Frequently Asked Questions
What is circular RNA? Why is it important?
Circular RNAs are formed by covalent linkage of the ends of a single RNA molecule. Animal genomes express many circular RNAs from diverse genomic locations (from coding and non- coding exons, intergenic regions or transcripts antisense to 5' and 3' UTRs). Recently Memczak et al and his group have identified 2000 human, 1900 mouse and 700 nematode circular RNA from RNA sequencing data.
Circular RNAs are targeted by endogenous miRNAs. Circular RNAs play a critical role in fine-tuning the level of miRNA mediated regulation of gene expression by sequestering the miRNAs. From their potential interaction with disease associated miRNAs it is speculated that they may have a role in disease regulation.
How the association between human circular RNAs and diseases was found?
We studied the potential association of reported circular RNAs with human diseases by two different approaches. Firstly, we studied the potential interaction of circular RNAs with disease associated miRNAs and secondly we studied disease and traits associated variations in the circular RNA loci.
How can I assess the likelihood of a circRNA to be associated with a particular disease?
we implemented a measure for showing the likelihood of a circRNA to be associated with a disease. While searching for the disease associated circRNAs, the users will see only the circRNAs with greater likelihood (p-value<0.01, calculated using hypergeometric test) for the disease association.
How can I visualize the circRNA-miRNA-mRNA-lncRNA interactome network for individual diseases?
Search by a particular disease name. The result page contains a small thumbnail image of the network. Click on the thumbnail. The resulting page contains a link for downloading the network image (above the interaction table). Click on the download link to download the network image in pdf format.
How can I view the GO enrichment for the genes involved in a particular disease?
Search by disease name. The result page contains a small thumbnail graph depicting the GO enrichment. Click on the thumbnail to download a word file that contains detailed information about the results from our GO enrichment analysis for the particular disease.
How can I get the information about disease associated SNPs on a circRNA?
Search by keyword for a particular trait or search by the circRNA name to see the GWAS associated SNPs identified in that circRNA loci.