 European ancestry individuals, up to 2,053 African American individuals NR 8p21.1 8 27905888 C8orf80 - 389643 rs6983473-A rs6983473 0 6983473 intron 0 NR 4E-6 5.397940008672037 (Continous Variable) .04 [0.02-0.06] ug/L decrease Affymetrix and Illumina [~2.5 Million] (imputed) N 02/27/2013 23237013 Power RA 12/14/2012 Psychol Med http://www.ncbi.nlm.nih.gov/pubmed/23237013 Estimating the heritability of reporting stressful life events captured by common genetic variants. Reporting of stressful life event 2,578 European ancestry individuals with and without depression 864 European ancestry individuals with depression, 257 European ancestry individuals without depression NR NR - NR NR NR NS NS NR NR Illumina [541,628] N 02/19/2013 23241943 Clark SL 12/12/2012 Pharmacogenet Genomics http://www.ncbi.nlm.nih.gov/pubmed/23241943 Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment. Response to antipsychotic treatment Up to 421 European ancestry Schizophrenia cases, up to 214 African American individuals, up to 103 individuals NR 11q14.1 11 80058479 Intergenic 100847000 729790 925.21 305.99 rs7395555-C rs7395555 0 7395555 1 0.145 2E-7 6.698970004336019 (Effect of Ziprasidone on CGI-S) NR NR Affymetrix [492,900] N 02/19/2013 23241943 Clark SL 12/12/2012 Pharmacogenet Genomics http://www.ncbi.nlm.nih.gov/pubmed/23241943 Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment. Response to antipsychotic treatment Up to 421 European ancestry Schizophrenia cases, up to 214 African American individuals, up to 103 individuals NR 2q22.1 2 139278922 SPOPL - 339745 rs10170310-G rs10170310 0 10170310 intron 0 0.213 1E-7 7 (Effect of Olanzapine on PGI) NR NR Affymetrix [492,900] N 02/19/2013 23241943 Clark SL 12/12/2012 Pharmacogenet Genomics http://www.ncbi.nlm.nih.gov/pubmed/23241943 Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment. Response to antipsychotic treatment Up to 421 European ancestry Schizophrenia cases, up to 214 African American individuals, up to 103 individuals NR 5q12.1 5 58979946 PDE4D - 5144 rs17382202-T rs17382202 0 17382202 intron 0 0.153 4E-8 7.397940008672037 (Effect of Quetiapine on PGI) NR NR Affymetrix [492,900] N 02/19/2013 23241943 Clark SL 12/12/2012 Pharmacogenet Genomics http://www.ncbi.nlm.nih.gov/pubmed/23241943 Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment. Response to antipsychotic treatment Up to 421 European ancestry Schizophrenia cases, up to 214 African American individuals, up to 103 individuals NR 4q24 4 106297513 PPA2 - 27068 rs2636697-G rs2636697 0 2636697 intron 0 0.038 4E-7 6.397940008672037 (Effect of Risperidone on CGI-S) NR NR Affymetrix [492,900] N 02/19/2013 23241943 Clark SL 12/12/2012 Pharmacogenet Genomics http://www.ncbi.nlm.nih.gov/pubmed/23241943 Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment. Response to antipsychotic treatment Up to 421 European ancestry Schizophrenia cases, up to 214 African American individuals, up to 103 individuals NR 1q23.2 1 160077854 ATP1A2 93185 477 9.24 7.67 rs6688363-T rs6688363 0 6688363 1 0.166 2E-7 6.698970004336019 (Effect of Olanzapine on CGI-S) NR NR Affymetrix [492,900] N 02/19/2013 23241943 Clark SL 12/12/2012 Pharmacogenet Genomics http://www.ncbi.nlm.nih.gov/pubmed/23241943 Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment. Response to antipsychotic treatment Up to 421 European ancestry Schizophrenia cases, up to 214 African American individuals, up to 103 individuals NR 16q21 16 66158736 Intergenic 1009 1003 1002.82 241.79 rs8050896-T rs8050896 0 8050896 1 0.161 4E-8 7.397940008672037 (Effect of Risperidone on CGI-S) NR NR Affymetrix [492,900] N 02/19/2013 23241943 Clark SL 12/12/2012 Pharmacogenet Genomics http://www.ncbi.nlm.nih.gov/pubmed/23241943 Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment. Response to antipsychotic treatment Up to 421 European ancestry Schizophrenia cases, up to 214 African American individuals, up to 103 individuals NR 18q21.33 18 60080112 TNFRSF11A 8792 100129584 25.17 2.77 rs2980976-A rs2980976 0 2980976 1 0.168 3E-7 6.522878745280337 (Effect of Risperidone on CGI-S) NR NR Affymetrix [492,900] N 02/19/2013 23241943 Clark SL 12/12/2012 Pharmacogenet Genomics http://www.ncbi.nlm.nih.gov/pubmed/23241943 Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment. Response to antipsychotic treatment Up to 421 European ancestry Schizophrenia cases, up to 214 African American individuals, up to 103 individuals NR 15q13.1 15 30193468 TJP1 7082 283698 78.76 143.18 rs711355-T rs711355 0 711355 1 0.33 2E-7 6.698970004336019 (Effect of Risperidone on PGI) NR NR Affymetrix [492,900] N 02/19/2013 23229837 Aragam N 12/11/2012 J Mol Neurosci http://www.ncbi.nlm.nih.gov/pubmed/23229837 TMPRSS9 and GRIN2B Are Associated with Neuroticism: a Genome-Wide Association Study in a European Sample. Neuroticism 2,748 European ancestry cases NR 19p13.3 19 2410484 TMPRSS9 - 360200 rs4806846-A rs4806846 0 4806846 intron 0 0.14 8E-6 5.096910013008055 NR NR Perlegen [437,547] N 03/15/2013 23233662 Ramsey LB 12/11/20